Quadrature LC VCO with passive coupling and phase combining network

A circuit and method for generating a signal is disclosed. The circuit includes a set of wide tuning LC tanks, a set of core transistors cross coupled to the set of wide tuning LC tanks, and a combining network coupled to the set of wide tuning LC tanks and the set of core transistors. The combining network further includes a set of inputs connected to the set of wide tuning LC tanks and the set of core transistors, a set of coupling transistors connected to the set of inputs, a set of source inductors connected to the set of coupling transistors, a coupling capacitor connected to the set of source inductors, a load resistor connected to the coupling capacitor. The combining network combines the set of inputs and the signal is delivered to the load resistor as a fourth order harmonic.Board of Regents, University of Texas Syste

Karonda and Jamun seeds’ in vitro anticancer efficacy

573-578In the search for potential anticancer agents from fruits, the present research work was carried out to examine the in vitro cytotoxic potential of seed part of Carissa carandas (karonda) and Syzygium cumini (jamun) against nine human cancer cell lines from eight different origins namely MCF-7, T-47D (breast), SF-295 (CNS), HCT-116 (colon), A-549 (lung), MDA-MB-435 (melanoma), OVCAR-5 (ovary), PC-3 (prostate) and A-498 (renal). Methanolic extracts were used as test material and anticancer activity was determined via SRB assayat 100 μg/mL. Results revealed that seeds suppressed the proliferation of human cancer cells with growth inhibition range of 78-100% (karonda) and 71-93% (jamun). Karonda seeds exhibited 100% growth inhibition of A-549 and OVCAR-5 cancer cells where as jamun seeds displayed 93% growth inhibition of SF-295 cancer cells. The seeds were then evaluated at lower concentrations of 50, 30, 10 and 1 μg/mL in which seeds exhibit significant in vitro cytotoxic effect against lung cancer cells (A-549). Further, IC50 values were calculated and it was observed that seed extracts from both the fruits showed IC50karonda seed extract also showed IC50karonda and jamun seeds possess certain constituents with cytotoxic properties that can be used to develop anticancer agents especially for lung cancer therapy and to provide a great service to cancer patients, further studies are required for the isolation of active ingredients from these seeds

Karonda and Jamun seeds’ in vitro anticancer efficacy

In the search for potential anticancer agents from fruits, the present research work was carried out to examine the in vitro cytotoxic potential of seed part of Carissa carandas (karonda) and Syzygium cumini (jamun) against nine human cancer cell lines from eight different origins namely MCF-7, T-47D (breast), SF-295 (CNS), HCT-116 (colon), A-549 (lung), MDA-MB-435 (melanoma), OVCAR-5 (ovary), PC-3 (prostate) and A-498 (renal). Methanolic extracts were used as test material and anticancer activity was determined via SRB assayat 100 μg/mL. Results revealed that seeds suppressed the proliferation of human cancer cells with growth inhibition range of 78-100% (karonda) and 71-93% (jamun). Karonda seeds exhibited 100% growth inhibition of A-549 and OVCAR-5 cancer cells where as jamun seeds displayed 93% growth inhibition of SF-295 cancer cells. The seeds were then evaluated at lower concentrations of 50, 30, 10 and 1 μg/mL in which seeds exhibit significant in vitro cytotoxic effect against lung cancer cells (A-549). Further, IC50 values were calculated and it was observed that seed extracts from both the fruits showed IC50<10 in case of lung cancer cells whereas karonda seed extract also showed IC50<10 in case of colon cancer cells. To conclude, karonda and jamun seeds possess certain constituents with cytotoxic properties that can be used to develop anticancer agents especially for lung cancer therapy and to provide a great service to cancer patients, further studies are required for the isolation of active ingredients from these seeds

Impact of Salt Stress on Carbohydrate Metabolism in Cicer Arietinum L.

Cereals are used as an important food of Indian diet. They are an important source of carbohydrates and proteins, so they are essential to a predominant diet. Chickpea (Cicer arietinum L.) is one of the important crops of India, mainly grown for their seeds which contain 20.6% protein, 2.2% fat and 61.2% carbohydrate, ranking next to wheat and barley both in acreage and in the production of grain. The major portion of crop production is consumed by the people in many forms like Dal, Besan, Crushed or whole grain, boiled or roasted gram or in sweet preparation. It is also used as a protein-rich diet for horses, and other cattle in the forms of soaked grain. Keeping the above views several Cicer varieties will be screened for their salt tolerance behaviour. Salt tolerant and salt susceptible variety will be selected for further comparative studies to expect that the findings of the present investigation would not only help with a better understanding of the mechanism of salt tolerant behaviour of Cicer at the physiological and biochemical levels and also suggest possibilities of selecting a variety suitable for salt stress condition

Impact of Salt stress on Carbohydrate Metabolism in Cicer arietinum L.

Cereals are used as an important food of Indian diet. They are an important source of carbohydrates and proteins, so they are essential to a predominant diet. Chickpea (Cicer arietinum L.) is one of the important crops of India, mainly grown for their seeds which contain 20.6% protein, 2.2% fat and 61.2% carbohydrate, ranking next to wheat and barley both in acreage and in the production of grain. The major portion of crop production is consumed by the people in many forms like Dal, Besan, Crushed or whole grain, boiled or roasted gram or in sweet preparation. It is also used as a protein-rich diet for horses, and other cattle in the forms of soaked grain. Keeping the above views several Cicer varieties will be screened for their salt tolerance behaviour. Salt tolerant and salt susceptible variety will be selected for further comparative studies to expect that the findings of the present investigation would not only help with a better understanding of the mechanism of salt tolerant behaviour of Cicer at the physiological and biochemical levels and also suggest possibilities of selecting a variety suitable for salt stress condition

Evaluation of the Acute Phase Reactants CRP in Unstable Angina Cases

Unstable angina, a syndrome of symptoms caused by ischemia of the heart muscles, is both frightening and disabling and may herald acute myocardial infarction. The immediate precipitating events of the atherosclerotic plaque responsible for that critical degree of ischemia resulting in the syndrome of unstable angina are progression of atherosclerosis platelet aggregation, thrombosis and vasospasm. Acute phase reactants are proteins in the plasma whose levels increase during acute inflammatory states or secondary to certain types of tissue damage. A cross-sectional descriptive study was done in Safdarjung Hospital on 40 subjects and controls to establish the acute phase reactants CRP in unstable angina cases and their relationships. In our study, we found that CRP levels are increased in cases as compared to controls, thus showing a direct correlation

Saraca indica

Medicinal plants are used as a complementary and alternative medicine in treatment of various diseases including cancer worldwide, because of their ease of accessibility and cost effectiveness. Multicomposed mixture of compounds present in a plant extract has synergistic activity, increases the therapeutic potential many folds, compensates toxicity, and increases bioavailability. Saraca indica (family Caesalpiniaceae) is one of the most ancient sacred plants with medicinal properties, exhibiting a number of pharmacological effects. Antioxidant, antibreast cancer activity and toxicological evaluation of Saraca indica bark extract (SIE) were carried out in the present study. The results of the study indicated that this herbal preparation has antioxidant and antibreast cancer activity. Toxicological studies suggest that SIE is safer to use and may have a potential to be used as complementary and alternative medicine for breast cancer therapy

Alcoholic Extract of Eclipta alba

As per WHO estimates, 80% of people around the world use medicinal plants for the cure and prevention of various diseases including cancer owing to their easy availability and cost effectiveness. Eclipta alba has long been used in Ayurveda to treat liver diseases, eye ailments, and hair related disorders. The promising medicinal value of E. alba prompted us to study the antioxidant, nontoxic, and anticancer potential of its alcoholic extract. In the current study, we evaluated the in vitro cytotoxic and antioxidant effect of the alcoholic extract of Eclipta alba (AEEA) in multiple cancer cell lines along with control. We have also evaluated its effect on different in vivo toxicity parameters. Here, we found that AEEA was found to be most active in most of the cancer cell lines but it significantly induced apoptosis in human breast cancer cell lines by disrupting mitochondrial membrane potential and DNA damage. Moreover, AEEA treatment inhibited migration in both MCF 7 and MDA-MB-231 cells in a dose dependent manner. Further, AEEA possesses robust in vitro antioxidant activity along with high total phenolic and flavonoid contents. In summary, our results indicate that Eclipta alba has enormous potential in complementary and alternative medicine for the treatment of cancer

Higher order antibunching in intermediate states

Since the introduction of binomial state as an intermediate state, different intermediate states have been proposed. Different nonclassical effects have also been reported in these intermediate states. But till now higher order antibunching or higher order subpoissonian photon statistics is predicted only in one type of intermediate state, namely shadowed negative binomial state. Recently we have shown the existence of higher order antibunching in some simple nonlinear optical processes to establish that higher order antibunching is not a rare phenomenon (J. Phys. B 39 (2006) 1137). To establish our earlier claim further, here we have shown that the higher order antibunching can be seen in different intermediate states, such as binomial state, reciprocal binomial state, hypergeometric state, generalized binomial state, negative binomial state and photon added coherent state. We have studied the possibility of observing the higher order subpoissonian photon statistics in different limits of intermediate states. The effect of different control parameters have also been studied in this connection and it has been shown that the depth of nonclassicality can be tuned by controlling various physical parameters.Comment: 12 Pages LaTeX 2e, 11 figure

Implantation Serine Proteinase 1 Exhibits Mixed Substrate Specificity that Silences Signaling via Proteinase-Activated Receptors

Implantation S1 family serine proteinases (ISPs) are tryptases involved in embryo hatching and uterine implantation in the mouse. The two different ISP proteins (ISP1 and ISP2) have been detected in both pre- and post-implantation embryo tissue. To date, native ISP obtained from uterus and blastocyst tissues has been isolated only as an active hetero-dimer that exhibits trypsin-like substrate specificity. We hypothesised that in isolation, ISP1 might have a unique substrate specificity that could relate to its role when expressed alone in individual tissues. Thus, we isolated recombinant ISP1 expressed in Pichia pastoris and evaluated its substrate specificity. Using several chromogenic substrates and serine proteinase inhibitors, we demonstrate that ISP1 exhibits trypsin-like substrate specificity, having a preference for lysine over arginine at the P1 position. Phage display peptide mimetics revealed an expanded but mixed substrate specificity of ISP1, including chymotryptic and elastase activity. Based upon targets observed using phage display, we hypothesised that ISP1 might signal to cells by cleaving and activating proteinase-activated receptors (PARs) and therefore assessed PARs 1, 2 and 4 as potential ISP1 targets. We observed that ISP1 silenced enzyme-triggered PAR signaling by receptor-disarming. This PAR-disarming action of ISP1 may be important for embryo development and implantation