Spectrofluorimetric Determination of Doxorubicin in Spiked Serum and Urine Samples

.A simple spectrofluorimetric method is described for the determination of doxorubicin (DXR) based on its quenching effect on the fluorescence intensity of Tb3+- deferasirox (DFX) complex as a fluorescent probe. The excitation and emission wavelengths were 328 and 545 nm, respectively. The effects of pH, time, order of addition of reagents, concentrations of Tb3+ and DFX and the buffer volume on the quenched fluorescence intensity were investigated and optimized. In the optimum conditions, the decrease of the fluorescence intensity of the system showed a good linear relationship with the concentration of DXR in the range of 20-1000 μg L-1, with a correlation coefficient 0.998. The detection limit (3s) was 6.1 μg L-1 and the relative standard deviation for four replicate determinations of different concentrations of DXR was in the range of 1.7–4.4%. The procedure was successfully applied to the determination of doxorubicin in urine and serum samples</table

Metal–Organic Frameworks-Based Analytical Devices for Chiral Sensing and Separations: A Review (2012–2022)

Metal–organic frameworks (MOFs), as high-surface-area materials, have shown promise in various areas of application, such as chiral sensing and separation, due to their flexibility in design and organized porous cages. Researchers have been striving to design and develop high-performance enantiorecognition and separation analytical techniques in chiral science fields. The main aim of this review is to provide a comprehensive overview of chirality, state-of-the-art MOFs in chirality, and chiral analysis in the past decade, 2012–2022. The classification of this review includes chirality, principles of chiral analysis, the attraction of functional materials in chirality, MOFs in chiral analysis, MOFs for designing enantioselective sensors (fluorescence, circular dichroism, quartz crystal microbalance, electrochemical), and MOFs as chiral stationary phases (CSPs) for chromatographic enantioseparation (high-performance liquid chromatography, gas chromatography, and capillary electrochromatography). Finally, this review covers the vital progress of these materials with attention to the available opportunities and challenges in this topic