Retention in Care and Connection to Care among HIV-Infected Patients on Antiretroviral Therapy in Africa: Estimation via a Sampling-Based Approach

Current estimates of retention among HIV-infected patients on antiretroviral therapy (ART) in Africa consider patients who are lost to follow-up (LTF) as well as those who die shortly after their last clinic visit to be no longer in care and to represent limitations in access to care. Yet many lost patients may have "silently" transferred and deaths shortly after the last clinic visit more likely represent limitations in clinical care rather than access to care after initial linkage.We evaluated HIV-infected adults initiating ART from 1/1/2004 to 9/30/2007 at a clinic in rural Uganda. A representative sample of lost patients was tracked in the community to obtain updated information about care at other ART sites. Updated outcomes were incorporated with probability weights to obtain "corrected" estimates of retention for the entire clinic population. We used the competing risks approach to estimate "connection to care"--the percentage of patients accessing care over time (including those who died while in care).Among 3,628 patients, 829 became lost, 128 were tracked and in 111, updated information was obtained. Of 111, 79 (71%) were alive and 35/48 (73%) of patients interviewed in person were in care and on ART. Patient retention for the clinic population assuming lost patients were not in care was 82.3%, 68.9%, and 60.1% at 1, 2 and 3 years. Incorporating updated care information from the sample of lost patients increased estimates of patient retention to 85.8% to 90.9%, 78.9% to 86.2% and 75.8% to 84.7% at the same time points.Accounting for "silent transfers" and early deaths increased estimates of patient retention and connection to care substantially. Deaths soon after the last clinic visit (potentially reflecting limitations in clinical effectiveness) and disconnection from care among patient who were alive each accounted for approximately half of failures of retention

High-levels of acquired drug resistance in adult patients failing first-line antiretroviral therapy in a rural HIV treatment programme in KwaZulu-Natal, South Africa.

OBJECTIVE: To determine the frequency and patterns of acquired antiretroviral drug resistance in a rural primary health care programme in South Africa. DESIGN: Cross-sectional study nested within HIV treatment programme. METHODS: Adult (≥ 18 years) HIV-infected individuals initially treated with a first-line stavudine- or zidovudine-based antiretroviral therapy (ART) regimen and with evidence of virological failure (one viral load >1000 copies/ml) were enrolled from 17 rural primary health care clinics. Genotypic resistance testing was performed using the in-house SATuRN/Life Technologies system. Sequences were analysed and genotypic susceptibility scores (GSS) for standard second-line regimens were calculated using the Stanford HIVDB 6.0.5 algorithms. RESULTS: A total of 222 adults were successfully genotyped for HIV drug resistance between December 2010 and March 2012. The most common regimens at time of genotype were stavudine, lamivudine and efavirenz (51%); and stavudine, lamivudine and nevirapine (24%). Median duration of ART was 42 months (interquartile range (IQR) 32-53) and median duration of antiretroviral failure was 27 months (IQR 17-40). One hundred and ninety one (86%) had at least one drug resistance mutation. For 34 individuals (15%), the GSS for the standard second-line regimen was <2, suggesting a significantly compromised regimen. In univariate analysis, individuals with a prior nucleoside reverse-transcriptase inhibitor (NRTI) substitution were more likely to have a GSS <2 than those on the same NRTIs throughout (odds ratio (OR) 5.70, 95% confidence interval (CI) 2.60-12.49). CONCLUSIONS: There are high levels of drug resistance in adults with failure of first-line antiretroviral therapy in this rural primary health care programme. Standard second-line regimens could potentially have had reduced efficacy in about one in seven adults involved

Patient Retention and Adherence to Antiretrovirals in a Large Antiretroviral Therapy Program in Nigeria: A Longitudinal Analysis for Risk Factors

Substantial resources and patient commitment are required to successfully scale-up antiretroviral therapy (ART) and provide appropriate HIV management in resource-limited settings. We used pharmacy refill records to evaluate risk factors for loss to follow-up (LTFU) and non-adherence to ART in a large treatment cohort in Nigeria.We reviewed clinic records of adult patients initiating ART between March 2005 and July 2006 at five health facilities. Patients were classified as LTFU if they did not return >60 days from their expected visit. Pharmacy refill rates were calculated and used to assess non-adherence. We identified risk factors associated with LTFU and non-adherence using Cox and Generalized Estimating Equation (GEE) regressions, respectively. Of 5,760 patients initiating ART, 26% were LTFU. Female gender (p < 0.001), post-secondary education (p = 0.03), and initiating treatment with zidovudine-containing (p = 0.004) or tenofovir-containing (p = 0.05) regimens were associated with decreased risk of LTFU, while patients with only primary education (p = 0.02) and those with baseline CD4 counts (cell/ml(3)) >350 and <100 were at a higher risk of LTFU compared to patients with baseline CD4 counts of 100-200. The adjusted GEE analysis showed that patients aged <35 years (p = 0.005), who traveled for >2 hours to the clinic (p = 0.03), had total ART duration of >6 months (p<0.001), and CD4 counts >200 at ART initiation were at a higher risk of non-adherence. Patients who disclosed their HIV status to spouse/family (p = 0.01) and were treated with tenofovir-containing regimens (p < or = 0.001) were more likely to be adherent.These findings formed the basis for implementing multiple pre-treatment visit preparation that promote disclosure and active community outreaching to support retention and adherence. Expansion of treatment access points of care to communities to diminish travel time may have a positive impact on adherence

Implementation of a Novel model to enhance Routine HIV care and Treatment capacity in South Africa: Outcomes, Costs, and Cost-effectiveness

Introduction: This research evaluated the implementation of a novel public-private partnership (PPP) between the provincial department of health, an NGO, and a local private sector general practitioner (GP) network, which provides routine HIV care and treatment to public sector patients in order to alleviate the patient burden at public sector primary care clinics. Methods: This was a retrospective cohort study that compared the PPP model to the status quo public primary healthcare clinic (PHC) model in terms of patient outcomes, costs and cost-effectiveness. Outcomes data (viral suppression, patient retention and other clinical outcomes) were collected from clinic records and patient files. Cost data included HIV and TB treatment, laboratory tests, down-referral care, and hospital-based outpatient and inpatient care. In addition, a new program performance metric proposed a cost associated with premature treatment attrition. Total and average costs for each model were based on resource utilization. Average cost and incremental cost per patient retained, cost per suppressed patient, and cost per suppressed patient remaining in down-referral care were calculated. Finally, a survey was conducted with a sub-set of study patients in order to incorporate patient experience and perceptions of each care model into the analysis. Results: The proportion of patients who remained in care at the down-referral site with suppressed viral loads was 83 and 55 percent in the PPP and PHC cohorts respectively. Eighty-eight percent of PPP patients had suppressed viral loads compared to 67 percent of PHC patients. Retention on treatment was 94 percent among PPP subjects and 75 percent among PHC subjects. Total model cost was higher in the PPP model (R2,153,233) compared to the PHC model (R1,556,591) during the study period. The average cost per suppressed patient in down-referral care was R646.41 per month in the PPP model and R724.00 per month in the PHC model, and the cost per patient retained was R570.85 in the PPP model and R516.45 in the PHC model. The incremental cost-effectiveness ratio (ICER) was R724.00 for the PHC model and R505.20 for the PPP model compared to a 'do nothing' alternative. The PHC model was dominated (extended dominance), and the ICER for the PPP model compared to a 'do nothing' alternative was R638.97. Discussion: Despite recent progress in scaling-up HIV services in South Africa, an intensified effort will be required to meet the rapidly growing demand for treatment over ii the next decade. A lack of human resources has been identified by experts as one of the biggest constraints to achieving further scale-up of ART. The PPP model evaluated here was designed to help alleviate some of the pressure on the public health system by utilizing local private sector GPs to provide routine care for treatment experienced patients in Matlosana, North West Province. Clinical outcomes in the PPP model were significantly better than in the PHC model, it was more cost-effective at producing virally suppressed patients in down-referral care, and PPP patients were equally as happy as PHC patients with the quality of care and the level of convenience that the model offered. Innovative partnerships like the one evaluated here may offer a strategy for boosting public health sector capacity by leveraging existing private sector health resources

Treatment and research options for paediatric HIV infection in South Africa: Towards improving care

This satellite meeting at the 2nd South African AIDS Conference was organised to facilitate and inspire paediatric networking opportunities within South Africa and Africa. The meeting was a collaborative venture between recipients of the Elizabeth Glaser Pediatric AIDS Foundation International Leadership Award (Clive Gray and Tammy Meyers), the African Network for the Care of Children Affected by AIDS (ANECCA) and the Institute of Healthcare Improvement (IHI). The treatment needs of many HIV-infected children in South Africa are not being met, the antiretroviral rollout for children lags behind that of adults, and there are many unanswered clinical and scientific questions that should be addressed by local researchers and scientists to improve paediatric care. The overall purpose of this satellite meeting was to introduce clinical and research networks that are working towards improving the care for HIV-infected children in Africa. More specifically, the objectives of the meeting were: to promote awareness pf paediatric networks functioning in Africa to link seemingly disparate areas of knowledge around treatment and research in immunology and health care, and to facilitate networking through established African paediatric networks

Retention in HIV care for individuals not yet eligible for antiretroviral therapy: rural KwaZulu-Natal, South Africa.

OBJECTIVES: To determine retention in HIV care for individuals not yet eligible for antiretroviral therapy (ART) and to explore factors associated with retention in a rural public health HIV program. METHODS: HIV-infected adults (≥16 years) not yet eligible for ART, with CD4 cell count >200 cells per microliter from January 2007 to December 2007 were included in the analysis. Retention was defined by repeat CD4 count within 13 months. Factors associated with retention were assessed using logistic regression with clustering at clinic level. RESULTS: Four thousand two hundred twenty-three were included in the analysis (83.9% female). Overall retention was 44.9% with median time to return 201 days [interquartile range (IQR): 127-274]. Retention by initial CD4 count 201-350, 351-500, and >500 cells per microliter was 51.6% [95% confidence interval (CI): 49.1 to 54.0], 43.2% (95% CI: 40.5 to 45.9), and 34.9% (95% CI: 32.4 to 37.4), respectively. Compared with CD4 201-350 cells per microliter, higher initial CD4 count was significantly associated with lower odds of retention [CD4: 351-500 cells/μL adjusted odds ratio (aOR): 0.72, 95% CI: 0.62 to 0.84; CD4 >500 cells/μL aOR: 0.51, 95% CI: 0.44 to 0.60]. Male sex was independently associated with lower odds (aOR: 0.80, 95% CI: 0.67 to 0.96), and older age with higher odds of retention (for each additional year of age aOR: 1.03, 95% CI: 1.03 to 1.04). CONCLUSIONS: Retention in HIV care before eligibility for ART is poor, particularly for younger individuals and those at an earlier stage of infection. Further work to optimize and evaluate care and monitoring strategies is required to realize the full benefits of the rapid expansion of HIV programs in sub-Saharan Africa

Special Report on the State of HIV/AIDS in South Africa

It is axiomatic that the global fight against HIV/AIDS cannot be won without a decisive victory in South Africa, home to 20 percent of all people living with HIV/AIDS. So how is South Africa doing? And what is the likelihood it will meet the demand for essential prevention and treatment interventions by 2015? On Jan. 21 in Cape Town, Council on Foreign Relations Global Health Fellow Dr. Peter Navario convened a meeting of South Africa's foremost HIV/AIDS thinkers, policy-makers and practitioners to discuss the state of prevention and treatment at the epicenter of the pandemic. In this article, the experts weigh in on program gaps, the major challenges to achieving universal coverage of essential prevention and treatment interventions, and what it will take to surmount these challenges

Special Report on the State of HIV/AIDS in South Africa

It is axiomatic that the global fight against HIV/AIDS cannot be won without a decisive victory in South Africa, home to 20 percent of all people living with HIV/AIDS. So how is South Africa doing? And what is the likelihood it will meet the demand for essential prevention and treatment interventions by 2015? On Jan. 21 in Cape Town, Council on Foreign Relations Global Health Fellow Dr. Peter Navario convened a meeting of South Africa's foremost HIV/AIDS thinkers, policy-makers and practitioners to discuss the state of prevention and treatment at the epicenter of the pandemic. In this article, the experts weigh in on program gaps, the major challenges to achieving universal coverage of essential prevention and treatment interventions, and what it will take to surmount these challenges