EVALUATION OF SELF-MEDICATION PRACTICE IN SECOND YEAR UNDERGRADUATE STUDENTS AT A MEDICAL COLLEGE IN SOUTH GUJARAT

Objectives: Self-medication is the use of medicines by owns self without proper consultation. The practice of self-medication has increased, especially in medical students. Hence, this study was carried out to evaluate the self-medication practices among 2nd year undergraduate students of our institute. Methods: This was a cross-sectional and observational study conducted among the 2nd year MBBS students for 1 month. The study comprised a pre-approved and pre-validated questionnaire in English consisting of two sections: Section 1 included questions regarding demographic details of the students and whether they practiced self-medication in the past 1 year. If they responded with a yes, they were asked to fill Section 2 which had questions about the details of their self-medication practice. The questionnaire was administered by the faculty of the pharmacology department after taking written informed consent. Only completely filled questionnaires were evaluated. The results were expressed using mean and percentages. Results: 139 questionnaires were analyzed. About 80.58% students practiced self-medication. Female students (87.18%) were self-medicating more than male students (72.13%). Majority of the students who practiced self-medication obtained the medicine from the pharmacy (78.57%) and used it for 7 or fewer days. Analgesics (90.18%) were the most common group of drugs used followed by antipyretics. The most common indication was pain or headache (87.50%). Minor illness (73.21%) was the most common reason for self-medication. Conclusion: The practice of self-medication was quite high in the 2nd year MBBS students of our institute. They lack awareness regarding the safe and rational use of medicines

Herbal used as Epigenetic for Cancer Treatment

Patterns of chromatin accessibility, which are in turn altered by epigenetic mechanisms, are responsible for determining the interactions that take place between transcription machinery, genes, and the cis-regulatory elements of those genes. Mutations that interfere with epigenetic processes frequently have the unfortunate side effect of causing cancer. Since these mutations can be undone, numerous anticancer treatments that target epigenetic pathways are now being developed and evaluated. (Cancer) is becoming more and more common everywhere. This decline in clinical outcomes is a result of a number of factors, including late diagnosis, a lack of efficient treatments for particular cancer subtypes, and drug resistance. Treatment resistance and stemness traits have been recognised as markers of this disease, and it has been demonstrated that epigenetic changes play a role in the process of cancer growth. Understanding these alterations and how they impact cancer carcinogenesis treatment is challenging but crucial. However, it may be able to provide the special knowledge needed to use these alterations as potential diagnostic, prognostic, therapeutic agents, and predictors of treatment efficacy. This underlines the importance of continued research to advance our knowledge of cancer carcinogenesis and epigenetics and help us overcome these challenges. This review aims to provide an overview of the state of the art in epigenetics research for cancer detection and treatment and to stimulate discussion on this subject

Spill over preseptal cellulitis from temporalis intramuscular abscess: A rare presentation

Predisposing causes of preseptal cellulitis includes sinusitis, impetigo, trauma, chronic dacrocystitis, and external hordeolum. Intramuscular abscess in temporalis muscle as a cause of preseptal cellulitis has never been reported in ophthalmic literature. We here report a case of preseptal cellulitis following temporoparietal cellulitis as a result of intramuscular (temporalis) abscess. Surgical removal of the abscess along with parenteral antibiotic therapy was the mainstay of the treatment in such a case