How model uncertainties influence tropical humidity in global storm-resolving simulations

We conduct a series of eight 45-day experiments with a global storm-resolving model (GSRM) to test the sensitivity of relative humidity R in the tropics to changes in model resolution and parameterizations. These changes include changes in horizontal and vertical grid spacing as well as in the parameterizations of microphysics and turbulence, and are chosen to capture currently existing differences among GSRMs. To link the R distribution in the tropical free troposphere with processes in the deep convective regions, we adopt a trajectory-based assessment of the last-saturation paradigm. The perturbations we apply to the model result in tropical mean R changes ranging from 0.5 to 8 (absolute) in the mid troposphere. The generated R spread is similar to that in a multi-model ensemble of GSRMs and smaller than the spread across conventional general circulation models, supporting that an explicit representation of deep convection reduces the uncertainty in tropical R. The largest R changes result from changes in parameterizations, suggesting that model physics represent a major source of humidity spread across GSRMs. The R in the moist tropical regions is disproportionately sensitive to vertical mixing processes within the tropics, which impact R through their effect on the last-saturation temperature rather than their effect on the evolution of the humidity since last-saturation. In our analysis the R of the dry tropical regions strongly depends on the exchange with the extra-tropics. The interaction between tropics and extratropics could change with warming and presage changes in the radiatively sensitive dry regions

Progression of myopathology in Kearns-Sayre syndrome

We report on the progression of myopathology by comparing two biopsies from a patient with a Kearns-Sayre-Syndrome. The first biopsy was taken in 1979 and showed 10% ragged-red fibers. Myopathic changes were slight including internal nuclei and fiber splitting in 10% of the fibers. Electron microscopy revealed typical mitochondrial abnormalities with regard to number and shape. In 1989 a second biopsy was performed for an extended analysis of mitochondrial DNA. This time less than 5% of all fibers were ragged-red. Severe myopathic changes could be detected which so far has rarely been reported in mitochondrial cytopathy

Predicting early psychiatric readmission with natural language processing of narrative discharge summaries

The ability to predict psychiatric readmission would facilitate the development of interventions to reduce this risk, a major driver of psychiatric health-care costs. The symptoms or characteristics of illness course necessary to develop reliable predictors are not available in coded billing data, but may be present in narrative electronic health record (EHR) discharge summaries. We identified a cohort of individuals admitted to a psychiatric inpatient unit between 1994 and 2012 with a principal diagnosis of major depressive disorder, and extracted inpatient psychiatric discharge narrative notes. Using these data, we trained a 75-topic Latent Dirichlet Allocation (LDA) model, a form of natural language processing, which identifies groups of words associated with topics discussed in a document collection. The cohort was randomly split to derive a training (70%) and testing (30%) data set, and we trained separate support vector machine models for baseline clinical features alone, baseline features plus common individual words and the above plus topics identified from the 75-topic LDA model. Of 4687 patients with inpatient discharge summaries, 470 were readmitted within 30 days. The 75-topic LDA model included topics linked to psychiatric symptoms (suicide, severe depression, anxiety, trauma, eating/weight and panic) and major depressive disorder comorbidities (infection, postpartum, brain tumor, diarrhea and pulmonary disease). By including LDA topics, prediction of readmission, as measured by area under receiver-operating characteristic curves in the testing data set, was improved from baseline (area under the curve 0.618) to baseline+1000 words (0.682) to baseline+75 topics (0.784). Inclusion of topics derived from narrative notes allows more accurate discrimination of individuals at high risk for psychiatric readmission in this cohort. Topic modeling and related approaches offer the potential to improve prediction using EHRs, if generalizability can be established in other clinical cohorts

Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection

Abstract: Bcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and Bmf is required for apoptosis induced by infection with Neisseria gonorrhoeae (Ngo). While Bim and Bmf were associated with the cytoskeleton of healthy cells, they both were released upon Ngo infection. Loss of Bim and Bmf from the cytoskeleton fraction required the activation of Jun-N-terminal kinase-1 (JNK-1), which in turn depended on Rac-1. Depletion and inhibition of Rac-1, JNK-1, Bim, or Bmf prevented the activation of Bak and Bax and the subsequent activation of caspases. Apoptosis could be reconstituted in Bim-depleted and Bmf-depleted cells by additional silencing of antiapoptotic Mcl-1 and Bcl-XL, respectively. Our data indicate a synergistic role for both cytoskeletal-associated BH3-only proteins, Bim, and Bmf, in an apoptotic pathway leading to the clearance of Ngo-infected cells. Author Summary: A variety of physiological death signals, as well as pathological insults, trigger apoptosis, a genetically programmed form of cell death. Pathogens often induce host cell apoptosis to establish a successful infection. Neisseria gonorrhoeae (Ngo), the etiological agent of the sexually transmitted disease gonorrhoea, is a highly adapted obligate human-specific pathogen and has been shown to induce apoptosis in infected cells. Here we unveil the molecular mechanisms leading to apoptosis of infected cells. We show that Ngo-mediated apoptosis requires a special subset of proapoptotic proteins from the group of BH3-only proteins. BH3-only proteins act as stress sensors to translate toxic environmental signals to the initiation of apoptosis. In a siRNA-based miniscreen, we found Bim and Bmf, BH3-only proteins associated with the cytoskeleton, necessary to induce host cell apoptosis upon infection. Bim and Bmf inactivated different inhibitors of apoptosis and thereby induced cell death in response to infection. Our data unveil a novel pathway of infection-induced apoptosis that enhances our understanding of the mechanism by which BH3-only proteins control apoptotic cell death

Postdeployment Battlemind training for the U.K. armed forces: a cluster randomized controlled trial

OBJECTIVE: Combat exposure can increase the risk of subsequent psychological ill-health in armed forces (AF) personnel. A U.S. postdeployment psycho-educational intervention, Battlemind, showed a beneficial effect on mental health in U.S. military personnel exposed to high combat levels. We evaluated the effectiveness of an anglicized version of postdeployment Battlemind. METHOD: Battlemind was adapted for the United Kingdom. The main amendments were to sections about carrying weapons, driving, and alcohol misuse. The anglicized Battlemind was compared with the U.K. standard postdeployment brief in a cluster randomized controlled trial. At baseline, 2,443 U.K. AF personnel returning from Afghanistan via Cyprus completed questionnaires about their combat experiences and mental health. Of these, 1,616 (66%) completed 6-month follow-up questionnaires. We used the Posttraumatic Stress Disorder Checklist (PCL-C) to measure probable posttraumatic stress disorder and the General Health Questionnaire (GHQ-12) to measure common mental disorders. Secondary outcomes included alcohol misuse, assessed with the Alcohol Use Disorders Identification Test (AUDIT), and binge drinking. Mixed-effects models were used to account for possible cluster effects. RESULTS: We did not find a difference in mental health or overall AUDIT score. Those who received Battlemind versus the standard brief were less likely to report binge drinking, although the effect size was small (adjusted odds ratio = 0.73, 95% CI [0.58, 0.92]). CONCLUSIONS: The anglicized Battlemind did not improve mental health but had a modest impact on the reporting of binge drinking. Alcohol misuse is problematic in military populations; therefore, an intervention that reduces binge drinking may be helpful

K+ and K- production in heavy-ion collisions at SIS-energies

The production and the propagation of K+ and of K- mesons in heavy-ion collisions at beam energies of 1 to 2 AGeV have systematically been investigated with the Kaon Spectrometer KaoS at the SIS at the GSI. The ratio of the K+ production excitation function for Au+Au and for C+C reactions increases with decreasing beam energy, which is expected for a soft nuclear equation-of-state. At 1.5 AGeV a comprehensive study of the K+ and of the K- emission as a function of the size of the collision system, of the collision centrality, of the kaon energy, and of the polar emission angle has been performed. The K-/K+ ratio is found to be nearly constant as a function of the collision centrality. The spectral slopes and the polar emission patterns are different for K- and for K+. These observations indicate that K+ mesons decouple earlier from the reaction zone than K- mesons.Comment: invited talk given at the SQM2003 conference in Atlantic Beach, USA (March 2003), to be published in Journal of Physics G, 10pages, 7 figure

Fermi surface of PtCoO2 from quantum oscillations and electronic structure calculations

The authors would like to acknowledge the financial support from the Max-Planck Society. E.H. and M.N. acknowledge support from Deutsche Forschungsgemeinschaft (DFG) through the Project No. 107745057 (TRR80: From Electronic Correlations to Functionality). This work is also supported by JSPS KAKENHI (No. 18K04715). A portion of this work was performed at the National High Magnetic Field Laboratory, which is supported by the National Science Foundation Cooperative Agreements No. DMR-1157490 and No. DMR-1644779 and the State of Florida.The delafossite series of layered oxides includes some of the highest conductivity metals ever discovered. Of these, PtCoO2, with a room-temperature resistivity of 1.8 μΩcm for in-plane transport, is the most conducting of all. The high conduction takes place in triangular lattice Pt layers, separated by layers of Co-O octahedra, and the electronic structure is determined by the interplay of the two types of layers. We present a detailed study of quantum oscillations in PtCoO2, at temperatures down to 35 mK and magnetic fields up to 30 T. As for PdCoO2 and PdRhO2, the Fermi surface consists of a single cylinder with mainly Pt character and an effective mass close to the free-electron value. Due to Fermi-surface warping, two close-lying high frequencies are observed. Additionally, a pronounced difference frequency appears. By analyzing the detailed angular dependence of the quantum-oscillation frequencies, we establish the warping parameters of the Fermi surface. We compare these results to the predictions of first-principles electronic-structure calculations including spin-orbit coupling on Pt and Co and on-site correlation U on Co, and hence demonstrate that electronic correlations in the Co-O layers play an important role in determining characteristic features of the electronic structure of PtCoO2.Publisher PDFPeer reviewe