Synaptic nanomodules underlie the organization and plasticity of spine synapses.

Experience results in long-lasting changes in dendritic spine size, yet how the molecular architecture of the synapse responds to plasticity remains poorly understood. Here a combined approach of multicolor stimulated emission depletion microscopy (STED) and confocal imaging in rat and mouse demonstrates that structural plasticity is linked to the addition of unitary synaptic nanomodules to spines. Spine synapses in vivo and in vitro contain discrete and aligned subdiffraction modules of pre- and postsynaptic proteins whose number scales linearly with spine size. Live-cell time-lapse super-resolution imaging reveals that NMDA receptor-dependent increases in spine size are accompanied both by enhanced mobility of pre- and postsynaptic modules that remain aligned with each other and by a coordinated increase in the number of nanomodules. These findings suggest a simplified model for experience-dependent structural plasticity relying on an unexpectedly modular nanomolecular architecture of synaptic proteins

Maritime Stock Prices and Information Flows: A Cointegration Study

In this study, the issue of how global maritime stock prices influence the stock prices of large transportation companies in the U.S. and other large markets is examined. Maritime stocks are chosen because they are central in global trade and thus may be good indicators of future global stock market and economic trends. Maritime companies are often owned by families or governments and are traded in stock markets with lower standards of accountability, hence information flows from maritime stocks may be slower than flows from other stocks. Cointegration and vector error-correction analysis is used to analyze the short-term and long-term relationships between maritime stocks, rail stocks, and trucking stocks. Evidence is found of a gradual diffusion of information from maritime stock prices to large rail or trucking stocks. This suggests that price changes in maritime stocks may help predict changes in prices in non-maritime transportation stocks

Taiko: Its Past and Present in Japanese Society

The significance of Taiko in Japanese culture is far beyond being a percussion instrument. “Taiko” also refers to the art of drumming and is claimed to represent the spirit of Japanese people. Since ancient times, Taiko was used in the battlefield, Shinto and Buddhist religious ceremonies, festivals, royal courts, and theatrical arts performance. However, the origin of the Taiko remains unclear as well as its connection with Korean drum. The sacred power of Taiko for Japanese people is difficult to clarify in modern context. Japan is moving toward modernization, while promoting the importance of cultural preservation. It is important to understand the connection of the belief in Taiko that has been passed down since it first evidence appeared in the 6th century in Japan, from generation to generation, and how it survives in this modern Japanese society. To study the norm, performance practices, and its reception by musicians, religious leaders, and the public, an in-depth study of Taiko is necessary. The research, therefore aims to trace back its evolution, value, and its function in Japanese society. Results of the research display Taiko in relation to Japanese legend, development of Taiko, types of Taiko drum, and material used in Taiko manufacturing. More over, through research conducted, the connection of the past and present has provided Taiko with a new function in the modern society including of fusion music, contemporary music composition, and film music. Popular ensembles have brought Taiko to bridge the gap of traditional music of the past and Pop-Rock music of this modern world

Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs

Cortical networks are characterized by sparse connectivity, with synapses found at only a subset of axo-dendritic contacts. Yet within these networks, neurons can exhibit high connection probabilities, suggesting that cell-intrinsic factors, not proximity, determine connectivity. Here, we identify ephrin-B3 (eB3) as a factor that determines synapse density by mediating a cell-cell competition that requires ephrin-B-EphB signaling. In a microisland culture system designed to isolate cell-cell competition, we find that eB3 determines winning and losing neurons in a contest for synapses. In a Mosaic Analysis with Double Markers (MADM) genetic mouse model system in vivo the relative levels of eB3 control spine density in layer 5 and 6 neurons. MADM cortical neurons in vitro reveal that eB3 controls synapse density independently of action potential-driven activity. Our findings illustrate a new class of competitive mechanism mediated by trans-synaptic organizing proteins which control the number of synapses neurons receive relative to neighboring neurons

Exploring the Future of Human Factors Education; Online Learning, MOOCs, Next Generation Standards, and the Technological Skills We Need to Impart

The objective of this panel was to examine how the future of human factors education is changing given the influx of technology, a push for online learning, and adapting to the changing market. The panel will begin by Heather Lum briefly giving an overview and the precipice for this discussion panel. The panelists then provided their views and experiences regarding this topic. Kelly Steelman will discuss the potential for MOOCs and other online formats to create faster and more flexible postgraduate programs. Christina Frederick will discuss her perspectives on the technological skills we should be equipping our human factors graduates with to be successful. Nathan Sonnenfeld will give his unique take on this as an undergraduate student currently obtaining a human factors education. Susan Amato-Henderson will discuss the Next Generation Science Standards and the ramifications for educators. Lastly, Thomas Smith will focus on the advantages and disadvantages of online learning at the K-12 level. Dr. Lum will foster discussion among the panelists and questions from the general audience. Discussion time: 90 minutes

Can Honey Bees Assist in Area Reduction and Landmine Detection?

Honey bees have recently received considerable attention from the popular press as an innovative method to detect a variety of explosives, landmines and UXO. Many of these reports are inaccurate and may encourage individuals and demining groups to “sell” a service that they poorly understand or lack the experience to properly apply. As the developers of this technology, we offer the following summary about the current status of this alternative for landmine detection, including its strengths and limitations

Evidence in support of the call to ban the tackle and harmful contact in school rugby: a response to World Rugby

In a paper published in BJSM (June 2016), World Rugby employees Ross Tucker and Martin Raftery and a third coauthor Evert Verhagen took issue with the recent call to ban tackling in school rugby in the UK and Ireland. That call (to ban tackling) was supported by a systematic review published in BJSM. Tucker et al claim that: (1) the mechanisms and risk factors for injury along with the incidence and severity of injury in youth rugby union have not been thoroughly identified or understood; (2) rugby players are at no greater risk of injury than other sports people, (3) this is particularly the case for children under 15 years and (4) removing the opportunity to learn the tackle from school pupils might increase rates of injuries. They conclude that a ban ‘may be unnecessary and may also lead to unintended consequences such as an increase in the risk of injury later in participation.’ Here we aim to rebut the case by Tucker et al. We share new research that extends the findings of our original systematic review and meta-analysis. A cautionary approach requires the removal of the tackle from school rugby as the quickest and most effective method of reducing high injury rates in youth rugby, a public health priority