8 research outputs found
Searching for Gravitational Waves from Binary Inspirals with LIGO
We describe the current status of the search for gravitational waves from
inspiralling compact binary systems in LIGO data. We review the result from the
first scientific run of LIGO (S1). We present the goals of the search of data
taken in the second scientific run (S2) and describe the differences between
the methods used in S1 and S2.Comment: 9 pages, 2 figures. Published in proceedings of the 8th Gravitational
Wave Data Analysis Workshop, Milwaukee, WI, USA, 17-20 December 200
Novel Genes Involved in Hypertrophic Cardiomyopathy: Data of Transcriptome and Methylome Profiling
Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease; its pathogenesis is still being intensively studied to explain the reasons for the significant genetic and phenotypic heterogeneity of the disease. To search for new genes involved in HCM development, we analyzed gene expression profiles coupled with DNA methylation profiles in the hypertrophied myocardia of HCM patients. The transcriptome analysis identified significant differences in the levels of 193 genes, most of which were underexpressed in HCM. The methylome analysis revealed 1755 nominally significant differentially methylated positions (DMPs), mostly hypomethylated in HCM. Based on gene ontology enrichment analysis, the majority of biological processes, overrepresented by both differentially expressed genes (DEGs) and DMP-containing genes, are involved in the regulation of locomotion and muscle structure development. The intersection of 193 DEGs and 978 DMP-containing genes pinpointed eight common genes, the expressions of which correlated with the methylation levels of the neighboring DMPs. Half of these genes (AUTS2, BRSK2, PRRT1, and SLC17A7), regulated by the mechanism of DNA methylation, were underexpressed in HCM and were involved in neurogenesis and synapse functioning. Our data, suggesting the involvement of innervation-associated genes in HCM, provide additional insights into disease pathogenesis and expand the field of further research
An experimental study of the biological effects of geomagnetic disturbances: The impact of a typical geomagnetic storm and its constituents on plants and animals
Ultrafast Acoustic Vibrations of Bimetallic Nanoparticles
Investigations of the ultrafast acoustic response of metal nanosystems yield important information on the validity of continuous elastic mechanics at the nanoscale and also provide an optical way to probe nanoobject morphologies. In this context, we used femtosecond time-resolved pump-probe spectroscopy to study two classes of bimetallic nanoparticles: chemically synthesized AuAg nanospheres in water in the 20-45 nm size range, both with alloyed and segregated core-shell morphologies, and mass-selected glass-embedded PtAu core-shell nanospheres in the very small size range (2.3-2.5 nm), synthesized by physical methods. The analysis of the corresponding breathing mode periods demonstrates validity of the predictions of the continuous elastic model for bimetallic nanoobjects with the investigated sizes, morphologies and composition. Moreover, discrimination of nanoparticles internal structure (alloy or core-shell) by measurement of their acoustic response is also demonstrated