Protection of Intellectual Property Rights in a Transition Economy

Market perestroika and integration into the world economy require strengthening protection of intellectual property rights (IPRs) in transition economies like Russia. This paper examines patterns and emerging trends in piracy and protection of IPRs in Russia and analyzes the economic effects of strengthening IPRs in the context of Russia's market transition. In the early 1990s, Russia brought IPR legislation up to international standards. Yet IPR enforcement remains weak, and piracy of foreign software, trademarks, audio- and videocassettes flourishes. Ineffective IPR protection stifles innovation, trade, and direct foreign investment, and may become an obstacle to Russia's future membership in the World Trade Organization.intellectual property rights, Russia, piracy, transition economy

Is Africa Integrated in the Global Economy?

The popular impression that Africa has not integrated into world trade, as suggested by the evolution in simple indicators, has been called into question recently by more formal analysis. This paper refines and generalizes this analysis and lends support to the popular view of disintegration, but only for countries in Francophone Africa. These countries are currently underexploiting their trading opportunities and have witnessed disintegration over time, a trend that is most pronounced in their trade with technologically advanced countries. There is some evidence, on the other hand, that countries in Anglophone Africa are reversing the trend of disintegration, particularly in their trade with advanced countries. Copyright 2003, International Monetary Fund

Trade Liberalization and Industry Protection in Russia

This paper presents an endogenous growth model for two regions with assymetric initial stocks of knowledge. The novel features of the paper lie in modelling the differentiation of regions into an innovator and an imitator as endogenous, and analyzing optimal intellectual property rights (IPRs) for the imitator's catching-up. Weak IPR protection and a high imitation rate allow the initially knowledge-scarce imitator region to accumulate sufficient knowledge and switch to innovation, at which time tight IPRs become socially optimal. Policy implications for the international harmonization of IPRs under are assessed in light of the theoretical results.innovation, imitation, intellectual property rights

Three Cycles: Housing, Credit and Real Activity

We examine the characteristics and comovement of cycles in house prices, credit, real activity and interest rates in advanced economies during the past 25 years, using a dynamic generalised factor model. House price cycles generally lead credit and business cycles over the long term, while in the short to medium run the relationship varies across countries. Interest rates tend to lag other cycles at all time horizons. While global factors are important, the U.S. business cycle, house price cycle and interest rate cycle tend to lead the respective cycles in other countries over all time horizons. However, the U.S. credit cycle leads mostly over the long term.Macro-financial linkages, house prices, credit, business cycle

Market Response to Policy Initiatives during the Global Financial Crisis

This paper examines the impact of macroeconomic and financial sector policy announcements in the United States, the United Kingdom, the euro area, and Japan during the recent crisis on interbank credit and liquidity risk premia. Announcements of interest rate cuts, liquidity support, liability guarantees, and recapitalization were associated with a reduction of interbank risk premia, albeit to a different degree during the subprime and global phases of the crisis. Decisions not to reduce interest rates and bail out individual banks in an ad hoc manner had adverse repercussions, both domestically and abroad. The results are robust to controlling for the surprise content of announcements and using alternative measures of financial distress.

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead