Designing Secured Services for Authentication, Authorization, and Accounting of Users

In this paperwork service for authentication, authorization, and user management has been designed and developed. The purpose of this work is to simplify the configuration of user security in web and mobile applications with a ready-made solution. The service can be implemented as a separate server on the Internet—you will be able to use it right after registering a client this method does not require the use of your resources, but it is less secure, especially for applications that keep vulnerable data. Still, the best and the most secure option is to download the source code and run the service on the local network. In this case, it will be only accessible to other applications or microservices in the case of microservice architectur

Agroecology as a strategic direction in the system of rational land use

Today there is growing demand for organic products principals to the growth in the production of ecological products and biologization of land. Traditional organic farming is a complex of elements of a reproductive nature with industry specifics and a set of elements. Agroecology does not involve the practice of biochemical vegetable defense product. The transition to organic farming requires agricultural producers to fulfill several conditions, which is an element that slows down the pace of development of both land biologization and the attractiveness of the organic products segment for producers. The Russian market is characterized by high average annual growth rates of organic lands; increasing the share of land for the production of organic agricultural products; unstable number of producers; stabilization of the volume of the internal market for organic products at the level of 120 million euro; stabilization of the export volume of organic products at the level of 4 million euro. Production of organic products is advisable in local product markets, since the production of organic products is a product with high added value, increased requirements for certification of organic products and a narrow segment of consumers

Devising A Procedure to Forecast the Level of Chemical Damage to the Atmosphere During Active Deposition of Dangerous Gases

This paper reports a procedure devised to forecast the level of chemical pollution of the atmosphere, which includes a mathematical model for the distribution of the concentration of dangerous gas in the atmosphere at its active deposition by dispersed jets of liquid, as well as a technique for its implementation. Based on the differential equations of gas distribution in space, a phased model of the propagation of a cloud of a dangerous chemical substance was built. The model describes stages in the discharge of a dangerous gaseous substance from emergency technological equipment, the deposition of dangerous gas by a finely-dispersed flow, and free propagation of the cloud in the air. The reported mathematical model makes it possible to calculate the size of pollution zones while determining the boundary safety conditions. When forecasting, the main meteorological parameters, the width of the deposition zone, and the chemical properties of both the gas and liquid are taken into consideration. The comparative analysis of the results of forecasting a conditional zone of chemical damage with the free propagation of the cloud, and at the active deposition by precipitation or technical devices, was carried out. The simulation results revealed that with an increase in the wind speed from 1 m/s to 5 m/s, the size of the affected area increases by 2.7 times, while the concentration of dangerous gas in the cloud falls by 2.5‒3 times. An algorithm has been proposed for integrating the devised methodology of forecasting the level of chemical pollution of the atmosphere into a general cycle of emergency management. It should be especially noted that the devised procedure contains the entire range of components that are necessary for its practical application. It includes a description of the procedure and practical recommendations for the use of the proposed technique in the elimination of emergencies, as well as a list of probable events when the use of the developed procedure would be most effective

Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling

The purpose of this study was to investigate whether caveolin-3 (Cav3) regulates localization of β(2)-adrenergic receptor (β(2)AR) and its cAMP signaling in healthy or failing cardiomyocytes. We co-expressed wildtype Cav3 or its dominant-negative mutant (Cav3DN) together with the Förster resonance energy transfer (FRET)-based cAMP sensor Epac2-camps in adult rat ventricular myocytes (ARVMs). FRET and scanning ion conductance microscopy were used to locally stimulate β(2)AR and to measure cytosolic cAMP. Cav3 overexpression increased the number of caveolae and decreased the magnitude of β(2)AR-cAMP signal. Conversely, Cav3DN expression resulted in an increased β(2)AR-cAMP response without altering the whole-cell L-type calcium current. Following local stimulation of Cav3DN-expressing ARVMs, β(2)AR response could only be generated in T-tubules. However, the normally compartmentalized β(2)AR-cAMP signal became diffuse, similar to the situation observed in heart failure. Finally, overexpression of Cav3 in failing myocytes led to partial β(2)AR redistribution back into the T-tubules. In conclusion, Cav3 plays a crucial role for the localization of β(2)AR and compartmentation of β(2)AR-cAMP signaling to the T-tubules of healthy ARVMs, and overexpression of Cav3 in failing myocytes can partially restore the disrupted localization of these receptors