Measurement of the analyzing power in pp elastic scattering in the peak CNI region at RHIC

We report the first measurements of the A_N absolute value and shape in the -t range from 0.0015 to 0.010GeV/c^2 with a precision better than 0.005 for each A_N data point using a polarized atomic hydrogen gas jet target and the 100 GeV RHIC proton beam.Comment: 4 pages, 5 figure

On the cosmological evolution of BL Lacs

We study the cosmological evolution of BL Lac objects by applying the Ve/Va analysis to a new sample of 55 objects presented for the first time in this paper. This sample has been selected from the 239 sources with the brightest X-ray flux (>4X10^-13 erg s^-1 cm^-2) and relatively bright optical counterpart (B<20.5) among the ~1600 objects included in the REX survey. The uniform distribution of the Ve/Va values found in the sample suggests that BL Lac objects are not affected by a strong cosmological evolution in contrast with the behavior observed in the emission line AGNs. The Ve/Va analysis applied to the subsample of the High energy peaked BL Lacs (HBL) does not reveal a significant departure from a uniform distribution. This result suggests either that the cosmological evolution is less extreme than that previously found in other samples or that it is carried out only by a minority of objects, namely by the most extreme HBLs.Comment: Accepted for publication in Part 1 of The Astrophysical Journa

In search for multi-target ligands as potential agents for diabetes mellitus and its complications—a structure-activity relationship study on inhibitors of aldose reductase and protein tyrosine phosphatase 1b

Diabetes mellitus (DM) is a complex disease which currently affects more than 460 million people and is one of the leading cause of death worldwide. Its development implies numerous metabolic dysfunctions and the onset of hyperglycaemia-induced chronic complications. Multiple ligands can be rationally designed for the treatment of multifactorial diseases, such as DM, with the precise aim of simultaneously controlling multiple pathogenic mechanisms related to the disease and providing a more effective and safer therapeutic treatment compared to combinations of selective drugs. Starting from our previous findings that highlighted the possibility to target both aldose reductase (AR) and protein tyrosine phosphatase 1B (PTP1B), two enzymes strictly implicated in the development of DM and its complications, we synthesised 3-(5-arylidene-4-oxothiazolidin-3-yl)propanoic acids and analogous 2-butenoic acid derivatives, with the aim of balancing the effectiveness of dual AR/PTP1B inhibitors which we had identified as designed multiple ligands (DMLs). Out of the tested compounds, 4f exhibited well-balanced AR/PTP1B inhibitory effects at low micromolar concentrations, along with interesting insulin-sensitizing activity in murine C2C12 cell cultures. The SARs here highlighted along with their rationalization by in silico docking experiments into both target enzymes provide further insights into this class of inhibitors for their development as potential DML antidiabetic candidates

Report and preliminary results of SONNE cruise SO175, Miami - Bremerhaven, 12.11 - 30.12.2003 : (GAP, Gibraltar Arc Processes)

Expedition SO175 using FS Sonne aimed for a multidisciplinerary geoscientific approach with an international group of researchers. Methods covered the entire span from geophysical data acquisition (seafloor mapping, echography, seismic reflection), sediment coring at sites of active fluid venting, in situ heat flow measurements across the entire length of the Gibraltar thrust wedge, the deformation front, landslide bodies, and mud volcanoes, and finally the deployment of a long-term pore pressure probe. Video-supported operations helped to identify fluid vent sites, regions with tectonic activity, and other attractive high priority targets. Qualitative and quantitative examinations took place on board and are continued on land with respect to pore pressure variation, geomicrobiology, sediment- and fluid mobilization, geochemical processes, faunal assemblages (e.g. cold water corals), and gas hydrates (flammable methane-ice-crystals). Main focus of the expedition has been a better understanding of interaction between dynamic processes in a seismically active region region with slow plate convergence. In the context of earthquake nucleation and subduction zone processes, the SO175 research programme had a variety of goals, such as: • To test the frictional behaviour of the abyssal plain sediments. • To explore the temperature field of the 1755 thrust earthquake event via heat flow measurements. • To assess the role of fluid venting and gas hydrate processes control slope stability and mud volcanic activity along the Iberian continental margin. • To measure isotope geochemistry of pore waters and carbonates of deep fluids. • To quantify microbial activity in Gibraltar wedge sediments. • To test whether microseismicity in the area corresponds to in situ pore pressure changes. • To find out if enhanced heat flow max be indicative of active subduction. Initial tentative results during the cruise suggest that there is a component of active thrusting at the base of the wedge, as attested by heat flow data. Based on mostly geochemical evidence, mud volcanism was found less active than previously assumed. Highlights from post-cruise research include the successful deployment of the long-term station and high frictional resistance of all incoming sediment on the three abyssal plains

Radio-loud Active Galaxies in the Northern ROSAT All-Sky Survey III: New Spectroscopic Identifications from the RGB BL Lac Survey

We present new spectroscopic identifications for 169 objects in the RASS-Green Bank (RGB) catalog of radio- and X-ray-emitting AGN. These data significantly increase the fraction of bright RGB objects with classifications. Specifically, we report and discuss the classification of 66 radio-loud quasars, 53 BL Lacs, 33 Broad Line Radio Galaxies, 5 Narrow Line Radio Galaxies, 1 Seyfert I galaxy and 11 galaxies or galaxies in clusters. Over 78% of the identifications we present here are new. The observations we report were undertaken as part of our targeted search program to identify a new, large unbiased sample of BL Lac Objects and we therefore discuss the BL Lac sample extensively. Unlike many previous surveys, we impose no selection criteria based on optical morphology, color or broadband spectral energy distribution. Our classifications are based solely on a carefully defined set of self-consistent spectroscopic classification criteria. We show the 53 RGB presented here exhibit transitional properties between normal galaxies and BL Lacs discovered previously. We show there is no clear separation in CaII break strength between RGB BL Lacs and galaxies, with the distribution of break strengths varying smoothly between 0% and 50%. We also show that the newly discovered RGB BL Lacs reside in a "zone of avoidance" in the log(S_x/S_r) vs. log(S_o/S_r) diagram. This has important implications for BL Lac search strategies since it shows that RASS BL Lac samples will be severely incomplete if candidates are chosen only from among those objects with the highest S_x/S_r flux ratios.Comment: 21 pages text, 189 Figures, 4 tables, LaTeX2E, 4.2MB tar file (compressed); special style file paper.sty provide

Might some gamma ray bursts be an observable signature of natural wormholes?

The extragalactic microlensing scenario for natural wormholes is examined. It is shown that the main features of wormhole lensing events upon the light of distant Active Galactic Nuclei (AGNs) are similar to some types of already observed Gamma Ray Bursts (GRBs). Using recent satellite data on GRBs, an upper limit to the negative mass density -- ${\cal O} (10^{-36})$ g cm$^{-3}$ -- under the form of wormhole-like objects is presented.Comment: extended version, additions on GRB physics, background sources and cosmological consequences. Two ps figures. Accpeted for publication in Phys. Rev.

Mejoramiento participativo en maíz; su contribución: en el empoderamiento comunitario en le municipio de Muqui, Brasil.

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Avoiding the uncanny valley : robot appearance, personality and consistency of behavior in an attention-seeking home scenario for a robot companion

“The original publication is available at www.springerlink.com”. Copyright Springer. DOI: 10.1007/s10514-007-9058-3This article presents the results of video-based Human Robot Interaction (HRI) trials which investigated people’s perceptions of different robot appearances and associated attention-seeking features and behaviors displayed by robots with different appearance and behaviors. The HRI trials studied the participants’ preferences for various features of robot appearance and behavior, as well as their personality attributions towards the robots compared to their own personalities. Overall, participants tended to prefer robots with more human-like appearance and attributes. However, systematic individual differences in the dynamic appearance ratings are not consistent with a universal effect. Introverts and participants with lower emotional stability tended to prefer the mechanical looking appearance to a greater degree than other participants. It is also shown that it is possible to rate individual elements of a particular robot’s behavior and then assess the contribution, or otherwise, of that element to the overall perception of the robot by people. Relating participants’ dynamic appearance ratings of individual robots to independent static appearance ratings provided evidence that could be taken to support a portion of the left hand side of Mori’s theoretically proposed ‘uncanny valley’ diagram. Suggestions for future work are outlined.Peer reviewe

Influence of pump laser fluence on ultrafast structural changes in myoglobin

High-intensity femtosecond pulses from an X-ray free-electron laser enable pump probe experiments for investigating electronic and nuclear changes during light-induced reactions. On time scales ranging from femtoseconds to milliseconds and for a variety of biological systems, time-resolved serial femtosecond crystallography (TR-SFX) has provided detailed structural data for light-induced isomerization, breakage or formation of chemical bonds and electron transfer. However, all ultra-fast TR-SFX studies to date have employed such high pump laser energies that several photons were nominally absorbed per chromophore. As multiphoton absorption may force the protein response into nonphysiological pathways, it is of great concern whether this experimental approach allows valid inferences to be drawn vis-a-vis biologically relevant single-photon-induced reactions. Here we describe ultrafast pump-probe SFX experiments on photodissociation of carboxymyoglobin, showing that different pump laser fluences yield markedly different results. In particular, the dynamics of structural changes and observed indicators of the mechanistically important coherent oscillations of the Fe-CO bond distance (predicted by recent quantum wavepacket dynamics) are seen to depend strongly on pump laser energy. Our results confirm both the feasibility and necessity of performing TR-SFX pump probe experiments in the linear photoexcitation regime. We consider this to be a starting point for reassessing design and interpretation of ultrafast TR-SFX pump probe experiments such that biologically relevant insight emerges