Both younger and older adults have difficulty updating emotional memories

Objective. The main purpose of the study was to examine whether emotion impairs associative memory for previously seen items in older adults, as previously observed in younger adults. Method. Thirty-two younger adults and 32 older adults participated. The experiment consisted of 2 parts. In Part 1, participants learned picture–object associations for negative and neutral pictures. In Part 2, they learned picture–location associations for negative and neutral pictures; half of these pictures were seen in Part 1 whereas the other half were new. The dependent measure was how many locations of negative versus neutral items in the new versus old categories participants remembered in Part 2. Results. Both groups had more difficulty learning the locations of old negative pictures than of new negative pictures. However, this pattern was not observed for neutral items. Discussion. Despite the fact that older adults showed overall decline in associative memory, the impairing effect of emotion on updating associative memory was similar between younger and older adults

Differential brain activity during emotional versus nonemotional reversal learning

The ability to change an established stimulus–behavior association based on feedback is critical for adaptive social behaviors. This ability has been examined in reversal learning tasks, where participants first learn a stimulus–response association (e.g., select a particular object to get a reward) and then need to alter their response when reinforcement contingencies change. Although substantial evidence demonstrates that the OFC is a critical region for reversal learning, previous studies have not distinguished reversal learning for emotional associations from neutral associations. The current study examined whether OFC plays similar roles in emotional versus neutral reversal learning. The OFC showed greater activity during reversals of stimulus–outcome associations for negative outcomes than for neutral outcomes. Similar OFC activity was also observed during reversals involving positive outcomes. Furthermore, OFC activity is more inversely correlated with amygdala activity during negative reversals than during neutral reversals. Overall, our results indicate that the OFC is more activated by emotional than neutral reversal learning and that OFC's interactions with the amygdala are greater for negative than neutral reversal learning

Age-related similarities and differences in brain activity underlying reversal learning

The ability to update associative memory is an important aspect of episodic memory and a critical skill for social adaptation. Previous research with younger adults suggests that emotional arousal alters brain mechanisms underlying memory updating; however, it is unclear whether this applies to older adults. Given that the ability to update associative information declines with age, it is important to understand how emotion modulates the brain processes underlying memory updating in older adults. The current study investigated this question using reversal learning tasks, where younger and older participants (age ranges 19-35 and 61-78 respectively) learn a stimulus–outcome association and then update their response when contingencies change. We found that younger and older adults showed similar patterns of activation in the frontopolar OFC and the amygdala during emotional reversal learning. In contrast, when reversal learning did not involve emotion, older adults showed greater parietal cortex activity than did younger adults. Thus, younger and older adults show more similarities in brain activity during memory updating involving emotional stimuli than during memory updating not involving emotional stimuli

PERAN KOPERASI SERBA USAHA (KSU) SITORAJO DALAM MENINGKATKAN EKONOMI MASYARAKAT DI DESA SITORAJO KARI KECAMATAN KUANTAN TENGAH KABUPATEN KUANTAN SINGINGI

Petani kecil selalu erat kaitannya dengan permasalahan mendasar yang dihadapi diantaranya masalah permodalan, bahan baku dan pemasaran produk. Sehingga mereka tidak dapat mengembangkan usahanya secara cepat. Permasalahan ini juga dialami oleh para petani sawit kecil di Desa Sitorajo Kari Kecamatan Kuantan Tengah Kabupaten Kuantan Singingi yang selalu dipermaikan oleh para tengkulak, dan terjerat sistem ijon. Penelitian ini bertujuan untuk mengetahui peran yang dilakukan oleh KSU Sitorajo dalam meningkatkan ekonomi masyarakat di desa Sitorajo Kari kecamatan Kuantan Tengah Kabupaten Kuantan Singingi. Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif kualitatif dengan teknik pengumpulan data yaitu observasi, wawancara dan dokumentasi. Hasil dari penelitian menunjukkan bahwa Koperasi Serba Usaha (KSU) Sitorajo telah berperan untuk penyediaan modal kerja KSU Sitorajo menyalurkan melalui modal kerja yang berbentuk uang dan pupuk, jasa angkut dan tempat pemasaran sebagai penunjang sarana penunjang kegiatan petani. Kerja sama yang telah dilakukan dengan dinas dan pihak swasta. Serta pembinaan dan pelatihan mengenai tanaman sawit, pendidikan untuk meningkatkan keterampilan anggota. Telah dilakukan oleh KSU Sitorajo

Resting-state networks associated with cognitive processing show more age-related decline than those associated with emotional processing

Correlations in activity across disparate brain regions during rest reveal functional networks in the brain. Although previous studies largely agree that there is an age-related decline in the “default mode network,” how age affects other resting-state networks, such as motion-related networks, is still controversial. Here we used a dual regression approach to investigate age-related alterations in resting-state networks. The results revealed age-related disruptions in functional connectivity in all five identified cognitive networks, namely the default mode network, cognitive-auditory, cognitive-speech (or speech-related somatosensory) and right and left fronto-parietal networks, whereas such age effects were not observed in the three identified emotion networks. In addition, we observed age-related decline in functional connectivity in three visual and three motor/visuospatial networks. Older adults showed greater functional connectivity in regions outside four out of the five identified cognitive networks, consistent with the dedifferentiation effect previously observed in task-based fMRI studies. Both reduced within-network connectivity and increased out-of-network connectivity were correlated with poor cognitive performance, providing potential biomarkers for cognitive aging

Connective Tissue Growth Factor Gene Expression in Tissue Sections From Localized Scleroderma, Keloid, and Other Fibrotic Skin Disorders

Connective tissue growth factor (CTGF) is a novel peptide that exhibits platelet-derived growth factor-like activities and is produced by skin fibroblasts after activation with transforming growth factor-β. Coordinate expression of transforming growth factor-β followed by CTGF during wound repair suggests a cascade process for control of tissue regeneration. We recently reported a significant correlation between CTGF mRNA expression and histologic sclerosis in systemic sclerosis. To confirm the relation between CTGF and skin fibrosis, we investigated CTGF gene expression in tissue sections from patients with localized scleroderma, keloid, and other sclerotic skin disorders using nonradioactive in situ hybridization. In localized scleroderma, the fibroblasts with positive signals for CTGF mRNA were scattered throughout the sclerotic lesions with no preferential distribution around the inflammatory cells or perivascular regions, whereas the adjacent nonaffected dermis was negative for CTGF mRNA. In keloid tissue, the fibroblasts positive for CTGF mRNA were diffusely distributed, especially in the peripheral expanding lesions. In scar tissue, however, the fibroblasts in the fibrotic lesions showed partially positive signals for CTGF mRNA. In eosinophilic fasciitis, nodular fasciitis, and Dupuytren's contracture, CTGF mRNA was also expressed partially in the fibroblasts of the fibrotic lesions. Our findings reinforce a correlation between CTGF gene expression and skin sclerosis and support the hypothesis that transforming growth factor-β plays an important role in the pathogenesis of fibrosis, as it is the only inducer for CTGF identified to date

Effects of a randomised trial of 5-week heart rate variability biofeedback intervention on mind wandering and associated brain function

Previous research suggests that excessive negative self-related thought during mind wandering involves the default mode network (DMN) core subsystem and the orbitofrontal cortex (OFC). Heart rate variability (HRV) biofeedback, which involves slow paced breathing to increase HRV, is known to promote emotional well-being. However, it remains unclear whether it has positive effects on mind wandering and associated brain function. We conducted a study where young adults were randomly assigned to one of two 5-week interventions involving daily biofeedback that either increased heart rate oscillations via slow paced breathing (Osc+ condition) or had little effect on heart rate oscillations (active control or Osc- condition). The two intervention conditions did not differentially affect mind wandering and DMN core-OFC functional connectivity. However, the magnitude of participants’ heart rate oscillations during daily biofeedback practice was associated with pre-to-post decreases in mind wandering and in DMN core-OFC functional connectivity. Furthermore, the reduction in the DMN core-OFC connectivity was associated with a decrease in mind wandering. Our results suggested that daily sessions involving high amplitude heart rate oscillations may help reduce negative mind wandering and associated brain function.</p

Emotional content and source memory for language: impairment in an incidental encoding task

Research into the effects of emotion on source memory (i.e., memory for certain contextual details of a stimulus, such as its location, color, or temporal context) has yielded inconsistent findings. Mather and her co-workers tried to account for such inconsistencies by pointing out the relevance of the characteristics of the feature examined. Specifically, they distinguished between intrinsic and extrinsic features (Mather, 2007) and between goal-relevant and goal-irrelevant information (Mather and Sutherland, 2011). In the current study, we investigated source memory for language, which is an intrinsic feature or words. Catalan-Spanish bilinguals were tested in three experiments involving a recognition task in which they were asked about the language of presentation (Catalan or Spanish) of emotional and neutral words. In Experiments 1 and 2, source memory for negative and neutral words was assessed. In Experiment 1 participants performed an intentional encoding task in which language was a goal-relevant feature. In Experiment 2, they did an incidental encoding task in which language was also goal-relevant. Experiment 3 replicated Experiment 2 but negative words were replaced by positive words. The results showed an impairment in source memory for the language of presentation of emotional words when the encoding task was incidental, but not when it was intentional. Such impairment was observed with both negative words and positive words. The results are discussed in relation to the proposals of Mather and co-workers and point to the relevance of modulating factors, such as the intentional/incidental nature of encoding.This research was funded by the Spanish Ministry of Economy and Competitiveness (PSI2015-63525-P, PCIN-2015-165-C02-02) and by the Research Promotion Program of the Universitat Rovira i Virgili (2017PFR-URV-B2-32). This research was funded by the FCT (Foundation for Science and Technology) through the state budget with reference IF / 00784/2013 / CP1158 / CT001

Thinking about a limited future enhances the positivity of younger and older adults’ recall: support for socioemotional selectivity theory

Compared with younger adults, older adults have a relative preference to attend to and remember positive over negative information. This is known as the “positivity effect,” and researchers have typically evoked socioemotional selectivity theory to explain it. According to socioemotional selectivity theory, as people get older they begin to perceive their time left in life as more limited. These reduced time horizons prompt older adults to prioritize achieving emotional gratification and thus exhibit increased positivity in attention and recall. Although this is the most commonly cited explanation of the positivity effect, there is currently a lack of clear experimental evidence demonstrating a link between time horizons and positivity. The goal of the current research was to address this issue. In two separate experiments, we asked participants to complete a writing activity, which directed them to think of time as being either limited or expansive (Experiments 1 and 2) or did not orient them to think about time in a particular manner (Experiment 2). Participants were then shown a series of emotional pictures, which they subsequently tried to recall. Results from both studies showed that regardless of chronological age, thinking about a limited future enhanced the relative positivity of participants’ recall. Furthermore, the results of Experiment 2 showed that this effect was not driven by changes in mood. Thus, the fact that older adults’ recall is typically more positive than younger adults’ recall may index naturally shifting time horizons and goals with age