EXPLICIT SOLUTION OF A DRUG EMANATING CONSTANT INFUSION WITH TIME DELAY

An archetype is evaluated to elucidate the Pharmacokinetics of Enterohepatic dissemination of a drug with time delay just as constant infusion administrated. Results for nonlinear differential equations are evolved using Laplace Transform. Matlab is inked to read the plasma degree of concentration

Kajian nilai Geguritan Cupak Gerantang

Di Bali naskah kuna masih memilid fungsi kultural dalam masyarakat di samping mengandung berbagai bahan keterangan tentang kehidupan sosial budaya masyarakat di masa lampau yang juga mendung ide-ide, gagasan utama, berbagai pengetahuan tentang alam semesta menurut persepsi budaya masyarakat yang betsangkutan, ajaran moral. filsafat, keagamaan dan unsur-unsur lain yang mendukung nllai-nilai luhur. Ini menandakan sastra Bali tradisional sebagai bagian dari warisan budaya lama perlu dikaji, baik untuk kepentingan ilmu sastra maupun meningkatkan pengetahuan apresiasi masyarakat terhadap sastra Bali, Dengan meningkatnya pengetahuan dan apresiasi masyarakat terhadap sastra Bali, berarti nilai yang terkandung di dalamnya dapat dihayati dengan baik dan mendalam. Geguritan Cupak Cerantang merupakan salah satu bukti bagi masyarakat Bali karena geguritan ini cukup populer di· kalangan pecinta sastra BalL di sampfag geguritan yang lainnya seperti : Geguritan Jayaprana, Sampik; Pakangraras, PanjiSemerang, Cilinaya, Basur, Tamtam, Bagus Diarsa, Bagus Umbara, Bagus Turunan, Megantaka, dan yang lainnya

Definición de la entidad inteligencia empresarial para un modelo de factoría aplicando inteligencia

In the last years our country have been establishing many strategies with the purpose to increase the software production and eliminate the handmade solutions in the way that remain in Cuban Software Industry, taking advantage of the human resources available. However, defects in themes like Business Intelligence and Knowledge Management do not allow the advances that we expect. We are into a new age, where the world is unpredictable and the information everyday is less, that ́s why is very important to take decisions to make it an analysis and to use the appropriated tools to do it. The Entity has as main goal the Strategic Orientation. In the Entity ́s description there is represented their main elements. The Entity has two fundamental units: Knowledge Management Unit and Intelligence Unit. The first one is in charge to apply techniques to knowledge management, and the second oriented to tasks like Techn ological Surveillance following the behavior of suppliers, clients, compet itors, allowing anticipating future situations.En el país en los últimos años se han llevado a cabo varias estrategias con el fin de elevar la producción de software, intentando eliminar las deficiencias en los modelos de producción que aún persisten en la actual industria cubana y aprovechando las ventajas del alto valor de los intangibles acumulados en el capital humano. Sin embargo, el poco uso de la inteligencia empresarial y gestión del conocimiento en la orientación estratégica a corto, mediano y largo plazo no propician los avances a los que se aspira. Se vive una nueva era donde en el mundo cada vez se vuelve más imprevisible y la información es cada vez menos confiable lo que implica que para la toma de decisiones se haga imprescindible el análisis de la información y el uso de herramientas para ello. La entidad que se propone tiene como objetivo fundamental la orientación estratégica. La Entidad que se describe consta de una dirección general que implementa un sistema de inteligencia que a su vez abarca dos unidades fundamentales, la unidad de gestión del conocimiento y la unidad de inteligencia. La primera encargada de aplicar técnicas para la gestión de conocimiento y la segunda orientada al monitoreo continuo de los proveedores, clientes y competidores permitiendo a las empresas anticiparse a situaciones futuras

LAPORAN KASUS: SINDROM BRUNS PADA NEUROSISTISERKOSIS INTRAVENTRIKULER

Latar Belakang: Sindrom Bruns adalah sekumpulan gejala peningkatan intrakranial seperti nyeri kepala, vertigo, dan muntah yang bersifat periodik dan dipicu oleh perubahan posisi kepala. Kasus: Laki-laki 38 tahun, suku Bali datang ke rumah sakit dengan keluhan pusing bergoyang selama dua bulan dan memberat dalam dua minggu terakhir, disertai muntah dan nyeri pada kepala yang bersifat periodik. Pemeriksaan fisik menunjukkan vertigo tipe sentral yang bersifat periodik. Pemeriksaan laboratorium darah normal, pemeriksaan feses tidak ditemukan telur cacing, dan tes serologi positif. Pemeriksaan pencitraan kepala menunjukkan hidrosefalus, kalsifikasi multipel parenkim, dan lesi kistik soliter di ventrikel empat. Pemberian albendazole dan kortikosteroid selama 10 hari menunjukkan perbaikan klinis. Diskusi: Kista neurosistiserkosis dapat ditemukan di ventrikel empat ( 43%-70%), ventrikel lateral (11%-43%), dan ventrikel ketiga (1%-29%). Kista yang bergerak bebas di sistem ventrikel dapat menimbulkan hidrosefalus yang bersifat periodik. Simpulan: Manifestasi neurosistiserkosis intraventrikuler yang jarang dapat berupa Sindrom Bruns. Penegakan diagnosis pada Sindrom Bruns memerlukan MRI kepala. Kata Kunci: Sindrom Bruns, Neurosistiserkosis Intraventrikuler, Hidrosefalu

Osteosarcoma of Urinary Bladder-A Rare But Distinct Clinicopathological Entity: A Case Report

ABSTRACT Primary osteogenic sarcoma of the urinary bladder is a rare tumor. We report a case of bladder mass in a 70 yr old male patient with histological features of osteogenic sarcoma. There was no prior history of malignancy elsewhere in the body. After the histopathological examination of the bladder mass, a thorough investigation including PET-CT did not reveal lesions elsewhere in the body. The histological features were similar to conventional osteogenic sarcoma. Immune marker studies were done to rule out other spindle cell sarcomas and carcinosarcoma

Shoulder isokinetic profile of male handball players of the Brazilian National Team

BACKGROUND:Data obtained on an isokinetic dynamometer are useful to characterize muscle status and have been reported in muscle imbalance studies in different types of sport. However, few studies have assessed elite handball players to establish reference values.OBJECTIVE:The purpose of this study was to compare, for the dominant (D) and non-dominant (ND) side, the isokinetic profile of shoulder rotator muscle strength between male handball players (H) and asymptomatic non-athletes (NA).METHOD:Isokinetic concentric and eccentric strength tests for D upper limbs were performed by the H group (n=20) and the NA group (n=12). Internal and external rotator muscle peak torque in concentric action was assessed at 60°/s and 300°/s and in eccentric action at 300°/s. We also calculated conventional balance (the ratio of external rotator peak torque to internal rotator peak torque in concentric action) and functional balance (the ratio of external rotator peak torque in eccentric action to internal rotator peak torque in concentric action).RESULTS:In the H group, dominant limbs were stronger in concentric action for external rotation at 60 and 300°/s. The conventional balance ratio for the D side was significantly lower at 60 and 300°/s for H compared to NA. The functional ratio for the D side was significantly lower at 300º/s for H compared to NA.CONCLUSIONS:Compared to asymptomatic non-athletes, handball players presented significant muscular imbalance resulting from daily sports practice, a known risk factor for shoulder injuries.Projects Finance Organization (Financiadora de Estudos e Projetos - FINEP)Universidade Federal de São Paulo (UNIFESP) Physiology DepartmentUniversidade Federal de Goias Human and Exercise Physiology SectorUniversidade Estadual de Campinas Faculty of Physical Education Sports Science DepartmentBrazilian Basketball ConfederationUNIFESP, Physiology DepartmentSciEL

Diseño de un modelo de Gestión del Conocimiento para mejorar el desarrollo de equipos de proyectos informáticos

There is a real need for elevating knowledge management activities and integrating them into the management of development projects in order to improve IT project teams. It is also necessary to retain the knowledge of professionals, to capture and share best practices, and to provide organizational training and learning. The present work aims to present a Knowledge Management Model for improving IT project teams, as expressed mainly through the teams’ scientific results. A survey was conducted on trends presented by leading authors and institutions in project management and on experience in the use of knowledge management, in order to achieve a proposal whose results are supported by current theoretical results.Elevar la actividad de gestión del conocimiento e integrarla a la gestión de proyectos para mejorar el desarrollo de equipos de proyectos informáticos es hoy una verdadera necesidad. Es necesidad también retener el conocimiento de los profesionales, capturar y compartir buenas prácticas, facilitar la formación y el aprendizaje organizacional. El trabajo que se pone a disposición tiene como objetivo presentar un Modelo de Gestión del Conocimiento para mejorar el desarrollo de equipos de proyectos informáticos expresado fundamentalmente a partir de los resultados científicos del equipo. En él se realizó un estudio acerca de tendencias presentadas por los principales autores e instituciones existentes para la gestión de proyectos y con experiencias en el uso de gestión del conocimiento, en aras de lograr una propuesta con resultados sustentados en fundamentos teóricos de actualidad

Naphthoquinone-mediated inhibition of lysine acetyltransferase KAT3B/p300, basis for non-toxic inhibitor synthesis

Hydroxynaphthoquinone-based inhibitors of the lysine acetyltransferase KAT3B (p300), such as plumbagin, are relatively toxic. Here, we report that free thiol reactivity and redox cycling properties greatly contribute to the toxicity of plumbagin. A reactive 3rd position in the naphthoquinone derivatives is essential for thiol reactivity and enhances redox cycling. Using this clue, we synthesized PTK1, harboring a methyl substitution at the 3rd position of plumbagin. This molecule loses its thiol reactivity completely and its redox cycling ability to a lesser extent. Mechanistically, non-competitive, reversible binding of the inhibitor to the lysine acetyltransferase (KAT) domain of p300 is largely responsible for the acetyltransferase inhibition. Remarkably, the modified inhibitor PTK1 was a nearly non-toxic inhibitor of p300. The present report elucidates the mechanism of acetyltransferase activity inhibition by 1,4-naphthoquinones, which involves redox cycling and nucleophilic adduct formation, and it suggests possible routes of synthesis of the non-toxic inhibitor

Duration and Mortality Characteristics of Patients with Cerebral Tumors Treated in the Intensive Care Unit of Sanglah General Hospital from January to December 2017

BACKGROUND: The incidence and survival rates of cerebral tumor patients are increasing, along with advances in medical technology. Severe complications, such as multiorgan failure in patients, cause the need for intensive care to improve. The effectiveness of intensive care in tumor patients is still controversial, considering that patients included in low and vulnerable performance status. Patients with cerebral tumors also require intensive care either before or after effective action. The controversy of economic and ethical issues still places aggressive action in intensive care on oncology patients. It is necessary to identify and know the characteristics of tumor patients that are useful in intensive management. AIM: The purpose of this study was to determine the demographic characteristics, length of stay, complications, and mortality rates of cerebral tumor patients undergoing intensive care at Sanglah Hospital Denpasar, the period January–December 2017. METHODS: This study is a cross-sectional descriptive where all sample data collection is secondarily based on existing medical records. The sample population in this study were cerebral tumor patients treated in the intensive care ward Sanglah period January–December 2017 who met the inclusion criteria. RESULTS: In the study, it found that 54 patients with the highest number of cerebral tumors treated in the intense sex with women (64.85%) and middle-aged adults (41–60 years) were 31 patients (57.4%). Most diagnoses of cerebral tumors were 39 non-glioma tumors (72.2%) followed by glioma tumors (20.4%) and tumor metastases (7.4%). Non-glioma tumors noted were meningiomas of around 48.1%, followed by glioblastoma multiforme tumors of 9.3%, tumors at the cerebellopontine angle and tumor metastases of 7.4%, respectively. All patients were treated intensively after receiving surgical therapy with a Karnofsky 50 score of about 29 patients (53.7%). All patients came out alive, and there were no recorded complications during treatment with the maximum length of stay of patients in the intensive care unit for up to 3 days by 45 patients (83.3%). CONCLUSION: The most brain tumor cases are meningioma, which occurred in women, middle-aged adults with no mortality and complications within 3 days during treatment intensive care