CO2 Laser Cutting of Glass Woven Fabric: An Experimental Investigation

Copyright: © 2014 Y Nukman, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Glass woven fabric is produced by interlacing fine fibres of glass (commonly known as fibreglass). A single-strand of these fibres has greater specific tensile strength than that of a steel wire of the same diameter. Due to its lightweight and strong tensile properties, glass woven fabric offers numerous benefits in many industries. Since it is impractical to use conventional methods for cutting the glass woven fabric, a CO2 laser seems to be an appropriate tool for such application. In the present study, an investigation is carried out to characterise the effects of laser cutting parameters, namely, laser power, cutting speed, compressed air pressure and stand-off distance, on the kerf width of the cut. Taguchi design of experiment is employed to account for the interaction between various process parameters, and their significance is further evaluated using ANOVA technique. This study indicates that laser power has dominant effect on the kerf width

The effect of the placental DROSHA rs10719 and rs6877842 polymorphisms on PE susceptibility and mRNA expression

Evidence showed that microRNA biosynthesis plays the main role in pathogenesis of several diseases including Preeclampsia (PE). Therefore, microRNA processing enzymes may involve in PE predisposition. The aim of the present study was to evaluate the relation between DROSHA rs10719 and rs6877842 polymorphisms and mRNA expression in the placenta of PE women and controls. This study recruited 110 PE women and 115 age matched normotensive pregnant women for genotyping of DROSHA polymorphisms and analyzing of mRNA expression. There was no association between alleles and genotypes of placental DROSHA rs10719 and rs6877842 polymorphisms and PE susceptibility. However, placental DROSHA rs10719 was associated with increased PE risk in the recessive model. The combination of CC/GG genotypes of DROSHA rs10719 and rs6877842 polymorphisms was associated with higher risk of PE. The frequency of C-G haplotype was higher in PE women, but the difference was not significant. The DROSHA mRNA expression was downregulated in the placenta of PE women. There was no relation between DROSHA mRNA expression and rs6877842 polymorphism, however, it was decreased in the placenta of women with rs10719CC genotype. The placental DROSHA rs10719 but not rs6877842 polymorphism could be a risk factor for PE susceptibility only in the recessive model. The combination of CC/GG genotypes could be risk factors for PE susceptibility. The DROSHA expression downregulated in the preeclamptic placentas and those carrying rs10719CC genotype. © 2019, Springer Nature Limited

Cancer incidence in Iran in 2014: Results of the Iranian National Population-based Cancer Registry

Background: We aimed to report, for the first time, the results of the Iranian National Population-based Cancer Registry (INPCR) for the year 2014. Methods: Total population of Iran in 2014 was 76,639,000. The INPCR covered 30 out of 31 provinces (98 of total population). It registered only cases diagnosed with malignant new primary tumors. The main sources for data collection included pathology center, hospitals as well as death registries. Quality assessment and analysis of data were performed by CanReg-5 software. Age standardized incidence rates (ASR) (per 100,000) were reported at national and subnational levels. Results: Overall, 112,131 new cancer cases were registered in INPCR in 2014, of which 60,469 (53.9) were male. The diagnosis of cancer was made by microscopic confirmation in 76,568 cases (68.28). The ASRs of all cancers were 177.44 and 141.18 in male and female, respectively. Cancers of the stomach (ASR = 21.24), prostate (18.41) and colorectum (16.57) were the most common cancers in men and the top three cancers in women were malignancies of breast (34.53), colorectum (11.86) and stomach (9.44). The ASR of cervix uteri cancer in women was 1.78. Our findings suggested high incidence of cancers of the esophagus, stomach and lung in North/ North West of Iran. Conclusion: Our results showed that Iran is a medium-risk area for incidence of cancers. We found differences in the most common cancers in Iran comparing to those reported for the World. Our results also suggested geographical diversifies in incidence rates of cancers in different subdivisions of Iran

Cancer in Iran 2008 to 2025: Recent incidence trends and short-term predictions of the future burden

Policymakers require estimates of the future number of cancer patients in order to allocate finite resources to cancer prevention, treatment and palliative care. We examine recent cancer incidence trends in Iran and present predicted incidence rates and new cases for the entire country for the year 2025. We developed a method for approximating population-based incidence from the pathology-based data series available nationally for the years 2008 to 2013, and augmented this with data from the Iranian National Population-based Cancer Registry (INPCR) for the years 2014 to 2016. We fitted time-linear age-period models to the recent incidence trends to quantify the future cancer incidence burden to the year 2025, delineating the contribution of changes due to risk and those due to demographic change. The number of new cancer cases is predicted to increase in Iran from 112 000 recorded cases in 2016 to an estimated 160 000 in 2025, a 42.6 increase, of which 13.9 and 28.7 were attributed to changes in risk and population structure, respectively. In terms of specific cancers, the greatest increases in cases are predicted for thyroid (113.8), prostate (66.7), female breast (63.0) and colorectal cancer (54.1). Breast, colorectal and stomach cancers were the most common cancers in Iran in 2016 and are predicted to remain the leading cancers nationally in 2025. The increasing trends in incidence of most common cancers in Iran reinforce the need for the tailored design and implementation of effective national cancer control programs across the country. © 2021 Union for International Cancer Control

A Critical Review of Multi-hole Drilling Path Optimization

Hole drilling is one of the major basic operations in part manufacturing. It follows without surprise then that the optimization of this process is of great importance when trying to minimize the total financial and environmental cost of part manufacturing. In multi-hole drilling, 70 % of the total process time is spent in tool movement and tool switching. Therefore, toolpath optimization in particular has attracted significant attention in cost minimization. This paper critically reviews research publications on drilling path optimization. In particular, this review focuses on three aspects; problem modeling, objective functions, and optimization algorithms. We conclude that most papers being published on hole drilling are simply basic Traveling Salesman Problems (TSP) for which extremely powerful heuristics exist and for which source code is readily available. Therefore, it is remarkable that many researchers continue developing “novel” metaheuristics for hole drilling without properly situating those approaches in the larger TSP literature. Consequently, more challenging hole drilling applications that are modeled by the Precedence Constrained TSP or hole drilling with sequence dependent drilling times do not much research focus. Sadly, these many low quality hole drilling research publications drown out the occasional high quality papers that describe specific problematic problem constraints or objective functions. It is our hope through this review paper that researchers’ efforts can be refocused on these problem aspects in order to minimize production costs in the general sense