Spatial Localization in Manufacturing: A Cross-Country Analysis

This paper employs a homogeneous-firm database to investigate industry localization in European countries. More specifically, it compares, across industries and countries, the predictions of two of the most popular localization indexes, that is, the Ellison and Glaeser index of 1997 and the Duranton and Overman index of 2005. Independently from the index used, it is found that localization is a pervasive phenomenon in all countries studied; and the degree of localization is very unevenly distributed across industries in each country. Furthermore, it is shown that in all countries localized sectors are mainly ‘traditional’ sectors or, if one controls for country industrial structures, science-based sectors. Moreover, it is found that the two indexes significantly diverge in predicting the intensity of localization of the same industry both across and within countries. In turn, these differences point to the different role played by pecuniary versus non-pecuniary externalities in driving firms' location decisions

Are Output Growth-Rate Distributions Fat-Tailed? Some Evidence from OECD Countries

This work explores some distributional properties of aggregate output growth-rate time series. We show that, in the majority of OECD countries, output growth-rate distributions are well approximated by symmetric exponential power densities with tails much fatter than those of a Gaussian (but with finite moments of any order). Fat tails robustly emerge in output growth rates independently of: (i) the way we measure aggregate output; (ii) the family of densities employed in the estimation; (iii) the length of time lags used to compute growth rates. We also show that fat tails still characterize output growth-rate distributions even after one washes away outliers, autocorrelation and heteroscedasticity

Dynamic links between mechanical forces and metabolism shape the tumor milieu

Cell function relies on the spatiotemporal dynamics of metabolic reactions. In all physiopathological processes of tissues, mechanical forces impact the structure and function of membranes, enzymes, organelles and regulators of metabolic gene programs, thus regulating cell metabolism. In turn, metabolic pathways feedback impacts the physical properties of cell and tissues. Hence, metabolism and tissue mechanics are dynamically intertwined and continuously interact. Cancer is akin to an ecosystem, comprising tumor cells and various subpopulations of stromal cells embedded in an altered extracellular matrix. The progression of cancer, from initiation to advanced stage and metastasis, is driven by genetic mutations and crucially influenced by physical and metabolic alterations in the tumor microenvironment. These alterations also play a pivotal role in cancer cells evasion from immune surveillance and in developing resistance to treatments. Here, we highlight emerging evidence showing that mechano-metabolic circuits in cancer and stromal cells regulate multiple processes crucial for tumor progression and discuss potential approaches to improve therapeutic treatments by interfering with these circuits

Un-biodegradable and biodegradable plastic sheets modify the soil properties after six months since their applications

Nowadays, microplastics represent emergent pollutants in terrestrial ecosystems that exert impacts on soil properties, affecting key soil ecological functions. In agroecosystems, plastic mulching is one of the main sources of plastic residues in soils. The present research aimed to evaluate the effects of two types of plastic sheets (un-biodegradable and biodegradable) on soil abiotic (pH, water content, concentrations of organic and total carbon, and total nitrogen) and biotic (respiration, and activities of hydrolase, dehydrogenase, β-glucosidase and urease) properties, and on phytotoxicity (germination index of Sorghum saccharatum L. and Lepidium sativum L.). Results revealed that soil properties were mostly affected by exposure time to plastics rather than the kind (un-biodegradable and biodegradable) of plastics. After six months since mesocosm setting up, the presence of un-biodegradable plastic sheets significantly decreased soil pH, respiration and dehydrogenase activity and increased total and organic carbon concentrations, and toxicity highlighted by S. saccharatum L. Instead, the presence of biodegradable plastic sheets significantly decreased dehydrogenase activity and increased organic carbon concentrations. An overall temporal improvement of the investigated properties in soils covered by biodegradable plastic sheets occurred

End-of-life in the operational functioning of public healthcare: ethical and legal issues

Background and aim: The article aims to outline the current scenario relative to the medical role in end-of-life issues. In order to do this, historical-legal references have been drawn upon relating to technical, legal and scientific thought and doctrine, as it has come down to us in the medical field through the evolution of ethical and philosophical frameworks. Methods: The authors have conducted a thorough analysis of end-of-life legislative initiatives, in Italy and across the EU, and court rulings to outline possible ways to harmonize and reconcile the current medical ethics frameworks with the needs and rights of all, especially the most vulnerable among us. To that end, the necessary operational choices and adjustments have not yet been made by our legal system, from a technical, as well as moral, standpoint. Results: An operational proposal has therefore been laid out to protect both healthcare providers and patients, in a relationship that goes beyond treatment in the strict sense, which prioritizes mutual needs as an integral part of a common, essential path. Conclusions: In order for doctors to consider themselves complete, they should in fact deal not only with life, but also with death

Variation of the chemical and biological properties of a Technosol during seven years after a single application of compost

Technosols are composed of natural soils mixed with artificial materials and can be an inhospitable environment for the soil microbial community. The main goal of the current research was to evaluate temporal variations of Technosol quality through an integrated approach, considering all of the evaluated chemical, physical and biological characteristics for a period of seven years after a single application of compost. The soil samples were evaluated using the following parameters: pH; water content; water holding capacity; bulk density; porosity; organic matter and N contents; C/N ratio; fungal biomass; microbial biomass; respiration; metabolic quotient (qCO 2 ); and endogenous mineralisation coefficient (CEM). The overall evaluation showed that a single application of compost improved the soil quality in the short term. A decrease in Technosol quality over the long term appears to be due to deterioration of the physical and chemical properties, rather than a change in biological properties

A Methodology to Account for the Finger Non-Uniformity in Photovoltaic Solar Cell

Abstract In this work we investigate the impact of a non-uniform finger in the front-side metallization on the performance of c-Si solar cells. For this purpose, we propose a methodology based on a mixed-mode simulation approach, which allows evaluating the solar cell properties by performing both numerical device simulations and circuit simulations. The finger roughness profile is modeled by means of Gaussian function. The impact of roughness on the solar cell efficiency is studied as a function of mean finger height, mean finger width and finger resistivity. The proposed methodology has been applied to typical roughness profiles realized with two different metallization techniques, the conventional single screen-printing (SP) and the double screen-printing (DP)

Experience of vaccination against invasive bacterial diseases in Veneto Region (North east Italy)

The goal of this study was to describe and comment the experience of the Veneto Region in the bacterial invasive disease. Vaccina- tion coverage was 93% against pneumococcus and 95% against haemophilus influenzae type B. Regard to meningococcus C the coverage rate was 90.1% In children, 81% at 6 years of age and 78.2% at 15 years . The preliminary data of an active surveillance of invasive bacterial diseases show that the Streptoccoccus pneumoniae was the main agent involved and that its consequences were particularly serious in elderly subjects. With regard to Neisseria meningitidis, we observed a substantial reduction in the number of cases due to serogroup C and a concomitant rise in the percentage of cases due to serogroup B. The suspension of mandatory vaccination should be maintained , the monitoring of vaccination coverage and the active surveillance proved to be a very good assessment tools. The full article is free available on www.jpmh.or

A catalogue of observed geo-effective CME/ICME characteristics

One of the goals of Space Weather studies is to achieve a better understanding of impulsive phenomena, such as Coronal Mass Ejections (CMEs), in order to improve our ability to forecast them and mitigate the risk to our technologically driven society. The essential part of achieving this goal is to assess the performance of forecasting models. To this end, the quality and availability of suitable data are of paramount importance. In this work, we have merged already publicly available data of CMEs from both in-situ and remote instrumentation in order to build a database of CME properties. To evaluate the accuracy of such a database and confirm the relationship between in-situ and remote observations, we have employed the drag-based model (DBM) due to its simplicity and inexpensive cost of computational resources. In this study, we have also explored the parameter space for the drag parameter and solar wind speed using a Monte Carlo approach to evaluate how well the DBM determines the propagation of CMEs for the events in the dataset. The dataset of geoeffective CMEs constructed as a result of this work provides validation of the initial hypothesis about DBM, and solar wind speed and also yields further insight into CME features like arrival time, arrival speed, lift-off time, etc. Using a data-driven approach, this procedure allows us to present a homogeneous, reliable, and robust dataset for the investigation of CME propagation. On the other hand, possible CME events are identified where DBM approximation is not valid due to model limitations and higher uncertainties in the input parameters, those events require more thorough investigation