dOCRL maintains immune cell quiescence in Drosophila by regulating endosomal traffic

Lowe Syndrome is a developmental disorder characterized by eye, kidney, and neurological pathologies, and is caused by mutations in the phosphatidylinositol-5-phosphatase OCRL. OCRL plays diverse roles in endocytic and endolysosomal trafficking, cytokinesis, and ciliogenesis, but it is unclear which of these cellular functions underlie specific patient symptoms. Here, we show that mutation of Drosophila OCRL causes cell-autonomous activation of hemocytes, which are macrophage-like cells of the innate immune system. Among many cell biological defects that we identified in docrl mutant hemocytes, we pinpointed the cause of innate immune cell activation to reduced Rab11-dependent recycling traffic and concomitantly increased Rab7-dependent late endosome traffic. Loss of docrl amplifies multiple immune-relevant signals, including Toll, Jun kinase, and STAT, and leads to Rab11-sensitive mis-sorting and excessive secretion of the Toll ligand Spåtzle. Thus, docrl regulation of endosomal traffic maintains hemocytes in a poised, but quiescent state, suggesting mechanisms by which endosomal misregulation of signaling may contribute to symptoms of Lowe syndrome

Observational Constraints on the Common Envelope Phase

The common envelope phase was first proposed more than forty years ago to explain the origins of evolved, close binaries like cataclysmic variables. It is now believed that the phase plays a critical role in the formation of a wide variety of other phenomena ranging from type Ia supernovae through to binary black holes, while common envelope mergers are likely responsible for a range of enigmatic transients and supernova imposters. Yet, despite its clear importance, the common envelope phase is still rather poorly understood. Here, we outline some of the basic principles involved, the remaining questions as well as some of the recent observational hints from common envelope phenomena - namely planetary nebulae and luminous red novae - which may lead to answering these open questions.Comment: 29 pages, 8 figures. To appear in the book "Reviews in Frontiers of Modern Astrophysics: From Space Debris to Cosmology" (eds. Kabath, Jones and Skarka; publisher Springer Nature) funded by the European Union Erasmus+ Strategic Partnership grant "Per Aspera Ad Astra Simul" 2017-1-CZ01-KA203-03556

ON THE ORIGIN OF THE METALLICITY DEPENDENCE IN DYNAMICALLY FORMED EXTRAGALACTIC LOW-MASS X-RAY BINARIES

ABSTRACT Globular clusters (GCs) effectively produce dynamically formed low-mass X-ray binaries (LMXBs). Observers detect ∼100 times more LMXBs per stellar mass in GCs compared to stars in the fields of galaxies. Observationally, metal-rich GCs are about three times more likely to contain an X-ray source than their metal-poor counterparts. Recent observations have shown that this ratio holds in extragalactic GCs for all bright X-ray sources with L X between 2 × 10 37 and 5 × 10 38 erg s −1 . In this Letter, we propose that the observed metallicity dependence of LMXBs in extragalactic GCs can be explained by the differences in the number densities and average masses of red giants in populations of different metallicities. Red giants serve as seeds for the dynamical production of bright LMXBs via two channels-binary exchanges and physical collisions-and the increase of the number densities and masses of red giants boost LMXB production, leading to the observed difference. We also discuss a possible effect of the age difference in stellar populations of different metallicities