The ministry of song : unmarried British women's hymn writing, 1760-1936

Because they were not obliged to take on the familial tasks which until recently have defined woman's role, unmarried British women of literary talent and Christian conviction have often seen themselves as being called to the vocation of hymn-writing. Through biographical study, historical contextualisation and close reading. this thesis examines hymns written by seven such writers, over the period 1760-1936. Chapter 1 examines how Anne Steele's hymns gained entry into print, and came to be circulated and popular. It also demonstrates how the image of Steele as a sickly spinster perpetuated by the Victorian hymnologists is too limited a picture of the writer. Chapter 2 considers two labouring-class hymn writers, Susanna Harrison and Eliza Westbury, and shows how they were heavily influenced by the images and stylistic features of the earlier male hymn writers from the Evangelical tradition. Chapter 3 looks at Charlotte Elliott's writings, which were mostly for invalids, and considers how nineteenth-century Evangelicals often envisaged invalidism as a time for refinement of faith and spiritual action, and the `cult of invalidism' is contextualised. Chapter 4 considers how the writings of Dora Greenwell championed the underprivileged, and envisaged the second coming of Christ as a time for the vanquishing of evil and injustice. Chapter 5 looks at the work of Frances Ridley Havergal, one of the most popular hymn writers of the Victorian era. It considers her Evangelical background, her interest in organisations which encouraged female fellowship and ministry (such as the YWCA, the Mildmay Deaconess Institution and the Zenana missionary organisations), and the transformation of her active faith into a more contemplative one after her experience of `Consecration'. Chapter 6 examines the work and life of the Anglo-Indian hymn writer Ellen Lakshmi Goreh, and considers in further detail the opportunities offered to British women by the call for Zenana missionaries. Chapter 7 looks at the life and writings of Amy Carmichael, founder of the Dohnavur Fellowship, who spent most of her life working as a missionary in India. It shows how her hymns, which owe a debt to the Holiness Movement and its stress on the `rest of faith', and were mostly written for Indian children, are an early example of Indian inculturation

Addressing the Well-Being of Young Children

The COVID-19 pandemic has disrupted young learners\u27 daily routines, learning environments, and home life stability, severely impacting their well-being. Children\u27s issues with mental health, such as anxiety, stress, and depression, significantly impact their ability and interest to achieve in school settings. Additionally, the pandemic affected parents, caregivers, and educators, which had repercussions on their children and students. The authors conducted a literature review, identifying 26 articles that reported on young children\u27s mental health and well-being with a particular interest in the impacts of the COVID-19 pandemic and identified gifted children. This review illuminated some main themes: young children have mental health issues; parents, caregivers, and the environment impact the well-being of young children; mental health services are not readily available to support families and their young children; COVID-19 adversely impacted students, caregivers, and teachers; and strategies exist to better understand and support young children, their families, caregivers, and teachers. Therefore, it is essential to understand the impacts on young children\u27s mental health and how to best support them during these unprecedented times

Regulation of the double-stranded RNA response through ADAR1 licenses metaplastic reprogramming in gastric epithelium

Cells recognize both foreign and host-derived double-stranded RNA (dsRNA) via a signaling pathway that is usually studied in the context of viral infection. It has become increasingly clear that the sensing and handling of endogenous dsRNA is also critical for cellular differentiation and development. The adenosine RNA deaminase, ADAR1, has been implicated as a central regulator of the dsRNA response, but how regulation of the dsRNA response might mediate cell fate during injury and whether such signaling is cell intrinsic remain unclear. Here, we show that the ADAR1-mediated response to dsRNA was dramatically induced in 2 distinct injury models of gastric metaplasia. Mouse organoid and in vivo genetic models showed that ADAR1 coordinated a cell-intrinsic, epithelium-autonomous, and interferon signaling-independent dsRNA response. In addition, dsRNA accumulated within a differentiated epithelial population (chief cells) in mouse and human stomachs as these cells reprogrammed to a proliferative, reparative (metaplastic) state. Finally, chief cells required ADAR1 to reenter the cell cycle during metaplasia. Thus, cell-intrinsic ADAR1 signaling is critical for the induction of metaplasia. Because metaplasia increases cancer risk, these findings support roles for ADAR1 and the response to dsRNA in oncogenesis

Grazing Management Effects on Sediment, Phosphorus, and Pathogen Loading of Streams in Cool-Season Grass Pastures

Erosion and runoff from pastures may lead to degradation of surface water. A 2-yr grazing study was conducted to quantify the effects of grazing management on sediment, phosphorus (P), and pathogen loading of streams in cool-season grass pastures. Six adjoining 12.1-ha pastures bisected by a stream in central Iowa were divided into three treatments: continuous stocking with unrestricted stream access (CSU), continuous stocking with restricted stream access (CSR), and rotational stocking (RS). Rainfall simulations on stream banks resulted in greater (P \u3c 0.10) proportions of applied precipitation and amounts of sediment and P transported in runoff from bare sites than from vegetated sites across grazing treatments. Similar differences were observed comparing vegetated sites in CSU and RS pastures with vegetated sites in CSR pastures. Bovine enterovirus was shed by an average of 24.3% of cows during the study period and was collected in the runoff of 8.3 and 16.7% of runoff simulations on bare sites in CSU pastures in June and October of 2008, respectively, and from 8.3% of runoff simulations on vegetated sites in CSU pastures in April 2009. Fecal pathogens (bovine coronavirus [BCV], bovine rotavirus group A, andEscherichia coli O157:H7) shed or detected in runoff were almost nonexistent; only BCV was detected in feces of one cow in August of 2008. Erosion of cut-banks was the greatest contributor of sediment and P loading to the stream; contributions from surface runoff and grazing animals were considerably less and were minimized by grazing management practices that reduced congregation of cattle by pasture streams

Grazing Management Effects on Sediment, Phosphorus, and Pathogen Loading of Pasture Streams

In order to quantify the sources of sediment, phosphorus (P), and pathogen loading of pasture streams, six 30-acre pastures, bisected by a stream, were stocked with 15 fall-calving cows from mid-May through midOctober of two years by continuous stocking with unrestricted stream access (CSU), continuous stocking with stream access restricted to 16-foot wide stabilized crossings (CSR), or rotational stocking (RS). Cows in RS pastures excreted less fecal P than cows in the CSU and CSR pastures. The proportion of water applied and the amounts of sediment and P in precipitation runoff during rainfall simulations were greater from bare sites on the stream banks of CSU or RS pastures than vegetated sites of CSU, RS, or CSR pastures. Amounts of stream bank erosion did not differ between grazing management treatments. When sources of sediment and P were compared, stream bank erosion contributed 99.5 and 94.4% of the sediment and P loading of the stream. At the stocking rate used in this experiment, direct fecal deposition in the pasture stream contributed more P than transport in precipitation runoff. The incidence of fecal pathogens E. coli O157:H7, bovine coronavirus, and bovine rotavirus shedding in the feces of the cows in this experiment as well as in the runoff from the rainfall simulations was extremely low. These results suggest that the major source of sediment and P loading of pasture streams is stream bank erosion primarily associated with stream hydrology. Grazing management practices that reduce congregation of grazing cattle near pasture streams will reduce sediment and nutrient loading resulting from direct fecal deposition or transport in precipitation runoff. While fecal pathogens may be potential pollutants of pasture streams, pathogen loading of pasture streams by grazing cattle is infrequent and dependent upon the pathogen shedding, temporal\spatial distribution of grazing cattle, and surface runoff from stream banks, in respective order

INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis

Genome-wide association studies (GWAS) have linked common single nucleotide polymorphisms (SNPs) on chromosome 9p21 near the INK4/ARF (CDKN2A/B) tumor suppressor locus with risk of atherosclerotic diseases and type 2 diabetes mellitus. To explore the mechanism of this association, we investigated whether expression of proximate transcripts (p16(INK4a), p15(INK4b), ARF, ANRIL and MTAP) correlate with genotype of representative 9p21 SNPs.We analyzed expression of 9p21 transcripts in purified peripheral blood T-cells (PBTL) from 170 healthy donors. Samples were genotyped for six selected disease-related SNPs spanning the INK4/ARF locus. Correlations among these variables were determined by univariate and multivariate analysis. Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm. Expression of MTAP was not influenced by rs10757278 genotype. No association of any these transcripts was noted with five other tested 9p21 SNPs.Genotypes of rs10757278 linked to increased risk of atherosclerotic diseases are also associated with decreased expression in PBTL of the INK4/ARF locus, which encodes three related anti-proliferative transcripts of known importance in tumor suppression and aging