Bis(chloro­acetato-κ2 O,O′)bis­(2-fluoro­benzyl-κC 1)tin(IV)

In the title complex, [Sn(C2H2ClO2)2(C7H6F)2], the SnIV atom is located on a twofold rotation axis and forms a strongly distorted trans-octa­hedral geometry. The equatorial plane is defined by two chelating chloro­acetate ligands with asymmetrical Sn—O bond lengths, while the axial positions are occupied by the C atoms of two 2-fluoro­benzyl groups. In the crystal, infinite chains in the [010] direction are formed through inter­molecular Sn⋯O inter­actions [Sn⋯O separation = 3.682 (3) Å]

Dense MoS2 Micro‐Flowers Planting on Biomass‐Derived Carbon Fiber Network for Multifunctional Sulfur Cathodes

The significant challenge in lithium‐sulfur batteries (LSBs) arises from low conductivity of sulfur cathode, loss of active sulfur species due to less anchoring sites and sluggish redox kinetics of lithium polysulfides (LPSs). Herein, the dense MoS2 micro‐flowers assembled by cross‐linked 2D MoS2 nanoflakes planting on biomass‐derived carbon fiber (CF) network (MoS2/CFs) are fabricated as multifunctional sulfur cathodes of LSBs. The 2D MoS2 nanoflakes supported on CF provide abundant anchoring sites for strong adsorption, while the 3D flowerlike structure prevents lamellar aggregation of 2D MoS2 nanoflakes. Importantly, the dense MoS2 micro‐flowers planting on the network weaved by biomass‐derived CFs ensures the high electronic conductivity of the MoS2/CFs composite, sufficient electrode/electrolyte interaction, fast electron and Li+ transportation. Moreover, the CF network weaved from cost‐effective tissue paper reduces the cost of LSBs. Thus, the S‐MoS2/CFs cathode exhibits a high rate capability (1149 and 608 mA h g−1 are obtained at 0.2 C and 4 C, respectively), excellent cyclic performance with ∼75% capacity retention and 99% Coulombic efficiency at 2 C after 500 cycles, corresponding to ∼0.05% capacity fading per cycle only, as well as structure integrity during the discharge/charge process.800 Dong Chuan Road, Minhang District, Shanghai 200240, ChinaA novel, cost‐effective, dense 3 D MoS2 micro‐flowers assembled by cross‐linked 2D MoS2 nanoflakes planting on biomass‐derived carbon fiber (CF) network (MoS2/CFs) are fabricated as multifunctional sulfur cathodes of LSBs. The 2D MoS2 nanoflakes provide abundant anchoring sites for strong adsorption, while the 3D flowerlike structure prevents lamellar aggregation of 2D MoS2 nanoflakes. Significantly, the dense MoS2 micro‐flowers supported on carbon fibers ensures the high electronic conductivity of the MoS2/CFs composite, sufficient electrode/electrolyte interaction, fast electron and Li+ transportation.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155938/1/slct202001729-sup-0001-misc_information.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155938/2/slct202001729_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155938/3/slct202001729.pd

Electrocatalytic conversion of lithium polysulfides by highly dispersed ultrafine Mo2C nanoparticles on hollow N‐doped carbon flowers for Li‐S batteries

The significant challenge in exploring novel nanostructured sulfur host materials for Li‐S batteries is to simultaneously mitigate the notorious shuttle effect and catalytically enhance the redox kinetics of lithium polysulfides (LPSs). Herein, a novel ultrafine Mo2C nanoparticles uniformly distributed on 2D nanosheet‐assembled 3D hollow nitrogen‐doped carbon flowers (HNCFs) is designed. The Mo2C/HNCFs architecture with unique flower‐like morphologies not only efficiently suppressed the aggregation of 2D nanosheets but also highly distributed the ultrafine Mo2C nanoparticles that act as catalytic active sites for efficient adsorption and conversion of LPSs. Furthermore, the 3D hierarchical arrangement can afford ample internal space to accommodate sulfur species, large volume expansion, 3D electron pathway, and physical/chemical blockage of LPSs to reduce the loss of active materials. The Mo2C/HNCFs composite exhibits a high rate capability, unprecedented capacity retention of 92% over 100 cycles at 0.5 C placing Mo2C/HNCFs one of the best LPSs adsorbents and electrocatalysts.Ultrafine Mo2C nanoparticles on hollow N‐doped carbon flowers have been employed as efficient catalytic active sites for conversion of LPSs, which can not only enhance the LPSs‐adsorption ability but also accelerate the redox kinetics of polysulfide conversion. Besides, the unique architecture of 2D nanosheets assembled 3D hollow N‐doped carbon flowers contributes to Li+ transportation and electrolyte infiltration.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/155989/1/eom212020.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/155989/2/eom212020_am.pd

Selective catalytic reduction of NOx with NH3 over short-range ordered W-O-Fe structures with high thermal stability

This work was supported by National Natural Science Foundation of China (Nos. 21477046, 21333003, and 21673072) and Key Technology R&D Program of Shandong Province (No. 2016ZDJS11A03).Peer reviewedPostprintPostprin

Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism

Cells with sphere forming capacity, spheroid cells, are present in the malignant ascites of patients with epithelial ovarian cancer (EOC) and represent a significant impediment to efficacious treatment due to their putative role in progression, metastasis and chemotherapy resistance. The exact mechanisms that underlie EOC metastasis and drug resistance are not clear. Understanding the biology of sphere forming cells may contribute to the identification of novel therapeutic opportunities for metastatic EOC. Here we generated spheroid cells from human ovarian cancer cell lines and primary ovarian cancer. Xenoengraftment of as few as 2000 dissociated spheroid cells into immune-deficient mice allowed full recapitulation of the original tumor, whereas >105 parent tumor cells remained non-tumorigenic. The spheroid cells were found to be enriched for cells with cancer stem cell-like characteristics such as upregulation of stem cell genes, self-renewal, high proliferative and differentiation potential, and high aldehyde dehydrogenase (ALDH) activity. Furthermore, spheroid cells were more aggressive in growth, migration, invasion, scratch recovery, clonogenic survival, anchorage-independent growth, and more resistant to chemotherapy in vitro. 13C-glucose metabolic studies revealed that spheroid cells route glucose predominantly to anaerobic glycolysis and pentose cycle to the detriment of re-routing glucose for anabolic purposes. These metabolic properties of sphere forming cells appear to confer increased resistance to apoptosis and contribute to more aggressive tumor growth. Collectively, we demonstrated that spheroid cells with cancer stem cell-like characteristics contributed to tumor generation, progression and chemotherapy resistance. This study provides insight into the relationship between tumor dissemination and metabolic attributes of human cancer stem cells and has clinical implications for cancer therapy

Active Site Identification and Modification of Electronic States by Atomic-Scale Doping To Enhance Oxide Catalyst Innovation

This work was supported by National Natural Science Foundation of China (No. 21477046) and Key Technology R&D Program of Shandong Province (No. 2016ZDJS11A03).Peer reviewedPostprin

Molecular-Level Insight into Selective Catalytic Reduction of NOx with NH3 to N-2 over a Highly Efficient Bifunctional V-alpha-MnOx Catalyst at Low Temperature

This work was supported by the National Natural Science Foundation of China (Nos. 21477046, 21333003, and 21673072) and Key Technology R&D Program of Shandong Province (No. 2016ZDJS11A03). The authors also acknowledge computing time support from the Special Program for Applied Research on Super Computation of the NSFC-Guangdong Joint Fund (the second phase) under Grant No. U1501501.Peer reviewedPostprin

Calcium Intake and Risk of Colorectal Cancer According to Tumor-infiltrating T Cells

Calcium intake has been associated with a lower risk of colorectal cancer. Calcium signaling may enhance T-cell proliferation and differentiation, and contribute to T-cell–mediated antitumor immunity. In this prospective cohort study, we investigated the association between calcium intake and colorectal cancer risk according to tumor immunity status to provide additional insights into the role of calcium in colorectal carcinogenesis. The densities of tumor-infiltrating T-cell subsets [CD3+, CD8+, CD45RO (PTPRC)+, or FOXP3+ cell] were assessed using IHC and computer-assisted image analysis in 736 cancer cases that developed among 136,249 individuals in two cohorts. HRs and 95% confidence intervals (CI) were calculated using Cox proportional hazards regression. Total calcium intake was associated with a multivariable HR of 0.55 (comparing ≥1,200 vs. <600 mg/day; 95% CI, 0.36–0.84; Ptrend = 0.002) for CD8+ T-cell–low but not for CD8+ T-cell–high tumors (HR = 1.02; 95% CI, 0.67–1.55; Ptrend = 0.47). Similarly, the corresponding HRs (95% CIs) for calcium for low versus high T-cell–infiltrated tumors were 0.63 (0.42–0.94; Ptrend = 0.01) and 0.89 (0.58–1.35; Ptrend = 0.20) for CD3+; 0.58 (0.39–0.87; Ptrend = 0.006) and 1.04 (0.69–1.58; Ptrend = 0.54) for CD45RO+; and 0.56 (0.36–0.85; Ptrend = 0.006) and 1.10 (0.72–1.67; Ptrend = 0.47) for FOXP3+, although the differences by subtypes defined by T-cell density were not statistically significant. These potential differential associations generally appeared consistent regardless of sex, source of calcium intake, tumor location, and tumor microsatellite instability status. Our findings suggest a possible role of calcium in cancer immunoprevention via modulation of T-cell function