Deep eutectic solvents for improved biomass pretreatment: current status and future prospective towards sustainable processes

Pretreatment processes - recognized as critical steps for efficient biomass refining - have received much attention over the last two decades. In this context, deep eutectic solvents (DES) have emerged as a novel alternative to conventional solvents representing a step forward in achieving more sustainable processes with both environmental and economic benefits. This paper presents an updated review of the state-of-the-art of DES-based applications in biorefinery schemes. Besides describing the fundamentals of DES composition, synthesis, and recycling, this study presents a comprehensive review of existing techno-economic and life cycle assessment studies. Challenges, barriers, and perspectives for the scale-up of DES-based processes are also discussed.publishe

Chlorambucil Conjugated Ugi Dendrimers with PAMAM-NH₂ Core and Evaluation of Their Anticancer Activity

Herein, a new Ugi multicomponent reaction strategy is described to enhance activity and solubility of the chemotherapeutic drug chlorambucil through its conjugation to poly(amidoamine) (PAMAM-NH2) dendrimers with the simultaneous introduction of lipidic (i-Pr) and cationic (⁻NH2) or anionic (⁻COOH) groups. Standard viability assays were used to evaluate the anticancer potential of the water-soluble dendrimers against PC-3 prostate and HT-29 colon cancer cell lines, as well as non-cancerous mouse NIH3T3 fibroblasts. It could be demonstrated that the anticancer activity against PC-3 cells was considerably improved when both chlorambucil and ⁻NH2 (cationic) groups were present on the dendrimer surface (1b). Additionally, this dendrimer showed activity only against the prostate cancer cells (PC-3), while it did not affect colon cancer cells and fibroblasts significantly. The cationic chlorambucil-dendrimer 1b blocks PC-3 cells in the G2/M phase and induces caspase independent apoptosis

Analysis of the kinematics of gait of young adult female carryng a computer bag with single handle

The aim of this study is to assess postural changes in young female adults carrying a personal computer and some auxiliary material in a shoulder bag. Images have been recorded in the frontal and sagittal planes. After recording, the anatomical landmarks were manually digitized with appropriate software. Analyzing the data and comparing the two situations - with and without carrying a load can be registered significant differences in posture and normal gait