Smoking and Psoriasis: From Epidemiology to Pathomechanisms

Smoking is a well-established environmental risk factor for psoriasis. It should be carefully considered in genetic studies because smoking can modify risk estimates for genetic markers. Genome-wide association studies may facilitate the analysis of genetic–environmental interaction in psoriasis

Face mask use in the community and cutaneous reactions to them during the COVID-19 pandemic: results of a national survey in Italy.

To mitigate the outbreak of coronavirus disease 2019 pandemic, many countries have imposed the public use of face masks. We investigated attitudes and skin reactions in the Italian individuals wearing face masks during the pandemic. A cross-sectional survey on a random sample (N=1001) of the Italian adult population was conducted in May 2020 by the Italian Group for Epidemiological Research in Dermatology, and the Gallup International Association. Univariable and multivariable regression analysis were used to estimate the odds ratios and their 95% confidence intervals. Most individuals (72.5%) wore a mask, 56.5% used a surgical mask and 53.0% a disposable mask. One-third changed the mask at least once a day, two-thirds kept a distance of at least one meter from each other, 50% washed their hands before wearing a mask, and 17.6% adopted multiple hygienic behaviors. Twenty percent of individuals reported redness, swelling, itching or erosions in the skin area of mask contact; the risk of this reaction was associated with young age, the use of respirators and a history of pre-existing contact eczema, psoriasis or atopic dermatitis. Health educational programs may improve compliance with combined preventive measures and reduce skin reactions

Conflicts of interest in dermatology

Conflicts of interest exist in dermatology when professional judgement concerning a primary interest, such as research validity, may be influenced by a secondary interest, such as financial gain from a for-profit organization. Conflict of interest is a condition and not a behaviour, although there is clear evidence that gifts influence behaviour. Little has been written about conflicts of interest in dermatology. This series of papers raises awareness of the subject by exploring it in greater depth from the perspective of a dermatology researcher, an industry researcher, a dermatology journal editor, a health services researcher and a patient representative. Collectively, they illustrate the many ways in which conflicts can pervade the world of dermatology publications and patient support group activities

Validity of Self-Reported Psoriasis in a General Population: The HUNT Study, Norway

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Double-blind placebo-controlled randomized clinical trial on the efficacy of Aerosal® in the treatment of sub-obstructive adenotonsillar hypertrophy and related diseases

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The Covid-19 explosion in the state of Amapá: how is the most preserved region in the Brazilian Amazon currently fighting the SARS-COV 2 pandemic?

The state of Amapá is located in the extreme north of Brazil, within the Amazon rainforest and is crossed by the Equator. It has a hot and humid climate with rains that last 8 months a year and 4 months of unrelenting sun that melts rubber from car seals, fries eggs on the floor and even cooks a whole egg tub, in case you forget in a car exposed to the sun . It was believed that with this potent solar incidence, the Sars-COV 2 virus would not have so much impact in this region, a terrible mistake! Today Amapá has the highest incidence of Covid-19 in the whole of Brazil, with a maid of 600 cases per hundred thousand inhabitants and in the Amazon it is the 3rd in deaths and loses in this item only to the state of Amazonas and Pará.The state of Amapá is located in the extreme north of Brazil, within the Amazon rainforest and is crossed by the Equator. It has a hot and humid climate with rains that last 8 months a year and 4 months of unrelenting sun that melts rubber from car seals, fries eggs on the floor and even cooks a whole egg tub, in case you forget in a car exposed to the sun . It was believed that with this potent solar incidence, the Sars-COV 2 virus would not have so much impact in this region, a terrible mistake! Today Amapá has the highest incidence of Covid-19 in the whole of Brazil, with a maid of 600 cases per hundred thousand inhabitants and in the Amazon it is the 3rd in deaths and loses in this item only to the state of Amazonas and Pará

Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe

<p>Abstract</p> <p>Background</p> <p>Stevens-Johnson syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare but extremely severe cutaneous adverse drug reactions in which drug-specific associations with HLA-B alleles were described.</p> <p>Objectives</p> <p>To investigate genetic association at a genome-wide level on a large sample of SJS/TEN patients.</p> <p>Methods</p> <p>We performed a genome wide association study on a sample of 424 European cases and 1,881 controls selected from a Reference Control Panel.</p> <p>Results</p> <p>Six SNPs located in the HLA region showed significant evidence for association (OR range: 1.53-1.74). The haplotype formed by their risk allele was more associated with the disease than any of the single SNPs and was even much stronger in patients exposed to allopurinol (OR_allopurinol= 7.77, 95%CI = [4.66; 12.98]). The associated haplotype is in linkage disequilibrium with the HLA-B*5801 allele known to be associated with allopurinol induced SJS/TEN in Asian populations.</p> <p>Conclusion</p> <p>The involvement of genetic variants located in the HLA region in SJS/TEN is confirmed in European samples, but no other locus reaches genome-wide statistical significance in this sample that is also the largest one collected so far. If some loci outside HLA play a role in SJS/TEN, their effect is thus likely to be very small.</p

Survival, efficacy and safety of tralokinumab after 32 and 52 weeks of treatment for moderate-to-severe atopic dermatitis in adults: A multicentre real-world study

, efficacy and safety of tralokinumab after 32 and 52weeks of treatment for moderate-to-severe atopic dermatitis in adults: A multicentre real-world stud