The Petz (lite) recovery map for scrambling channel

We study properties of the Petz recovery map in chaotic systems, such as the Hayden-Preskill setup for evaporating black holes and the SYK model. Since these systems exhibit the phenomenon called scrambling, we expect that the expression of the recovery channel $\mathcal{R}$ gets simplified, given by just the adjoint $\mathcal{N}^{\dagger}$ of the original channel $\mathcal{N}$ which defines the time evolution of the states in the code subspace embedded into the physical Hilbert space. We check this phenomenon in two examples. The first one is the Hayden-Preskill setup described by Haar random unitaries. We compute the relative entropy $S(\mathcal{R}\left[\mathcal{N}[\rho]\right] ||\rho)$ and show that it vanishes when the decoupling is archived. We further show that the simplified recovery map is equivalent to the protocol proposed by Yoshida and Kitaev. The second example is the SYK model where the two dimensional code subspace is defined by an insertion of a fermionic operator, and the system is evolved by the SYK Hamiltonian. We check the recovery phenomenon by relating some matrix elements of an output density matrix $\langle T|\mathcal{R}[\mathcal{N}[\rho]]|T' \rangle$ to R\'enyi-two modular flowed correlators, and show that they coincide with the elements for the input density matrix with small error after twice the scrambling time.Comment: 47pages with 19 figure

Analysis of IGZO crystalline structure and its stability by first-principles calculations

In-Ga-Zn oxide (IGZO), an oxide semiconductor, has been actively researched as a semiconductor material having features different from those of silicon in recent years [1]. IGZO is used as a transistor material in backplanes of commercially available displays. Transistors including crystalline IGZO have high stability and thus are suitable for mass production [2]. Our previous studies revealed that the selected area diffraction pattern of an IGZO film formed at room temperature by sputtering is a halo pattern, whereas diffraction spots are observed in the diffraction pattern obtained by nanobeam electron diffraction with a probe diameter of 1 nm [3,4]. These results suggest that the IGZO film has rather nanometer-sized crystalline structures than a completely amorphous structure. We named this film “nano-crystalline IGZO (nc-IGZO) film.” Other researchers have reported that the nc-IGZO film has a crystalline-cluster composite structure, according to the analysis results obtained by grazing-incidence X-ray diffraction, anomalous X-ray scattering, and reverse-Monte-Carlo simulation [5]. In this study, an IGZO structure having a minute crystalline region, which was considered to exist in nc-IGZO as a local structure, was created by first-principles calculations and its stability was analyzed. The IGZO model having a crystalline region used in this study was obtained by a melt-quench method in the following manner. Note that the initial structure had a hexagonal-prism crystalline region at the center and an amorphous region (random atomic arrangement) around the crystalline region. The composition ratio was In:Ga:Zn:O = 1:1:1:4 and the density was 6.1 g/cm3. First, for structural relaxation with the crystalline region maintained, the amorphous region was fused in quantum molecular dynamics simulation (3500 K, 6 ps) while the atomic arrangement of the crystalline region was fixed, and the structure was cooled to 500 K at a rate of 500 K/ps and held at 300 K for 5 ps. Finally, the entire structure including the crystalline region was optimized towards the target structure (Fig. 1). An amorphous model was also created for reference. The amorphous model was obtained by quantum molecular dynamics simulation of the entire structure under similar temperature conditions without fixing the atomic arrangement of the crystalline region, followed by structural optimization. The comparison between the two models showed that the total energy of the IGZO model having a crystalline region was lower than that of the amorphous model (not having a crystalline region). This suggests that the crystalline region contributes to structure stabilization. Please click Additional Files below to see the full abstract

Crystallinity of In-Ga-Zn-oxide (IGZO) in CAAC-IGZO vertical FET

Oxide semiconductor field-effect transistors (OSFETs) are actively developed [1]. In particular, there are many reports on a typical oxide semiconductor, In-Ga-Zn oxide (IGZO) [2]. An OSFET is fabricated with a planar structure in many cases; however, a vertical FET (VFET) with a current path perpendicular to a substrate can be fabricated with an area overhead comparable to one trench hole, and is gathering attention [3]. The VFET structure enables OSFETs to be highly integrated, and also allows the resolution of displays to be higher. Please click Download on the upper right corner to see the full abstract

Vertical oxide semiconductor field-effect transistor with extremely low off-state current

Oxide semiconductor field-effect transistors (OSFETs) are actively developed for display applications. An OSFET exhibits a lower off-state current than a silicon FET and enables low-frequency driving. We developed the measurement method and revealed the OSFET exhibits an extremely low off-state current [1]. In addition, we discovered a c-axis aligned crystalline indium-gallium-zinc oxide (CAAC-IGZO) which was unique crystal morphology [2]. A display with a backplane formed using CAAC-IGZO FETs achieves low power consumption owing to idling-stop driving that allows an extremely low refresh rate [3]. Please click Download on the upper right corner to see the full abstract

Bioinformatics for Functional Analyses of Odorant Receptors

In order to delineate the functional aspects of odorant receptors as protein molecules, we here employed computational and biological approaches, each of which could eventually highlight different aspects of odorant receptors. We first characterized the non-redundant protein database to depict the general nature of proteins with a comprehensive database search strategy. We also employed a computational method called self-organizing map to understand possible relations of odorant receptors to other G-protein-coupled receptors. Furthermore, we have studied how to deliver foreign genes or proteins to olfactory sensory neurons in mice in vivo. Systematic synthesis of these computational and biological results could pave the way to our understanding of the whole nature of odorant receptors as protein molecules

Attempts to increase the rate of organ donation confirmation at emergency medical department

富山大学・富医薬博甲第328号・高橋 絹代・2020/03/24関連論文Importance of Continuing Education for Medical Staff to Improve the Confirmation Rate of Intent for Organ Donationdoi：10.1016/j.transproceed.2019.08.043富山大

Human NK cell development in hIL-7 and hIL-15 knockin NOD/SCID/IL2rgKO mice.

The immune system encompasses acquired and innate immunity that matures through interaction with microenvironmental components. Cytokines serve as environmental factors that foster functional maturation of immune cells. Although NOD/SCID/IL2rgKO (NSG) humanized mice support investigation of human immunity in vivo, a species barrier between human immune cells and the mouse microenvironment limits human acquired as well as innate immune function. To study the roles of human cytokines in human acquired and innate immune cell development, we created NSG mice expressing hIL-7 and hIL-15. Although hIL-7 alone was not sufficient for supporting human NK cell development in vivo, increased frequencies of human NK cells were confirmed in multiple organs of hIL-7 and hIL-15 double knockin (hIL-7xhIL-15 KI) NSG mice engrafted with human hematopoietic stem cells. hIL-7xhIL-15 KI NSG humanized mice provide a valuable in vivo model to investigate development and function of human NK cells

A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.

Funder: Japan Foundation for Applied Enzymology; doi: https://doi.org/10.13039/100008695Funder: Pancreas Research Foundation of Japan Collaborative Research Project Program of the Medical Institute of Bioregulation, Kyushu University, Japan Joint Research Program of the Institute for Molecular and Cellular Regulation, Gunma University, Japan Grant for Joint Research Project of the Research Institute for Microbial Diseases Osaka UniversityFunder: European Research Council (ERC (639050) and the Interpark Bio-Convergence Center Grant Program.Frequent mutation of the tumour suppressor RNF43 is observed in many cancers, particularly colon malignancies. RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity requires phosphorylation at a triplet of conserved serines. This phospho-regulation of RNF43 is required for zebrafish development and growth of mouse intestinal organoids. Cancer-associated mutations that abrogate RNF43 phosphorylation cooperate with active Ras to promote tumorigenesis by abolishing the inhibitory function of RNF43 in Wnt signalling while maintaining its inhibitory function in p53 signalling. Our data suggest that RNF43 mutations cooperate with KRAS mutations to promote multi-step tumorigenesis via the Wnt-Ras-p53 axis in human colon cancers. Lastly, phosphomimetic substitutions of the serine trio restored the tumour suppressive activity of extracellular oncogenic mutants. Therefore, harnessing phospho-regulation of RNF43 might be a potential therapeutic strategy for tumours with RNF43 mutations

Feasibility of methotrexate discontinuation following tocilizumab and methotrexate combination therapy in patients with long-standing and advanced rheumatoid arthritis: a 3-year observational cohort study

Objectives: Methotrexate (MTX) is associated with extensive side effects, including myelosuppression, interstitial pneumonia, and infection. It is, therefore, critical to establish whether its administration is required after achieving remission with tocilizumab (TCZ) and MTX combination therapy in patients with rheumatoid arthritis (RA). Therefore, the aim of this multicenter, observational, cohort study was to evaluate the feasibility of MTX discontinuation for the safety of these patients. Methods: Patients with RA were administered TCZ, with or without MTX, for 3 years; those who received TCZ+MTX combination therapy were selected. After remission was achieved, MTX was discontinued without flare development in one group (discontinued [DISC] group, n = 33) and continued without flare development in another group (maintain [MAIN] group, n = 37). The clinical efficacy of TCZ+MTX therapy, patient background characteristics, and adverse events were compared between groups. Results: The disease activity score in 28 joints-erythrocyte sedimentation rate (DAS28-ESR) at 3, 6, and 9 months was significantly lower in the DISC group (P < .05, P < .01, and P < .01, respectively). Further, the DAS28-ESR remission rate at 6 and 9 months and Boolean remission rate at 6 months were significantly higher in the DISC group (P < .01 for all). Disease duration was significantly longer in the DISC group (P < .05). Furthermore, the number of patients with stage 4 RA was significantly higher in the DISC group (P < .01). Conclusions: Once remission was achieved, MTX was discontinued in patients who responded favorably to TCZ+MTX therapy, despite the prolonged disease duration and stage progression