The General Type N Solution of New Massive Gravity

We find the most general algebraic type N solution with non-vanishing scalar curvature, which comprises all type N solutions of new massive gravity in three dimensions. We also give the special forms of this solution, which correspond to certain critical values of the topological mass. Finally, we show that at the special limit, the null Killing isometry of the spacetime is restored and the solution describes AdS pp-waves.Comment: 7 pages, twocolumn REVTeX; minor changes, new references adde

A Complete Classification of Higher Derivative Gravity in 3D and Criticality in 4D

We study the condition that the theory is unitary and stable in three-dimensional gravity with most general quadratic curvature, Lorentz-Chern-Simons and cosmological terms. We provide the complete classification of the unitary theories around flat Minkowski and (anti-)de Sitter spacetimes. The analysis is performed by examining the quadratic fluctuations around these classical vacua. We also discuss how to understand critical condition for four-dimensional theories at the Lagrangian level.Comment: 20 pages, v2: minor corrections, refs. added, v3: logic modified, v4: typos correcte

Quadratic Curvature Gravity with Second Order Trace and Massive Gravity Models in Three Dimensions

The quadratic curvature lagrangians having metric field equations with second order trace are constructed relative to an orthonormal coframe. In $n>4$ dimensions, pure quadratic curvature lagrangian having second order trace constructed contains three free parameters in the most general case. The fourth order field equations of some of these models, in arbitrary dimensions, are cast in a particular form using the Schouten tensor. As a consequence, the field equations for the New massive gravity theory are related to those of the Topologically massive gravity. In particular, the conditions under which the latter is "square root" of the former are presented.Comment: 24 pages, to appear in GR

T-cell subpopulations αβ and γδ in cord blood of very preterm infants : The influence of intrauterine infection

Open Access: This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are creditedPreterm infants are very susceptible to infections. Immune response mechanisms in this group of patients and factors that influence cord blood mononuclear cell populations remain poorly understood and are considered insufficient. However, competent immune functions of the cord blood mononuclear cells are also described. The aim of this work was to evaluate the T-cell population (CD3+) with its subpopulations bearing T-cell receptor (TCR) αβ or TCR γδ in the cord blood of preterm infants born before 32 weeks of gestation by mothers with or without an intrauterine infection. Being a pilot study, it also aimed at feasibility check and assessment of an expected effect size. The cord blood samples of 46 infants age were subjected to direct immunofluorescent staining with monoclonal antibodies and then analyzed by flow cytometry. The percentage of CD3+ cells in neonates born by mothers with diagnosis of intrauterine infection was significantly lower than in neonates born by mothers without infection (p = 0.005; Mann-Whitney U test). The number of cells did not differ between groups. Infection present in the mother did not have an influence on the TCR αβ or TCR γδ subpopulations. Our study contributes to a better understanding of preterm infants' immune mechanisms, and sets the stage for further investigations.Peer reviewedFinal Published versio

Recurrent spontaneous hip dislocation in a patient with neurofibromatosis type 1: a case report

<p>Abstract</p> <p>Introduction</p> <p>Neurofibromatosis type-1 is a common genetic disorder which often affects the skeleton. Skeletal manifestations of neurofibromatosis type-1 include scoliosis, congenital pseudarthrosis of the tibia and intraosseous cystic lesions. Dislocation of the hip associated with neurofibromatosis type-1 is a rare occurrence and is underreported in the literature.</p> <p>Case presentation</p> <p>We report a case of hip dislocation resulting from an intra-articular neurofibroma in an 18-year-old Caucasian woman following minor trauma. This was originally suggested by the abnormalities on early radiographs of her pelvis and later confirmed with computed tomography and magnetic resonance imaging. Treatment was successful with skeletal traction for six weeks with no further hip dislocations at a 12-year follow-up.</p> <p>Conclusion</p> <p>This case illustrates the radiological features of this rare complication of neurofibromatosis type-1 using the modalities of plain radiograph, magnetic resonance imaging and computed tomography reconstruction. The radiological images give a clear insight into the mechanism by which neurofibromatosis type-1 leads to hip dislocation. It also demonstrates one treatment option with excellent results on long-term follow-up.</p

Podridões em raízes de mandioca: problemas e soluções para o seu controle.

O objetivo deste trabalho foi apresentar de modo simples e objetivo medidas para superação dos principais fatores relacionados com a ocorrência das podridões das raízes da mandioca.bitstream/item/214557/1/DOC455.pd

Finding needles in haystacks: linking scientific names, reference specimens and molecular data for Fungi

DNA phylogenetic comparisons have shown that morphology-based species recognition often underestimates fungal diversity. Therefore, the need for accurate DNA sequence data, tied to both correct taxonomic names and clearly annotated specimen data, has never been greater. Furthermore, the growing number of molecular ecology and microbiome projects using high-throughput sequencing require fast and effective methods for en masse species assignments. In this article, we focus on selecting and re-annotating a set of marker reference sequences that represent each currently accepted order of Fungi. The particular focus is on sequences from the internal transcribed spacer region in the nuclear ribosomal cistron, derived from type specimens and/or ex-type cultures. Re-annotated and verified sequences were deposited in a curated public database at the National Center for Biotechnology Information (NCBI), namely the RefSeq Targeted Loci (RTL) database, and will be visible during routine sequence similarity searches with NR_prefixed accession numbers. A set of standards and protocols is proposed to improve the data quality of new sequences, and we suggest how type and other reference sequences can be used to improve identification of Fungi

Efeito de extratos vegetais na inibição do crescimento micelial de Lasiodiplodia pseudotheobromae e Cylindrocladium sp.

O presente trabalho teve o objetivo de avaliar o efeito de extratos de plantas alimentícias não convencionais (PANCs) e de plantas medicinais no crescimento de Lasiodiplodiapseudotheobromae e Cylindrocladium sp. Foram avaliados sete extratos de PANCs e nove extratos de plantas medicinais. Os extratos foram incorporados ao meio de cultura na concentração de 1%. Um disco de micélio fúngico foi depositado no centro de cada placa. A avaliação foi realizada diariamente até que o crescimento micelial atingisse uma das extremidades da placa em um dos tratamentos. O delineamento experimental foi inteiramente casualizado com cinco repetições. Para L. pseudotheobromae, os extratos de flor de jambu, gengibre, eucalipto, folha de jambu, batata-doce, erva-cidreira, vinagreira, mastruz e alfavaca proporcionaram reduções entre 8,33% e 38,55%. Para Cylindrocladium sp., os extratos de flor de jambu, alfavaca, noni, nim, erva- -cidreira, cipó-d?alho, gengibre, coramina, capim-santo, mastruz, batata-doce, folha de jambu, ora-pro-nobis e vinagreira reduziram o crescimento micelial entre 7,48% e 18,04%. O extrato de flor de jambu apresentou os melhores resultados do estudo para ambos os fungos, representando assim, uma alternativa potencial a ser estudada no controle de doenças associadas a estes patógenos.bitstream/item/220566/1/BPD145.pd

Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting

Cell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic virus, Seprehvir, into primary and metastatic tumour sites in mice. To achieve this, we magnetically label macrophages with super-paramagnetic iron oxide nanoparticles and apply pulsed magnetic field gradients in the direction of the tumour sites. Magnetic resonance targeting guides macrophages from the bloodstream into tumours, resulting in increased tumour macrophage infiltration and reduction in tumour burden and metastasis. Our study indicates that clinical MRI scanners can not only track the location of magnetically labelled cells but also have the potential to steer them into one or more target tissues