Anti-tumor-promoting activity of simple models of galactoglycerolipids with branched and unsaturated acyl chains

Six new galactoglycerolipid analogs, in which one or two 4-methylpentanoyl or trans-2-butenoyl groups are linked to the 2-O-beta-D-galactosylglycerol skeleton, were tested for their anti-tumor-promoting activity using a short-term in vitro assay for Epstein-Barr virus early antigen (EBV-EA) activation. All these compounds were more active than their linear or saturated reference compounds in inhibiting the EBV activation promoted by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA), the diester 1-O-(4-methylpentanoyl)-2-O-[6-O-(4-methylpentanoyl)-beta-D-galactopyran osyl]-sn-glyceroI resulting the most active glycoglycerolipid analog till now tested. Four compounds (three butenoates and one 4-methylpentanoate), when tested in the in vivo two-stage carcinogenesis test, exhibited also inhibitory effects on mouse skin tumor promotion. (C) 2004 Elsevier SAS. All rights reserved

Global configuration of Saturn's magnetic field derived from observations

Magnetic field observations from the Cassini spacecraft are averaged into 1 × 1 RS (1 RS = 60238 km) meridional bins at Saturn. A Runge-Kutta procedure uses the bin-averaged field components to estimate the global configuration of Saturn's magnetic field and map field lines from the equator to Saturn's ionosphere. Within ∼18 RS of Saturn, the mapping gives a good representation of the meridional shape of Saturn's magnetic field and confirms that beyond L ∼ 6, the field departs from a dipole and becomes a smoothly-warped magnetodisk. The disk warps upwards by as much as ∼1 RS at radial distances of ∼15 RS, with the warping increasing with radial distance. When traced back to Saturn, the bin average field lines intersect the ionosphere at latitudes similar to those expected on the basis of recent magnetic field models; the ionospheric pierce latitudes can differ by as much as 6° from those expected from a simple offset dipole

Dynamics of the flowfield generated by the interaction of twin inclined jets of variable temperatures with an oncoming crossflow

International audienceThe present paper examines the common configuration of ``twin inclined jets in crossflow'' that is widely present in several industrial and academic, small and large-scale applications. It is particularly found in aerodynamic and engineering applications like VTOL aircrafts, the combustion mixing process and other chemical chambers. It can also be found in some domestic applications like chimney stacks or water discharge piping systems in rivers and seas. The twin jets considered in this work are elliptic as inclined with a 60A degrees angle and arranged inline with the oncoming crossflow according to a jet spacing of three diameters. They are examined experimentally in a wind tunnel. The corresponding data is tracked by means of the particle image velocimetry technique in order to obtain the different instantaneous and mean dynamic features (different velocity components, vortices, etc.). The same case is numerically reproduced by the resolution of the Navier-Stokes equations by means of the finite volume method together with the Reynolds stress model second order turbulent closure model. A non-uniform mesh system tightened close to the emitting nozzles is also adopted. The comparison of the measured and calculated data gave a satisfying agreement. Further assumptions are adopted later in order to improve the examined configuration: a non-reactive fume is injected within the discharged jets and the jets' temperature is varied with reference to a constant mainstream temperature. Our aim is to evaluate precisely the impact of this temperature difference on the flow field, particularly on the dynamics of the jets in a crossflow. This parameter, namely the temperature difference, proved mainly to accelerate the discharged jet plumes in the direction of the main flow, which enhanced the mixing, particularly in the longitudinal direction. The mixing in the other directions was also increased due to the weaker density of the jets, which enabled them to progress relatively unhindered before undergoing the impact of the crossflow