Adaptive Reuse of the Industrial Building: A case of Energy Museum in Sanatistanbul, Turkey

Industrial buildings as an example of cultural heritage transform our cultural identity from the past to the present and even for the future. Unfortunately, there are lots of industrial building which lost its function by converting the place to live and identifiable place. This research will clarify the reasons for conserving of the industrial heritage and by classification of international charters which are dealing with industrial heritage will introduce conservation methods for adaptive reuse of industrial buildings. As a case study, the research will focus on Energy Museum in Istanbul. To assess the building based on reusing principals. The study concludes that the Energy Museum is one of the successful examples of reuse of the building. It also concludes that less intervention in reusing a building can save the identity of the building

The Pedestrianisation and Its Relation with Enhancing Walkability in Urban Spaces

The study aimed to answer the question of how pedestrianisation can influence walkability to increase physical activity vitality and livability of urban spaces. Therefore, after the theoretical understanding of the framework of the research, the study will focus on experimental research on the Salamis rode of Famagusta to assess the problems of walkability in the street to propose a sustainable and human-friendly solution for this area. The main aim of the research is to find what is the interrelation between pedestrianisation in public urban spaces and walkability? Therefore, it concludes that walkability as a part of the pedestrianisation scheme will lead to an increase in the quality of the urban environment by increasing safety and organization in urban infra-instructors

The Pedestrianisation and Its Relation with Enhancing Walkability in Urban Spaces

The study aimed to answer the question of how pedestrianisation can influence walkability to increasing physical activity vitality and livability of urban spaces. Therefore, after the theoretical understanding of the framework of the research, the study will focus on experimental research on the Salamis rode of Famagusta to assess the problems of walkability in the street to propose a sustainable and human friendly solution for this area. The main aim of the research is to find what is the interrelation between pedestrianisation in public urban spaces and walkability? Therefore, it concludes that walkability as a part of pedestrianisation scheme will lead to increase the quality of the urban environment by increasing safety and organization in urban infra-instructors

Adaptive Reuse of the Industrial Building: a Case of Energy Museum in Sanatistanbul, Turkey

Industrial buildings as an example of cultural heritage transforms our cultural identity from past to the present and even for the future. Unfortunately, there are lots of industrial building which lost its function by converting the place to live and identifiable place. This research will clarify the reasons of conserving of the industrial heritage and by classification of International charters which are dealing with industrial heritage will introduce conservation methods for adaptive reuse of industrial buildings. As a case study, the research will focus on Energy Museum in Istanbul. To assess the building based on reusing principals. The study concludes that Energy Museum is one of the successful examples of reuse of the building. It also concludes that less intervention in reusing a building can save the identity of the building

Chronic myeloid leukemia as a stem cell-derived malignancy

Chronic myeloid leukemia (CML) is a myeloproliferative disease of the hematopoietic stem cells, characterized by the presence of the Philadelphia (Ph) chromosome. Although imatinib inhibits the BCR-ABL kinase activity, clinical experiences confirm that imatinib may not target CML stem cells in vivo. The identification of signaling pathways responsible for the self-renewal properties of leukemic stem cells in CML will help in the discovery of novel therapeutic targets. Here we review signaling pathways including Wnt/β-catenin, Hedgehog, Alox5, and Foxo which play crucial roles in the maintenance of stem cell functions in CML. It is thought that inhibition of key genes that are part of self-renewal associated signaling pathways may provide an effective way to reduce aberrant stem cell renewal in CML

Phytochemistry and Biological Activities of Iris Species Growing in Iraqi Kurdistan and Phenolic Constituents of the Traditional Plant Iris postii

A dozen Iris species (Iridaceae) are considered traditional remedies in Kurdistan, especially for treating inflammations. Phytochemical studies are still scarce. The information reported in the literature about Iris species growing in Kurdistan has been summarized in the first part of this paper, although, except for Iris persica, investigations have been performed on vegetal samples collected in countries different from Kurdistan. In the second part of the work, we have investigated, for the first time, the contents of the methanolic extracts of Iris postii aerial parts and rhizomes that were collected in Kurdistan. Both extracts exhibited a significant dose-dependent free radical scavenging and total antioxidant activities, comparable to those of ascorbic acid. Medium-pressure liquid chromatographic separations of the two extracts afforded l-tryptophan, androsin, isovitexin, swertisin, and 2″-O-α-l-rhamnopyranosyl swertisin from the aerial parts, whereas ε-viniferin, trans-resveratrol 3,4′-O-di-β-d-glucopyranoside, and isotectorigenin were isolated from the rhizomes. This is the first finding of the last three metabolites from an Iris species. The various remarkable biological activities of isolated compounds scientifically sustain the traditional use of I. postii as a medicinal plant

The association between subclinical hypothyroidism and diabetic retinopathy in the patient with type 2 diabetic

The present study aimed to determine the relationship between subclinical hypothyroidism and diabetic retinopathy in patients with type 2 diabetes mellitus. In this cross-sectional analytical study, 150 patients with type 2 diabetes mellitus were assessed. The eye fundus examination was performed using fundoscopy to confirm or rule out retinopathy. Thyroid hormones were also measured by special kits to diagnose subclinical hypothyroidism. The criteria for diagnosis of this disorder include the high serum thyrotropin concentration (� 4mIU/L) plus normal serum free thyroxin levels. Statistical analyses were done using IBM-SPSS. In the study, 34.66 suffered retinopathy. A total of 24.0 suffered subclinical hypothyroidism with higher prevalence rate in those with retinopathy as compared with the group without retinopathy (p = 0.001). Those with diabetic retinopathy also experienced longer duration of diabetes than those without this event. (p = 0.006). Analysis show a significant role for type 2 diabetes mellitus (OR = 1.121, P = 0.003), and high TSH level (OR = 1.342, P = 0.006) to predict diabetic retinopathy.This study showed an association between hypothyroidism, diabetes and increased TSH with retinopathy. Retinopathy is significantly predicable with the presence of subclinical hypothyroidism and longer duration of diabetes. © 2021, Institute of Medico-Legal Publications. All rights reserved

Toward a noncytotoxic glioblastoma therapy: blocking MCP-1 with the MTZ Regimen

To improve the prognosis of glioblastoma, we developed an adjuvant treatment directed to a neglected aspect of glioblastoma growth, the contribution of nonmalignant monocyte lineage cells (MLCs) (monocyte, macrophage, microglia, dendritic cells) that infiltrated a main tumor mass. These nonmalignant cells contribute to glioblastoma growth and tumor homeostasis. MLCs comprise of approximately 10%-30% of glioblastoma by volume. After integration into the tumor mass, these become polarized toward an M2 immunosuppressive, pro-angiogenic phenotype that promotes continued tumor growth. Glioblastoma cells initiate and promote this process by synthesizing 13 kDa MCP-1 that attracts circulating monocytes to the tumor. Infiltrating monocytes, after polarizing toward an M2 phenotype, synthesize more MCP-1, forming an amplification loop. Three noncytotoxic drugs, an antibiotic - minocycline, an antihypertensive drug - telmisartan, and a bisphosphonate - zoledronic acid, have ancillary attributes of MCP-1 synthesis inhibition and could be re-purposed, singly or in combination, to inhibit or reverse MLC-mediated immunosuppression, angiogenesis, and other growth-enhancing aspects. Minocycline, telmisartan, and zoledronic acid - the MTZ Regimen - have low-toxicity profiles and could be added to standard radiotherapy and temozolomide. Re-purposing older drugs has advantages of established safety and low drug cost. Four core observations support this approach: 1) malignant glioblastoma cells require a reciprocal trophic relationship with nonmalignant macrophages or microglia to thrive;2) glioblastoma cells secrete MCP-1 to start the cycle, attracting MLCs, which subsequently also secrete MCP-1 perpetuating the recruitment cycle;3) increasing cytokine levels in the tumor environment generate further immunosuppression and tumor growth;and 4) MTZ regimen may impede MCP-1-driven processes, thereby interfering with glioblastoma growth