Day-Ahead Scheduling for Economic Dispatch of Combined Heat and Power with Uncertain Demand Response

This paper presents an energy management method for the interconnected operation of power, heat, Combined Heat and Power (CHP) units to settle the Day-Ahead market in the presence of a demand response program (DRP). A major challenge in this regard is the price uncertainty for DRP participants. First, the definitive model of the problem is introduced from the perspective of the Regional Market Manager (RMM) in order to minimize the total supply cost in the presence of TOU program, which is a type of DRP. Furthermore, a market-oriented tensile model is presented in the form of a combination of over-lapping generations (OLG) and price elasticity (PE) formulations to determine the amount of electricity demand in the TOU program. Then, a price uncertainty model of the proposed problem is introduced according to the IGDT risk aversion and risk-taking strategies considering information gap decision theory (IGDT). The above problem is solved through the use of the co-evolutionary particle swarm optimization (C-PSO) algorithm and the proposed model is implemented on a standard seven-unit system for a period of 24 hours.© 2022 authors. Published by IEEE. This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/fi=vertaisarvioitu|en=peerReviewed

The nanobiosensor of rfbE geneof detection

زمینه و هدف: علائم بالینی بیماران آلوده به باکتری اشریشیاکولی O157:H7 دامنه وسیعی دارد و تشخیص بیماری از روی علایم آن دشوار است. روش‌های تشخیص متعارف عوامل بیولوژیک دارای معایب بسیاری می باشند. هدف از انجام این تحقیق، تشخیص توالی ژن rfbE در نمونه واقعی باکتری اشریشیاکولی O157:H7 به وسیله نانوبیوسنسور الکتروشیمیایی بود. روش بررسی: در این مطالعه تجربی، برای آماده سازی نمونه قبل از سنجش با نانوبیوسنسور، ژنوم باکتری اشریشیاکولی O157 به روش CTAB-NaCl و با استفاده از کیت تخلیص DynaBioTM DNA Extraction Mini Kit استخراج گردید. هضم آنزیمی DNA ژنومی باکتری اشریشیاکولی O157 در دمای 37 درجه سانتی گراد و به مدت 4 دقیقه و دناتوراسیون حرارتی صورت گرفت. به منظور اطمینان، ژن rfbE باکتری اشریشیاکولی O157: H7 توسط واکنش PCR تشخیص داده شد. توالی ژن rfbE در نمونه واقعی باکتری اشریشیاکولی O157: H7 به وسیله نانوبیوسنسور مبتنی بر هیبریداسیون DNA مورد سنجش قرار گرفت. یافته ها: نتایج به دست آمده از مقاومت انتقال بار بیانگر بر هم کنش مناسب بین ssDNA تثبیت شده روی الکترود با DNA ژنوم هضم شده باکتری اشریشیاکولی O157:H7 و محصول PCR بوده و نشان دهنده تشخیص موفقیت آمیز قطعه ‌ای از ژن rfbE باکتری اشریشیاکولی O157:H7 می ‌باشد. این نانوبیوسنسور قادر به تشخیص ژنوم هضم شده باکتری تا رقت 6-10 بود که این رقت متناظر با غلظت 102 باکتری اشریشیاکولی در میلی لیتر است. نتیجه گیری: در این تحقیق، نانوبیوسنسور مبتنی بر هیبریداسیون DNA برای تشخیص توالی ژن rfbE در نمونه واقعی باکتری اشریشیاکولی O157:H7 با دقت و حساسیت مطلوب به کارگیری شد که می تواند زمینه ای برای ساخت ابزار تشخیص DNA باشد

An Efficient Framework for Improving Microgrid Resilience against Islanding with Battery Swapping Stations

In this paper, an efficient bi-level framework is proposed to enhance the resilience of microgrids (MGs) against islanding due to low probability-high impact events by incorporating battery swapping stations (BSSs). In the emergency condition, MG solves the upper-level of the proposed model to report the desired energy transaction including surplus energy and unsupplied loads during the islanding period to the BSSs coordinator. The lower-level problem will be solved with an iterative algorithm by BSSs coordinator to report different plans of energy transactions and their prices to the MG during the emergency period. The price of each energy transaction plan is determined based on a bonus mechanism. Finally, MG will choose the best plan of energy trading considering a new proposed perspective of resilience improvement. Furthermore, a new formulation for BSS operation with fewer variables in comparison to the previous works is proposed in this paper. Simulations are carried out on an MG with two BSSs to verify the proposed model

Rapid screening of diabetic polyneuropathy : Selection of accurate symptoms and signs in an outpatient clinical setting

Authors would like to thank Ms. Ameneh Ebrahim Valojerdi for her great help in preparation of this manuscript.Peer reviewedPublisher PD

Gene Networks and Pathways Involved in LPS-Induced Proliferative Response of Bovine Endometrial Epithelial Cells

Lipopolysaccharide (LPS) is a component of the outer membrane of Gram-negative bacteria involved in the pathogenic processes leading to mastitis and metritis in animals such as dairy cattle. LPS causes cell proliferation associated with endometrium inflammation. Former in vitro studies have demonstrated that LPS induces an intense stimulation of the proliferation of a pure population of bovine endometrial epithelial cells. In a follow-up transcriptomic study based on RNA-sequencing data obtained after 24 h exposure of primary bovine endometrial epithelial cells to 0, 2, and 8 mu g/mL LPS, 752 and 727 differentially expressed genes (DEGs) were detected between the controls and LPS-treated samples that encode proteins known to be associated with either proliferation or apoptosis, respectively. The present bioinformatic analysis was performed to decipher the gene networks involved to obtain a deeper understanding of the mechanisms underlying the proliferative and apoptosis processes. Our findings have revealed 116 putative transcription factors (TFs) and the most significant number of interactions between these TFs and DEGs belong to NFK beta 1, TP53, STAT1, and HIF1A. Moreover, our results provide novel insights into the early signaling and metabolic pathways in bovine endometrial epithelial cells associated with the innate immune response and cell proliferation to Escherichia coli-LPS infection. The results further indicated that LPS challenge elicited a strong transcriptomic response, leading to potent activation of pro-inflammatory pathways that are associated with a marked endometrial cancer, Toll-like receptor, NFK beta, AKT, apoptosis, and MAPK signaling pathways. This effect may provide a mechanistic explanation for the relationship between LPS and cell proliferation

Porównanie wpływu leczenia metforminą i insuliną na kontrolę glikemii u krytycznie chorych pacjentów

Introduction: It is accepted that preventing hyperglycaemia during critical illness while assuring adequate caloric intake can reduce mortality and morbidity. The aim of this study was to compare the metabolic effects of metformin and insulin on hyperglycaemia in ICU patients. Methods: This double-blind randomised clinical trial was performed on 24 patients who were admitted to the intensive care unit (ICU) from 20 March to 20 September 2007. All patients with serious injuries or with major non-abdominal surgeries were included if they met the inclusion criteria, and were assigned randomly to one of the study groups. Patients in Group 1 received intensive insulin therapy, and patients in Group 2 were treated with metformin. Moreover, the Acute Physiology And Chronic Health Evaluation (APACHE) II scoring system was used to grade disease severity. Results: Both glycaemic management protocols led to significantly improved glucose levels without any report of hypoglycaemia. The mean initial glucose levels for the insulin group decreased significantly after the intravenous infusion of insulin (p < 0.001). Additionally, the blood glucose concentration was significantly lower after two weeks of metformin administration compared to baseline measurements (p < 0.001). Moreover, the blood glucose concentration decrease during these two weeks was significantly higher in the insulin group (p = 0.01). Besides, APACHE II score was lower than baseline at the end of the study for both therapeutic groups (score of 10 vs. 15 [insulin] and 16 [metformin]). Finally, new renal dysfunction (maximum serum creatinine level at least double the initial value) was observed in three of the patients (two patients from the metformin group and one from the insulin group) in the last days of the protocol, although none of the patients showed lactic acidosis after ICU admission. Conclusions: Both metformin and intensive insulin therapy significantly decreased hyperglycaemia in ICU patients. Insulin caused a greater reduction in blood glucose concentration but required more attention and trained personnel.Wstęp: Dowody naukowe wskazują, że zapobieganie hiperglikemii u osób w stanie krytycznym przy zapewnieniu odpowiedniego poboru kalorii może zmniejszyć śmiertelność i chorobowość. Celem niniejszego badania było porównanie wpływu metforminy i insuliny na występowanie hiperglikemii u pacjentów leczonych na oddziale intensywnej opieki medycznej (OIOM). Materiał i metody: Badanie z randomizacją przeprowadzone metodą podwójnie ślepej próby obejmowało 24 chorych przyjętych na OIOM w okresie od 20 marca do 20 października 2007 roku. Wszystkich pacjentów z ciężkimi obrażeniami lub po poważnych zabiegach chirurgicznych niedotyczących jamy brzusznej, którzy spełniali kryteria włączenia, przydzielono losowo do jednej z grup terapeutycznych. U chorych przydzielonych do grupy 1. stosowano intensywną insulinoterapię, natomiast chorym z grupy 2. podawano metforminę. Do oceny ciężkości stanu chorych wykorzystano skalę APACHE (Acute Physiologic Assessment and Chronic Health Evaluation) II. Wyniki: Oba protokoły leczenia hipoglikemizującego spowodowały istotną poprawę wyrównania glikemii, przy czym nie odnotowano żadnego przypadku hipoglikemii. W grupie stosującej insulinoterapię średnie stężenie glukozy obniżyło się istotnie w stosunku do wartości wyjściowych po dożylnym wlewie insuliny (p < 0, 001). U osób leczonych metforminą po 2 tygodniach przyjmowania leku stężenie glukozy we krwi było istotnie niższe od poziomu wyjściowego (p < 0,001). Redukcja stężenia glukozy w ciągu tych 2 tygodni była istotnie większa w grupie przyjmującej insulinę (p = 0,01). W obu grupach terapeutycznych punktacja w skali APACHE II w momencie zakończenia badania była niższa od wartości wyjściowych (10 punktów v. 15 [insulina] i 16 [metformina]). U 3 chorych (2 osoby przydzielone do leczenia metforminą i 1 osoba przydzielona do insulinoterapii) zaobserwowano rozwój niewydolności nerek de novo (maksymalne stężenie kreatyniny w surowicy co najmniej 2-krotnie większe od wartości wyjściowych) w ostatnich dniach stosowania protokołu leczenia hipoglikemizującego, chociaż u żadnego z pacjentów nie stwierdzono kwasicy mleczanowej po przyjęciu na OIOM. Wnioski: Zarówno leczenie metforminą, jak i intensywna insulinoterapia istotne zmniejszają hiperglikemię u pacjentów na OIOM. Insulina powoduje większą redukcję stężenia glukozy, jednak jej stosowanie wymaga większej uwagi, a personel medyczny musi być odpowiednio przeszkolony

Effect of vitamin C on coagulation factors and endothelium function in patients with sepsis

Objective: Sepsis is one of the leading causes of mortality in intensive care unit. Despite advances in its management, its mortality rate remains high. Recently, high dose of vitamin C in sepsis treatment has attracted the attention of researchers. In the current study, the impacts of 25 mg/kg of vitamin C every 6 hours as a bolus for 3 days were assessed in septic patients in intensive care unit (ICU).&nbsp;Methods: This was a prospective cohort study that was performed on adult patients with diagnosis of sepsis. Patients were assigned to control group (administration of placebo) or intervention group, i.e., those receiving a 25 mg/kg dose of vitamin C every 6 hours as a bolus for 3 days. Clinical data were recorded before and after the experiment. Also, plasma levels of antithrombin III, syndecan-1, fibrin degradation product (FDP), D-dimer, and C-reactive protein (CRP) were measured at 0, 24, 48, and 72 hours.&nbsp;Results: In septic patients receiving vitamin C, a significant upregulation of antithrombin III and significant decreases in the levels of syndecan-1 (at 48 hours; P-value=0.046 and at 72 hours; P-value=0.007), D-dimer and CRP were observed compared to the control. Reductions in sequential organ failure assessment (SOFA) score, in-hospital mortality, and ICU length of stay were seen in septic patients receiving vitamin C.&nbsp;Conclusion: Prescribing high dose of intravenous vitamin C can reduce the mortality of sepsis patients and reduce the length of stay in the ICU

Phylogenetic Groups of Escherichia coli Strains from Patients with Urinary Tract Infection in Iran Based on the New Clermont Phylotyping Method

Objectives.In2013,ClermontclassifiedE.colistrainsintoeightphylogeneticgroupsusinganewquadruplexPCRmethod.Theaims ofthisstudyweretoidentifythephylogeneticgroupsofE.colibasedonthismethodandtoassesstheirantibioticresistancepatterns inBushehr,Iran.Methods.Inthiscross-sectionalstudy,140E.coliisolatesweresubjectedtophylogenetictypingbyaquadruplex PCR method. Antimicrobial susceptibility testing was performed by disk diffusion method. Results. Phylogenetic group B2 was mostpredominant(39.3%),followedbyunknown(27.1%),E(9.3%),CandcladeI(each6.4%),B1(5%),FandD(each2.9%),and A(0.7%).Themostcommonantibioticresistancewasrelatedtoamoxicillin(82.1%)andtheleasttomeropenem(0.7%).82.14%of isolatesweremultipledrugresistant(MDR).AntibioticresistancewasmainlydetectedingroupB2(50%).Conclusions.Ourfindings showedthehighprevalenceofMDRE.coliisolateswithdominanceofgroupB2.About25%ofE.coliisolatesbelongtothenewly describedphylogroupsC,E,F,andcladeI.Suchstudiesneedtobedonealsoinotherregionstoprovidegreaterunderstandingof theantibioticresistancepatternandtheprevalencesofdifferentphylogeneticgroups

Water repellent effect and dimension stability of beech wood impregnated with nano-zinc oxide

The objective of this study was to quantify the influence of zinc oxide nanoparticles (nano-ZnO) on the water repellency and dimensional stability of beech wood. Beech wood blocks were treated with a nano-ZnO solution at four treatment levels (0, 10,000, 20,000, and 40,000 ppm) using a modified dip method. Also, a thermal treatment was performed at 60 and 120°C. After conditioning the samples, water absorption, volumetric swelling, water repellency effectiveness, and anti-shrink/anti-swell efficiency were determined within 24 h of soaking time. The results indicated that the nano-ZnO used for wood modification greatly improved dimensional stability and reduced the hygroscopicity of the wood. In addition, the Fourier-transform infrared spectroscopy (FTIR) analysis suggested a strong interaction between the nano-ZnO and the chemical components of wood. The heat treatment effectively improved the effects of nano-ZnO