Prevalence Of Job Strain And Risk Factors For Job-Related Depression In Laboratory Technicians In Hospital Unversiti Sains Malaysia (HUSM) And Kementerian Kesihatan Malaysia (KKM) Hospitals In Kelantan.

A cross-sectional study was conducted to determine the prevalence of job strain and association between high job strain and other risk factors with job-related depression in laboratory technicians in Hospital Universiti Sains Malaysia (HUSM) and Kementerian Kesihatan Malaysia (KKM) Hospitals in Kelantan between June 2001 and February 2002

Quasilocal energy for rotating charged black hole solutions in general relativity and string theory

We explore the (non)-universality of Martinez's conjecture, originally proposed for Kerr black holes, within and beyond general relativity. The conjecture states that the Brown-York quasilocal energy at the outer horizon of such a black hole reduces to twice its irreducible mass, or equivalently, to \sqrt{A} /(2\sqrt{pi}), where `A' is its area. We first consider the charged Kerr black hole. For such a spacetime, we calculate the quasilocal energy within a two-surface of constant Boyer-Lindquist radius embedded in a constant stationary-time slice. Keeping with Martinez's conjecture, at the outer horizon this energy equals the irreducible mass. The energy is positive and monotonically decreases to the ADM mass as the boundary-surface radius diverges. Next we perform an analogous calculation for the quasilocal energy for the Kerr-Sen spacetime, which corresponds to four-dimensional rotating charged black hole solutions in heterotic string theory. The behavior of this energy as a function of the boundary-surface radius is similar to the charged Kerr case. However, we show that in this case it does not approach the expression conjectured by Martinez at the horizon.Comment: 15 page

Accident causation and pre-accidental driving situations: Part 1. Overview and general statistics

WP2 of the European Project TRACE is concerned with “Types of Situations” to analyse the causation of road traffic accidents from the pre-accidental driving situation point of view. Four complementary situations were defined: stabilized situations, intersection, specific manoeuvre and degradation scenario. To reach this objective, the analysis is based on a common methodology composed on 3 steps: the “descriptive analysis” which from general statistics will allow to identify among the studied situations those them relevant and to give their characteristics, the “in-depth analysis” allowing to obtain accident causes from the generic description of the problems identified in the previous step and the risk analysis identifying the risk of being involved in an accident taking into account the results obtained from the ‘in–depth’ level. This report is dedicated to the descriptive analysis with the identification of the most relevant scenario regarding the situation in which the driver is involved just prior the accident. The results are based on the literature review, general statistics and the analysis of the national databases available in TRACE via WP8. Because the information level differ from databases to another, the available scenario presented here for the 4 predefined types of situations are generics and some specific situations could not have be distinguished. For each situation some key indicators are given, such as prevalence, severity, KSI (killed x severely injured), etc. When it is possible, these indicators are estimated at the EU27 level

Anastrozole and everolimus in advanced gynecologic and breast malignancies: activity and molecular alterations in the PI3K/AKT/mTOR pathway.

BackgroundSince PI3K/AKT/mTOR pathway activation diminishes the effects of hormone therapy, combining aromatase inhibitors (anatrozole) with mTOR inhibitors (everolimus) was investigated.Patients and methodsWe evaluated anastrozole and everolimus in 55 patients with metastatic estrogen (ER) and/or progesterone receptor (PR)-positive breast and gynecologic tumors. Endpoints were safety, antitumor activity and molecular correlates.ResultsFull doses of anastrozole (1 mg PO daily) and everolimus (10 mg PO daily) were well tolerated. Twelve of 50 evaluable patients (24%) (median = 3 prior therapies) achieved stable disease (SD) ≥ 6 months/partial response (PR)/complete response (CR) (n = 5 (10%) with PR/CR): 9 of 32 (28%) with breast cancer (n=5 (16%) with PR/CR); 2 of 10 (20%), ovarian cancer; and 1 of 6 (17%), endometrial cancer. Six of 22 patients (27%) with molecular alterations in the PI3K/AKT/mTOR pathway achieved SD ≥ 6 months/PR/CR. Six of 8 patients (75%) with SD ≥ 6 months/PR/CR with molecular testing demonstrated at least one alteration in the PI3K/AKT/mTOR pathway: mutations in PIK3CA (n=3) and AKT1 (n=1) or PTEN loss (n=3). All three responders (CR (n = 1); PR (n=2)) who had next generation sequencing demonstrated additional alterations: amplifications in CCNE1, IRS2, MCL1, CCND1, FGFR1 and MYC and a rearrangement in PRKDC.ConclusionsCombination anastrozole and everolimus is well tolerated at full approved doses, and is active in heavily-pretreated patients with ER and/or PR-positive breast, ovarian and endometrial cancers. Responses were observed in patients with multiple molecular aberrations. CLINICAL TRAILS INCLUDED: NCT01197170

Risk Factors Of Job-Related Depression In Laboratory Technicians In Hospital Universiti Sains Malaysia (HUSM) And Kementerian Kesihatan Malaysia (KKM) Hospitals In Kelantan.

Across-sectional study was conducted to determine the risk factors of job-related depression in laboratory technicians in Hospital Universiti Sains Malaysia (HUSM) and Kementerian Kesihatan Malaysia(KKM) Hospitals in Kelantan, between September 2001 and February 2002