EFFECT OF DURATION AND TEMPERATURE OF CURING ON COMPRESSIVE STRENGTH OF FLY ASH BASED GEOPOLYMER CONCRETE

The optimum temperature and duration of curing is essential in geopolymerization reaction to achieve higher strength. As such, fly ash based geopolymer concrete were prepared by varying the curing temperature of 600, 900 and 120°C, for the duration of 6,12,16 and 24 hours. The fly ash was activated by sodium silicate and sodium hydroxide solution with ratio between sodium silicate and alkaline activator was 2.5. The result show that with increase in duration and temperature of curing the compressive strength of fly ash based geopolymer concrete increase

Generic Construction of Certificateless Signcryption Scheme

Confidentiality and message authentication are the most important security goals that can be achieved simultaneously by Signcryption scheme. It is a cryptographic technique that performs both the functions of digital signature and public key encryption in a single logical step significantly at a lower cost than that of conventional method of signature-then-encryption. The paper proposes an efficient Certificateless Signcryption Scheme(CLSC) in random oracle model on bilinear mapping. It is provably secure under the assumptions of intractability of k-CAA, Inv-CDH, q-BDHI and CDH problems

Diaphyseal fractures of the forearm in adults, comparative study of dynamic compression plate versus intramedullary nail

Background: Forearm fractures are common nowadays because of road traffic accident. It is important to achieve anatomical reduction of both bone forearm fractures to regain function of upper limb. This study is undertaken to observe functional and radiological outcome using two different surgical modalities like dynamic compression plating (DCP), and intramedullary nailing in both bone forearm fractures and also to indivualize the optimal treatment method for different fracture pattern.Methods: Our study included 60 patients with diaphyseal forearm fractures in adults presenting to orthopaedic outpatient department. Among 60 patients, 30 patients underwent open reduction and internal fixation by dynamic compression plate and other 30 patients underwent closed reduction/open reduction by square nail after detailed pre-operative evaluation.Results: In our study average union time in DCP group is 23.39 weeks and square nail group is 28.89 weeks. Union in DCP group was 27 (90%) and square nail group 22 (73.33%). Delayed union in DCP group was 03 (10%) and in Square nail group was 6 (20%), non-union in DCP group was 0 (nil) and in square nail group was 2 (06%).Conclusions: Open reduction and internal fixation with DCP plates for both bone diaphyseal forearm fractures gives good results with early union rates. We also found that in open fractures and complex fracture like segmental fractures square nailing was better option compared to dynamic compression plate to reduce infection rates, retain periosteal blood supply from soft tissue. Thus we conclude that both implants are equally important and we should prioritize based on preoperative planning

Cure of human immunodeficiency virus/acquired immune deficiency syndrome: promising future prospects at horizon

Acquired immune deficiency syndrome (AIDS) is a disease caused by humanimmunodeficiency virus and characterized by profound immunosuppression thatleads to opportunistic infections, secondary neoplasms, and neurologic complications.AIDS is among the leading causes of death worldwide. Current therapeutic optionsare directed only toward management of AIDS, but not toward its prevention or cure.In addition, it also possesses numerous problems like drug resistance, drug toxicity,drug interactions, non-adherence to therapy, life-long and expensive treatment, etc.Recent years in drug development have shown promising prospects for prevention/treatment/cure of AIDS like histone deacetylase inhibitors, Vpu ion channel inhibitors,viral decay acceleration, maturation inhibitors, tat antagonists, gene/stem cell therapy,and antiretroviral vaccines

Genotypic Distribution and Antimicrobial Susceptibilities of Carbapenemase-Producing Enterobacteriaceae Isolated in Tertiary Care Hospital in South India

Antimicrobial resistance has emerged as a major danger to contemporary medicine around the world. Carbapenems are the highest class of B-lactam drugs which are considered as the most effective and safest antibiotics available. Increasing spread of carbapenemases has been noted across the world which restricts treatment options. The aim of this study was to determine the incidence of carbapenem resistant genotypic pathways in a tertiary care hospital. 130 clinical strains of Enterobacteriaceae were subjected to Kirby-Bauer disk diffusion tests and genotypic methods (PCR) for the identification of the genes NDM, VIM, and OXA-48. Carbapenem resistance was detected in 30% of the isolates by phenotypic methods. These 37 isolates on being subject to PCR showed OXA-48 followed by VIM and NDM as the most frequently isolated genotypes. All isolates had multiple genes encoding carbapenem resistance. Carbapenemases resistance is on the rise and is associated with multi drug resistance pattern. To minimize spread and initiate early appropriate therapy, early detection of carbapenem resistance is essential. Molecular methods remain gold standard for detection

Cardiotonic Activity of Coconut Water (Cocos nucifera)

The coconut (Cocos nucifera) is a member of the family Arecaceae (Palm family). Various parts of this tree is used in the treatment of, cancer (due to hexane fraction of coconut peel), indomethacin-induced ulceration (coconut milk).Coconut water consumption reduces diastolic blood pressure (due to the presence of potassium).In the present work fresh coconut water, dilution 1:1(coconut water: distilled water), are used to evaluate cardiac activity on the isolated frog heart and are labeled as T1, & T2 respectively and compared with Digoxin (S1) as standard solution. It was found that sample T1(Undiluted coconut water) showed better response as compared to the diluted coconut water(T2).These preliminary studies confirm the cardiotonic activity of the coconut water(Cocos nucifera)

A Heuristic-Based Appliance Scheduling Scheme for Smart Homes

The ever-growing demand for electricity in the residential sector results in creating a severe burden on electric grids. However, with the emergence of smart homes (SHs) and smart grids (SGs), this burden can be reduced to some extent. To address this issue, we propose an energy management system in this paper which manages the power requirements of SHs automatically according to the utility constraints and user priorities. The proposed system is based on a heuristic technique which considers the users priority and power available from the grid as well as distributed energy resources (DERs) for scheduling of appliances. It works by dividing the appliance scheduling problem in an SH into sub-problems for different time-slots. Results show that the proposed scheme efficiently manages the load demand of the SH with respect to power available from the utility, battery energy storage system, and user preferences

Universal Coronavirus Testing to Control the Pandemic: Ethical Issues and Dilemmas

Every country had to make several difficult decisions in the initial phase of the Coronavirus (COVID-19) pandemic to allocate resources for COVID testing. Decisions on who should be tested for COVID-19 testing are extremely vital for pandemic preparedness. In this article, we highlight the need for prioritization of testing resources including direct-to-consumer testing methods, ethical dilemmas involved in obligatory testing, and testing of refugees and immigrants

Deciphering the regulatory landscapte of fetal and adult γδ T-cell development at single-cell resolution

γδ T cells with distinct properties develop in the embryonic and adult thymus and have been identified as critical players in a broad range of infections, antitumor surveillance, autoimmune diseases, and tissue homeostasis. Despite their potential value for immunotherapy, differentiation of γδ T cells in the thymus is incompletely understood. Here, we establish a high‐resolution map of γδ T‐cell differentiation from the fetal and adult thymus using single‐cell RNA sequencing. We reveal novel sub‐types of immature and mature γδ T cells and identify an unpolarized thymic population which is expanded in the blood and lymph nodes. Our detailed comparative analysis reveals remarkable similarities between the gene networks active during fetal and adult γδ T‐cell differentiation. By performing a combined single‐cell analysis of Sox13, Maf, and Rorc knockout mice, we demonstrate sequential activation of these factors during IL ‐17‐producing γδ T‐cell (γδT17) differentiation. These findings substantially expand our understanding of γδ T‐cell ontogeny in fetal and adult life. Our experimental and computational strategy provides a blueprint for comparing immune cell differentiation across developmental stages