Ostomates: diagnosis, surgery and rehabilitation. A symbolic interactionist perspective on an illustration of spoiled identity

From the introduction: This investigation examines from a symbolic interactionist perspective, a case of spoiled identity - a segment of the physically disabled who find themselves subject to ostomatic status. Spoiled identity evolves when a person has had, or believes that he has had, the characteristics which normally define his presence in day to day interaction compromised. In these situations, the person is perceived by himself and/or others as possessing characteristics which are often negatively defined. Spoiled identity, as defined by self or others, often serves to create barriers in interaction between the bearer of the spoiled identity and various members of society

Spin-dynamics of the low-dimensional magnet (CH3)2NH2CuCl3

Dimethylammonium copper (II) chloride (also known as DMACuCl3 or MCCL) is a low dimensional S=1/2 quantum spin system proposed to be an alternating ferro-antiferromagnetic chain with similar magnitude ferromagnetic (FM) and antiferromagnetic (AFM) exchange interactions. Subsequently, it was shown that the existing bulk measurements could be adequately modeled by considering DMACuCl3 as independent AFM and FM dimer spin pairs. We present here new inelastic neutron scattering measurements of the spin-excitations in single crystals of DMACuCl3. These results show significant quasi-one-dimensional coupling, however the magnetic excitations do not propagate along the expected direction. We observe a band of excitations with a gap of 0.95 meV and a bandwidth of 0.82 meV.Comment: 3 pages, 2 figures included in text, submitted to proceedings of International Conference on Neutron Scattering, December 200

Regional Mucosa-Associated Microbiota Determine Physiological Expression of TLR2 and TLR4 in Murine Colon

Many colonic mucosal genes that are highly regulated by microbial signals are differentially expressed along the rostral-caudal axis. This would suggest that differences in regional microbiota exist, particularly mucosa-associated microbes that are less likely to be transient. We therefore explored this possibility by examining the bacterial populations associated with the normal proximal and distal colonic mucosa in context of host Toll-like receptors (TLR) expression in C57BL/6J mice housed in specific pathogen-free (SPF) and germ-free (GF) environments. 16S rRNA gene-based terminal restriction fragment length polymorphism (T-RFLP) and clone library analysis revealed significant differences in the community structure and diversity of the mucosa-associated microbiota located in the distal colon compared to proximal colon and stool, the latter two clustering closely. Differential expression of colonic TLR2 and TLR4 along the proximal-distal axis was also found in SPF mice, but not in GF mice, suggesting that enteric microbes are essential in maintaining the regional expression of these TLRs. TLR2 is more highly expressed in proximal colon and decreases in a gradient to distal while TLR4 expression is highest in distal colon and a gradient of decreased expression to proximal colon is observed. After transfaunation in GF mice, both regional colonization of mucosa-associated microbes and expression of TLRs in the mouse colon were reestablished. In addition, exposure of the distal colon to cecal (proximal) microbiota induced TLR2 expression. These results demonstrate that regional colonic mucosa-associated microbiota determine the region-specific expression of TLR2 and TLR4. Conversely, region-specific host assembly rules are essential in determining the structure and function of mucosa-associated microbial populations. We believe this type of host-microbial mutualism is pivotal to the maintenance of intestinal and immune homeostasis

Successful umbilical cord blood transplantation for Fanconi anemia using preimplantation genetic diagnosis for HLAmatched donor

Fanconi anemia is a rare autosomal recessive disease characterized by bone marrow failure, developmental anomalies, and a high incidence of myelodysplasia and acute myeloid leukemia. Stem cell transplantation is the only curative treatment. In the absence of matched-sibling donor, an alternative mismatched family or matched unrelated donor can be used, but the results are inferior to the matched-sibling transplant and carry a high risk of morbidity and mortality. Preimplantation genetic diagnosis (PGD) has been increasingly used in recent years for mutation analysis for many genetic disorders and results in the birth of healthy children, saving the need for the termination of pregnancy of an affected embryo. The use of PGD for combined analysis of mutation and HLAmatching was reported for the first time in 2001. This enables the birth of an unaffected child who can serve as a donor for an affected sibling in need for stem cell transplantation. We report successful cord blood transplantation for a Fanconi anemia patient from his HLA-matched sibling, born after PGD that included mutation analysis for Fanconi anemia and HLA typing. PGD can provide an unaffected donor for a sibling affected by genetic disease in the absence of a compatible related donor. Am

Speckle from phase ordering systems

The statistical properties of coherent radiation scattered from phase-ordering materials are studied in detail using large-scale computer simulations and analytic arguments. Specifically, we consider a two-dimensional model with a nonconserved, scalar order parameter (Model A), quenched through an order-disorder transition into the two-phase regime. For such systems it is well established that the standard scaling hypothesis applies, consequently the average scattering intensity at wavevector _k and time t' is proportional to a scaling function which depends only on a rescaled time, t ~ |_k|^2 t'. We find that the simulated intensities are exponentially distributed, with the time-dependent average well approximated using a scaling function due to Ohta, Jasnow, and Kawasaki. Considering fluctuations around the average behavior, we find that the covariance of the scattering intensity for a single wavevector at two different times is proportional to a scaling function with natural variables mt = |t_1 - t_2| and pt = (t_1 + t_2)/2. In the asymptotic large-pt limit this scaling function depends only on z = mt / pt^(1/2). For small values of z, the scaling function is quadratic, corresponding to highly persistent behavior of the intensity fluctuations. We empirically establish a connection between the intensity covariance and the two-time, two-point correlation function of the order parameter. This connection allows sensitive testing, either experimental or numerical, of existing theories for two-time correlations in systems undergoing order-disorder phase transitions. Comparison between theory and our numerical results requires no adjustable parameters.Comment: 18 pgs RevTeX, to appear in PR

Spinon continuum in the Heisenberg quantum chain compound Sr2_2V3_3O9_9

Magnetic excitations in the spin chain candidate Sr$_2$V$_3$O$_9$ have been investigated by inelastic neutron scattering on a single crystal sample. A spinon continuum with a bandwidth of $\sim22$ meV is observed along the chain formed by alternating magnetic V$^{4+}$ and nonmagnetic V$^{5+}$ ions. Incipient magnetic Bragg peaks due to weak ferromagnetic interchain couplings emerge when approaching the magnetic transition at $T_N\sim 5.3$ K while the excitations remain gapless within the instrumental resolution. Comparisons to the Bethe ansatz, density matrix renormalization group (DMRG) calculations, and effective field theories confirm Sr$_2$V$_3$O$_9$ as a host of weakly coupled $S = 1/2$ chains dominated by antiferromagnetic intrachain interactions of $\sim7.1$(1) meV.Comment: 19 pages, 9 figures. arXiv admin note: text overlap with arXiv:2102.0837

Sub-Annual Calving Front Migration, Area Change and Calving Rates from Swath Mode CryoSat-2 Altimetry, on Filchner-Ronne Ice Shelf, Antarctica

Mapping the time-variable calving front location (CFL) of Antarctic ice shelves is important for estimating the freshwater budget, as an indicator of changing ocean and structural conditions or as a precursor of dynamic instability. Here, we present a novel approach for deriving regular and consistent CFLs based on CryoSat-2 swath altimetry. The CFL detection is based on the premise that the shelf edge is usually characterized by a steep ice cliff, which is clearly resolved in the surface elevation data. Our method applies edge detection and vectorization of the sharp ice edge in gridded elevation data to generate vector shapefiles of the calving front. To show the feasibility of our approach, we derived a unique data set of ice-front positions for the Filchner-Ronne Ice Shelf (FRIS) between 2011 and 2018 at a 200 m spatial resolution and biannual temporal frequency. The observed CFLs compare well with independently derived ice front positions from Sentinel-1 Synthetic Aperture Radar imagery and are used to calculate area change, advance rates, and iceberg calving rates. We measure an area increase of 810 ± 40 km2 a−1 for FRIS and calving rates of 9 ± 1 Gt a−1 and 7 ± 1 Gt a−1 for the Filchner and Ronne Ice Shelves, respectively, which is an order of magnitude smaller than their steady-state calving flux. Our findings demonstrate that the “elevation-edge” method is complementary to standard CFL detection techniques. Although at a reduced spatial resolution and less suitable for smaller glaciers in steep terrain, it enables to provide CFLs at regular intervals and to fill existing gaps in time and space. Moreover, the method simultaneously provides ice thickness, required for mass budget calculation, and has a degree of automation which removes the need for heavy manual intervention. In the future, altimetry data has the potential to deliver a systematic and continuous record of change in ice shelf calving front positions around Antarctica. This will greatly benefit the investigation of environmental forcing on ice flow and terminus dynamics by providing a valuable climate data record and improving our knowledge of the constraints for calving models and ice shelf freshwater budget

1951 Influenza Epidemic, England and Wales, Canada, and the United States

Death rates were substantially higher for England and Canada than for the United States

Neutron scattering in the proximate quantum spin liquid α-RuCl3.

The Kitaev quantum spin liquid (KQSL) is an exotic emergent state of matter exhibiting Majorana fermion and gauge flux excitations. The magnetic insulator α-RuCl3 is thought to realize a proximate KQSL. We used neutron scattering on single crystals of α-RuCl3 to reconstruct dynamical correlations in energy-momentum space. We discovered highly unusual signals, including a column of scattering over a large energy interval around the Brillouin zone center, which is very stable with temperature. This finding is consistent with scattering from the Majorana excitations of a KQSL. Other, more delicate experimental features can be transparently associated with perturbations to an ideal model. Our results encourage further study of this prototypical material and may open a window into investigating emergent magnetic Majorana fermions in correlated materials