Chemical constituents and antimicrobial activities of the essential oils from Sedum pallidum var. bithynicum and S. spurium grown in Turkey

PubMed: 20645839Chemical compositions of the essential oil of Sedum pallidum Bieb. var. bithynicum (Boiss.) and S. spurium Bieb. (Crassulaceae) from Turkey were investigated by GC-MS, and antimicrobial activity of the oil samples were assessed against Gram-positive/negative bacteria and yeast-like fungi. Thirty-eight and thirty-five components were identified in the essential oils and the main components of these species were found to be caryophyllene oxide from S. pallidum var. bithynicum and hexahydrofarnesyl acetone from S. spurium in the ratios of 12.8% and 15.7%, respectively. The isolated essential oils of the plants showed low antimicrobial activity against Gram-negative/positive bacteria and yeast-like fungi, having the MIC values of 500-2000?g/mL. Antibacterial activity was not observed against Bacillus cereus. © 2010 Informa UK Ltd.Karadeniz Teknik ÜniversitesiThis study was supported by grants from Karadeniz Technical University and State Planning Agency (DPT) of Turkey.Karadeniz Teknik Üniversitesi ve Türkiye Devlet Planlama Teşkilatı (DPT

Long-Term Balance Outcomes in Vestibular Ablative Surgeries

Objective:To evaluate the long-term balance outcomes of vestibular nerve section (VNS) and labyrinthectomy (L) operations. The indirect outcomes will be the correlation of objective and subjective test results and an analysis of anterior-posterior versus medial-lateral computerized posturography (CP) scores.Methods:This retrospective study evaluated objective CP and subjective Dizziness Handicap Inventory (DHI) results of patients who underwent VNS and L surgeries for Ménière’s disease.Results:A total of 55 (31 VNS and 24 L) patients were included in the study. The two operation groups were similar in terms of age, and mean time between surgery and the tests (p=0.465 and p=0.616) respectively. The vestibular and global scores at anterior-posterior CP showed statistically significant differences between the groups (p=0.000 and p=0.007) respectively in favor of the VNS group. In addition, the comparison of the vestibular CP scores of anterior-posterior and medial-lateral evaluations of the entire study population was lower in the medial-lateral evaluation (p=0.000). The mean DHI scores did not show statistically significant differences (p=0.359) between operation groups, nor did the correlation analysis between CP and DHI scores reveal statistical significance (p values >0.05).Conclusion:In the long term, objective balance outcomes are better for VNS patients than for L patients. Additionally, medial-lateral balance outcomes are more affected than anterior-posterior balance outcomes from unilateral ablative surgeries. Subjective balance perception is not different between the two surgery groups, and DHI scores do not show a correlation with CP scores

Helmint parasites of the Antolian worm lizard, blanus strauchi (Bedriaga, 1884) from Hatay

Hatay'dan toplanmış olan 15 Kör Kertenkele (1 Jüvenil, 9 Erkek, 5 Dişi ) helmint faunasını belirlenmek üzere incelenmiştir.Çalışma sonucunda 2 helmint türüne rastlanmıştır. Bunlar Nemathelminthes'e ait Thelostoma sp. ve Parapharyngodon micipsae'dir.Bu çalışma Dünya'da ve Türkiye'de Kör Kertenkele üzerinde yapılan ilk çalışmadır. Bulunan parazit türleri ülkemiz için yeni kayıttır.15 worm lizards which were collected in Hatay province of Turkey were studied to identify the helmint fauna.At the end of the study, 2 species of helmint were found. These are Thelostoma sp. and Parapharyngodon micipsae ( Nemathelminthes)This is the first study that has done on "Blanus struchi" in both Turkey and the world. The parasites found are the first records for Turkey

A novel highly sensitive carbon-based HMPD/GC sensor electrode: copper ions analysis in flour and water samples

5th International Conference on Sustainable Solid Waste Management (ATHENS) -- JUN 21-24, 2017 -- Athens, GREECEWOS:000445125900005In this research, (Z)-2-(2-(hydroxyimino)-2-(3-methyl-3-phenylcyclobutyl) ethyl)-3a,7a-dihy-dro-1H-isoindole-1,3(2H)-dione, HMPD molecule has been grafted to the glassy carbon (GC) electrode surface. The HMPD-modified GC electrode has been originally developed and it used for the quantitative determination of Cu(II) in flour and water samples. The modification steps have been performed using cyclic voltammetry (CV). CV, electrochemical impedance spectroscopy and scanning electron microscopy have been employed for the characterization processes. Cu(II) standard solutions changing from 1.0 x 10(-9) to 1.0 x 10(-3) M have been prepared and the corresponding peak currents have been measured. From the obtained data calibration equation has been calculated I-p = -1.555C(cu) + 15.86 which is having a 0.9974 correlation coefficient. 10.0 mL of flour and water samples have been mixed with 10.0 mL Britton-Robinson (BR) buffer solution (pH = 5.00) and HMPD/GC sensor electrode has been kept in these mixed solutions for 90 min. Differential pulse voltammetric (DPV) technique has been applied for the measurement of the peak currents. After the application of the developed sensor electrode for Cu(II) detection in flour and water samples, Cu(II) ion concentrations have been calculated from the obtained peak current values, 1.97 and 2.46 mu A. The Cu(II) ion concentrations have been calculated as 1.17 x 10(-9) and 2.41 x 10(-9) M, respectively

Myocarditis and intracardiac thrombus due to Henoch-Schönlein purpura: case report and literature review

Cardiac involvement is very rare in patients with Henoch-Schönlein purpura (HSP). In this case study, we present an 8-year-old girl presenting with HSP-induced myocarditis and thrombus in the right atrium and HSP nephritis. To date, 15 cases of HSP-related cardiac involvement have been reported in the PubMed/MEDLINE, Scopus, and Google Scholar databases. These cases, together with our case, are included in this review. We excluded those patients with other rheumatologic diseases (acute rheumatic fever, acute post-streptococcal glomerulonephritis, Kawasaki disease) accompanied by HSP. Three were children and 13 were adults and all were male except our case. This review revealed tachyarrhythmia, chest pain, dyspnea, murmur, and heart failure as the major signs. Cardiac tests, electrocardiogram (ECG), and imaging methods (echocardiography in all patients, cardiac magnetic resonance imaging (MRI) in three, cardiac biopsy in one, and post-mortem necropsy in three) showed that the cardiac involvements were pericardial effusion, intra-atrial thrombus, myocarditis, coronary artery changes, myocardial ischemia, infarction and necrosis, subendocardial hemorrhage, and left ventricular dilatation. Kidney involvement was not observed in three patients. As the treatment, high-dose prednisolone and cyclophosphamide, oral corticosteroid, azathioprine, nadroparin calcium, ACE inhibitors, calcium antagonists, beta-blockers, and diuretics were used. Eleven patients (all three children and eight of the adults) had a complete cardiac recovery. Cardiac involvement in adults was more likely to be fatal. Death (three patients), ischemia, and infarct have been reported only in adults. We suggested that early and aggressive treatment can be life-saving. MRI examination is effective at identifying cardiac involvement. © 2020, International League of Associations for Rheumatology (ILAR)

Comparing the application of sedation with ramsey sedation scale versus bispectral index monitoring during endoscopic retrograde cholangiopancreatography procedures

Amaç: Endoskopik retrograd kolanjiopankreatografi (ERKP) pankreas, safra kesesi ve karaciğerin drenajını sağlayan kanalların görüntülenmesi işlemidir. Bu işlem esnasında bilinçli sedasyon amacıyla propofol sıklıkla kullanılmaktadır. Bu çalışmamızda, ERKP işlemi esnasında propofolle uygulanan hekim kontrollü sedasyon ile bispektral indeks kontrollü sedasyonu (BİS) karşılaştırmayı amaçladık. Gereç ve Yöntem: 18-75 yaşları arasında, 60 olgu çalışmaya alındı. Hastalar rastgele iki gruba ayrıldıktan sonra grup 1 hastalara ramsey sedasyon skalası 3-4 olacak şekilde hekim tarafından propofol aralıklı bolus dozlar şeklinde verildi. Grup 2 hastalara ise BİS değeri 60-85 arasında olacak şekilde propofol bolus dozlar uygulandı. Hastaların her 5 dakikada bir SpO2, sistolik, diastolik ve ortalama kan basınçları, kalp atım hızı, komplikasyonlar ve yan etkiler, işlem süresi, hastanın uyanıklık durumu kaydedildi. Bulgular: Her iki grupta demografik veriler arasında anlamlı bir fark yoktu. Hastaların vital bulguları benzerdi. Gruplar arasında komplikasyonlar açısından istatistiksel olarak anlamlı fark bulunmadı. Her iki gruba bakıldığında ortalama işlem süreleri birbirlerine yakınken, hastaların derlenme süresi BİS kontrollü grupta anlamlı olarak daha kısa tespit edildi. Sonuç: ERKP esnasında uygulanan sedasyonda, bisipektral indeks monitörizasyonu hekim kontrollü sedasyon kadar güvenlidir.Objective: Endoscopic retrograde cholangiopancreatography (ERCP) is the process of displaying channels that provide pancreas, gall bladder and liver drainage Propofol is often used for conscious sedation during this procedure. In this study we aimed to compare the physician controlled sedation with propofol versus bispectral index controlled sedation (BIS) during ERCP. Material and Methods: 60 patients aged between 18 and 75 were enrolled in this study. Patients were divided randomly into two groups; Group 1 patients were administered intermittent doses of propofol to provide Ramsey Sedation Scale 3-4 by the physician monitorization whether Group 2 patients were given intermittent doses of propofol to maintain the BIS level between 60 and 85. SPO2, systolic, diastolic and, mean blood pressures, heart rates, complications, adverse effects, duration of operation, patient awakeness were recorded five minutes periodically. Results: There was no statistically significant difference between the groups in terms of demographic characteristics. Patients’ hemodynamic data were similar too. There was no statistically significance in terms of complications between the groups. Both groups were close to each other considering the average processing time whether recovery time of patients in the BIS group was detected significantly shorter than the Ramsey group. Conclusion: Application of sedation with BIS is as safe as physician-controlled sedation in ERCP

Antibiotic resistance profiles of Pseudomonas aeruginosa strains isolated from patients with acute exacerbation of chronic obstructive pulmonary disease

AMAÇ: Kronik obstru?ktif akciğer hastalığı (KOAH) akut alevlenmeler ile seyreden bir hastalıktır. Alevlenmeler dispne, balgam miktarı ve pu?ru?lansında artış ile kendini göstermektedir. Hastalığın tedavisinde bronkodilatatör ve antibiyotik kullanımı gerekebilmektedir. Hava akımı kısıtlılığının artışı ile alevlenme riskinin de arttığı bildirilmektedir. Akut alevlenmeler hastanın yaşam kalitesinde azalmaya, ciddi morbidite ve mortaliteye sebep olurken ekonomik açıdan yu?k oluşturmaktadır. KOAH’lı hastalarda Ku?resel Kronik Obstru?ktif Akciğer Hastalığı Girişim Grubu (Global Initiative for Chronic Obstructive Lung Disease: GOLD)’nun yapmış olduğu spirometrik sınıflamada (GOLD 1-4) GOLD 2’de alevlenme sayısı yılda 0,7 - 0,9 iken GOLD 4 hastalarda yılda 1,2 - 2,0 alevlenme göru?lmektedir. Akut alevlenmelerde en sık göru?len bakteriyel patojenler sırası ile Haemophilus influenzae, Streptococcus pneumoniae ve Moraxella catarrhalis’dir. GOLD 3 ve GOLD 4 KOAH akut alevlenmeli hastalarda Pseudomonas aeruginosa önemli etkendir. P. aeruginosa suşlarında antimikrobiyal ajanlara karşı giderek artan direnç tedavide sorun oluşturmaktadır. Enfeksiyonun tedavisi için ampirik tedavi başlamadan önce antibiyotik duyarlılık paternlerinin bilinmesi tedavide etkin olabilir. Ampirik antibiyotik tedavisine cevap alınamaması durumunda hastaya balgam ku?ltu?ru? ve antibiyotik direnç testleri yapılmalıdır. Bu nedenle bu çalışmada, hastanemize başvuran KOAH akut ataklı hastaların balgamından izole edilen P. aeruginosa suşlarının antibiyotik direnç paternlerinin belirlenmesi amaçlanmıştır. YÖNTEMLER: Haziran 2007 ile Aralık 2010 tarihleri arasında Trabzon Ahi Evren Göğu?s, Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi’ne başvuran kronik obstru?ktif akciğer hastalığı akut atağı olan hastaların balgam örneklerinden izole edilen 78 P. aeruginosa suşunun antibiyotik hassasiyet sonuçları retrospektif olarak değerlendirilmiştir. İzolatların tiplendirilmesi ve antibiyotik duyarlılıkları için Phoenix (Becton Dickinson, USA) bakteri tanımlama sistemi kullanılmıştır. BULGULAR: Çalışmaya alınan P. aeruginosa suşlarında %42,3 sefepim, %41 levofloksasin, %38,7 siprofloksasin, %29,4 seftazidim, %21,7 sefoperazon / sulbaktam, %17,9 gentamisin, %17,9 piperasilin / tazobaktam, %8,9 imipenem, %5,1 amikasin ve %2,5 meropenem direnci saptanmıştır. İzolatların 28 (%35,9)’i bu antibiyotiklerden tu?mu?ne hassas olarak bulunmuştur. Hastaların 46 (%58,9)’sında steroid, 56 (%71,8)’sında geniş spektrumlu antibiyotik kullanım öyku?su? tespit edilmiştir. SONUÇ: Kronik obstru?ktif akciğer hastalığının akut ataklarında, Pseudomonas enfeksiyonlarının antibiyotik duyarlılıklarının belirli periyotlarla incelenmesi hasta sağlığı ve u?lke ekonomisi açısından yararlı olacaktır.OBJECTIVE: Chronic Obstructive Pulmonary Disease (COPD) disease is characterized with acute exacerbation. Exacerbations are manifested with dyspnea and increased volume and purulence of sputum. Treatment may require the use of bronchodilators and antibiotics. With an increase in airflow restriction it is reported to also increase the risk of exacerbations. Acute exacerbations decrease the quality of life of the patients, cause significant morbidity, mortality and economic hardship. The Global Initiative for Chronic Obstructive Lung Disease (GOLD) group classified the COPD patients from 1 to 4. Number of exacerbation is 0.7-0.9 in GOLD 2 and 1.2-2.0 in GOLD 4 per year. The most common bacterial pathogens for acut exacerbation of COPD are Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis, respectively. Pseudomonas aeruginosa is the more important agent for GOLD3 and GOLD4 COPD patients. The rising antimicrobial resistance to P. aeruginosa strains is a problem in the treatment. For the treatment of infection, antibiotic susceptability pattern knowledge before starting empiric therapy may improve effectiveness. The sputum culture and antibiotic resistance tests should be performed if the patient has failed to respond to empirical antibiotic treatment. For this reason, in the current study we aimed to determine resistance patterns in P. aeruginosa strains isolated from the sputum with acute exacerbation of COPD patients in our hospital. METHODS: Patients who were admitted to Trabzon Ahi Evren Chest and Cardiovascular Surgery Training and Research Hospital, with acute exacerbation of COPD between June 2007 and December 2010, had their sputum culture results reviewed. The results of antibiotics susceptibilities test in 78 P. aeruginosa strains isolated from sputum were evaluated retrospectively. For typing and antibiotic susceptibility of isolates the Phoenix bacterial identification system (Becton Dickinson, USA) was used. RESULTS: The antibiotic resistance rates of P. aeruginosa were 42.3% for cefepime, 41% for levofloxacin, 38.7% for ciprofloxacin, 29.4% for ceftazidime, 21.7% for cefoperazone / sulbactam, 17.9% for gentamicin, 17.9% for piperacillin / tazobactam, 8.9% for imipenem, 5.1% for amikacin and 2.5% for meropenem. Twenty eight (35.9%) of the isolates were found to be sensitive to all of these antibiotics. Forty six (58.9%) of the patients had steroid and 56 (71.8%) of the patients had broad-spectrum antibiotic use. CONCLUSION: In acute exacerbations of chronic obstructive pulmonary disease, the inspection of antibiotic susceptibility of Pseudomonas infection would be beneficial for patient’s health and the country’s economy

SAĞLIK BİLİMLERİ FAKÜLTESİ VE İKTİSADİ VE İDARİ BİLİMLER FAKÜLTESİ ÖĞRENCİLERİNİN YAŞLI AYRIMCILIĞINA İLİŞKİN TUTUMLARI

Bu çalışma üniversite öğrencilerinin yaşlı bireylere ilişkin tutumlarını belirlemek amacıyla yapılmıştır. Araştırma örneklemini yaşlılık ve yaşlı bakımı ile ilgili eğitim alan Sağlık Bilimleri Fakültesi ve yaşlılığa yönelik özel bir eğitim almayan İktisadi ve İdari Bilimler Fakültesi’nde öğrenim görmekte olan toplamda 150 öğrenci oluşturmaktadır. Verilerin toplanmasında Kişisel Bilgi Formu ve Yaşlı Ayrımcılığı Tutum Ölçeği kullanılmıştır. Verilerin analizinde T Testi ve Tek Yön Anova Testi kullanılmıştır. Ayrıca Kişisel Bilgi Formu ile elde edilen bilgiler yüzde ve frekans olarak verilmiştir. Çalışmanın sonucunda kadın öğrencilerin erkek öğrencilere göre ve Sağlık Bilimleri Fakültesi öğrencilerinin diğer öğrencilere göre yaşlı bireylere yönelik daha olumlu tutumlara sahip olduğu saptanmıştır. Ayrıca, ailede yaşlı bir bireyin olması, evde yaşlı bir bireyle birlikte yaşama ve yaşlı bireylerle yüksek oranda karşılaşma sıklığına sahip olma gibi yaşlılarla teması arttıran özelliklerin de olumlu tutumları arttırdığı bulgulanmıştır