Facile Synthesis of N α -Protected Amino/Peptide Hydroxamic Acids Mediated by Comu

One-pot preparation of N α -protected amino/peptide hydroxamic acids from corresponding carboxylic acids is described using uronium-type coupling reagent COMU. The present protocol is simple and mild conditions are used. Thus the resulting hydroxamic acids are obtained in good yields without racemization

Facile Synthesis of N (alpha) -Protected Amino/Peptide Hydroxamic Acids Mediated by COMU

One-pot preparation of N (alpha) -protected amino/peptide hydroxamic acids from corresponding carboxylic acids is described using uronium-type coupling reagent COMU. The present protocol is simple and mild conditions are used. Thus the resulting hydroxamic acids are obtained in good yields without racemization

3,​3-​dichloro-​1,​2-​diphenylcyclopropene (CPICl)​-​mediated synthesis of Nα-​protected amino acid azides and α-​ureidopeptides

Rapid synthesis of acid azides via in situ generation of acid chlorides using CPICl as chlorinating agent from the corresponding Nα -protected amino acids is described. Also the conversion of acid azides into ureidopeptides through the Curtius rearrangement under ultrasonication is delineated. The mildness of the protocol renders the acid-sensitive substrates to afford the corresponding amino acid azides and ureidopeptides in good yields. Diphenylcyclopropenone has also been recovered from the reaction mixture and reused

Synthesis of Nα-​Z protected amino alkyl triazole acids and their application to neo-​glycopeptides synthesis

The synthesis of triazole linked glycopeptides employing 2-​chloro-​4,​6-​dimethoxy-​1,​3,​5-​triazine (CDMT) mediated coupling of Z-​protected triazole acids (Z = benzyloxycarbonyl) with glycosyl amines and amino acid esters is described. The coupling proceeded smoothly at room temp. and the products are obtained in good yields. Z-​protected triazole acids have been synthesized via Click chem. protocol through the cycloaddn. of Z-​protected alkyl azides with propiolic acid

Synthesis of <i style="mso-bidi-font-style:normal">N^α</i>-Z protected amino alkyl triazole acids and their application to neo-glycopeptides synthesis

858-864The synthesis of triazole linked glycopeptides employing 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) mediated coupling of Z-protected triazole acids with glycosyl amines and amino acid esters is described. The coupling proceeded smoothly at room temperature and the products are obtained in good yields. Z-Protected triazole acids have been synthesized via click chemistry protocol through the cycloaddition of Z-protected alkyl azides with propiolic acid

Iodine-accelerated synthesis of <i style="mso-bidi-font-style:normal">N^α</i>-urethane protected amino/peptide hydroxamic acids from amino/peptide thioacids

1430-1435A facile and mild synthesis of Nα-protected amino/peptide hydroxamic acids is accomplished from the corresponding Nα-protected amino/peptide thioacids using I2, 1-hydroxybenzotriazole (HOBt) and NH2OH at RT. The protocol can be extended to bifunctional as well as sterically hindered amino acids, to afford amino/peptide hydroxamic acids in good yields

Alternative Protocol for the Synthesis of Symmetrical Dibenzyl Diselenides and Disulfides

A one-​pot protocol for the prepn. of sym. dibenzyl diselenides and disulfides from the corresponding benzyl alcs. employing NaBH2Se3 and NaBH2S3 as selenium-​transfer and sulfur-​transfer reagent, resp., was described. Structurally diverse substituted benzyl alcs. afforded the corresponding diselenides and disulfides in good to excellent yields. The protocol was simple, mild and the products were obtained within a short reaction time

Design and synthesis of spirotruxene and spirofluorene derivatives

1489-1492The work presented here describes a facile and efficient method for the synthesis of spirotruxene and spirofluorene compounds using allylation and RCM as key steps from readily available starting materials