A Double Planetary System around the Evolved Intermediate-Mass Star HD 4732

We report the detection of a double planetary system orbiting around the evolved intermediate-mass star HD 4732 from precise Doppler measurements at Okayama Astrophysical Observatory (OAO) and Anglo-Australian Observatory (AAO). The star is a K0 subgiant with a mass of 1.7 M_sun and solar metallicity. The planetary system is composed of two giant planets with minimum mass of msini=2.4 M_J, orbital period of 360.2 d and 2732 d, and eccentricity of 0.13 and 0.23, respectively. Based on dynamical stability analysis for the system, we set the upper limit on the mass of the planets to be about 28 M_J (i>5 deg) in the case of coplanar prograde configuration.Comment: 12 pages, 7 figures, accepted for publication in Ap

A Trio of Giant Planets Orbiting Evolved Star HD 184010

We report the discovery of a triple-giant-planet system around an evolved star HD 184010 (HR 7421, HIP 96016). This discovery is based on observations from Okayama Planet Search Program, a precise radial velocity survey, undertaken at Okayama Astrophysical Observatory between 2004 April and 2021 June. The star is K0 type and located at beginning of the red-giant branch. It has a mass of $1.35_{-0.21}^{+0.19} M_{\odot}$, a radius of $4.86_{-0.49}^{+0.55} R_{\odot}$, and a surface gravity $\log g$ of $3.18_{-0.07}^{+0.08}$. The planetary system is composed of three giant planets in a compact configuration: The planets have minimum masses of $M_{\rm{b}}\sin i = 0.31_{-0.04}^{+0.03} M_{\rm{J}}$, $M_{\rm{c}}\sin i = 0.30_{-0.05}^{+0.04} M_{\rm{J}}$, and $M_{\rm{d}}\sin i = 0.45_{-0.06}^{+0.04} M_{\rm{J}}$, and orbital periods of $P_{\rm{b}}=286.6_{-0.7}^{+2.4}\ \rm{d}$, $P_{\rm{c}}=484.3_{-3.5}^{+5.5}\ \rm{d}$, and $P_{\rm{d}}=836.4_{-8.4}^{+8.4}\ \rm{d}$, respectively, which are derived from a triple Keplerian orbital fit to three sets of radial velocity data. The ratio of orbital periods are close to$P_{\rm{d}}:P_{\rm{c}}:P_{\rm{b}} \sim 21:12:7$, which means the period ratios between neighboring planets are both lower than$2:1$. The dynamical stability analysis reveals that the planets should have near-circular orbits. The system could remain stable over 1 Gyr, initialized from co-planar orbits, low eccentricities ($e=0.05$), and planet masses equal to the minimum mass derived from the best-fit circular orbit fitting. Besides, the planets are not likely in mean motion resonance. HD 184010 system is unique: it is the first system discovered to have a highly evolved star ($\log g < 3.5$cgs) and more than two giant planets all with intermediate orbital periods ($10^2\ \rm{d} < P < 10^3\ \rm{d}$).Comment: 20 pages, 5 figures, Published in PAS

Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus

Subcellular localization of glucocorticoid receptor protein in the human kidney glomerulus.BackgroundThe detailed mechanisms of glucocorticoid action in idiopathic nephrotic syndrome and progressive glomerulonephritides have not been clearly elucidated. The pharmacological actions of glucocorticoids are mediated by their binding to an intracellular protein, the glucocorticoid receptor (GR). The determination of GR localization in normal glomerular cells is essential to elucidate the mechanisms of glucocorticoid action in various glomerular diseases.MethodsWe carried out an immunoblot examination using antihuman GR-specific antibody and homogenates of isolated normal human glomeruli and mesangial cells in culture. Immunohistochemical examinations were also performed on normal human kidney specimens at light and electron microscopic levels. The nuclear translocation of GRs elicited by ligand binding was further investigated by confocal laser-scanning microscopic inspection of freshly isolated glomeruli and mesangial cells cultured with dexamethasone.ResultsAn immunoblot examination demonstrated the presence of a 94 kDa protein, a molecular weight consistent with that of GRs, in the homogenates of glomeruli and cultured mesangial cells. By light microscopic examination, GRs were strongly detected in the nucleus and moderately in the cytoplasm of all glomerular cells, parietal and visceral epithelial cells, endothelial cells, and mesangial cells. By electron microscopic examination, the nuclear GRs of all glomerular cells were found to be diffusely distributed in the euchromatin. Additionally, the immunofluorescence intensities of nuclear GRs in isolated glomeruli and mesangial cells in culture became more intense by the addition of dexamethasone.ConclusionsOur findings suggest that all subsets of human glomerular cells definitely express the GR protein, which potentially undergoes translocation by glucocorticoids

Lymph Node Stromal Cell Subsets

The spatiotemporal regulation of immune responses in the lymph node (LN) depends on its sophisticated tissue architecture, consisting of several subcompartments supported by distinct fibroblastic stromal cells (FSCs). However, the intricate details of stromal structures and associated FSC subsets are not fully understood. Using several gene reporter mice, we sought to discover unrecognized stromal structures and FSCs in the LN. The four previously identified FSC subsets in the cortex are clearly distinguished by the expression pattern of reporters including PDGFRb, CCL21-ser, and CXCL12. Herein, we identified a unique FSC subset expressing both CCL21-ser and CXCL12 in the deep cortex periphery (DCP) that is characterized by preferential B cell localization. This subset was clearly different fromCXCL12highLepRhigh FSCs in themedullary cord, which harbors plasma cells. B cell localization in the DCP was controlled chiefly by CCL21-ser and, to a lesser extent, CXCL12. Moreover, the optimal development of the DCP as well as medulla requires B cells. Together, our findings suggest the presence of a unique microenvironment in the cortex-medulla boundary and offer an advanced view of the multi-layered stromal framework constructed by distinct FSC subsets in the LN

Non-Abelian Global Vortices

We study topologically stable non-Abelian global vortices in the U(N) linear sigma model. The profile functions of the solutions are numerically obtained. We investigate the behaviour of vortices in two limits in which masses of traceless or trace parts of massive bosons are much larger than the others. In the limit that the traceless parts are much heavier, we find a somewhat bizarre vortex solution carrying a non-integer U(1) winding number 1/\sqrt{N} which is irrational in general.Comment: 28 pages, 6 figure

A double planetary system around the evolved intermediate-mass star HD 4732

We report the detection of a double planetary system orbiting around the evolved intermediate-mass star HD 4732 from precise Doppler measurements at Okayama Astrophysical Observatory and Australian Astronomical Observatory. The star is a K0 subgiant with a mass of 1.7 M⊙ and solar metallicity. The planetary system is composed of two giant planets with minimum mass of m sin i = 2.4 MJ, orbital period of 360.2 days and 2732 days, and eccentricity of 0.13 and 0.23, respectively. Based on dynamical stability analysis for the system, we set the upper limit on the mass of the planets to be about 28 MJ (i greater than 5°) in the case of coplanar prograde configuration

Support for UNRWA's survival

The United Nations Relief and Works Agency for Palestine Refugees in the Near East (UNRWA) provides life-saving humanitarian aid for 5·4 million Palestine refugees now entering their eighth decade of statelessness and conflict. About a third of Palestine refugees still live in 58 recognised camps. UNRWA operates 702 schools and 144 health centres, some of which are affected by the ongoing humanitarian disasters in Syria and the Gaza Strip. It has dramatically reduced the prevalence of infectious diseases, mortality, and illiteracy. Its social services include rebuilding infrastructure and homes that have been destroyed by conflict and providing cash assistance and micro-finance loans for Palestinians whose rights are curtailed and who are denied the right of return to their homeland

A Distinct Subset of Fibroblastic Stromal Cells Constitutes the Cortex-Medulla Boundary Subcompartment of the Lymph Node

The spatiotemporal regulation of immune responses in the lymph node (LN) depends on its sophisticated tissue architecture, consisting of several subcompartments supported by distinct fibroblastic stromal cells (FSCs). However, the intricate details of stromal structures and associated FSC subsets are not fully understood. Using several gene reporter mice, we sought to discover unrecognized stromal structures and FSCs in the LN. The four previously identified FSC subsets in the cortex are clearly distinguished by the expression pattern of reporters including PDGFRβ, CCL21-ser, and CXCL12. Herein, we identified a unique FSC subset expressing both CCL21-ser and CXCL12 in the deep cortex periphery (DCP) that is characterized by preferential B cell localization. This subset was clearly different from CXCL12highLepRhigh FSCs in the medullary cord, which harbors plasma cells. B cell localization in the DCP was controlled chiefly by CCL21-ser and, to a lesser extent, CXCL12. Moreover, the optimal development of the DCP as well as medulla requires B cells. Together, our findings suggest the presence of a unique microenvironment in the cortex-medulla boundary and offer an advanced view of the multi-layered stromal framework constructed by distinct FSC subsets in the LN