A Modified Underwater Weighing Method Without Complete Immersion

This study was designed to examine the validity of a modified underwater weighing method for measuring human body volume (BV) that does not require head submersion (MUW). Results were compared with those obtained by the underwater weighing method (UW). The true head volume was calculated from the difference in BV, with and without head submersion. Stepwise regression analysis provided an equation to predict the head volume (HV) from the head girth (HG), the head length (HL), the head breadth (HB), the neck girth (NG), the face length I (FLI), the face length II (FLII), and the cheek girth. The equation for males was HV=0.185^*(HG) +0.122^*(FLII) -8.925, r^2=0.678, SEE=0.216. The equation for females was HV=0.131^*(HG) -0.026^*(NG) +0.112^*(FLI) -6.760, r^2=0.747, SEE=0.154. Cross-validation of predicted HV showed that the correlation coefficients were r=0.759, SEE=0.193 and r=0.749, SEE=0.193, for males and females respectively. Correlation coefficients and SEE between MUW and MW for body volume and % body fat were r=1.000, SEE=0.207 and r=0.983, SEE=1.339 for males and r=1.000, SEE=0.196 and r=0.946, SEE=1.915 for females. It can be concluded that this new method offers promising possibilities for future research with people who are unable to submerge their heads

SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression

臓器チップ技術を用いて新型コロナウイルスが血管へ侵入するメカニズムを解明 --Claudin-5発現抑制による呼吸器の血管内皮バリア破壊--. 京都大学プレスリリース. 2022-09-22.A study using an organ-on-a-chip reveals a mechanism of SARS-CoV-2 invasion into blood vessels --Disruption of vascular endothelial barrier in respiratory organs by decreasing Claudin-5 expression--. 京都大学プレスリリース. 2022-09-27.In the initial process of coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects respiratory epithelial cells and then transfers to other organs the blood vessels. It is believed that SARS-CoV-2 can pass the vascular wall by altering the endothelial barrier using an unknown mechanism. In this study, we investigated the effect of SARS-CoV-2 on the endothelial barrier using an airway-on-a-chip that mimics respiratory organs and found that SARS-CoV-2 produced from infected epithelial cells disrupts the barrier by decreasing Claudin-5 (CLDN5), a tight junction protein, and disrupting vascular endothelial cadherin–mediated adherens junctions. Consistently, the gene and protein expression levels of CLDN5 in the lungs of a patient with COVID-19 were decreased. CLDN5 overexpression or Fluvastatin treatment rescued the SARS-CoV-2–induced respiratory endothelial barrier disruption. We concluded that the down-regulation of CLDN5 expression is a pivotal mechanism for SARS-CoV-2–induced endothelial barrier disruption in respiratory organs and that inducing CLDN5 expression is a therapeutic strategy against COVID-19

Sp(n) ノ Samelson セキ ニ ツイテ

京都大学0048新制・課程博士博士(理学)甲第14897号理博第3466号新制||理||1507(附属図書館)27335UT51-2009-M811京都大学大学院理学研究科数学・数理解析専攻(主査)准教授 岸本 大祐, 教授 河野 明, 准教授 浅岡 正幸学位規則第4条第1項該当Doctor of ScienceKyoto UniversityDA

Commutativity of localized self-homotopy groups of symplectic groups

The self-homotopy group of a topological group G is the set of homotopy classes of self-maps of G equipped with the group structure inherited from G. We determine the set of primes p such that the p-localization of the self-homotopy group of Sp(n) is commutative. As a consequence, we see that this group detects the homotopy commutativity of p-localized Sp(n) by its commutativity almost all cases

Commutativity in special unitary groups at odd primes

AbstractIt is a classical result by Bott that SU(s) and SU(t) homotopy commute in SU(n) if and only if s+t⩽n. We consider the p-localization analog of this problem and give an answer at odd primes