Development and Mechanistic Investigation of Indium(III)-Catalysed Hydrosilane Reduction of Imines

Asymmetric catalysis continues to be of utmost importance inter alia for the development of enantiomerically pure drugs. The application of computational methods in understanding how enantioselectivity is induced in specific reactions is a powerful time-saving tool for organic chemists. By investigating the reaction pathway, specifically the enantiodetermining transition state, factors that result in an increased energy difference between the two enantiomeric transition states can be identified and thus employed for increasing the enantiomeric excess. Little is known regarding the achievement of enantioselectivity in indium(III)-catalysed reactions. Hence, the project described in this dissertation has started from scratch by generating the experimental data from which to build computational models. This dissertation starts with an introduction to the field of asymmetric catalysis, the advantages of indium as a catalyst and recent progress within indium-catalysed reactions. Following is a discussion of an extensive methodology project where complexes of In(III) and various functionalised BINOL ligands or BINOL derivatives have been investigated as catalysts for the hydrosilane reduction of imines. The functionalised BINOL ligands employed include a range of C1-symmetric BINOL ligands, which were synthesised as part of a project on optimising BINOL phosphoric acid ligands described in Chapter 2. Significant progress has been made towards the development of a catalyst complex capable of achieving an enantioselective In(III)-catalysed reduction. The developed methodology presented in this thesis represents a novel method for achieving enantioselectivity in prochiral substrates by the use of chiral ligands co-ordinating to an indium metal-centre. Enantiomeric excess was obtained only in polar, protic solvent systems, where up to 73% e.e. was achieved. The experimental work has been combined with computational investigations of potential complexes and mechanistic pathway calculations. The most plausible pathway, established from the computational investigations presented in this thesis, proceeds via the formation of an In(III)-hydride species. This hydride is then transferred to the imine in the manner observed in ruthenium-catalysed reactions. Preliminary results for an alternative active In(III)-In(III) dimeric complex is discussed. Extensive experimental mechanistic investigations are presented along with a substrate scope of the reaction. Finally, future perspectives are given on how the knowledge obtained regarding the enantiodetermining mode in the investigated hydrosilane reduction might be employed to achieve enantioselectivity in other In(III)-catalysed reactions.EPSRC and Cambridge Trus

Human Resource Practices and Innovativeness: A Conceptual Paper

Purpose: The purpose of this study is to review and produce a set of propositions about the function of human resource practises and innovativeness in a business environment.   Implications of research: Growing worldwide rivalry, extremely unpredictable markets, and even greater customer expectations have resulted as a result of the globalisation of the world, making it important for enterprises to be open to the possibility of innovation.   Findings: According to the findings of this research, a paradigm for understanding the relationship between human resource practises and innovativeness, as well as the moderating effect of innovation capability, is proposed.   Originality/Value: This document contains a series of propositions that constitute an empirically driven research agenda, as well as descriptions of the correlations between the focus variables that are given to improve the understanding of the audience in a business setting

El costo directo del programa de entrenamiento em resucitación cardiopulmonar en un hospital universitário

A presente pesquisa teve por objetivo mapear o processo de treinamento compartilhado em ressuscitação cardiopulmonar para técnicos e auxiliares de enfermagem da UTI e Semi-Intensiva de Adulto do HU-USP, e aferir os custos diretos das principais atividades do processo. Trata-se de um estudo exploratório, retrospectivo, de levantamento documental, nos moldes de estudo de caso. Seus resultados mostraram que o custo direto total do programa de treinamento em ressuscitação cardio-pulmonar foi de R$9.081,44. O custo direto com pessoal representou 96,74$ 5.451,60 (62,04%). Os custos diretos relacionados com o material utilizado foram maiores, também, no subprocesso planejamento do treinamento, R$188,80 (63,73$ 206,40.En la presente investigación se tuvo como objetivo mapear el proceso de entrenamiento compartido en resucitación cardio-pulmonar para técnicos y auxiliares de enfermería de la UCI y Semi Intensiva de Adulto del HU-USP y cotejar los costos directos de las principales actividades del proceso. Se trata de un estudio exploratorio, retrospectivo, de levantamiento documental, en los moldes del estudio de caso. Sus resultados mostraron que el costo directo total del programa de entrenamiento en resucitación cardiopulmonar fue de R$9.081,44. El costo directo con personal representó el 96,74$ 5.451,60 (62,04%). Los costos directos relacionados con el material utilizado fueron mayores, también, en el subproceso planificación del entrenamiento, R$188,80 (63,73$ 206,40.This study was aimed at mapping the process of shared training in cardiopulmonary resuscitation for technicians and assistant nurses of the Intensive Care and Semi-Intensive Care units at the University of São Paulo's Hospital Universitário (HU-USP), and at checking the direct costs of the main activities in the process. This is an exploratory research, a retrospective, documental survey, using the case study model. The results showed that the total direct cost of the cardiopulmonary resuscitation training program was 9,081.44 reals. The direct cost with personnel represented 96.74%, and with material 3.26%. In the training planning sub-process, most of the direct cost was represented by the instructor-assisting nurse, with 5,451.60 reals (62.04%). The direct costs related to the material that was used were also higher in the training program sub-process, 188.80 reals (63.73%). The total cost per trainee was 206.40 reals

Dimensiones de la personalidad en estudiantes universitarios: estudio descriptivo correlacional a realizarse con estudiantes de la Facultades de Ciencias Sociales, Ciencias económicas e Ingeniería y Arquitectura en el ciclo 02-2010

El presente trabajo muestra los resultados de la investigación realizada sobre las dimensiones de personalidad predominantes en los estudiantes de la UFG. Para la evaluación de las dimensiones de la personalidad se utilizo el test NEO-FFI que ofrece una medida abreviada de los cinco factores de la personalidad y de algunos de las más importantes facetas o rasgos que definen cada dimensión. El test consta de sesenta frases que deben ser contestadas según el sistema de escala psicométrica de Likert. CAPITULO I PLANTEAMIENTO DEL PROBLEMA, se formula el problema investigado, se justifica el porque de la investigación: se describe el alcance y la limitación principal del estudio y se presentan los objetivos de la investigación. CAPITULO II MARCO TEÓRICO. Describe investigaciones realizadas en otros países y en la UFG, presenta las bases teóricas del fenómeno investigado. CAPITULO III SISTEMA DE HIPOTESIS. Presenta el planteamiento de las hipótesis de investigación, general y especificas, con sus respectivas hipótesis nulas, así como también se definen las variables sometidas a comprobación empírica. CAPITULO IV METODOLOGIA DE LA INVESTIGACION. Describe el tipo de estudio realizado, el diseño en el que se enmarca la investigación, la población y muestra; el instrumento utilizado para la recolección de los datos y el respectivo procedimiento para la realización de la investigación. CAPITULO V. PRESENTACION Y ANALISIS DE LOS RESULTADOS. Detalla los resultados obtenidos en la investigación, el análisis de los datos y la comprobación de la hipótesis. CAPITULO VI. CONCLUSIONES Y RECOMENDACIONES expone las conclusiones a las que se llego con la investigación, así como las recomendaciones respectiva

Communication Between Dentists and Dental Technicians During the Fabrication of Removable Partial Dentures in Khartoum State, Sudan

Svrha rada: Željela se istražiti kvaliteta komunikacije između doktora dentalne medicine i zubnih tehničara u privatnim dentalnim laboratorijima u sudanskoj pokrajini Khartoumu kad je riječ o izradi mobilnih djelomičnih proteza. Metode: Obavljena je deskriptivna analiza poprečnog presjeka te se razgovaralo sa zubnim tehničarima o kvaliteti uputa koje su dobili od doktora dentalne medicine u vezi s izradom mobilnih djelomičnih proteza (removable partial denture – RPD). Bilo je uključeno 69 akrilatnih proteza (A-RPD) i 11 od kobalt-kroma (CC-RPD). Rezultati: Doktori dentalne medicine nisu dali upute u 21,7 % slučajeva za izradu A-RPD-a, no dali su ih u svim slučajevima za CC-RPD-e. Upute su uglavnom bile usmene (55,1 % za A-RPD, 54,5 % za CC-RPD), a rjeđe napisane (23,3 % za A-RPD, 45,5 % za CC-RPD). Većina konstrukcijskih komponenti za A-RPD i CC-RPD nisu bile jasno opisane, a izričite su bile samo u 8,7 % slučajeva za A-RPD-e i 36,4 % slučajeva za CC-RPD-e. Značajno je da je liječnik modele kontrolirao u samo u 18,2 % slučajeva kad je riječ o CC-RPD-u. Većina tehničara (84,2 %) vjeruje da je oblikovanje proteze odgovornost doktora. Tehničari su u vezi s CC-RPD-om trebali znatno češće (p = 0,004) razgovarati s doktorima te ih tražiti objašnjenje za njihovo oblikovanje. Zaključak: Kvaliteta komunikacije između doktora dentalne medicine i privatnih laboratorijskih zubnih tehničara u pokrajini Khartoumu o izradi mobilne parcijalne proteze bila je uglavnom nedovoljna.Objectives: To investigate the quality of communication between dentists and dental laboratory technicians in private dental laboratories in Khartoum State related to fabrication of removable partial dentures. Methods: This was a descriptive cross-sectional study, in which dental technicians were interviewed regarding the quality of instructions they received from dentists concerning the construction of removable partial dentures (RPD). Eighty cases were investigated, 69 acrylic (A-RPD) and 11 cobalt chromium (CC-RPD) dentures. Results: Although dentists provided no instructions in 21.7% of A-RPD cases, they gave instructions in all CC-RPD cases. Instructions were primarily given verbally (55.1% in A-RPD, 54.5% in CC-RPD cases), as opposed to written (23.3% in A-RPD, 45.5% in CCRPD cases). Most design components for A-RPD and CC-RPD cases were not clearly prescribed, and instructions were clear in only 8.7% of A-RPD and 36.4% of CC-RPD cases. Notably, surveying of casts by dentists was only done in 18.2% of CC-RPD cases. Most technicians (84.2%) believed that prosthesis design was the dentists’ responsibility. Technicians needed to contact dentists for clarification of design significantly more frequently for CC-RPD (p=0.004) cases. Conclusion: Quality of communication between dentists and private laboratory technicians in Khartoum State with regard to removable partial denture construction was largely inadequate

Nonsilica Oxide Glass Fiber Laser Sources: Part I

Nonsilica oxide glasses have been developed and studied for many years as promising alternatives to the most used silica glass for the development of optical fiber lasers with unique features and properties. Depending on the glass former of choice, these glasses can offer very distinctive physical properties if compared to silica-based glasses. With regard to the development of photonic fiber devices, these key properties include low phonon energy, high rare-earth ion solubility, high optical nonlinearity and easy handling procedures. This chapter, part I of a detailed study concerning nonsilica oxide glass–based optical fiber laser sources, reviews the main properties of three different nonsilica oxide glass families, namely phosphate, germanate and tellurite. The manufacturing process of an optical fiber using these glass materials is also discussed in Section 3 of this chapter

Response of Canola Advanced Lines to Delay Plantings upon Late Season Drought Stress

     In order to evaluation of canola advanced lines response to delay plantings under late season drought stress conditions, an experiment was carried out in a factorial split-plot arrangement based on RCBD with three replications during two years (2012-2014) in Karaj of Iran. Treatments were; (1): Planting date in two levels (16 October and 1 November), (2): irrigation, in two levels (I1: normal irrigation as control and I2: restricted irrigation after pod formation stage) as main plots and (3): twelve oilseed rape genotypes as sub plots such as BAL2, BAL1, BAL3, BAL6, BAL8, BAL9, BAL11, BAL15, L72, R15, L109 and Okapi. The interaction effects of planting date, irrigation and genotype on pod number per plant, seed number per pod, 1000-seed weight, seed yield, and oil yield were significant at 1% level probability. The maximum seed yield under planting at the appropriate time (16 October), normal irrigation and drought stress conditions (restricted irrigation after pod formation stage) was observed in Okapi and L109, respectively). Among genotypes, R15 line under delay planting (1 November) and both normal irrigation and drought stress conditions (restricted irrigation after pod formation stage) showed the maximum seed yield

Evaluation of the efficacy and safety of endovascular management for transplant renal artery stenosis

OBJECTIVES: To evaluate the safety and efficacy of endovascular intervention with angioplasty and stent placement in patients with transplant renal artery stenosis. METHODS: All patients diagnosed with transplant renal artery stenosis and graft dysfunction or resistant systemic hypertension who underwent endovascular treatment with stenting from February 2011 to April 2016 were included in this study. The primary endpoint was clinical success, and the secondary endpoints were technical success, complication rate and stent patency. RESULTS: Twenty-four patients with transplant renal artery stenosis underwent endovascular treatment, and three of them required reinterventions, resulting in a total of 27 procedures. The clinical success rate was 100%. All graft dysfunction patients showed decreased serum creatinine levels and improved estimated glomerular filtration rates and creatinine levels. Patients with high blood pressure also showed improved control of systemic blood pressure and decreased use of antihypertensive drugs. The technical success rate of the procedure was 97%. Primary patency and assisted primary patency rates at one year were 90.5% and 100%, respectively. The mean follow-up time of patients was 794.04 days after angioplasty. CONCLUSION: Angioplasty with stent placement for the treatment of transplant renal artery stenosis is a safe and effective technique with good results in both the short and long term