Sensitivity to oscillation with a sterile fourth generation neutrino from ultralow threshold neutrino-nucleus coherent scattering

We discuss prospects for probing short-range sterile neutrino oscillation using neutrino-nucleus coherent scattering with ultra-low energy ($\sim 10$ eV - 100 eV) recoil threshold cryogenic Ge detectors. The analysis is performed in the context of a specific and contemporary reactor-based experimental proposal, developed in cooperation with the Nuclear Science Center at Texas A\&M University, and references developing technology based upon economical and scalable detector arrays. The baseline of the experiment is substantially shorter than existing measurements, as near as about 2 meters from the reactor core, and is moreover variable, extending continuously up to a range of about 10 meters. This proximity and variety combine to provide extraordinary sensitivity to a wide spectrum of oscillation scales, while facilitating the tidy cancellation of leading systematic uncertainties in the reactor source and environment. With 100~eV sensitivity, for exposures on the order of 200 kg$\cdot$y, we project an estimated sensitivity to first/fourth neutrino oscillation with a mass gap $\Delta m^2 \sim 1 \, {\rm eV}^2$ at an amplitude $\sin^2 2\theta \sim 10^{-1}$, or $\Delta m^2 \sim 0.2 \, {\rm eV}^2$ at unit amplitude. Larger exposures, around 5,000 kg$\cdot$y, together with 10 eV sensitivity are capable of probing more than an additional order of magnitude in amplitude.Comment: 4 figures, PRD version, New author added, analysis updated with stat. estimates based on new measurements and simulation

Gas and gas hydrate distribution around seafloor seeps in Mississippi Canyon, Northern Gulf of Mexico, using multi-resolution seismic imagery

This paper is not subject to U.S. copyright. The definitive version was published in Marine and Petroleum Geology 25 (2008): 952-959, doi:10.1016/j.marpetgeo.2008.01.015.To determine the impact of seeps and focused flow on the occurrence of shallow gas hydrates, several seafloor mounds in the Atwater Valley lease area of the Gulf of Mexico were surveyed with a wide range of seismic frequencies. Seismic data were acquired with a deep-towed, Helmholz resonator source (220–820 Hz); a high-resolution, Generator-Injector air-gun (30–300 Hz); and an industrial air-gun array (10–130 Hz). Each showed a significantly different response in this weakly reflective, highly faulted area. Seismic modeling and observations of reversed-polarity reflections and small scale diffractions are consistent with a model of methane transport dominated regionally by diffusion but punctuated by intense upward advection responsible for the bathymetric mounds, as well as likely advection along pervasive filamentous fractures away from the mounds.This work was funded through ONR program element 61153N, and U.S. Department of Energy Grant DE-A126-97FT3423

Global, regional, and national burden of disorders affecting the nervous system, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021

BackgroundDisorders affecting the nervous system are diverse and include neurodevelopmental disorders, late-life neurodegeneration, and newly emergent conditions, such as cognitive impairment following COVID-19. Previous publications from the Global Burden of Disease, Injuries, and Risk Factor Study estimated the burden of 15 neurological conditions in 2015 and 2016, but these analyses did not include neurodevelopmental disorders, as defined by the International Classification of Diseases (ICD)-11, or a subset of cases of congenital, neonatal, and infectious conditions that cause neurological damage. Here, we estimate nervous system health loss caused by 37 unique conditions and their associated risk factors globally, regionally, and nationally from 1990 to 2021.MethodsWe estimated mortality, prevalence, years lived with disability (YLDs), years of life lost (YLLs), and disability-adjusted life-years (DALYs), with corresponding 95% uncertainty intervals (UIs), by age and sex in 204 countries and territories, from 1990 to 2021. We included morbidity and deaths due to neurological conditions, for which health loss is directly due to damage to the CNS or peripheral nervous system. We also isolated neurological health loss from conditions for which nervous system morbidity is a consequence, but not the primary feature, including a subset of congenital conditions (ie, chromosomal anomalies and congenital birth defects), neonatal conditions (ie, jaundice, preterm birth, and sepsis), infectious diseases (ie, COVID-19, cystic echinococcosis, malaria, syphilis, and Zika virus disease), and diabetic neuropathy. By conducting a sequela-level analysis of the health outcomes for these conditions, only cases where nervous system damage occurred were included, and YLDs were recalculated to isolate the non-fatal burden directly attributable to nervous system health loss. A comorbidity correction was used to calculate total prevalence of all conditions that affect the nervous system combined.FindingsGlobally, the 37 conditions affecting the nervous system were collectively ranked as the leading group cause of DALYs in 2021 (443 million, 95% UI 378–521), affecting 3·40 billion (3·20–3·62) individuals (43·1%, 40·5–45·9 of the global population); global DALY counts attributed to these conditions increased by 18·2% (8·7–26·7) between 1990 and 2021. Age-standardised rates of deaths per 100 000 people attributed to these conditions decreased from 1990 to 2021 by 33·6% (27·6–38·8), and age-standardised rates of DALYs attributed to these conditions decreased by 27·0% (21·5–32·4). Age-standardised prevalence was almost stable, with a change of 1·5% (0·7–2·4). The ten conditions with the highest age-standardised DALYs in 2021 were stroke, neonatal encephalopathy, migraine, Alzheimer's disease and other dementias, diabetic neuropathy, meningitis, epilepsy, neurological complications due to preterm birth, autism spectrum disorder, and nervous system cancer.InterpretationAs the leading cause of overall disease burden in the world, with increasing global DALY counts, effective prevention, treatment, and rehabilitation strategies for disorders affecting the nervous system are needed