4 research outputs found
Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
- Aali Amirali
- Abbafati Cristiana
- Abbas Jaffar
- Abbasgholizadeh Rouzbeh
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed
- Abdollahi Mohammad
- Abdoun Meriem
- Abdullahi Auwal
- Abdurehman Ame Mehadi
- Abebe Mesfin
- Abedi Aidin
- Abedi Armita
- Abegaz Tadesse M
- Abeldaño Zuñiga Roberto Ariel
- Abhilash E S
- Abiodun Olugbenga Olusola
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Abreu Lucas Guimarães
- Abrha Woldu Aberhe
- Abrigo Michael R M
- Abtahi Dariush
- Abu Rumeileh Samir
- Abu-Rmeileh Niveen ME
- Abu-Zaid Ahmed
- Aburuz Salahdein
- Acuna Juan Manuel
- Adair Tim
- Addo Isaac Yeboah
- Adebayo Oladimeji M
- Adegboye Oyelola A
- Adekanmbi Victor
- Aden Bashir
- Adepoju Abiola Victor
- Adetunji Charles Oluwaseun
- Adeyeoluwa Temitayo Esther
- Adeyomoye Olorunsola Israel
- Adha Rishan
- Adibi Amin
- Adikusuma Wirawan
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afework Abel
- Afolabi Aanuoluwapo Adeyimika
- Afraz Ali
- Afyouni Shadi
- Afzal Saira
- Agasthi Pradyumna
- Aghamiri Shahin
- Agodi Antonella
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadzade Amir Mahmoud
- Ahmadzade Mohadese
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Ajumobi Olufemi
- Akalu Gizachew Taddesse
- Akara Essona Matatom
- Akinosoglou Karolina
- Akkala Sreelatha
- Akyirem Samuel
- Al Hamad Hanadi
- Al Hasan Syed Mahfuz
- Al Homsi Ammar
- Al Qadire Mohammad
- AL-Ahdal Tareq Mohammed Ali
- Al-Aly Ziyad
- Al-amer Rasmieh Mustafa
- Al-Eyadhy Ayman
- Al-Gheethi Adel Ali Saeed
- Al-Hanawi Mohammed Khaled
- Al-Jumaily Adel
- Al-Marwani Sabah
- Al-Maweri Sadeq Ali Ali
- Al-Mekhlafi Hesham M
- Al-Sabah Salman Khalifah
- Al-Tawfiq Jaffar A
- Al-Worafi Yaser Mohammed
- Ala Moein
- Aladelusi Timothy Olukunle
- Alalalmeh Samer O
- Alam Khurshid
- Alam Manjurul
- Alam Zufishan
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Albashtawy Mohammed
- AlBataineh Mohammad T
- Aldridge Robert W
- Alemi Sharifullah
- Alhabib Khalid F
- Alhalaiqa Fadwa Alhalaiqa Naji
- Ali Abid
- Ali Akhtar
- Ali Beriwan Abdulqadir
- Ali Hassam
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Ali Zahid
- Alian Samakkhah Shohreh
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Aligol Mohammad
- Alimi Rasoul
- Aliyi Ahmednur Adem
- Aljunid Syed Mohamed
- Almahmeed Wael
- Almazan Joseph Uy
- Almidani Omar
- Alomari Mahmoud A
- Alonso Nivaldo
- Alqahtani Jaber S
- Alqutaibi Ahmed Yaseen
- Altaf Awais
- Altirkawi Khalid A
- Alvi Farrukh Jawad
- Alwafi Hassan
- Aly Hany
- Alzoubi Karem H
- Amare Azmeraw T
- Ameyaw Edward Kwabena
- Amhare Abebe Feyissa
- Amin Tarek Tawfik
- Amindarolzarbi Alireza
- Aminian Dehkordi Javad
- Amiri Sohrab
- Amu Hubert
- Amugsi Dickson A
- Amzat Jimoh
- Ancuceanu Robert
- Anderlini Deanna
- Andrade Pedro Prata
- Andrei Catalina Liliana
- Andrei Tudorel
- Angappan Dhanalakshmi
- Anil Abhishek
- Anjum Afifa
- Antony Catherine M
- Antriyandarti Ernoiz
- Anuoluwa Iyadunni Adesola
- Anwar Sumadi Lukman
- Anyasodor Anayochukwu Edward
- Appiah Seth Christopher Yaw
- Aqeel Muhammad
- Arab-Zozani Morteza
- Arabloo Jalal
- Arabzadeh Bahri Razman
- Arafat Mosab
- Araújo Ana Margarida
- Aravkin Aleksandr Y
- Aremu Abdulfatai
- Ariffin Hany
- Aripov Timur
- Armocida Benedetta
- Arooj Mahwish
- Artamonov Anton A
- Artanti Kurnia Dwi
- Arulappan Judie
- Aruleba Idowu Thomas
- Aruleba Raphael Taiwo
- Arumugam Ashokan
- Asaad Malke
- Asgary Saeed
- Ashemo Mubarek Yesse
- Ashraf Muhammad
- Asika Marvellous O
- Athari Seyyed Shamsadin
- Atout Maha Moh'd Wahbi
- Atreya Alok
- Attia Sameh
- Aujayeb Avinash
- Avan Abolfazl
- Awotidebe Adedapo Wasiu
- Ayala Quintanilla Beatriz Paulina
- Ayanore Martin Amogre
- Ayele Getnet Melaku
- Ayuso-Mateos Jose L
- Ayyoubzadeh Seyed Mohammad
- Azadnajafabad Sina
- Azhar Gulrez Shah
- Aziz Shahkaar
- Azzam Ahmed Y
- Babashahi Mina
- Babu Abraham Samuel
- Badar Muhammad
- Badawi Alaa
- Badiye Ashish D
- Baghdadi Soroush
- Bagheri Nasser
- Bagherieh Sara
- Bah Sulaiman
- Bahadorikhalili Saeed
- Bai Jianjun
- Bai Ruhai
- Baker Jennifer L
- Bakkannavar Shankar M
- Bako Abdulaziz T
- Balakrishnan Senthilkumar
- Balogun Saliu A
- Baltatu Ovidiu Constantin
- Bam Kiran
- Banach Maciej
- Bandyopadhyay Soham
- Banik Biswajit
- Banik Palash Chandra
- Bansal Hansi
- Barati Shirin
- Barchitta Martina
- Bardhan Mainak
- Barker-Collo Suzanne Lyn
- Barone-Adesi Francesco
- Barqawi Hiba Jawdat
- Barr Ronald D
- Barrero Lope H
- Basharat Zarrin
- Bashir Asma'u I J
- Bashiru Hameed Akande
- Baskaran Pritish
- Basnyat Buddha
- Bassat Quique
- Basso João Diogo
- Basu Saurav
- Batra Kavita
- Batra Ravi
- Baune Bernhard T
- Bayati Mohsen
- Bayileyegn Nebiyou Simegnew
- Beaney Thomas
- Bedi Neeraj
- Begum Tahmina
- Behboudi Emad
- Behnoush Amir Hossein
- Beiranvand Maryam
- Bejarano Ramirez Diana Fernanda
- Belgaumi Uzma Iqbal
- Bell Michelle L
- Bello Aminu K
- Bello Muhammad Bashir
- Bello Olorunjuwon Omolaja
- Belo Luis
- Beloukas Apostolos
- Bendak Salaheddine
- Bennett Derrick A
- Bensenor Isabela M
- Benzian Habib
- Berezvai Zombor
- Berman Adam E
- Bermudez Amiel Nazer C
- Bettencourt Paulo J G
- Beyene Habtamu B
- Beyene Kebede A
- Bhagat Devidas S
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhalla Ashish
- Bhandari Dinesh
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhardwaj Prarthna V
- Bhargava Ashish
- Bhaskar Sonu
- Bhat Vivek
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Manpreet S
- Bhatti Rajbir
- Bhutta Zulfiqar A
- Bikbov Boris
- Binmadi Nada
- Bintoro Bagas Suryo
- Biondi Antonio
- Bisignano Catherine
- Bisulli Francesca
- Biswas Atanu
- Biswas Raaj Kishore
- Bitaraf Saeid
- Bjørge Tone
- Bleyer Archie
- Boampong Mary Sefa
- Bodolica Virginia
- Bodunrin Aadam Olalekan
- Bolarinwa Obasanjo Afolabi
- Bonakdar Hashemi Milad
- Bonny Aime
- Bora Basara Berrak
- Bora Kaustubh
- Borodo Safiya Bala
- Borschmann Rohan
- Botero Carvajal Alejandro
- Bouaoud Souad
- Boudalia Sofiane
- Boyko Edward J
- Bragazzi Nicola Luigi
- Braithwaite Dejana
- Brenner Hermann
- Britton Gabrielle
- Browne Annie J
- Brunoni Andre R
- Bulamu Norma B
- Bulto Lemma N
- Buonsenso Danilo
- Burkart Katrin
- Burns Richard A
- Burugina Nagaraja Sharath
- Busse Reinhard
- Bustanji Yasser
- Butt Zahid A
- Caetano dos Santos Florentino Luciano
- Cai Tianji
- Calina Daniela
- Campos Luciana Aparecida
- Campos-Nonato Ismael R
- Cao Chao
- Cardenas Carlos Alberto
- Carr Sinclair
- Carreras Giulia
- Carrero Juan J
- Carugno Andrea
- Carvalho Felix
- Carvalho Márcia
- Castaldelli-Maia Joao Mauricio
- Castañeda-Orjuela Carlos A
- Castelpietra Giulio
- Catalá-López Ferrán
- Catapano Alberico L
- Cattaruzza Maria Sofia
- Caye Arthur
- Cámera Luis Alberto
- Cárdenas Rosario
- Cederroth Christopher R
- Cembranel Francieli
- Cenderadewi Muthia
- Cercy Kelly M
- Cerin Ester
- Cevik Muge
- Chacón-Uscamaita Pamela R Uscamaita
- Chahine Yaacoub
- Chakraborty Chiranjib
- Chan Jeffrey Shi Kai
- Chang Chin-Kuo
- Charalampous Periklis
- Charan Jaykaran
- Chattu Vijay Kumar
- Chatzimavridou-Grigoriadou Victoria
- Chavula Malizgani Paul
- Cheema Huzaifa Ahmad
- Chen An-Tian
- Chen Haowei
- Chen Lingxiao
- Chen Meng Xuan
- Chen Simiao
- Cherbuin Nicolas
- Chew Derek S
- Chi Gerald
- Chirinos-Caceres Jesus Lorenzo
- Chitheer Abdulaal
- Cho So Mi Jemma
- Cho William C S
- Chong Bryan
- Chopra Hitesh
- Choudhary Rahul
- Chowdhury Rajiv
- Chu Dinh-Toi
- Chukwu Isaac Sunday
- Chung Eric
- Chung Eunice
- Chung Sheng-Chia
- Cini Karly I
- Clark Cain C T
- Coberly Kaleb
- Columbus Alyssa
- Comfort Haley
- Conde Joao
- Conti Sara
- Cortesi Paolo Angelo
- Costa Vera Marisa
- Cousin Ewerton
- Cowden Richard G
- Criqui Michael H
- Cruz-Martins Natália
- Culbreth Garland T
- Cullen Patricia
- Cunningham Matthew
- D'Amico Emanuele
- da Silva e Silva Daniel
- Dadana Sriharsha
- Dadras Omid
- Dai Zhaoli
- Dalal Koustuv
- Dalli Lachlan L
- Damiani Giovanni
- Daneshvar Sara
- Darwesh Aso Mohammad
- Das Jai K
- Das Saswati
- Dash Nihar Ranjan
- Dashti Mohsen
- Davis Weaver Nicole
- Davletov Kairat
- Dávila-Cervantes Claudio Alberto
- De Leo Diego
- Debele Aklilu Tamire
- Degenhardt Louisa
- Dehbandi Reza
- Deitesfeld Lee
- Delgado-Enciso Ivan
- Delgado-Ortiz Laura
- Demant Daniel
- Demessa Berecha Hundessa
- Demetriades Andreas K
- Deng Xinlei
- Denova-Gutiérrez Edgar
- Deribe Kebede
- Dervenis Nikolaos
- Des Jarlais Don C
- Desai Hardik Dineshbhai
- Desai Rupak
- Deuba Keshab
- Devanbu Vinoth Gnana Chellaiyan
- Dey Sourav
- Dhali Arkadeep
- Dhama Kuldeep
- Dhimal Mandira Lamichhane
- Dhimal Meghnath
- Dhingra Sameer
- Dias da Silva Diana
- Diaz Daniel
- Dima Adriana
- Ding Delaney D
- Dirac M Ashworth
- Dixit Abhinav
- Dixit Shilpi Gupta
- do Prado Camila Bruneli
- Do Thanh Chi
- Do Thao Huynh Phuong
- Dodangeh Masoud
- Dokova Klara Georgieva
- Dolecek Christiane
- Dorsey E Ray
- dos Santos Wendel Mombaque
- Doshi Rajkumar
- Doshmangir Leila
- Douiri Abdel
- Dowou Robert Kokou
- Driscoll Tim Robert
- Dsouza Haneil Larson
- Dube John
- Dumith Samuel C
- Dunachie Susanna J
- Duncan Bruce B
- Duraes Andre Rodrigues
- Duraisamy Senbagam
- Durojaiye Oyewole Christopher
- Dutta Sulagna
- Dzianach Paulina Agnieszka
- Dziedzic Arkadiusz Marian
- Ebenezer Oluwakemi
- Eboreime Ejemai
- Ebrahimi Alireza
- Echieh Chidiebere Peter
- Ed-Dra Abdelaziz
- Edinur Hisham Atan
- Edvardsson David
- Edvardsson Kristina
- Efendi Defi
- Efendi Ferry
- Eghdami Shayan
- Eikemo Terje Andreas
- Eini Ebrahim
- Ekholuenetale Michael
- Ekpor Emmanuel
- Ekundayo Temitope Cyrus
- El Arab Rabie Adel
- El Morsi Doaa Abdel Wahab
- El Sayed Zaki Maysaa
- El Tantawi Maha
- Elbarazi Iffat
- Elemam Noha Mousaad
- Elgar Frank J
- Elgendy Islam Y
- ElGohary Ghada Metwally Tawfik
- Elhabashy Hala Rashad
- Elhadi Muhammed
- Elmeligy Omar Abdelsadek Abdou
- Elshaer Mohammed
- Elsohaby Ibrahim
- Emami Zeydi Amir
- Emamverdi Mehdi
- Emeto Theophilus I
- Engelbert Bain Luchuo
- Erkhembayar Ryenchindorj
- Eshetie Tesfahun C
- Eskandarieh Sharareh
- Espinosa-Montero Juan
- Estep Kara
- Etaee Farshid
- Eze Ugochukwu Anthony
- Fabin Natalia
- Fadaka Adewale Oluwaseun
- Fagbamigbe Adeniyi Francis
- Fahimi Saman
- Falzone Luca
- Farinha Carla Sofia e Sá
- Faris MoezAlIslam Ezzat Mahmoud
- Farjoud Kouhanjani Mohsen
- Faro Andre
- Farrokhpour Hossein
- Fatehizadeh Ali
- Fattahi Hamed
- Fauk Nelsensius Klau
- Fazeli Pooria
- Feigin Valery L
- Fekadu Ginenus
- Fereshtehnejad Seyed-Mohammad
- Feroze Abdullah Hamid
- Ferrante Daniela
- Ferrara Pietro
- Ferreira Nuno
- Fetensa Getahun
- Filip Irina
- Fischer Florian
- Flavel Joanne
- Flaxman Abraham D
- Flor Luisa S
- Florin Bobirca Teodor
- Folayan Morenike Oluwatoyin
- Foley Kristen Marie
- Fomenkov Artem Alekseevich
- Force Lisa M
- Fornari Carla
- Foroutan Behzad
- Foschi Matteo
- Francis Kate Louise
- Franklin Richard Charles
- Freitas Alberto
- Friedman Joseph
- Friedman Sara D
- Fukumoto Takeshi
- Fuller John E
- Gaal Peter Andras
- Gadanya Muktar A
- Gaihre Santosh
- Gaipov Abduzhappar
- Gakidou Emmanuela
- Galali Yaseen
- Galehdar Nasrin
- Gallus Silvano
- Gan Quan
- Gandhi Aravind P
- Ganesan Balasankar
- Garg Jalaj
- Gau Shuo-Yan
- Gautam Prem
- Gautam Rupesh K
- Gazzelloni Federica
- Gebregergis Miglas W
- Gebrehiwot Mesfin
- Gebremariam Tesfay Brhane
- Gerema Urge
- Getachew Motuma Erena
- Getachew Tamirat
- Gething Peter W
- Ghafourifard Mansour
- Ghahramani Sulmaz
- Ghailan Khalid Yaser
- Ghajar Alireza
- Ghanbarnia Mohammad Javad
- Ghasemi MohammadReza
- Ghasemzadeh Afsaneh
- Ghassemi Fariba
- Ghazy Ramy Mohamed
- Ghimire Sailaja
- Gholamian Asadollah
- Gholamrezanezhad Ali
- Ghorbani Vajargah Pooyan
- Ghozali Ghozali
- Ghozy Sherief
- Ghuge Arun Digambarrao
- Gialluisi Alessandro
- Gibson Ruth Margaret
- Gil Artyom Urievich
- Gill Paramjit Singh
- Gill Tiffany K
- Gillum Richard F
- Ginindza Themba G
- Girmay Alem
- Glasbey James C
- Gnedovskaya Elena V
- Goel Amit
- Goldust Mohamad
- Golechha Mahaveer
- Goleij Pouya
- Golestanfar Arefeh
- Golinelli Davide
- Gona Philimon N
- Goudarzi Houman
- Goudarzian Amir Hossein
- Goyal Anmol
- Göbölös Laszlo
- Greenhalgh Scott
- Grivna Michal
- Guarducci Giovanni
- Gubari Mohammed Ibrahim Mohialdeen
- Gudeta Mesay Dechasa
- Guha Avirup
- Guicciardi Stefano
- Gunawardane Damitha Asanga
- Gunturu Sasidhar
- Guo Cui
- Gupta Anish Kumar
- Gupta Bhawna
- Gupta Indarchand Ratanlal
- Gupta Rajat Das
- Gupta Sapna
- Gupta Veer Bala
- Gupta Vijai Kumar
- Gupta Vivek Kumar
- Gutiérrez Reyna Alma
- Habibzadeh Farrokh
- Habibzadeh Parham
- Hachinski Vladimir
- Haddadi Mohammad
- Haddadi Rasool
- Haep Nils
- Hajj Ali Adel
- Halboub Esam S
- Halim Sobia Ahsan
- Hall Brian J
- Haller Sebastian
- Halwani Rabih
- Hamadeh Randah R
- Hamagharib Abdullah Kanaan
- Hamidi Samer
- Hamiduzzaman Mohammad
- Hammoud Ahmad
- Hanifi Nasrin
- Hankey Graeme J
- Hannan Md Abdul
- Haque Md Nuruzzaman
- Harapan Harapan
- Haro Josep Maria
- Hasaballah Ahmed I
- Hasan Faizul
- Hasan Ikramul
- Hasan M Tasdik
- Hasani Hamidreza
- Hasanian Mohammad
- Hasanpour- Dehkordi Ali
- Hassan Abbas M
- Hassan Amr
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- Hassanipour Soheil
- Haubold Johannes
- Havmoeller Rasmus J
- Hay Simon I
- Hbid Youssef
- Hebert Jeffrey J
- Hegazi Omar E
- Heidari Golnaz
- Heidari Mohammad
- Heidari-Foroozan Mahsa
- Heidari-Soureshjani Reza
- Helfer Bartosz
- Herteliu Claudiu
- Hesami Hamed
- Hettiarachchi Dineshani
- Heyi Demisu Zenbaba
- Hezam Kamal
- Hiraike Yuta
- Hoffman Howard J
- Holla Ramesh
- Horita Nobuyuki
- Hossain Md Belal
- Hossain Md Mahbub
- Hossain Sahadat
- Hosseini Mohammad-Salar
- Hosseinzadeh Hassan
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Hsairi Mohamed
- Hsieh Vivian Chia-rong
- Hu Chengxi
- Huang Junjie
- Huda Md Nazmul
- Hugo Fernando N
- Hultström Michael
- Hussain Javid
- Hussain Salman
- Hussein Nawfal R
- Huy Le Duc
- Huynh Hong-Han
- Hwang Bing-Fang
- Ibitoye Segun Emmanuel
- Idowu Oluwatope Olaniyi
- Ijo Desta
- Ikuta Kevin S
- Ilaghi Mehran
- Ilesanmi Olayinka Stephen
- Ilic Irena M
- Ilic Milena D
- Immurana Mustapha
- Inbaraj Leeberk Raja
- Iradukunda Arnaud
- Iravanpour Farideh
- Iregbu Kenneth Chukwuemeka
- Islam Md Rabiul
- Islam Mohammad Mainul
- Islam Sheikh Mohammed Shariful
- Islami Farhad
- Ismail Nahlah Elkudssiah
- Isola Gaetano
- Iwagami Masao
- Iwu Chidozie C D
- Iwu-Jaja Chinwe Juliana
- Iyer Mahalaxmi
- J Linda Merin
- Jaafari Jalil
- Jacob Louis
- Jacobsen Kathryn H
- Jadidi-Niaragh Farhad
- Jafarinia Morteza
- Jaggi Khushleen
- Jahankhani Kasra
- Jahanmehr Nader
- Jahrami Haitham
- Jain Akhil
- Jain Nityanand
- Jairoun Ammar Abdulrahman
- Jakovljevic Mihajlo
- Jalilzadeh Yengejeh Reza
- Jamshidi Elham
- Jani Chinmay T
- Janko Mark M
- Jatau Abubakar Ibrahim
- Jayapal Sathish Kumar
- Jayaram Shubha
- Jeganathan Jayakumar
- Jema Alelign Tasew
- Jemere Digisie Mequanint
- Jeong Wonjeong
- Jha Anil K
- Jha Ravi Prakash
- Ji John S
- Jiang Heng
- Jin Yingzhao
- Jin Yinzi
- Johnson Olatunji
- Jomehzadeh Nabi
- Jones Darwin Phan
- Joo Tamas
- Joseph Abel
- Joseph Nitin
- Joshua Charity Ehimwenma
- Jozwiak Jacek Jerzy
- Jürisson Mikk
- Kaambwa Billingsley
- Kabir Ali
- Kabir Hannaneh
- Kabir Zubair
- Kadashetti Vidya
- Kahe Farima
- Kakodkar Pradnya Vishal
- Kalani Rizwan
- Kalankesh Leila R
- Kaliyadan Feroze
- Kalra Sanjay
- Kamath Ashwin
- Kamireddy Arun
- Kanagasabai Thanigaivelan
- Kandel Himal
- Kanmiki Edmund Wedam
- Kanmodi Kehinde Kazeem
- Kantar Rami S
- Kapoor Neeti
- Karajizadeh Mehrdad
- Karami Matin Behzad
- Karanth Shama D
- Karaye Ibraheem M
- Karim Asima
- Karimi Behnagh Arman
- Karimi Hanie
- Karimi Salah Eddin
- Karkhah Samad
- Karna Ajit K
- Kashoo Faizan Zaffar
- Kasraei Hengameh
- Kassaw Nigussie Assefa
- Kassebaum Nicholas J
- Kassel Molly B
- Katamreddy Adarsh
- Katikireddi Srinivasa Vittal
- Katoto Patrick DMC
- Kauppila Joonas H
- Kaur Navjot
- Kaydi Neda
- Kayibanda Jeanne Françoise
- Kayode Gbenga A
- Kazemi Foad
- Kazemian Sina
- Kazeminia sara
- Keikavoosi-Arani Leila
- Keller Cathleen
- Kempen John H
- Kerr Jessica A
- Kesse-Guyot Emmanuelle
- Keykhaei Mohammad
- Khadembashiri Mohamad Mehdi
- Khadembashiri Mohammad Amin
- Khafaie Morteza Abdullatif
- Khajuria Himanshu
- Khalafi Mohammad
- Khalaji Amirmohammad
- Khalid Nauman
- Khalil Ibrahim A
- Khamesipour Faham
- Khan suheb Mahammed Ziauddin
- Khan Asaduzzaman
- Khan Gulfaraz
- Khan Ikramullah
- Khan Imteyaz A
- Khan Maseer
- Khan Moien AB
- Khan Taimoor
- Khanmohammadi Shaghayegh
- Khatab Khaled
- Khatami Fatemeh
- Khavandegar Armin
- Khayat Kashani Hamid Reza
- Kheirallah Khalid A
- Khidri Feriha Fatima
- Khodadoust Elaheh
- Khormali Moein
- Khosrowjerdi Mahmood
- Khubchandani Jagdish
- Khusun Helda
- Kifle Zemene Demelash
- Kim Grace
- Kim Jihee
- Kimokoti Ruth W
- Kinzel Kasey E
- Kiross Girmay Tsegay
- Kisa Adnan
- Kisa Sezer
- Kiss Juniper Boroka
- Kivimäki Mika
- Klu Desmond
- Knudsen Ann Kristin Skrindo
- Kolahi Ali-Asghar
- Kompani Farzad
- Koren Gerbrand
- Kosen Soewarta
- Kostev Karel
- Kotnis Ashwin Laxmikant
- Koul Parvaiz A
- Koulmane Laxminarayana Sindhura Lakshmi
- Koyanagi Ai
- Kravchenko Michael A
- Krishan Kewal
- Krishna Hare
- Krishnamoorthy Vijay
- Krishnamoorthy Yuvaraj
- Krohn Kris J
- Kuate Defo Barthelemy
- Kubeisy Connor M
- Kucuk Bicer Burcu
- Kuddus Md Abdul
- Kuddus Mohammed
- Kuitunen Ilari
- Kujan Omar
- Kulimbet Mukhtar
- Kulkarni Vishnutheertha
- Kumar Ashish
- Kumar Harish
- Kumar Nithin
- Kumar Rahul
- Kumar Shiv
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- Zhai Chunxia
- Zhang Chen
- Zhang Haijun
- Zhang Hongwei
- Zhang Yunquan
- Zhang Zhaofeng
- Zhang Zhenyu
- Zhao Hanqing
- Zhao Yang
- Zhao Yong
- Zheng Peng
- Zhong Chenwen
- Zhou Juexiao
- Zhu Bin
- Zhu Zhaohua
- Ziaeefar Pardis
- Zielińska Magdalena
- Zou Zhiyong
- Zumla Alimuddin
- Zweck Elric
- Zyoud Samer H
- Publication venue
- Publication date
- 01/01/2024
- Field of study
Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period. Methods: 22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution. Findings: Global all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations. Interpretation: Global adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic
Hereditary Angioedema Type II: First Presentation in Adulthood with Recurrent Severe Abdominal Pain
- Publication venue
- 'Hindawi Limited'
- Publication date
- 01/01/2018
- Field of study
A 27-year-old Emirate man presented to Cleveland Clinic Abu Dhabi emergency department with a 4 year history of recurrent episodes of severe swellings affecting different parts of his body. He used to get 2 swelling episodes every week affecting either his face, hands, feet or scrotum and severe abdominal pain twice a week. Abdominal CT scan and a colonoscopy showed bowel wall oedema. There was no family history of similar complaint or of hereditary angioedema (HAE). Complement studies confirmed the diagnosis of HAE type II. He was commenced on danazol 100 mg twice daily and his symptoms resolved. This case report highlights the importance of considering HAE in patients with recurrent unexplained abdominal pain even in the absence of positive family history of HAE
Global age-sex-specific mortality, life expectancy, and population estimates in 204 countries and territories and 811 subnational locations, 1950–2021, and the impact of the COVID-19 pandemic: a comprehensive demographic analysis for the Global Burden of Disease Study 2021
- Author
- Aali Amirali
- Abbafati Cristiana
- Abbas Jaffar
- Abbasgholizadeh Rouzbeh
- Abbasi Madineh Akram
- Abbasian Mohammadreza
- Abd ElHafeez Samar
- Abd-Elsalam Sherief
- Abdelmasseh Michael
- Abdelwahab Ahmed
- Abdollahi Mohammad
- Abdoun Meriem
- Abdullahi Auwal
- Abdurehman Ame Mehadi
- Abebe Mesfin
- Abedi Aidin
- Abedi Armita
- Abegaz Tadesse M
- Abeldaño Zuñiga Roberto Ariel
- Abhilash E S
- Abiodun Olugbenga Olusola
- Aboagye Richard Gyan
- Abolhassani Hassan
- Abouzid Mohamed
- Abreu Lucas Guimarães
- Abrha Woldu Aberhe
- Abrigo Michael R M
- Abtahi Dariush
- Abu Rumeileh Samir
- Abu-Rmeileh Niveen ME
- Abu-Zaid Ahmed
- Aburuz Salahdein
- Acuna Juan Manuel
- Adair Tim
- Addo Isaac Yeboah
- Adebayo Oladimeji M
- Adegboye Oyelola A
- Adekanmbi Victor
- Aden Bashir
- Adepoju Abiola Victor
- Adetunji Charles Oluwaseun
- Adeyeoluwa Temitayo Esther
- Adeyomoye Olorunsola Israel
- Adha Rishan
- Adibi Amin
- Adikusuma Wirawan
- Adnani Qorinah Estiningtyas Sakilah
- Adra Saryia
- Afework Abel
- Afolabi Aanuoluwapo Adeyimika
- Afraz Ali
- Afyouni Shadi
- Afzal Saira
- Agasthi Pradyumna
- Aghamiri Shahin
- Agodi Antonella
- Agyemang-Duah Williams
- Ahinkorah Bright Opoku
- Ahmad Aqeel
- Ahmad Danish
- Ahmad Firdos
- Ahmad Muayyad M
- Ahmad Tauseef
- Ahmadi Keivan
- Ahmadzade Amir Mahmoud
- Ahmadzade Mohadese
- Ahmed Ayman
- Ahmed Haroon
- Ahmed Luai A
- Ahmed Muktar Beshir
- Ahmed Syed Anees
- Ajami Marjan
- Aji Budi
- Ajumobi Olufemi
- Akalu Gizachew Taddesse
- Akara Essona Matatom
- Akinosoglou Karolina
- Akkala Sreelatha
- Akyirem Samuel
- Al Hamad Hanadi
- Al Hasan Syed Mahfuz
- Al Homsi Ammar
- Al Qadire Mohammad
- AL-Ahdal Tareq Mohammed Ali
- Al-Aly Ziyad
- Al-amer Rasmieh Mustafa
- Al-Eyadhy Ayman
- Al-Gheethi Adel Ali Saeed
- Al-Hanawi Mohammed Khaled
- Al-Jumaily Adel
- Al-Marwani Sabah
- Al-Maweri Sadeq Ali Ali
- Al-Mekhlafi Hesham M
- Al-Sabah Salman Khalifah
- Al-Tawfiq Jaffar A
- Al-Worafi Yaser Mohammed
- Ala Moein
- Aladelusi Timothy Olukunle
- Alalalmeh Samer O
- Alam Khurshid
- Alam Manjurul
- Alam Zufishan
- Alanezi Fahad Mashhour
- Alanzi Turki M
- Albashtawy Mohammed
- AlBataineh Mohammad T
- Aldridge Robert W
- Alemi Sharifullah
- Alhabib Khalid F
- Alhalaiqa Fadwa Alhalaiqa Naji
- Ali Abid
- Ali Akhtar
- Ali Beriwan Abdulqadir
- Ali Hassam
- Ali Mohammed Usman
- Ali Rafat
- Ali Syed Shujait Shujait
- Ali Zahid
- Alian Samakkhah Shohreh
- Alicandro Gianfranco
- Alif Sheikh Mohammad
- Aligol Mohammad
- Alimi Rasoul
- Aliyi Ahmednur Adem
- Aljunid Syed Mohamed
- Almahmeed Wael
- Almazan Joseph Uy
- Almidani Omar
- Alomari Mahmoud A
- Alonso Nivaldo
- Alqahtani Jaber S
- Alqutaibi Ahmed Yaseen
- Altaf Awais
- Altirkawi Khalid A
- Alvi Farrukh Jawad
- Alwafi Hassan
- Aly Hany
- Alzoubi Karem H
- Amare Azmeraw T
- Ameyaw Edward Kwabena
- Amhare Abebe Feyissa
- Amin Tarek Tawfik
- Amindarolzarbi Alireza
- Aminian Dehkordi Javad
- Amiri Sohrab
- Amu Hubert
- Amugsi Dickson A
- Amzat Jimoh
- Ancuceanu Robert
- Anderlini Deanna
- Andrade Pedro Prata
- Andrei Catalina Liliana
- Andrei Tudorel
- Angappan Dhanalakshmi
- Anil Abhishek
- Anjum Afifa
- Antony Catherine M
- Antriyandarti Ernoiz
- Anuoluwa Iyadunni Adesola
- Anwar Sumadi Lukman
- Anyasodor Anayochukwu Edward
- Appiah Seth Christopher Yaw
- Aqeel Muhammad
- Arab-Zozani Morteza
- Arabloo Jalal
- Arabzadeh Bahri Razman
- Arafat Mosab
- Aravkin Aleksandr Y
- Araújo Ana Margarida
- Aremu Abdulfatai
- Ariffin Hany
- Aripov Timur
- Armocida Benedetta
- Arooj Mahwish
- Artamonov Anton A
- Artanti Kurnia Dwi
- Arulappan Judie
- Aruleba Idowu Thomas
- Aruleba Raphael Taiwo
- Arumugam Ashokan
- Asaad Malke
- Asgary Saeed
- Ashemo Mubarek Yesse
- Ashraf Muhammad
- Asika Marvellous O
- Athari Seyyed Shamsadin
- Atout Maha Moh'd Wahbi
- Atreya Alok
- Attia Sameh
- Aujayeb Avinash
- Avan Abolfazl
- Awotidebe Adedapo Wasiu
- Ayala Quintanilla Beatriz Paulina
- Ayanore Martin Amogre
- Ayele Getnet Melaku
- Ayuso-Mateos Jose L
- Ayyoubzadeh Seyed Mohammad
- Azadnajafabad Sina
- Azhar Gulrez Shah
- Aziz Shahkaar
- Azzam Ahmed Y
- Babashahi Mina
- Babu Abraham Samuel
- Badar Muhammad
- Badawi Alaa
- Badiye Ashish D
- Baghdadi Soroush
- Bagheri Nasser
- Bagherieh Sara
- Bah Sulaiman
- Bahadorikhalili Saeed
- Bai Jianjun
- Bai Ruhai
- Baker Jennifer L
- Bakkannavar Shankar M
- Bako Abdulaziz T
- Balakrishnan Senthilkumar
- Balogun Saliu A
- Baltatu Ovidiu Constantin
- Bam Kiran
- Banach Maciej
- Bandyopadhyay Soham
- Banik Biswajit
- Banik Palash Chandra
- Bansal Hansi
- Barati Shirin
- Barchitta Martina
- Bardhan Mainak
- Barker-Collo Suzanne Lyn
- Barone-Adesi Francesco
- Barqawi Hiba Jawdat
- Barr Ronald D
- Barrero Lope H
- Basharat Zarrin
- Bashir Asma'u I J
- Bashiru Hameed Akande
- Baskaran Pritish
- Basnyat Buddha
- Bassat Quique
- Basso João Diogo
- Basu Saurav
- Batra Kavita
- Batra Ravi
- Baune Bernhard T
- Bayati Mohsen
- Bayileyegn Nebiyou Simegnew
- Beaney Thomas
- Bedi Neeraj
- Begum Tahmina
- Behboudi Emad
- Behnoush Amir Hossein
- Beiranvand Maryam
- Bejarano Ramirez Diana Fernanda
- Belgaumi Uzma Iqbal
- Bell Michelle L
- Bello Aminu K
- Bello Muhammad Bashir
- Bello Olorunjuwon Omolaja
- Belo Luis
- Beloukas Apostolos
- Bendak Salaheddine
- Bennett Derrick A
- Bensenor Isabela M
- Benzian Habib
- Berezvai Zombor
- Berman Adam E
- Bermudez Amiel Nazer C
- Bettencourt Paulo J G
- Beyene Habtamu B
- Beyene Kebede A
- Bhagat Devidas S
- Bhagavathula Akshaya Srikanth
- Bhala Neeraj
- Bhalla Ashish
- Bhandari Dinesh
- Bhardwaj Nikha
- Bhardwaj Pankaj
- Bhardwaj Prarthna V
- Bhargava Ashish
- Bhaskar Sonu
- Bhat Vivek
- Bhatti Gurjit Kaur
- Bhatti Jasvinder Singh
- Bhatti Manpreet S
- Bhatti Rajbir
- Bhutta Zulfiqar A
- Bikbov Boris
- Binmadi Nada
- Bintoro Bagas Suryo
- Biondi Antonio
- Bisignano Catherine
- Bisulli Francesca
- Biswas Atanu
- Biswas Raaj Kishore
- Bitaraf Saeid
- Bjørge Tone
- Bleyer Archie
- Boampong Mary Sefa
- Bodolica Virginia
- Bodunrin Aadam Olalekan
- Bolarinwa Obasanjo Afolabi
- Bonakdar Hashemi Milad
- Bonny Aime
- Bora Basara Berrak
- Bora Kaustubh
- Borodo Safiya Bala
- Borschmann Rohan
- Botero Carvajal Alejandro
- Bouaoud Souad
- Boudalia Sofiane
- Boyko Edward J
- Bragazzi Nicola Luigi
- Braithwaite Dejana
- Brenner Hermann
- Britton Gabrielle
- Browne Annie J
- Brunoni Andre R
- Bulamu Norma B
- Bulto Lemma N
- Buonsenso Danilo
- Burkart Katrin
- Burns Richard A
- Burugina Nagaraja Sharath
- Busse Reinhard
- Bustanji Yasser
- Butt Zahid A
- Caetano dos Santos Florentino Luciano
- Cai Tianji
- Calina Daniela
- Campos Luciana Aparecida
- Campos-Nonato Ismael R
- Cao Chao
- Cardenas Carlos Alberto
- Carr Sinclair
- Carreras Giulia
- Carrero Juan J
- Carugno Andrea
- Carvalho Felix
- Carvalho Márcia
- Castaldelli-Maia Joao Mauricio
- Castañeda-Orjuela Carlos A
- Castelpietra Giulio
- Catalá-López Ferrán
- Catapano Alberico L
- Cattaruzza Maria Sofia
- Caye Arthur
- Cederroth Christopher R
- Cembranel Francieli
- Cenderadewi Muthia
- Cercy Kelly M
- Cerin Ester
- Cevik Muge
- Chacón-Uscamaita Pamela R Uscamaita
- Chahine Yaacoub
- Chakraborty Chiranjib
- Chan Jeffrey Shi Kai
- Chang Chin-Kuo
- Charalampous Periklis
- Charan Jaykaran
- Chattu Vijay Kumar
- Chatzimavridou-Grigoriadou Victoria
- Chavula Malizgani Paul
- Cheema Huzaifa Ahmad
- Chen An-Tian
- Chen Haowei
- Chen Lingxiao
- Chen Meng Xuan
- Chen Simiao
- Cherbuin Nicolas
- Chew Derek S
- Chi Gerald
- Chirinos-Caceres Jesus Lorenzo
- Chitheer Abdulaal
- Cho So Mi Jemma
- Cho William C S
- Chong Bryan
- Chopra Hitesh
- Choudhary Rahul
- Chowdhury Rajiv
- Chu Dinh-Toi
- Chukwu Isaac Sunday
- Chung Eric
- Chung Eunice
- Chung Sheng-Chia
- Cini Karly I
- Clark Cain C T
- Coberly Kaleb
- Columbus Alyssa
- Comfort Haley
- Conde Joao
- Conti Sara
- Cortesi Paolo Angelo
- Costa Vera Marisa
- Cousin Ewerton
- Cowden Richard G
- Criqui Michael H
- Cruz-Martins Natália
- Culbreth Garland T
- Cullen Patricia
- Cunningham Matthew
- Cámera Luis Alberto
- Cárdenas Rosario
- D'Amico Emanuele
- da Silva e Silva Daniel
- Dadana Sriharsha
- Dadras Omid
- Dai Zhaoli
- Dalal Koustuv
- Dalli Lachlan L
- Damiani Giovanni
- Daneshvar Sara
- Darwesh Aso Mohammad
- Das Jai K
- Das Saswati
- Dash Nihar Ranjan
- Dashti Mohsen
- Davis Weaver Nicole
- Davletov Kairat
- De Leo Diego
- Debele Aklilu Tamire
- Degenhardt Louisa
- Dehbandi Reza
- Deitesfeld Lee
- Delgado-Enciso Ivan
- Delgado-Ortiz Laura
- Demant Daniel
- Demessa Berecha Hundessa
- Demetriades Andreas K
- Deng Xinlei
- Denova-Gutiérrez Edgar
- Deribe Kebede
- Dervenis Nikolaos
- Des Jarlais Don C
- Desai Hardik Dineshbhai
- Desai Rupak
- Deuba Keshab
- Devanbu Vinoth Gnana Chellaiyan
- Dey Sourav
- Dhali Arkadeep
- Dhama Kuldeep
- Dhimal Mandira Lamichhane
- Dhimal Meghnath
- Dhingra Sameer
- Dias da Silva Diana
- Diaz Daniel
- Dima Adriana
- Ding Delaney D
- Dirac M Ashworth
- Dixit Abhinav
- Dixit Shilpi Gupta
- do Prado Camila Bruneli
- Do Thanh Chi
- Do Thao Huynh Phuong
- Dodangeh Masoud
- Dokova Klara Georgieva
- Dolecek Christiane
- Dorsey E Ray
- dos Santos Wendel Mombaque
- Doshi Rajkumar
- Doshmangir Leila
- Douiri Abdel
- Dowou Robert Kokou
- Driscoll Tim Robert
- Dsouza Haneil Larson
- Dube John
- Dumith Samuel C
- Dunachie Susanna J
- Duncan Bruce B
- Duraes Andre Rodrigues
- Duraisamy Senbagam
- Durojaiye Oyewole Christopher
- Dutta Sulagna
- Dzianach Paulina Agnieszka
- Dziedzic Arkadiusz Marian
- Dávila-Cervantes Claudio Alberto
- Ebenezer Oluwakemi
- Eboreime Ejemai
- Ebrahimi Alireza
- Echieh Chidiebere Peter
- Ed-Dra Abdelaziz
- Edinur Hisham Atan
- Edvardsson David
- Edvardsson Kristina
- Efendi Defi
- Efendi Ferry
- Eghdami Shayan
- Eikemo Terje Andreas
- Eini Ebrahim
- Ekholuenetale Michael
- Ekpor Emmanuel
- Ekundayo Temitope Cyrus
- El Arab Rabie Adel
- El Morsi Doaa Abdel Wahab
- El Sayed Zaki Maysaa
- El Tantawi Maha
- Elbarazi Iffat
- Elemam Noha Mousaad
- Elgar Frank J
- Elgendy Islam Y
- ElGohary Ghada Metwally Tawfik
- Elhabashy Hala Rashad
- Elhadi Muhammed
- Elmeligy Omar Abdelsadek Abdou
- Elshaer Mohammed
- Elsohaby Ibrahim
- Emami Zeydi Amir
- Emamverdi Mehdi
- Emeto Theophilus I
- Engelbert Bain Luchuo
- Erkhembayar Ryenchindorj
- Eshetie Tesfahun C
- Eskandarieh Sharareh
- Espinosa-Montero Juan
- Estep Kara
- Etaee Farshid
- Eze Ugochukwu Anthony
- Fabin Natalia
- Fadaka Adewale Oluwaseun
- Fagbamigbe Adeniyi Francis
- Fahimi Saman
- Falzone Luca
- Farinha Carla Sofia e Sá
- Faris MoezAlIslam Ezzat Mahmoud
- Farjoud Kouhanjani Mohsen
- Faro Andre
- Farrokhpour Hossein
- Fatehizadeh Ali
- Fattahi Hamed
- Fauk Nelsensius Klau
- Fazeli Pooria
- Feigin Valery L
- Fekadu Ginenus
- Fereshtehnejad Seyed-Mohammad
- Feroze Abdullah Hamid
- Ferrante Daniela
- Ferrara Pietro
- Ferreira Nuno
- Fetensa Getahun
- Filip Irina
- Fischer Florian
- Flavel Joanne
- Flaxman Abraham D
- Flor Luisa S
- Florin Bobirca Teodor
- Folayan Morenike Oluwatoyin
- Foley Kristen Marie
- Fomenkov Artem Alekseevich
- Force Lisa M
- Fornari Carla
- Foroutan Behzad
- Foschi Matteo
- Francis Kate Louise
- Franklin Richard Charles
- Freitas Alberto
- Friedman Joseph
- Friedman Sara D
- Fukumoto Takeshi
- Fuller John E
- Gaal Peter Andras
- Gadanya Muktar A
- Gaihre Santosh
- Gaipov Abduzhappar
- Gakidou Emmanuela
- Galali Yaseen
- Galehdar Nasrin
- Gallus Silvano
- Gan Quan
- Gandhi Aravind P
- Ganesan Balasankar
- Garg Jalaj
- Gau Shuo-Yan
- Gautam Prem
- Gautam Rupesh K
- Gazzelloni Federica
- Gebregergis Miglas W
- Gebrehiwot Mesfin
- Gebremariam Tesfay Brhane
- Gerema Urge
- Getachew Motuma Erena
- Getachew Tamirat
- Gething Peter W
- Ghafourifard Mansour
- Ghahramani Sulmaz
- Ghailan Khalid Yaser
- Ghajar Alireza
- Ghanbarnia Mohammad Javad
- Ghasemi MohammadReza
- Ghasemzadeh Afsaneh
- Ghassemi Fariba
- Ghazy Ramy Mohamed
- Ghimire Sailaja
- Gholamian Asadollah
- Gholamrezanezhad Ali
- Ghorbani Vajargah Pooyan
- Ghozali Ghozali
- Ghozy Sherief
- Ghuge Arun Digambarrao
- Gialluisi Alessandro
- Gibson Ruth Margaret
- Gil Artyom Urievich
- Gill Paramjit Singh
- Gill Tiffany K
- Gillum Richard F
- Ginindza Themba G
- Girmay Alem
- Glasbey James C
- Gnedovskaya Elena V
- Goel Amit
- Goldust Mohamad
- Golechha Mahaveer
- Goleij Pouya
- Golestanfar Arefeh
- Golinelli Davide
- Gona Philimon N
- Goudarzi Houman
- Goudarzian Amir Hossein
- Goyal Anmol
- Greenhalgh Scott
- Grivna Michal
- Guarducci Giovanni
- Gubari Mohammed Ibrahim Mohialdeen
- Gudeta Mesay Dechasa
- Guha Avirup
- Guicciardi Stefano
- Gunawardane Damitha Asanga
- Gunturu Sasidhar
- Guo Cui
- Gupta Anish Kumar
- Gupta Bhawna
- Gupta Indarchand Ratanlal
- Gupta Rajat Das
- Gupta Sapna
- Gupta Veer Bala
- Gupta Vijai Kumar
- Gupta Vivek Kumar
- Gutiérrez Reyna Alma
- Göbölös Laszlo
- Habibzadeh Farrokh
- Habibzadeh Parham
- Hachinski Vladimir
- Haddadi Mohammad
- Haddadi Rasool
- Haep Nils
- Hajj Ali Adel
- Halboub Esam S
- Halim Sobia Ahsan
- Hall Brian J
- Haller Sebastian
- Halwani Rabih
- Hamadeh Randah R
- Hamagharib Abdullah Kanaan
- Hamidi Samer
- Hamiduzzaman Mohammad
- Hammoud Ahmad
- Hanifi Nasrin
- Hankey Graeme J
- Hannan Md Abdul
- Haque Md Nuruzzaman
- Harapan Harapan
- Haro Josep Maria
- Hasaballah Ahmed I
- Hasan Faizul
- Hasan Ikramul
- Hasan M Tasdik
- Hasani Hamidreza
- Hasanian Mohammad
- Hasanpour- Dehkordi Ali
- Hassan Abbas M
- Hassan Amr
- Hassanian-Moghaddam Hossein
- Hassanipour Soheil
- Haubold Johannes
- Havmoeller Rasmus J
- Hay Simon I
- Hbid Youssef
- Hebert Jeffrey J
- Hegazi Omar E
- Heidari Golnaz
- Heidari Mohammad
- Heidari-Foroozan Mahsa
- Heidari-Soureshjani Reza
- Helfer Bartosz
- Herteliu Claudiu
- Hesami Hamed
- Hettiarachchi Dineshani
- Heyi Demisu Zenbaba
- Hezam Kamal
- Hiraike Yuta
- Hoffman Howard J
- Holla Ramesh
- Horita Nobuyuki
- Hossain Md Belal
- Hossain Md Mahbub
- Hossain Sahadat
- Hosseini Mohammad-Salar
- Hosseinzadeh Hassan
- Hosseinzadeh Mehdi
- Hostiuc Mihaela
- Hostiuc Sorin
- Hsairi Mohamed
- Hsieh Vivian Chia-rong
- Hu Chengxi
- Huang Junjie
- Huda Md Nazmul
- Hugo Fernando N
- Hultström Michael
- Hussain Javid
- Hussain Salman
- Hussein Nawfal R
- Huy Le Duc
- Huynh Hong-Han
- Hwang Bing-Fang
- Ibitoye Segun Emmanuel
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- Swain Chandan Kumar
- Sykes Bryan L
- Szarpak Lukasz
- Szeto Mindy D
- Szócska Miklós
- Tabaee Damavandi Payam
- Tabatabaei Malazy Ozra
- Tabatabaeizadeh Seyed-Amir
- Tabatabai Shima
- Tabb Karen M
- Tabish Mohammad
- Taborda-Barata Luis M
- Tabuchi Takahiro
- Tadesse Birkneh Tilahun
- Taheri Abkenar Yasaman
- Taheri Soodejani Moslem
- Taheri Amirmasoud
- Taherkhani Amir
- Taiba Jabeen
- Tajbakhsh Ardeshir
- Talaat Iman M
- Talukder Ashis
- Tamuzi Jacques Lukenze
- Tan Ker-Kan
- Tang Haosu
- Tang Hong K
- Tat Nathan Y
- Tat Vivian Y
- Tavakoli Oliaee Razieh
- Tavangar Seyed Mohammad
- Taveira Nuno
- Tebeje Tsion Mulat
- Tefera Yibekal Manaye
- Teimoori Mojtaba
- Temsah Mohamad-Hani
- Temsah Reem Mohamad Hani
- Teramoto Masayuki
- Tesfaye Solomon Hailemariam
- Thangaraju Pugazhenthan
- Thankappan Kavumpurathu Raman
- Thapa Rajshree
- Thapar Rekha
- Thomas Nihal
- Thrift Amanda G
- Thum Chern Choong Chern
- Tian Jing
- Tichopad Ales
- Ticoalu Jansje Henny Vera
- Tiruye Tenaw Yimer
- Tohidast Seyed Abolfazl
- Tonelli Marcello
- Touvier Mathilde
- Tovani-Palone Marcos Roberto
- Tram Khai Hoan
- Tran Nghia Minh
- Trico Domenico
- Trihandini Indang
- Tromans Samuel Joseph
- Truong Vien T
- Truyen Thien Tan Tri Tai
- Tsermpini Evangelia Eirini
- Tumurkhuu Munkhtuya
- Tung Kang
- Tyrovolas Stefanos
- Ubah Chukwudi S
- Udoakang Aniefiok John
- Udoh Arit
- Ulhaq Inam
- Ullah Saeed
- Ullah Sana
- Umair Muhammad
- Umar Tungki Pratama
- Umeokonkwo Chukwuma David
- Umesh Anushri
- Unim Brigid
- Unnikrishnan Bhaskaran
- Upadhyay Era
- Urso Daniele
- Vacante Marco
- Vahdani Amir Mohammad
- Vaithinathan Asokan Govindaraj
- Valadan Tahbaz Sahel
- Valizadeh Rohollah
- Van den Eynde Jef
- Varavikova Elena
- Varga Orsolya
- Varma Siddhartha Alluri
- Vart Priya
- Varthya Shoban Babu
- Vasankari Tommi Juhani
- Veerman Lennert J
- Venketasubramanian Narayanaswamy
- Venugopal Deneshkumar
- Verghese Nicholas Alexander
- Verma Madhur
- Verma Pratibha
- Veroux Massimiliano
- Verras Georgios-Ioannis
- Vervoort Dominique
- Vieira Rafael José
- Villafañe Jorge Hugo
- Villani Leonardo
- Villanueva Gabriela Ines
- Villeneuve Paul J
- Violante Francesco S
- Visontay Rachel
- Vlassov Vasily
- Vo Bay
- Vollset Stein Emil
- Volovat Simona Ruxandra
- Volovici Victor
- Vongpradith Avina
- Vos Theo
- Vujcic Isidora S
- Vukovic Rade
- Wado Yohannes Dibaba
- Wafa Hatem A
- Waheed Yasir
- Wamai Richard G
- Wang Cong
- Wang Denny
- Wang Fang
- Wang Shu
- Wang Song
- Wang Yanzhong
- Wang Yuan-Pang
- Ward Paul
- Watson Stefanie
- Weaver Marcia R
- Weerakoon Kosala Gayan
- Weiss Daniel J
- Weldemariam Abrha Hailay
- Wells Katherine M
- Wen Yi Feng
- Werdecker Andrea
- Westerman Ronny
- Wickramasinghe Dakshitha Praneeth
- Wickramasinghe Nuwan Darshana
- Wijeratne Tissa
- Wilson Shadrach
- Wojewodzic Marcin W
- Wool Eve E
- Woolf Anthony D
- Wu Dongze
- Wulandari Ratna Dwi
- Xiao Hong
- Xu Bin
- Xu Xiaoyue
- Yadav Lalit
- Yaghoubi Sajad
- Yang Lin
- Yano Yuichiro
- Yao Yao
- Ye Pengpeng
- Yesera Gesila Endashaw
- Yesodharan Renjulal
- Yesuf Subah Abderehim
- Yip Paul
- Yiğit Arzu
- Yiğit Vahit
- Yon Dong Keon
- Yonemoto Naohiro
- You Yuyi
- Younis Mustafa Z
- Yu Chuanhua
- Zadey Siddhesh
- Zadnik Vesna
- Zafari Nima
- Zahedi Mohammad
- Zahid Muhammad Nauman
- Zahir Mazyar
- Zakham Fathiah
- Zaki Nazar
- Zakzuk Josefina
- Zamagni Giulia
- Zaman Burhan Abdullah
- Zaman Sojib Bin
- Zamora Nelson
- Zand Ramin
- Zandi Milad
- Zandieh Ghazal G Z
- Zanghì Aurora
- Zare Iman
- Zastrozhin Mikhail Sergeevich
- Zeariya Mohammed G M
- Zeng Youjie
- Zhai Chunxia
- Zhang Chen
- Zhang Haijun
- Zhang Hongwei
- Zhang Yunquan
- Zhang Zhaofeng
- Zhang Zhenyu
- Zhao Hanqing
- Zhao Yang
- Zhao Yong
- Zheng Peng
- Zhong Chenwen
- Zhou Juexiao
- Zhu Bin
- Zhu Zhaohua
- Ziaeefar Pardis
- Zielińska Magdalena
- Zou Zhiyong
- Zumla Alimuddin
- Zweck Elric
- Zyoud Samer H
- Šekerija Mario
- Publication venue
- Elsevier
- Publication date
- 01/03/2024
- Field of study
BackgroundEstimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021 provides new demographic estimates for 204 countries and territories and 811 additional subnational locations from 1950 to 2021, with a particular emphasis on changes in mortality and life expectancy that occurred during the 2020–21 COVID-19 pandemic period.Methods22 223 data sources from vital registration, sample registration, surveys, censuses, and other sources were used to estimate mortality, with a subset of these sources used exclusively to estimate excess mortality due to the COVID-19 pandemic. 2026 data sources were used for population estimation. Additional sources were used to estimate migration; the effects of the HIV epidemic; and demographic discontinuities due to conflicts, famines, natural disasters, and pandemics, which are used as inputs for estimating mortality and population. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate under-5 mortality rates, which synthesised 30 763 location-years of vital registration and sample registration data, 1365 surveys and censuses, and 80 other sources. ST-GPR was also used to estimate adult mortality (between ages 15 and 59 years) based on information from 31 642 location-years of vital registration and sample registration data, 355 surveys and censuses, and 24 other sources. Estimates of child and adult mortality rates were then used to generate life tables with a relational model life table system. For countries with large HIV epidemics, life tables were adjusted using independent estimates of HIV-specific mortality generated via an epidemiological analysis of HIV prevalence surveys, antenatal clinic serosurveillance, and other data sources. Excess mortality due to the COVID-19 pandemic in 2020 and 2021 was determined by subtracting observed all-cause mortality (adjusted for late registration and mortality anomalies) from the mortality expected in the absence of the pandemic. Expected mortality was calculated based on historical trends using an ensemble of models. In location-years where all-cause mortality data were unavailable, we estimated excess mortality rates using a regression model with covariates pertaining to the pandemic. Population size was computed using a Bayesian hierarchical cohort component model. Life expectancy was calculated using age-specific mortality rates and standard demographic methods. Uncertainty intervals (UIs) were calculated for every metric using the 25th and 975th ordered values from a 1000-draw posterior distribution.FindingsGlobal all-cause mortality followed two distinct patterns over the study period: age-standardised mortality rates declined between 1950 and 2019 (a 62·8% [95% UI 60·5–65·1] decline), and increased during the COVID-19 pandemic period (2020–21; 5·1% [0·9–9·6] increase). In contrast with the overall reverse in mortality trends during the pandemic period, child mortality continued to decline, with 4·66 million (3·98–5·50) global deaths in children younger than 5 years in 2021 compared with 5·21 million (4·50–6·01) in 2019. An estimated 131 million (126–137) people died globally from all causes in 2020 and 2021 combined, of which 15·9 million (14·7–17·2) were due to the COVID-19 pandemic (measured by excess mortality, which includes deaths directly due to SARS-CoV-2 infection and those indirectly due to other social, economic, or behavioural changes associated with the pandemic). Excess mortality rates exceeded 150 deaths per 100 000 population during at least one year of the pandemic in 80 countries and territories, whereas 20 nations had a negative excess mortality rate in 2020 or 2021, indicating that all-cause mortality in these countries was lower during the pandemic than expected based on historical trends. Between 1950 and 2021, global life expectancy at birth increased by 22·7 years (20·8–24·8), from 49·0 years (46·7–51·3) to 71·7 years (70·9–72·5). Global life expectancy at birth declined by 1·6 years (1·0–2·2) between 2019 and 2021, reversing historical trends. An increase in life expectancy was only observed in 32 (15·7%) of 204 countries and territories between 2019 and 2021. The global population reached 7·89 billion (7·67–8·13) people in 2021, by which time 56 of 204 countries and territories had peaked and subsequently populations have declined. The largest proportion of population growth between 2020 and 2021 was in sub-Saharan Africa (39·5% [28·4–52·7]) and south Asia (26·3% [9·0–44·7]). From 2000 to 2021, the ratio of the population aged 65 years and older to the population aged younger than 15 years increased in 188 (92·2%) of 204 nations.InterpretationGlobal adult mortality rates markedly increased during the COVID-19 pandemic in 2020 and 2021, reversing past decreasing trends, while child mortality rates continued to decline, albeit more slowly than in earlier years. Although COVID-19 had a substantial impact on many demographic indicators during the first 2 years of the pandemic, overall global health progress over the 72 years evaluated has been profound, with considerable improvements in mortality and life expectancy. Additionally, we observed a deceleration of global population growth since 2017, despite steady or increasing growth in lower-income countries, combined with a continued global shift of population age structures towards older ages. These demographic changes will likely present future challenges to health systems, economies, and societies. The comprehensive demographic estimates reported here will enable researchers, policy makers, health practitioners, and other key stakeholders to better understand and address the profound changes that have occurred in the global health landscape following the first 2 years of the COVID-19 pandemic, and longer-term trends beyond the pandemic
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- Abellán Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akçay Özlem
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia González
- Aleem Muhammad
- Alegre Inês
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz Amorós
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-Díez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado Fabíola
- Amador Cristina García
- Amanullah Nazli
- Amaral Hélida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- Andrés Beatriz Díaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Aşkar Ahmet
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
- Avseren Goksu
- Awead Marwa
- Ayandipo Omobolaji
- Aybar Engin
- Aydin Funda
- Aydin Gaye
- Ayoub Kusay
- Aytac Erman
- Aytaç Erman
- Azevedo Jose
- Azevedo Patricia
- Azhar Najia
- Aziz Gowhar
- Azman Zairul Azwan Mohd
- Álvarez-Llano Laura
- Ângelo Miguel Duarte
- Babatunde Olanrewaju
- Badawi Marwa
- Baek Jeong-Heum
- Baez Noelia Fernández
- Baeza-Murcia Melody
- Bagnardi Francesco
- Baharom Salahudin
- Baik Seung Hyuk
- Baimakhanov Abylai
- Bains Lovenish
- Baker Aleksandra
- Bakmaz Bernarda
- Bala Abubakar Muhammad
- Balaban Vladimir
- Balalis Dimitrios
- Balasubramaniam Dinesh
- Balathayalan Yathev
- Baldi Claudio
- Balestri Riccardo
- Balfour James
- Ballah Abubakar
- Ballian Nikiforos
- Balooshi Iman Al
- Baloyiannis Ioannis
- Bamford Richard
- Bandar Mahdi Al
- Banham Gail
- Bannoud Mohammad Hassan
- Baños Pedro Antonio Parra
- Baptista Victor
- Baral Jörg
- Barbalace Nicolas
- Barbato Giuseppe
- Barbosa Anderson
- Bareka Metaxia
- Baris Baver
- Barradas Renato
- Barreda Sara Castillo
- Barrena-Blazquez Silvestra
- Barton Jess
- Bartosiak Katarzyna
- Bashilkina Olga
- Bashir Mohammed
- Basile Raffaele
- Basnyat Pradeep
- Batool Sana
- Bautista Wilson Manuel Sánchez
- Bayhan Zülfü
- Bayo José Manuel Muros
- Bayón Raquel Álvaro
- Bánky Balázs
- Beard David
- Bedzhanyan Arkady
- Behilil Chakib
- Bekele Kebebe
- Belarmino Armin
- Belay Million
- Belev Nikolay
- Bellato Vittoria
- Beltrán de Heredia Juan
- Belvedere Angela
- Benetti Emilio
- Benetti Sara
- Bengueddach Aicha
- Benjelloun El Bachir
- Benkabbou Amine
- Bennett James
- Bensafir Salim
- Bergamini Carlo
- Bernotaite Vlada
- Beron Reinaldo Isaacs
- Bethune Robert
- Bezede Cosmin
- Beznosenko Andriy
- Bhangu Aneel
- Bhargava Aman
- Bhat Rama Rani Krishna
- Bianchi Romina
- Bianco Francesco
- Bigoni Irene
- Binetti Margherita
- Bintintan Vasile
- Biondi Alberto
- Biondo Santino Antonio
- Bisgin Tayfun
- Bisheet George
- Bissett Ian
- Biswas Jyotirmoy
- Blackwell Sue
- Blanco Pablo
- Blanco Raquel Ríos
- Blanco-Colino Ruth
- Blasco Laura Fraile
- Blazquez-Martin Alma
- Bobadilla Billy Jimenez
- Bocancia Raluca
- Boccia Giuseppe
- Bogatikov Alexander
- Bolanle Olajide Edward
- Bomfa-Barbosa Alysson
- Bompou Effrosyni
- Bonardello Michela
- Bonci Eduard-Alexandru
- Bordom Daniel Osei
- Borges Filipe
- Borghi Felice
- Boschiero Matheus Negri
- Bose Bodhisattva
- Bouchagier Konstantinos
- Boudjenan-Serradj Nabil
- Boudoux Sabrina
- Bourazani Maria
- Boyce Stephen
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bradulskis Saulius
- Brainsa Eneida
- Brandström Gustav
- Braumille Markus
- Bravo Ana Minaya
- Bravo Raquel
- Bredikhin Mikhail
- Brito Noelia
- Bruni Andrea
- Buccianti Piero
- Buchs Nicolas
- Buchwald Pamela
- Budnikova Ina
- Budrikienė Rima
- Buey Lourdes
- Buijs Louis
- Buleje Jorge Alejandro Benavides
- Burlov Nikita
- Butt Anam
- Byshetty Rajendar
- Bywater Edward
- Bzikha Ilham
- Bælum Jens Kristian
- Caballero-Delgado Javier
- Cabrera Claudia
- Cafranga Estíbaliz Gutiérrez
- Cagnazzo Federica
- Calabria Mariangela
- Calabro' Marcello
- Caliendo Domenico
- Calin Camelia
- Caliskan Cemil
- Callan Rory
- Callari Cosimo
- Caltea Mihaela
- Calvo Almudena Castro
- Camacho Amparo
- Cammarata Francesco
- Campanati Renato
- Campanelli Michela
- Campbell Marion
- Canals Lucía Otazu
- Canda Aras Emre
- Cano-Matias Auxiliadora
- Cao Victor Hugo Bruno
- Capolupo Gabriella Teresa
- Cappiello Antonio
- Capuano Marianna
- Capusan Alina
- Carannante Filippo
- Carbone Ludovico
- Cardelli Stefano
- Carden Claire
- Cardoso Diogo
- Caricato Marco
- Carlin Patricia Saez
- Carlini Massimo
- Carlos Sandra
- Carneros Virginia Jimenez
- Caroço Teresa Vieira
- Carosso Fabio
- Carpelan Anu
- Carpenter Holly
- Carrascosa-Morales Irene
- Carrie Augusto
- Carrizo Claudia
- Carta Giuseppina
- Carvalho Alexandre
- Carvello Michele
- Casanova Daniel
- Cascais Raquel
- Cassia Gabriela
- Castaldi Antonio
- Castaño Renata
- Castiglioni Simone
- Castillo Enrique Roca
- Castro Marta Cuartero
- Catalano Pablo
- Cato Liam
- Caz Esra
- Cebolla Elena Sagarra
- Cecchini Ilaria
- Celdrán Rebeca González
- Celik Hale Kefeli
- Ceretti Andrea Pisani
- Ceron Silvia Ferrer
- Cervellera Maurizio
- Cervone Carmela
- Chacko Anil
- Chandrasinghe Pramodh
- Charakopoulou Alexandra
- Chardalias Leonidas
- Chaturvedi Arun
- Chatzikomnitsa Paraskevi
- Chaudhari Abhishek
- Chaudhry Sanjay
- Chawla Tabish
- Chee Corissa
- Chen Nevin
- Cheng Kuang I
- Chiarugi Massimo
- Chisthi Meer
- Chitnis Abhishek
- Chitul Andrei
- Chmielewski Gaspard
- Cholewa Hanna
- Chornet Marta Roselló
- Chowdhary Manish
- Chowdhury Sharfuddin
- Chowdhury Sharfuddin M
- Chowdri Nisar
- Christensen Peter
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Chua Lorna
- Chubukova Natlia
- Chung Jun Seong
- Church Robert
- Chwat Carina
- Ciabattari Paula
- Cianchi Fabio
- Cianci Pasquale
- Ciccarese Angelo Antonio
- Ciftci Ahmet Burak
- Cigagna Luca
- Cini Charles
- Ciotarla Danut Constantin
- Cirocchi Nicholas
- Ciubotaru Cezar
- Ciulli Cristina
- Ck Harikumar
- Clark Thomas
- Clarke Nicola
- Coccolini Federico
- Codes Lina
- Coelho Ana Margarida
- Cois Alessandro
- Coladonato Massimiliano
- Colak Elif
- Colás-Ruiz Enrique
- Coldwell Chris
- Collins Jen
- Colombo Francesco
- Conceição Luis
- Conde Juan Guillermo Ais
- Connolly Lewis
- Conversano Ivana
- Convertini Ornella
- Cook Esther
- Cooke Fiachra
- Coppolino Francesco
- Coratti Francesco
- Cordeiro Lisbete
- Correia Angela
- Correia Débora
- Cortes Bruno Giusti Werneck
- Cortés Guillermo Felipe Valderas
- Coskun Nurcan
- Costa Breno Xaia Martins
- Costa Sílvia
- Costa Susana
- Cour Kenn La
- Crabtree Nicholas
- Creavin Ben
- Cremonini Camilla
- Crescentini Giacomo
- Cricrì Michele
- Crisan Dana
- Cristian Daniel
- Croce Gianni Di
- Cruz Isabela
- Cucinotta Eugenio
- Cuichan Marco Vinicio Yugsi
- Cullinane Carolyn
- Cuneo Davide
- Cunha Miguel
- Curbelo Jacqueline
- Curcio Silvia
- Currà Maria Cristina
- Currás Rosana Pérez
- Curro Giuseppe
- Custódio Pedro
- Cutellè Clelia
- Czarnecki Roman
- Ćoza Ivo
- D'Angelo Salvatore
- D'Ugo Stefano
- da Luz Magda
- da Silveira Sete Alexandre
- Dainius Edvinas
- Dalton Richard
- Damieta Marta Pascual
- Danassi Despoina
- Danelli Piergiorgio
- Danial Aghyad Kudra
- Daniels Ian R
- Daniyan Muhammad
- Danna Riccardo
- Danys Donatas
- Dardanov Dragomir
- Daryanani Deepu
- Dassanayake Vihara
- Daugėla Edvardas
- Dauri Mario
- Davidovskaja Larisa
- Davies Emma
- Davis Cian
- Dawson Brett E
- Dawson Carmel
- de Andrés-Asenjo Beatriz
- de Deken Julie
- de Franciscis Silvia
- de Kort Chantal
- de La Plaza Llamas Roberto
- de Lacy Antonio Maria
- de Lebrusant Fernández Sara
- de León Rendón Jorge Luis
- de Luca Michele
- de Lucia Chiara
- de Miranda Silvestre Simone Chaves
- de Oliveira Góes Igor Arantes
- de Oliveira Flávia Gomes
- de Oliveira João Carlos Costa
- de Palma Giovanni Domenico
- de Paoli Massimo
- de Queiroz Fábio Lopes
- de San Pío Carvajal Eduardo
- de Silva Dulantha
- de Simone Giuseppe
- de Souza Artioli Luana Maria
- de Souza Pires Bruno Lucena
- de Stefano Mauro
- de Zoysa Ishan
- Deac Vasile
- Debono Marianne
- Dedeu-Bastardas Imma
- Degiuli Maurizio
- Del Carmen Casas García Maria
- Del Castillo Vanesa Crespo Garcia
- Del Olmo Maria Inmaculada Ureña
- Del Pueblo Cristina Sanchez
- Del-Rio-Lafuente Francisco-Javier
- Delgado Eduardo
- Delgado Marina
- Delibegovic Samir
- Delimpalta Christina
- Delrio Paolo
- Demir Mehmet
- Demirel Emel
- Demirgan Serdar
- Dempsy Charlotte
- Deniz Nuri
- Depalma Norma
- Desai Neha
- Deus Ana Cláudia
- Devesa Helena
- Dhali Arkadeep
- Dhali Gopal Krishna
- Dhar Puneet
- Diaconescu Cati
- Diego Alejandro Romero-De
- Diez-Alonso Manuel
- Diéguez Beatriz
- Dijan Emilio
- Dilawar Maha
- Dimitriou Nikoletta
- Dimitrov Dobromir
- Dimitrova Slavina
- Dimofte Mihail-Gabriel
- Dindelegan George
- Dindri Franco
- Dinkci Mustafa Deniz
- Díez Miguel Cuende
- Djumabayev Khasan
- Dobkowski Grzegorz
- Dodhy Afia Arshed
- Dolhai Erika
- Domanskiy Andrei
- Domingos Hugo
- Dominguez Fabiana
- Dominguez Sara Hernández
- Dominioni Tommaso
- Donatiello Valerio
- Doniquian Alejandro Marcelo
- Doree Nicholas
- Dorovinis Panagiotis
- Dos Santos José Mauro
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- Yadev I P
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- Yakunina Natalia
- Yalkin Ömer
- Yanishev Alexey
- Yao Hongwei
- Yazici Pinar
- Yemez Kursat
- Yew Chor Kuan
- Yiğit Direnç
- Yılmaz Gülseren
- Yilmazlar Tuncay
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- Zadrożna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah Kağan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)