The Extracellular Matrix and Blood Vessel Formation: Not Just a Scaffold

The extracellular matrix plays a number of important roles, among them providing structural support and information to cellular structures such as blood vessels imbedded within it. As more complex organisms have evolved, the matrix ability to direct signalling towards the vasculature and remodel in response to signalling from the vasculature has assumed progressively greater importance. This review will focus on the molecules of the extracellular matrix, specifically relating to vessel formation and their ability to signal to the surrounding cells to initiate or terminate processes involved in blood vessel formation

Automated Identification and Measurement of Objects via Populations of Medial Primitives, with Application to Real Time 3D Echocardiography

We suggest that identification and measurement of objects in 3D images can be automatic, rapid and stable, based on the statistical properties of populations of medial primitives sought throughout the image space. These properties include scale, orientation, endness, and medial dimensionality. The property of medial dimensionality is 0.0 for the sphere, 1.0 for the cylinder, and 2.0 for the slab, with non-integer dimensionality also possible. Endness results at the cap of a cylinder or the edge of a slab. The values of these medial properties at just a few locations provide an intuitive and robust model for complex shape. For example, the left ventricle during systole can be described as a large cylinder with an apical cap at one end, a slab-like mitral valve at the other (closed during systole), and appropriate interrelations among components in terms of their scale, orientation, and location. To look for such geometric components we extract populations of medial primitives we call co..