Flow patterns through vascular graft models with and without cuffs

The shape of a bypass graft plays an important role on its efficacy. Here, we investigated flow through two vascular graft designs±with and without cuff at the anastomosis. We conducted Digital Particle Image Velocimetry (DPIV) measurements to obtain the flow field information through these vascular grafts. Two pulsatile flow waveforms corresponding to cardiac cycles during the rest and the excitation states, with 10% and without retrograde flow out the proximal end of the native artery were examined. In the absence of retrograde flow, the straight end-to-side graft showed recirculation and stagnation regions that lasted throughout the full cardiac cycle with the stagnation region more pronounced in the excitation state. The contoured end-to-side graft had stagnation region that lasted only for a portion of the cardiac cycle and was less pronounced. With 10% retrograde flow, extended stagnation regions under both rest and excitation states for both bypass grafts were eliminated. Our results show that bypass graft designers need to consider both the type of flow waveform and presence of retrograde flow when sculpting an optimal bypass graft geometry

Government Procurement with Strings Attached? The Uneven Control of Offsets by the World Trade Organization and Regional Trade Agreements

This article explores the practice of governments imposing domestic content based requirements known as “offsets” on suppliers in order to secure public procurement contracts. Known to cause distortions in international trade, offsets are forbidden under the WTO’s GPA and in the procurement chapters of several RTAs, although these restrictions have severe limitations with full offset prohibitions only accepted by a handful of developed countries. Given the sensitivity of procurement policy and the need to stimulate local economies, Asian countries in particular show an unwillingness to address offsets in their international agreements. While other WTO agreements restrain the use of local content rules, these regimes are ill-suited to control the harmful effects of offsets in a procurement context because of their focus on traditional commercial markets. The article suggests that an enlargement of offset prohibitions would be advisable given the expected expansion of global procurement markets commensurate with economic development

On the spine of a PDE surface

yesThe spine of an object is an entity that can characterise the object¿s topology and describes the object by a lower dimension. It has an intuitive appeal for supporting geometric modelling operations. The aim of this paper is to show how a spine for a PDE surface can be generated. For the purpose of the work presented here an analytic solution form for the chosen PDE is utilised. It is shown that the spine of the PDE surface is then computed as a by-product of this analytic solution. This paper also discusses how the of a PDE surface can be used to manipulate the shape. The solution technique adopted here caters for periodic surfaces with general boundary conditions allowing the possibility of the spine based shape manipulation for a wide variety of free-form PDE surface shapes

The Extracellular Matrix and Blood Vessel Formation: Not Just a Scaffold

The extracellular matrix plays a number of important roles, among them providing structural support and information to cellular structures such as blood vessels imbedded within it. As more complex organisms have evolved, the matrix ability to direct signalling towards the vasculature and remodel in response to signalling from the vasculature has assumed progressively greater importance. This review will focus on the molecules of the extracellular matrix, specifically relating to vessel formation and their ability to signal to the surrounding cells to initiate or terminate processes involved in blood vessel formation

Flow patterns through vascular graft models with and without cuffs

The shape of a bypass graft plays an important role on its efficacy. Here, we investigated flow through two vascular graft designs±with and without cuff at the anastomosis. We conducted Digital Particle Image Velocimetry (DPIV) measurements to obtain the flow field information through these vascular grafts. Two pulsatile flow waveforms corresponding to cardiac cycles during the rest and the excitation states, with 10% and without retrograde flow out the proximal end of the native artery were examined. In the absence of retrograde flow, the straight end-to-side graft showed recirculation and stagnation regions that lasted throughout the full cardiac cycle with the stagnation region more pronounced in the excitation state. The contoured end-to-side graft had stagnation region that lasted only for a portion of the cardiac cycle and was less pronounced. With 10% retrograde flow, extended stagnation regions under both rest and excitation states for both bypass grafts were eliminated. Our results show that bypass graft designers need to consider both the type of flow waveform and presence of retrograde flow when sculpting an optimal bypass graft geometry

Automated Identification and Measurement of Objects via Populations of Medial Primitives, with Application to Real Time 3D Echocardiography

We suggest that identification and measurement of objects in 3D images can be automatic, rapid and stable, based on the statistical properties of populations of medial primitives sought throughout the image space. These properties include scale, orientation, endness, and medial dimensionality. The property of medial dimensionality is 0.0 for the sphere, 1.0 for the cylinder, and 2.0 for the slab, with non-integer dimensionality also possible. Endness results at the cap of a cylinder or the edge of a slab. The values of these medial properties at just a few locations provide an intuitive and robust model for complex shape. For example, the left ventricle during systole can be described as a large cylinder with an apical cap at one end, a slab-like mitral valve at the other (closed during systole), and appropriate interrelations among components in terms of their scale, orientation, and location. To look for such geometric components we extract populations of medial primitives we call co..