916 research outputs found
The chromatin remodeller ACF acts as a dimeric motor to space nucleosomes.
Evenly spaced nucleosomes directly correlate with condensed chromatin and gene silencing. The ATP-dependent chromatin assembly factor (ACF) forms such structures in vitro and is required for silencing in vivo. ACF generates and maintains nucleosome spacing by constantly moving a nucleosome towards the longer flanking DNA faster than the shorter flanking DNA. How the enzyme rapidly moves back and forth between both sides of a nucleosome to accomplish bidirectional movement is unknown. Here we show that nucleosome movement depends cooperatively on two ACF molecules, indicating that ACF functions as a dimer of ATPases. Further, the nucleotide state determines whether the dimer closely engages one or both sides of the nucleosome. Three-dimensional reconstruction by single-particle electron microscopy of the ATPase-nucleosome complex in an activated ATP state reveals a dimer architecture in which the two ATPases face each other. Our results indicate a model in which the two ATPases work in a coordinated manner, taking turns to engage either side of a nucleosome, thereby allowing processive bidirectional movement. This novel dimeric motor mechanism differs from that of dimeric motors such as kinesin and dimeric helicases that processively translocate unidirectionally and reflects the unique challenges faced by motors that move nucleosomes
Controlling Stray Electric Fields on an Atom Chip for Rydberg Experiments
Experiments handling Rydberg atoms near surfaces must necessarily deal with
the high sensitivity of Rydberg atoms to (stray) electric fields that typically
emanate from adsorbates on the surface. We demonstrate a method to modify and
reduce the stray electric field by changing the adsorbates distribution. We use
one of the Rydberg excitation lasers to locally affect the adsorbed dipole
distribution. By adjusting the averaged exposure time we change the strength
(with the minimal value less than at
from the chip) and even the sign of the perpendicular field component. This
technique is a useful tool for experiments handling Ryberg atoms near surfaces,
including atom chips
On the differential geometry of curves in Minkowski space
We discuss some aspects of the differential geometry of curves in Minkowski
space. We establish the Serret-Frenet equations in Minkowski space and use them
to give a very simple proof of the fundamental theorem of curves in Minkowski
space. We also state and prove two other theorems which represent Minkowskian
versions of a very known theorem of the differential geometry of curves in
tridimensional Euclidean space. We discuss the general solution for torsionless
paths in Minkowki space. We then apply the four-dimensional Serret-Frenet
equations to describe the motion of a charged test particle in a constant and
uniform electromagnetic field and show how the curvature and the torsions of
the four-dimensional path of the particle contain information on the
electromagnetic field acting on the particle.Comment: 10 pages. Typeset using REVTE
Polar distortions in hydrogen bonded organic ferroelectrics
Although ferroelectric compounds containing hydrogen bonds were among the
first to be discovered, organic ferroelectrics are relatively rare. The
discovery of high polarization at room temperature in croconic acid [Nature
\textbf{463}, 789 (2010)] has led to a renewed interest in organic
ferroelectrics. We present an ab-initio study of two ferroelectric organic
molecular crystals, 1-cyclobutene-1,2-dicarboxylic acid (CBDC) and
2-phenylmalondialdehyde (PhMDA). By using a distortion-mode analysis we shed
light on the microscopic mechanisms contributing to the polarization, which we
find to be as large as 14.3 and 7.0\,C/cm for CBDC and PhMDA
respectively. These results suggest that it may be fruitful to search among
known but poorly characterized organic compounds for organic ferroelectrics
with enhanced polar properties suitable for device applications.Comment: Submitte
PMH11 ANTIPSYCHOTIC MEDICATION PATTERNS IN SCHIZOPHRENIA OUTPATIENTS AND INPATIENTS TREATED WITH OLANZAPINE AND HALOPERIDOL IN GERMANY: RESULTS FROM THE GEO OBSERVATIONAL STUDY
The geometry of entanglement: metrics, connections and the geometric phase
Using the natural connection equivalent to the SU(2) Yang-Mills instanton on
the quaternionic Hopf fibration of over the quaternionic projective space
with an fiber the geometry of
entanglement for two qubits is investigated. The relationship between base and
fiber i.e. the twisting of the bundle corresponds to the entanglement of the
qubits. The measure of entanglement can be related to the length of the
shortest geodesic with respect to the Mannoury-Fubini-Study metric on between an arbitrary entangled state, and the separable state nearest to
it. Using this result an interpretation of the standard Schmidt decomposition
in geometric terms is given. Schmidt states are the nearest and furthest
separable ones lying on, or the ones obtained by parallel transport along the
geodesic passing through the entangled state. Some examples showing the
correspondence between the anolonomy of the connection and entanglement via the
geometric phase is shown. Connections with important notions like the
Bures-metric, Uhlmann's connection, the hyperbolic structure for density
matrices and anholonomic quantum computation are also pointed out.Comment: 42 page
Bundle Theory of Improper Spin Transformations
{\it We first give a geometrical description of the action of the parity
operator () on non relativistic spin Pauli spinors in
terms of bundle theory. The relevant bundle, , is a
non trivial extension of the universal covering group .
is the non relativistic limit of the corresponding Dirac matrix
operator and obeys . Then, from the direct
product of O(3) by , naturally induced by the structure of the galilean
group, we identify, in its double cover, the time reversal operator ()
acting on spinors, and its product with . Both, and
, generate the group . As in the case of parity,
is the non relativistic limit of the corresponding Dirac matrix
operator , and obeys .}Comment: 8 pages, Plaintex; titled changed, minor text modifications, one
reference complete
Magnetic-film atom chip with 10 m period lattices of microtraps for quantum information science with Rydberg atoms
We describe the fabrication and construction of a setup for creating lattices
of magnetic microtraps for ultracold atoms on an atom chip. The lattice is
defined by lithographic patterning of a permanent magnetic film. Patterned
magnetic-film atom chips enable a large variety of trapping geometries over a
wide range of length scales. We demonstrate an atom chip with a lattice
constant of 10 m, suitable for experiments in quantum information science
employing the interaction between atoms in highly-excited Rydberg energy
levels. The active trapping region contains lattice regions with square and
hexagonal symmetry, with the two regions joined at an interface. A structure of
macroscopic wires, cut out of a silver foil, was mounted under the atom chip in
order to load ultracold Rb atoms into the microtraps. We demonstrate
loading of atoms into the square and hexagonal lattice sections simultaneously
and show resolved imaging of individual lattice sites. Magnetic-film lattices
on atom chips provide a versatile platform for experiments with ultracold
atoms, in particular for quantum information science and quantum simulation.Comment: 7 pages, 7 figure
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