MIMO Underwater Visible Light Communications: Comprehensive Channel Study, Performance Analysis, and Multiple-Symbol Detection

In this paper, we analytically study the bit error rate (BER) performance of underwater visible light communication (UVLC) systems with binary pulse position modulation (BPPM). We simulate the channel fading-free impulse response (FFIR) based on Monte Carlo numerical method to take into account the absorption and scattering effects. Additionally, to characterize turbulence effects, we multiply the aforementioned FFIR by a fading coefficient which for weak oceanic turbulence can be modeled as a lognormal random variable (RV). Moreover, to mitigate turbulence effects, we employ multiple transmitters and/or receivers, i.e., spatial diversity technique over UVLC links. Closed-form expressions for the system BER are provided, when equal gain combiner (EGC) is employed at the receiver side, thanks to Gauss-Hermite quadrature formula and approximation to the sum of lognormal RVs. We further apply saddle-point approximation, an accurate photon-counting-based method, to evaluate the system BER in the presence of shot noise. Both laser-based collimated and light emitting diode (LED)-based diffusive links are investigated. Since multiple-scattering effect of UVLC channels on the propagating photons causes considerable inter-symbol interference (ISI), especially for diffusive channels, we also obtain the optimum multiple-symbol detection (MSD) algorithm to significantly alleviate ISI effects and improve the system performance. Our numerical analysis indicates good matches between the analytical and photon-counting results implying the negligibility of signal-dependent shot noise, and also between analytical results and numerical simulations confirming the accuracy of our derived closed-form expressions for the system BER. Besides, our results show that spatial diversity significantly mitigates fading impairments while MSD considerably alleviates ISI deteriorations

Statistical Studies of Fading in Underwater Wireless Optical Channels in the Presence of Air Bubble, Temperature, and Salinity Random Variations (Long Version)

Optical signal propagation through underwater channels is affected by three main degrading phenomena, namely absorption, scattering, and fading. In this paper, we experimentally study the statistical distribution of intensity fluctuations in underwater wireless optical channels with random temperature and salinity variations as well as the presence of air bubbles. In particular, we define different scenarios to produce random fluctuations on the water refractive index across the propagation path, and then examine the accuracy of various statistical distributions in terms of their goodness of fit to the experimental data. We also obtain the channel coherence time to address the average period of fading temporal variations. The scenarios under consideration cover a wide range of scintillation index from weak to strong turbulence. Moreover, the effects of beam-collimator at the transmitter side and aperture averaging lens at the receiver side are experimentally investigated. We show that the use of a transmitter beam-collimator and/or a receiver aperture averaging lens suits single-lobe distributions such that the generalized Gamma and exponential Weibull distributions can excellently match the histograms of the acquired data. Our experimental results further reveal that the channel coherence time is on the order of $10^{-3}$ seconds and larger which implies to the slow fading turbulent channels

Multi-Element Mobile Optical Wireless Communication Networks

The capacity of traditional wireless radio-frequency (RF) networks such as wireless fidelity (Wi-Fi) is insufficient to meet ever-increasing demand for bandwidth stemming from growth in smart, connected devices. The omni-directional nature of RF signals does not allow easy solutions that involve adding more access points to support more devices and capacity because they start to interfere with each other. Optical wireless communications (OWC) have already extended the superb bandwidth capacity of wired optical datalinks to sites that cannot be connected by traditional optical fibers, such as satellites and disaster recovery areas. Development of OWC technologies for dense, multi-user environments promises to bring these advantages to the home, office and other end-user environments. Optical spectral bands (0.1-10 micrometers) are suitable for directional antennas amenable to high spatial reuse and offer promising complementary wireless channels to help solve the spectrum crunch we are facing. Visible Light Communication (VLC), operating in the visible spectrum (0.4-0.7 micrometers) as a special case of OWC, offers great potential to increase Wi-Fi throughput as it can reuse dual-purpose solid-state light bulbs to provide optical datalinks in addition to lighting. The limited field-of-view of the receiver and the high probability of the mobile user blocking the receiver\u27s active detection area are two significant impediments to the availability and communication range of line-of-sight links in VLC networks. We design and prototype a diversity combining VLC receiver with a multi-detector array, multistage amplifier, and Intensity Modulation-Direct Detection decoder capable of achieving highspeed data rates for white phosphorous LED light. We also design and prototype a multi-element, multi-datastream VLC transmitter for providing mobile data connectivity in dense VLC networks, using imaging-based beam-steering to enable dense deployment. Finally, we investigate OWC receiver design and channel behavior in photon-starving environments such as water-to-air links

Statistical Studies Of Fading In Underwater Wireless Optical Channels In The Presence Of Air Bubble, Temperature, And Salinity Random Variations

Optical signal propagation through underwater channels is affected by three main degrading phenomena, namely, absorption, scattering, and fading. In this paper, we experimentally study the statistical distribution of intensity fluctuations in underwater wireless optical channels with random temperature and salinity variations, as well as the presence of air bubbles. In particular, we define different scenarios to produce random fluctuations on the water refractive index across the propagation path and, then, examine the accuracy of various statistical distributions in terms of their goodness of fit to the experimental data. We also obtain the channel coherence time to address the average period of fading temporal variations. The scenarios under consideration cover a wide range of scintillation index from weak to strong turbulence. Moreover, the effects of beam-expander-and-collimator (BEC) at the transmitter side and aperture averaging lens (AAL) at the receiver side are experimentally investigated. We show that the use of a transmitter BEC and/or a receiver AAL suits single-lobe distributions, such that the generalized Gamma and exponentiated Weibull distributions can excellently match the histograms of the acquired data. Our experimental results further reveal that the channel coherence time is on the order of 10-3 s and larger which implies to the slow fading turbulent channels

Statistical studies of fading in underwater wireless optical channels in the presence of air bubble, temperature, and salinity random variations

Optical signal propagation through underwater channels is affected by three main degrading phenomena, namely, absorption, scattering, and fading. In this paper, we experimentally study the statistical distribution of intensity fluctuations in underwater wireless optical channels with random temperature and salinity variations, as well as the presence of air bubbles. In particular, we define different scenarios to produce random fluctuations on the water refractive index across the propagation path and, then, examine the accuracy of various statistical distributions in terms of their goodness of fit to the experimental data. We also obtain the channel coherence time to address the average period of fading temporal variations. The scenarios under consideration cover a wide range of scintillation index from weak to strong turbulence. Moreover, the effects of beam-expander-and-collimator (BEC) at the transmitter side and aperture averaging lens (AAL) at the receiver side are experimentally investigated. We show that the use of a transmitter BEC and/or a receiver AAL suits single-lobe distributions, such that the generalized Gamma and exponentiated Weibull distributions can excellently match the histograms of the acquired data. Our experimental results further reveal that the channel coherence time is on the order of 10-3 s and larger which implies to the slow fading turbulent channels

Statistical studies of fading in underwater wireless optical channels in the presence of air bubble, temperature, and salinity random variations

Optical signal propagation through underwater channels is affected by three main degrading phenomena, namely, absorption, scattering, and fading. In this paper, we experimentally study the statistical distribution of intensity fluctuations in underwater wireless optical channels with random temperature and salinity variations, as well as the presence of air bubbles. In particular, we define different scenarios to produce random fluctuations on the water refractive index across the propagation path and, then, examine the accuracy of various statistical distributions in terms of their goodness of fit to the experimental data. We also obtain the channel coherence time to address the average period of fading temporal variations. The scenarios under consideration cover a wide range of scintillation index from weak to strong turbulence. Moreover, the effects of beam-expander-and-collimator (BEC) at the transmitter side and aperture averaging lens (AAL) at the receiver side are experimentally investigated. We show that the use of a transmitter BEC and/or a receiver AAL suits single-lobe distributions, such that the generalized Gamma and exponentiated Weibull distributions can excellently match the histograms of the acquired data. Our experimental results further reveal that the channel coherence time is on the order of 10-3 s and larger which implies to the slow fading turbulent channels

Chitosan-based nanoscale delivery systems in hepatocellular carcinoma: Versatile bio-platform with theranostic application

The field of nanomedicine has provided a fresh approach to cancer treatment by addressing the limitations of current therapies and offering new perspectives on enhancing patients' prognoses and chances of survival. Chitosan (CS) is isolated from chitin that has been extensively utilized for surface modification and coating of nanocarriers to improve their biocompatibility, cytotoxicity against tumor cells, and stability. HCC is a prevalent kind of liver tumor that cannot be adequately treated with surgical resection in its advanced stages. Furthermore, the development of resistance to chemotherapy and radiotherapy has caused treatment failure. The targeted delivery of drugs and genes can be mediated by nanostructures in treatment of HCC. The current review focuses on the function of CS-based nanostructures in HCC therapy and discusses the newest advances of nanoparticle-mediated treatment of HCC. Nanostructures based on CS have the capacity to escalate the pharmacokinetic profile of both natural and synthetic drugs, thus improving the effectiveness of HCC therapy. Some experiments have displayed that CS nanoparticles can be deployed to co-deliver drugs to disrupt tumorigenesis in a synergistic way. Moreover, the cationic nature of CS makes it a favorable nanocarrier for delivery of genes and plasmids. The use of CS-based nanostructures can be harnessed for phototherapy. Additionally, the incur poration of ligands including arginylglycylaspartic acid (RGD) into CS can elevate the targeted delivery of drugs to HCC cells. Interestingly, smart CS-based nanostructures, including ROS- and pH-sensitive nanoparticles, have been designed to provide cargo release at the tumor site and enhance the potential for HCC suppression

Epigenetic regulation of temozolomide resistance in human cancers with an emphasis on brain tumors: Function of non-coding RNAs

Brain tumors, which are highly malignant, pose a significant threat to health and often result in substantial rates of mortality and morbidity worldwide. The brain cancer therapy has been challenging due to obstacles such as the BBB, which hinders effective delivery of therapeutic agents. Additionally, the emergence of drug resistance further complicates the management of brain tumors. TMZ is utilized in brain cancer removal, but resistance is a drawback. ncRNAs are implicated in various diseases, and their involvement in the cancer is particularly noteworthy. The focus of the current manuscript is to explore the involvement of ncRNAs in controlling drug resistance, specifically in the context of resistance to the chemotherapy drug TMZ. The review emphasizes the function of ncRNAs, particularly miRNAs, in modulating the growth and invasion of brain tumors, which significantly influences their response to TMZ treatment. Through their interactions with various molecular pathways, miRNAs are modulators of TMZ response. Similarly, lncRNAs also associate with molecular pathways and miRNAs, affecting the efficacy of TMZ chemotherapy. Given their functional properties, lncRNAs can either induce or suppress TMZ resistance in brain tumors. Furthermore, circRNAs, which are cancer controllers, regulate miRNAs by acting as sponges, thereby impacting the response to TMZ chemotherapy. The review explores the correlation between ncRNAs and TMZ chemotherapy, shedding light on the underlying molecular pathways involved in this process