Optimal queue placement in dynamic system optimum solutions for single origin-destination traffic networks

The Dynamic System Optimum (DSO) traffic assignment problem aims to determine a time-dependent routing pattern of travellers in a network such that the given time-dependent origin-destination demands are satisfied and the total travel time is at a minimum, assuming some model for dynamic network loading. The network kinematic wave model is now widely accepted as such a model, given its realism in reproducing phenomena such as transient queues and spillback to upstream links. An attractive solution strategy for DSO based on such a model is to reformulate as a set of side constraints apply a standard solver, and to this end two methods have been previously proposed, one based on the discretisation scheme known as the Cell Transmission Model (CTM), and the other based on the Link Transmission Model (LTM) derived from variational theory. In the present paper we aim to combine the advantages of CTM (in tracking time-dependent congestion formation within a link) with those of LTM (avoiding cell discretisation, providing a more computationally attractive with much fewer constraints). The motivation for our work is the previously-reported possibility for DSO to have multiple solutions, which differ in where queues are formed and dissipated in the network. Our aim is to find DSO solutions that optimally distribute the congestion over links inside the network which essentially eliminate avoidable queue spillbacks. In order to do so, we require more information than the LTM can offer, but wish to avoid the computational burden of CTM for DSO. We thus adopt an extension of the LTM called the Two-regime Transmission Model (TTM), which is consistent with LTM at link entries and exits but which is additionally able to accurately track the spatial and temporal formation of the congestion boundary within a link (which we later show to be a critical element, relative to LTM). We set out the theoretical background necessary for the formulation of the network-level TTM as a set of linear side constraints. Numerical experiments are used to illustrate the application of the method to determine DSO solutions avoiding spillbacks, reduce/eliminate the congestion and to show the distinctive elements of adopting TTM over LTM. Furthermore, in comparison to a fine-level CTM-based DSO method, our formulation is seen to significantly reduce the number of linear constraints while maintaining a reasonable accuracy

Energy Management and Time Scheduling for Heterogeneous IoT Wireless-Powered Backscatter Networks

© 2019 IEEE. In this paper, we propose a novel approach to jointly address energy management and network throughput maximization problems for heterogeneous IoT low-power wireless communication networks. In particular, we consider a low-power communication network in which the IoT devices can harvest energy from a dedicated RF energy source to support their transmissions or backscatter the signals of the RF energy source to transmit information to the gateway. Different IoT devices may have dissimilar hardware configurations, and thus they may have various communications types and energy requirements. In addition, the RF energy source may have a limited energy supply source which needs to be minimized. Thus, to maximize the network throughput, we need to jointly optimize energy usage and operation time for the IoT devices under different energy demands and communication constraints. However, this optimization problem is non-convex due to the strong relation between energy supplied by the RF energy source and the IoT communication time, and thus obtaining the optimal solution is intractable. To address this problem, we study the relation between energy supply and communication time, and then transform the non-convex optimization problem to an equivalent convex-optimization problem which can achieve the optimal solution. Through simulation results, we show that our solution can achieve greater network throughputs (up to five times) than those of other conventional methods, e.g., TDMA. In addition, the simulation results also reveal some important information in controlling energy supply and managing low-power IoT devices in heterogeneous wireless communication networks

Fast or Slow: An Autonomous Speed Control Approach for UAV-assisted IoT Data Collection Networks

Unmanned Aerial Vehicles (UAVs) have been emerging as an effective solution for IoT data collection networks thanks to their outstanding flexibility, mobility, and low operation costs. However, due to the limited energy and uncertainty from the data collection process, speed control is one of the most important factors while optimizing the energy usage efficiency and performance for UAV collectors. This work aims to develop a novel autonomous speed control approach to address this issue. To that end, we first formulate the dynamic speed control task of a UAV as a Markov decision process taking into account its energy status and location. In this way, the Q-learning algorithm can be adopted to obtain the optimal speed control policy for the UAV. To further improve the system performance, we develop a highly-effective deep dueling double Q-learning algorithm utilizing outstanding features of the deep neural networks as well as advanced dueling architecture to quickly stabilize the learning process and obtain the optimal policy. Through simulations, we show that our proposed solution can achieve up to 40% greater performance, i.e., an average throughput of the system, compared with other conventional methods. Importantly, the simulation results also reveal significant impacts of UAV’s energy and charging time on the system performance

Blockchain-based Secure Platform for Coalition Loyalty Program Management

In this paper, we propose a novel blockchain-based platform for the coalition loyalty program management. The platform allows the customers to freely exchange loyalty points from different existing blockchain-based loyalty programs by utilizing the sidechain technology. Moreover, by adopting the Proof-of-Stake consensus mechanism, we can further increase customer engagement by allowing the customers to participate in the consensus process to earn additional tokens. However, this might lead to situations where the customers centralize all tokens to a single chain/loyalty program if the chain offers more rewards for consensus participation. Through security and performance analyses, we show that such centralization of stakes poses a threat to the security and performance of the platform. Therefore, we develop a non-cooperative game model to analyze the rational behavior of the users. We reveal that the consensus participation rewards govern the user behavior and the decentralization of the system. Numerical experiments confirm our analytical results and show that the ratios between the consensus rewards have a significant impact on the system’s security and performance

Molecular targeted therapies in head and neck cancer - An update of recent developements -

Targeted therapies have made their way into clinical practice during the past decade. They have caused a major impact on the survival of cancer patients in many areas of clinical oncology and hematology. Indeed, in some hematologic malignancies, such as chronic myelogenous leukemia or non-Hodgkin's lymphomas, biologicals and antibodies specifically designed to target tumour-specific proteins have revolutionized treatment standards. In solid tumours, new drugs targeting EGF- or VEGF- receptors are now approved and are entering clinical practise for treatment of colon, lung, kidney and other cancers, either alone or in combination with conventional treatment approaches

A Retrospective Analysis of the Haemodynamic and Metabolic Effects of Fluid Resuscitation in Vietnamese Adults with Severe Falciparum Malaria

BACKGROUND: Optimising the fluid resuscitation of patients with severe malaria is a simple and potentially cost-effective intervention. Current WHO guidelines recommend central venous pressure (CVP) guided, crystalloid based, resuscitation in adults. METHODS: Prospectively collected haemodynamic data from intervention trials in Vietnamese adults with severe malaria were analysed retrospectively to assess the responses to fluid resuscitation. RESULTS: 43 patients were studied of whom 24 received a fluid load. The fluid load resulted in an increase in cardiac index (mean increase: 0.75 L/min/m(2) (95% Confidence interval (CI): 0.41 to 1.1)), but no significant change in acid-base status post resuscitation (mean increase base deficit 0.6 mmol/L (95% CI: -0.1 to 1.3). The CVP and PAoP (pulmonary artery occlusion pressure) were highly inter-correlated (r(s) = 0.7, p<0.0001), but neither were correlated with acid-base status (arterial pH, serum bicarbonate, base deficit) or respiratory status (PaO(2)/FiO(2) ratio). There was no correlation between the oxygen delivery (DO(2)) and base deficit at the 63 time-points where they were assessed simultaneously (r(s) = -0.09, p = 0.46). CONCLUSIONS: In adults with severe falciparum malaria there was no observed improvement in patient outcomes or acid-base status with fluid loading. Neither CVP nor PAoP correlated with markers of end-organ perfusion or respiratory status, suggesting these measures are poor predictors of their fluid resuscitation needs

Sequential induction of three recombination directionality factors directs assembly of tripartite integrative and conjugative elements

Tripartite integrative and conjugative elements (ICE3) are a novel form of ICE that exist as three separate DNA regions integrated within the genomes of Mesorhizobium spp. Prior to conjugative transfer the three ICE3 regions of M. ciceri WSM1271 ICEMcSym1271 combine and excise to form a single circular element. This assembly requires three coordinated recombination events involving three site-specific recombinases IntS, IntG and IntM. Here, we demonstrate that three excisionases–or recombination directionality factors—RdfS, RdfG and RdfM are required for ICE3 excision. Transcriptome sequencing revealed that expression of ICE3 transfer and conjugation genes was induced by quorum sensing. Quorum sensing activated expression of rdfS, and in turn RdfS stimulated transcription of both rdfG and rdfM. Therefore, RdfS acts as a “master controller” of ICE3 assembly and excision. The dependence of all three excisive reactions on RdfS ensures that ICE3 excision occurs via a stepwise sequence of recombination events that avoids splitting the chromosome into a non-viable configuration. These discoveries expose a surprisingly simple control system guiding molecular assembly of these novel and complex mobile genetic elements and highlight the diverse and critical functions of excisionase proteins in control of horizontal gene transfer

The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017

© 2019 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Background: Accurate childhood cancer burden data are crucial for resource planning and health policy prioritisation. Model-based estimates are necessary because cancer surveillance data are scarce or non-existent in many countries. Although global incidence and mortality estimates are available, there are no previous analyses of the global burden of childhood cancer represented in disability-adjusted life-years (DALYs). Methods: Using the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 methodology, childhood (ages 0–19 years) cancer mortality was estimated by use of vital registration system data, verbal autopsy data, and population-based cancer registry incidence data, which were transformed to mortality estimates through modelled mortality-to-incidence ratios (MIRs). Childhood cancer incidence was estimated using the mortality estimates and corresponding MIRs. Prevalence estimates were calculated by using MIR to model survival and multiplied by disability weights to obtain years lived with disability (YLDs). Years of life lost (YLLs) were calculated by multiplying age-specific cancer deaths by the difference between the age of death and a reference life expectancy. DALYs were calculated as the sum of YLLs and YLDs. Final point estimates are reported with 95% uncertainty intervals. Findings: Globally, in 2017, there were 11·5 million (95% uncertainty interval 10·6–12·3) DALYs due to childhood cancer, 97·3% (97·3–97·3) of which were attributable to YLLs and 2·7% (2·7–2·7) of which were attributable to YLDs. Childhood cancer was the sixth leading cause of total cancer burden globally and the ninth leading cause of childhood disease burden globally. 82·2% (82·1–82·2) of global childhood cancer DALYs occurred in low, low-middle, or middle Socio-demographic Index locations, whereas 50·3% (50·3–50·3) of adult cancer DALYs occurred in these same locations. Cancers that are uncategorised in the current GBD framework comprised 26·5% (26·5–26·5) of global childhood cancer DALYs. Interpretation: The GBD 2017 results call attention to the substantial burden of childhood cancer globally, which disproportionately affects populations in resource-limited settings. The use of DALY-based estimates is crucial in demonstrating that childhood cancer burden represents an important global cancer and child health concern. Funding: Bill & Melinda Gates Foundation, American Lebanese Syrian Associated Charities (ALSAC), and St. Baldrick's Foundation

Self-piercing riveting-a review

© The Author(s) 2017. This article is published with open access at Springerlink.com.Self-piercing riveting (SPR) is a cold mechanical joining process used to join two or more sheets of materials by driving a rivet piercing through the top sheet or the top and middle sheets and subsequently lock into the bottom sheet under the guidance of a suitable die. SPR is currently the main joining method for aluminium and mixed-material lightweight automotive structures. SPR was originated half century ago, but it only had significant progress in the last 25 years due to the requirement of joining lightweight materials, such as aluminium alloy structures, aluminium-steel structures and other mixed-material structures, from the automotive industry. Compared with other conventional joining methods, SPR has many advantages including no pre-drilled holes required, no fume, no spark and low noise, no surface treatment required, ability to join multi-layer materials and mixed materials and ability to produce joints with high static and fatigue strengths. In this paper, research investigations that have been conducted on self-piercing riveting will be extensively reviewed. The current state and development of SPR process is reviewed and the influence of the key process parameters on joint quality is discussed. The mechanical properties of SPR joints, the corrosion behaviour of SPR joints, the distortion of SPR joints and the simulation of SPR process and joint performance are reviewed. Developing reliable simulation methods for SPR process and joint performance to reduce the need of physical testing has been identified as one of the main challenges.Peer reviewe