The Complex Wind Torus and Jets of PSR B1706-44

We report on Chandra ACIS imaging of the pulsar wind nebula (PWN) of the young Vela-like PSR B1706-44, which shows the now common pattern of an equatorial wind and polar jets. The structure is particularly rich, showing a relativistically boosted termination shock, jets with strong confinement, a surrounding radio/X-ray PWN and evidence for a quasi-static `bubble nebula'. The structures trace the pulsar spin geometry and illuminate its possible relation to SNR G343.1-2.3. We also obtain improved estimates of the pulsar flux and nebular spectrum, constraining the system age and energetics.Comment: To appear in the Astrophysical Journal. 15pp, 4 figures in 7 file

The Age of the Solar Neighbourhood

High-quality Hipparcos data for a complete sample of nearly 12000 main-sequence and subgiant stars, together with Padua isochrones, are used to constrain the star-formation history of the solar neigbourhood and the processes that stochastically accelerate disk stars. The velocity dispersion of a coeval group of stars is found to increase with time from ~8 kms at birth as t^{0.33}. In the fits, the slope of the IMF near 1 Msun proves to be degenerate with the rate at which the star-formation rate declines. If the slope of the IMF is to lie near Salpeter's value, -2.35, the star-formation rate has to be very nearly constant. The age of the solar neighbourhood is found to be 11.2+/-0.75 Gyr with remarkably little sensitivity to variations in the assumed metallicity distribution of old disk stars. This age is only a Gyr younger than the age of the oldest globular clusters when the same isochrones and distance scale are employed. It is compatible with current indications of the redshift of luminous galaxy formation only if there is a large cosmological constant. A younger age is formally excluded because it provides a poor fit to the number density of red stars. Since this density is subject to a significantly uncertain selection function, ages as low as 9 Gyr are plausible even though they lie outside our formal error bars.Comment: 7 pages; typographical corrections onl

Genomic Signatures of Historical Allopatry and Ecological Divergence in an Island Lizard

Geographical variation amongcontiguouspopulations is frequently attributed to ecological divergence or historical isolation followed by secondary contact.Distinguishing between these effects is key to studies of incipient speciation and could be revealed by different genomic signatures. We used RAD-seq analyses to examine morphologically divergent populations of the endemic lizard (Gallotia galloti) from the volcanic island of Tenerife. Previous analyses have suggested ecological and historical causes to explain the morphological diversity. Analyses of 276,483 single nucleotide polymorphisms (SNPs) from>20 Mbp of the genome revealed one genetically divergent population from Anaga, a region associated with divergent mtDNA lineages in other Tenerife endemics. This population also has a high number of private alleles, and its divergence can be explained by historical isolation. Bayesian outlier analyses identified a small proportion of SNPs as candidates for selection (0.04%) which were strongly differentiated between xeric andmesic habitat types. Individual testing for specific xeric–mesic selection using an alternative approach also supported ecological divergence in a similarly small proportion of SNPs. The study indicates the roles of both historical isolation and ecological divergence in shaping genomic diversity in G. galloti.However, north–southmorphological divergence appears solely associated with the latter and likely involves a relatively small proportion of the genome

Human intestinal epithelial and smooth muscle cells are potent producers of IL-6.

BACKGROUND: Interleukin-6 (IL-6), a pluripotent cytokine, has traditionally been considered the product of proinflammatory cells. However, many other cell types have been shown to produce IL-6. Since intestinal inflammation is commonly associated with a vigorous systemic inflammatory response, we hypothesized that intestinal epithelial and smooth muscle cells might contribute to that response by producing IL-6. We therefore studied the capacity of differentiated human intestinal epithelial and smooth muscle cell lines to produce IL-6 in response to various proinflammatory stimuli. MATERIALS AND METHODS: CCL-241, a human intestinal epithelial cell line, and HISM, a human intestinal muscle cell line, were grown to confluency and then treated for 24 h with various concentrations of lipopolysaccharide, Clostridium difficile culture extract containing both toxin A and toxin B, recombinant human tumor necrosis factor-alpha (TNF-alpha), or recombinant human interleukin-1 beta (IL-1beta). Supernatants were then collected for IL-6 determination using an enzyme-linked immunosorbent assay. Cell numbers were determined using a Coulter counter. For comparison, parallel studies were performed using phorbol ester-primed U-937 and THP-1 human macrophage cell lines. RESULTS: Both human intestinal epithelial and smooth muscle cells produced IL-6 under basal conditions. In HISM cells, but not in CCL-241 cells, IL-6 release was increased slightly by treatment with C. difficile culture extract containing both toxin A and toxin B and with lipopolysaccharide. In both cell lines, IL-6 production was profoundly stimulated by treatment with IL-1beta and less so with TNF-alpha. Combinations of high-dose TNF-alpha and IL-1beta may have a slightly additive, but not synergistic, effect on IL-6 release. The amount of IL-6 produced by IL-1-stimulated intestinal cell lines was 70-fold higher than that produced by stimulated macrophage cell lines. CONCLUSIONS; Both intestinal epithelial and smooth muscle cells demonstrate the ability to release significant amounts of IL-6. The profound response to IL-1beta and TNF-alpha stimulation by both cell lines suggests that human intestinal parenchymal cells, influenced by paracrine mediators liberated from proinflammatory cells, might significantly contribute to the overall systemic inflammatory response by producing IL-6

Simultaneous confidence sets for several effective doses.

Construction of simultaneous confidence sets for several effective doses currently relies on inverting the Scheffé type simultaneous confidence band, which is known to be conservative. We develop novel methodology to make the simultaneous coverage closer to its nominal level, for both two-sided and one-sided simultaneous confidence sets. Our approach is shown to be considerably less conservative than the current method, and is illustrated with an example on modeling the effect of smoking status and serum triglyceride level on the probability of the recurrence of a myocardial infarction

A Heuristic for the Analysis of Truncated Standard Normal Distribution Assemblies

The analysis of data sets and process conditions commonly assume the use of standard normal distributions and truncated standard normal distributions (TSND). The use of these distributions has application to various engineering disciplines along with numerous other industries (e.g., financial industries, medical fields, management, etc.). For engineering managers, the use of truncated standard normal distributions has particular relevance when evaluating process conditions commonly associated with assembly tolerances, manufacturing, and associated measures of quality. This article summarizes a heuristic approach for the analysis of assembly-level truncated standard normal distributions and associated research from a recent dissertation (Ralls, 2014). This article provides a cursory review of the literature presented by that research, briefly reviews key analysis equations, and provides a heuristic procedure from that research. The approach presented summarizes TSND assembly analysis utilizing a distributions characteristic function and an inversion factor for a single doubly truncated standard normal distribution is also reviewed. Applications, research recommendations, and future investigations for engineering managers in the following areas of truncated distribution analysis are proposed: heuristic improvement, distributions expansion, simulation expansion, and further application to storage and part allocations