Comparative susceptibility of mosquito populations in North Queensland, Australia to oral infection with dengue virus.

Dengue is the most prevalent arthropod-borne virus, with at least 40% of the world's population at risk of infection each year. In Australia, dengue is not endemic, but viremic travelers trigger outbreaks involving hundreds of cases. We compared the susceptibility of Aedes aegypti mosquitoes from two geographically isolated populations to two strains of dengue virus serotype 2. We found, interestingly, that mosquitoes from a city with no history of dengue were more susceptible to virus than mosquitoes from an outbreak-prone region, particularly with respect to one dengue strain. These findings suggest recent evolution of population-based differences in vector competence or different historical origins. Future genomic comparisons of these populations could reveal the genetic basis of vector competence and the relative role of selection and stochastic processes in shaping their differences. Lastly, we show the novel finding of a correlation between midgut dengue titer and titer in tissues colonized after dissemination

Planck Oscillators in the Background Dark Energy

We consider a model for an underpinning of the universe: there are oscillators at the Planck scale in the background dark energy. Starting from a coherent array of such oscillators it is possible to get a description from elementary particles to Black Holes including the usual Hawking-Beckenstein theory. There is also a description of Gravitation in the above model which points to a unified description with electromagnetism.Comment: 18 pages latex; talk at the Max Born Symposium 2009, Wrocla

Cancellations in Neutrinoless Double Beta Decay and the Neutrino Mass Matrix

In a degenerate scheme with mass m_0 a complete analysis of the allowed range of the effective electron neutrino Majorana mass is performed. Special attention is paid to effects of cancellations caused either by intrinsic CP parities of the eigenstates (CP invariance) or by complex mixing matrix elements (CP violation). We investigate all possibilities and give in each case constraints on the phases, the relative CP parities or the neutrino mass scale. A solar mixing angle \sin^2 2 \theta smaller than 0.7 jeopardizes the degenerate mass scheme. A key value of /m_0 is identified, which is independent on the solar solution and would rule out certain schemes. Also it would answer the question regarding the presence of CP violation. Even if a total neutrino mass scale and an effective mass is measured, the value of the phases or parities is not fixed, unless in some special cases. The resulting uncertainty in the other mass matrix elements is at least of the same order than the one stemming from nuclear matrix elements calculations.Comment: 20 pages, 10 figures. Title, abstract and parts of the text change

Observations of the Askaryan Effect in Ice

We report on the first observations of the Askaryan effect in ice: coherent impulsive radio Cherenkov radiation from the charge asymmetry in an electromagnetic (EM) shower. Such radiation has been observed in silica sand and rock salt, but this is the first direct observation from an EM shower in ice. These measurements are important since the majority of experiments to date that rely on the effect for ultra-high energy neutrino detection are being performed using ice as the target medium. As part of the complete validation process for the Antarctic Impulsive Transient Antenna (ANITA) experiment, we performed an experiment at the Stanford Linear Accelerator Center (SLAC) in June 2006 using a 7.5 metric ton ice target, yielding results fully consistent with theoretical expectations

New Limits on the Ultra-high Energy Cosmic Neutrino Flux from the ANITA Experiment

We report initial results of the first flight of the Antarctic Impulsive Transient Antenna (ANITA-1) 2006-2007 Long Duration Balloon flight, which searched for evidence of a diffuse flux of cosmic neutrinos above energies of 3 EeV. ANITA-1 flew for 35 days looking for radio impulses due to the Askaryan effect in neutrino-induced electromagnetic showers within the Antarctic ice sheets. We report here on our initial analysis, which was performed as a blind search of the data. No neutrino candidates are seen, with no detected physics background. We set model-independent limits based on this result. Upper limits derived from our analysis rule out the highest cosmogenic neutrino models. In a background horizontal-polarization channel, we also detect six events consistent with radio impulses from ultra-high energy extensive air showers.Comment: 4 pages, 2 table

Determinants of drug absorption in different ECMO circuits

Purpose: The aim of this in vitro study was to evaluate potential determinants of drug loss in different ECMO circuits. Methods: Midazolam, morphine, fentanyl, paracetamol, cefazolin, meropenem and vancomycin were injected into three neonatal roller pump, two paediatric roller pump and two clinically used neonatal roller pump circuits, all with a silicone membrane, and two neonatal centrifugal pump circuits with polypropylene hollow-fibre membranes. Serial blood samples were taken from a post-oxygenator site. Drug recovery was calculated as the ratio between the determined and the theoretical maximum concentration. The latter was obtained by dividing dose by theoretical circuit volume. Results: Average drug recoveries at 180 min in three neonatal silicone membrane roller pump circuits were midazolam 0.62%, morphine 23.9%, fentanyl 0.35%, paracetamol 34.0%, cefazolin 84.3%, meropenem 82.9% and vancomycin 67.8%. There was a significant correlation between the lipophilicity of the drug expressed as log P and the extent of drug absorption, p < 0.001. The recovery of midazolam and fentanyl in centrifugal pump circuits with hollow-fibre membrane oxygenator was significantly higher compared to neonatal roller pump circuits with silicone membranes: midazolam 63.4 versus 0.62%, fentanyl 33.8 versus 0.35%, p < 0.001. Oxygenator size and used circuits do not significantly affect drug losses. Conclusions: Significant absorption of drugs occurs in the ECMO circuit, correlating with increased lipophilicity of the drug. Centrifugal pump circuits with hollow-fibre membrane oxygenators show less absorption for all drugs, most pronounced for lipophilic drugs. These results suggest that pharmacokinetics and hence optimal doses of these drugs may be altered during ECMO

The High Time Resolution Universe Survey VI: An Artificial Neural Network and Timing of 75 Pulsars

We present 75 pulsars discovered in the mid-latitude portion of the High Time Resolution Universe survey, 54 of which have full timing solutions. All the pulsars have spin periods greater than 100 ms, and none of those with timing solutions are in binaries. Two display particularly interesting behaviour; PSR J1054-5944 is found to be an intermittent pulsar, and PSR J1809-0119 has glitched twice since its discovery. In the second half of the paper we discuss the development and application of an artificial neural network in the data-processing pipeline for the survey. We discuss the tests that were used to generate scores and find that our neural network was able to reject over 99% of the candidates produced in the data processing, and able to blindly detect 85% of pulsars. We suggest that improvements to the accuracy should be possible if further care is taken when training an artificial neural network; for example ensuring that a representative sample of the pulsar population is used during the training process, or the use of different artificial neural networks for the detection of different types of pulsars.Comment: 15 pages, 8 figure

Observations of the Askaryan Effect in Ice

We report on the first observations of the Askaryan effect in ice: coherent impulsive radio Cherenkov radiation from the charge asymmetry in an electromagnetic (EM) shower. Such radiation has been observed in silica sand and rock salt, but this is the first direct observation from an EM shower in ice. These measurements are important since the majority of experiments to date that rely on the effect for ultra-high energy neutrino detection are being performed using ice as the target medium. As part of the complete validation process for the Antarctic Impulsive Transient Antenna (ANITA) experiment, we performed an experiment at the Stanford Linear Accelerator Center (SLAC) in June 2006 using a 7.5 metric ton ice target, yielding results fully consistent with theoretical expectations.Comment: 4 pages, 5 figures, minor correction

Observation of Ultra-high-energy Cosmic Rays with the ANITA Balloon-borne Radio Interferometer

We report the observation of sixteen cosmic ray events of mean energy of 1.5 x 10^{19} eV, via radio pulses originating from the interaction of the cosmic ray air shower with the Antarctic geomagnetic field, a process known as geosynchrotron emission. We present the first ultra-wideband, far-field measurements of the radio spectral density of geosynchrotron emission in the range from 300-1000 MHz. The emission is 100% linearly polarized in the plane perpendicular to the projected geomagnetic field. Fourteen of our observed events are seen to have a phase-inversion due to reflection of the radio beam off the ice surface, and two additional events are seen directly from above the horizon.Comment: 5 pages, 5 figures, new figure adde