Features of the combined flow of pulmonary tuberculosis and diabetes mellitus

The aim of the study was to investigate the features of the course, clinical manifestations, diagnosis and treatment of the combination of pulmonary tuberculosis and diabetes mellitus

New composites of betulin esters with arabinogalactan as highly potent anti-cancer agents

<p>Betulin and its esters are the natural compounds with high <i>in vitro</i> cytotoxicity toward many cancer cells. However, the poor water solubility of these compounds has limited their applications. We prepared new composites of betulin esters using two methods, namely ball-milling of the mixtures of betulin esters with arabinogalactan and preparation of thin films of these mixtures by evaporating the aqueous solutions. These composites revealed higher water solubility as compared with the initial substances without losing the structural integrity and functionality. As a result, the new composites have shown much higher inhibitory effects against different cancer cell lines such as Ehrlich ascites carcinoma cells and lung carcinoma cells (A549) in comparison with the initial substances. The cell viability studies based on Annexin V and Propidium iodide probes have confirmed the high proapoptotic effect of betulin ester derivatives against cancer cells.</p