Marketing of innovations. Innovations in marketing (2020). Materials of the International Scientific Internet Conference

The key objective of marketing communication is to inform, persuade and remind. It intends to create interest and awareness from the target customers and enables them to know more or the existence of the products and the place to get it. It also has the function to persuade customers that the product or service that an organization providing is the best in term of value compare to competitors

Marketing of innovations. Innovations in marketing (2020). Materials of the International Scientific Internet Conference

The key objective of marketing communication is to inform, persuade and remind. It intends to create interest and awareness from the target customers and enables them to know more or the existence of the products and the place to get it. It also has the function to persuade customers that the product or service that an organization providing is the best in term of value compare to competitors

Економічний вісник ДВНЗ УДХТУ

The authors analyze the classical and modern approaches to consumer behavior. The main behavior characteristics depend on whether the digital or physical consumer is. The differences and approaches to characterize such types of consumers have been considered by authors in the article. The main psychological models of behavioral features have been investigated by authors in the article. Differences in class and group behavioral aspects have determined. The key attention is given environment which makes influences on them during behavioral decisions. Physical consumer more predictable and stable and, conversely, digital consumer is sensitive with variable perception. During analysis of available theoretic and practice approaches of behavioral models of physical consumers and digital consumers, authors was found the difference between information delivering way about new products and services which are proposing to them. Digital consumer has characterized as a specific category of net-citizens who make many decisions during one purchasing process. Physical consumer, unlike digital, makes a reasonable decision during long term purchasing process. Authors have analyzed the models that exist for the study of consumer purchasing decisions and how all these aspects affect their behavior towards the product. Investigations have shown that the lack of research on digital consumers leads to a lack of information about the peculiarities of their behavior and purchasing decisions. Based on the analysis, consumers are grouped by their physical and digital affiliation. This made it possible to divide into groups and identify the distinctive features between the behavioral characteristics of physical and digital consumers. Research and the results, proposed in the article, can be tangible benefits for businesses in competing for customers.The behavior of the consumer and his decisions in front of the different offers that are presented to him when he is going to buy a something is a wide field of investigation for the specialists of marketing and sales. There are many factors that affect a consumer, from his inner part as his fears, his paradigms and beliefs, his argumentation and mental justification, the cultural heritage and what he/she has learned throughout its life, is one of the approaches in front of a product to buy

Економічний вісник ДВНЗ УДХТУ

The authors analyze the classical and modern approaches to consumer behavior. The main behavior characteristics depend on whether the digital or physical consumer is. The differences and approaches to characterize such types of consumers have been considered by authors in the article. The main psychological models of behavioral features have been investigated by authors in the article. Differences in class and group behavioral aspects have determined. The key attention is given environment which makes influences on them during behavioral decisions. Physical consumer more predictable and stable and, conversely, digital consumer is sensitive with variable perception. During analysis of available theoretic and practice approaches of behavioral models of physical consumers and digital consumers, authors was found the difference between information delivering way about new products and services which are proposing to them. Digital consumer has characterized as a specific category of net-citizens who make many decisions during one purchasing process. Physical consumer, unlike digital, makes a reasonable decision during long term purchasing process. Authors have analyzed the models that exist for the study of consumer purchasing decisions and how all these aspects affect their behavior towards the product. Investigations have shown that the lack of research on digital consumers leads to a lack of information about the peculiarities of their behavior and purchasing decisions. Based on the analysis, consumers are grouped by their physical and digital affiliation. This made it possible to divide into groups and identify the distinctive features between the behavioral characteristics of physical and digital consumers. Research and the results, proposed in the article, can be tangible benefits for businesses in competing for customers.The behavior of the consumer and his decisions in front of the different offers that are presented to him when he is going to buy a something is a wide field of investigation for the specialists of marketing and sales. There are many factors that affect a consumer, from his inner part as his fears, his paradigms and beliefs, his argumentation and mental justification, the cultural heritage and what he/she has learned throughout its life, is one of the approaches in front of a product to buy

Recent progress in oxide scintillation crystals development by low-thermal gradient Czochralski technique for particle physics experiments

International audienceModern particle physics experiments call for high performance scintillation detectors with unique properties: radiation-resistant in high energy and astrophysics, highly radiopure, containing certain elements or enriched isotopes in astroparticle physics. The low-thermal gradient Czochralski (LTG CZ) crystal growth technique provides excellent quality large volume radiopure crystal scintillators. Absence of thermoelastic stress in the crystal and overheating of the melt in the LTG CZ method is particularly significant in production of crystalline materials with strong thermal anisotropic properties and low mechanical strength, with a very high yield of crystalline boules and low losses of initial charge, crucially important in production of crystal scintillators from enriched isotopes for double beta decay experiments. Here we discuss progress in development of the well known scintillators (Bi(4)Ge(3)O(12) (BGO), CdWO(4), ZnWO(4), CaMoO(4), PbMoO(4)), as well as R{&}D of new materials (ZnMoO(4), Li(2)MoO(4), Na(2)Mo(2)O(7)) for the next generation experiments in particle physics

СОКРАЩЕННЫЙ КУРС «ТРОЙНОЙ» ПРОТИВОВИРУСНОЙ ТЕРАПИИ С ТЕЛАПРЕВИРОМ: ПРИНЦИПЫ ОТБОРА ПАЦИЕНТОВ

Background: The beginning of a new era of direct acting antivirals sets up its own rules, that is, to achieve the highest efficacy with the shortest duration of treatment. It is assumed that the use of the first generation of direct acting antivirals, similarly to interferon-free regimens, would allow for personalization of approaches to their prescriptions.Aim: To identify the most important parameters that can predict the greatest efficacy of triple antiviral therapy of 12 week duration in patients with chronic hepatitis C genotype 1.Materials and methods: The study included 204 patients with chronic hepatitis C virus (HCV) genotype 1 at an early stage of liver disease (METAVIR score F0-F2), who were either treatment-naive or had a history of relapse after standard of care antiviral therapy. In addition to routine work-up, all patients were screened for IL28B polymorphism; in the course of the treatment viral kinetics was assessed by an ultrasensitive polymerase chain reaction (PCR) (with lower limit of quantification of 12 IU/ml). Duration of the triple therapy (pegylated interferon-α2a, ribavirin and telaprevir) was reduced to 12 weeks if a rapid virological response was achieved; otherwise the patients continued their treatment in according with guidelines. Results: A complete rapid virological response was achieved in 174 patients (81.6%), in whom the duration of triple therapy was 12 weeks. According to the protocol, 25 patients with a partial rapid virological response continued their standard antiviral therapy for 12 weeks more. In those who achieved a rapid virological response, there was an association between IL28B-CC genotype at rs12979860 and maintenance of zero viremia at 12 weeks after termination of antiviral therapy (r = 0.38, p 0.001). In all such patients there was a stable virological response at 12 weeks of the follow-up. Monitoring of viral load after 14 days of antiviral treatment was not predictive of its success. The preliminary results of a shortened (12 week) course of triple telaprevir-based viral therapy allowed to identify the most significant parameters of 100% efficacy, i.e., absence of the virus in blood at 12 weeks after termination of antiviral therapy. Conclusion: A 12 week course of triple telaprevir-based combination therapy is an optimal regimen for achievement of a stable virological response after 12 weeks of the follow-up in treatment-naïve patients with HCV genotype 1 or with a relapse after previous conventional antiviral treatment, who have IL28B – CC polymorphism, are at an early stage of liver disease and who achieve a rapid complete virological response confirmed by a highly sensitive PCR.Актуальность. Наступление новой эры препаратов прямого противовирусного действия диктует свои правила – достижение максимальной эффективности при наименьшей продолжительности курса лечения. Предположительно, выровнять шансы на излечение при применении первых представителей этой группы препаратов – аналогично безинтерфероновым схемам противовирусной терапии – позволит персонифицированный подход к их назначению.Цель – определить наиболее значимые параметры, позволяющие прогнозировать наибольшую эффективность противовирусной терапии в «тройном» режиме с длительностью курса 12 недель у пациентов с хроническим гепатитом С 1-го генотипа. Материал и методы. В исследование включены 204 пациента с хроническим гепатитом С 1-го генотипа на начальных стадиях заболевания печени (F0–F2 по шкале METAVIR), ранее не получавших лечение или с рецидивом после предшествующего курса стандартной противовирусной терапии. На скрининге каждому пациенту помимо спектра необходимых лабораторно-инструментальных исследований проводилось определение полиморфизма IL28B, в процессе лечения изучали вирусную кинетику ультрачувствительным методом полимеразной цепной реакции (ПЦР) (аналитическая чувствительность – 12 МЕ/мл). Условием сокращения курса «тройной» противовирусной терапии (пегилированный интерферон α2а, рибавирин, телапревир) до 12 недель было достижение быстрого вирусологического ответа. Остальные пациенты продолжали лечение в соответствии с рекомендованными сроками.Результаты. Полный быстрый вирусологический ответ был достигнут у 174 пациентов, для которых курс противовирусной терапии в «тройном» режиме составил 12 недель. По итогам лечения 81,6% больных достигли устойчивого вирусологического ответа через 12 недель периода наблюдения. По требованиям протокола 25 пациентов с наличием неполного быстрого вирусологического ответа продолжили стандартную противовирусную терапию на протяжении еще 12 недель. У лиц, достигших быстрого вирусологического ответа, выявлено наличие зависимости между генотипом СС IL28B в позиции rs12979860 и сохранением авиремии через 12 недель после окончания противовирусной терапии (r = 0,38, p 0,001). У всех пациентов с подобными характеристиками был зафиксирован устойчивый вирусологический ответ через 12 недель периода наблюдения.Мониторируемая вирусная кинетика через 14 суток противовирусной терапии не сыграла роли в оценке шансов на успех лечения. Предварительные результаты укороченного до 12 недель курса «тройной» противовирусной терапии с использованием телапревира позволили определить наиболее значимые параметры, позволяющие достигнуть 100% эффективности – авиремии через 12 недель после окончания противовирусной терапии. Заключение. Двенадцатинедельный курс «тройной» комбинированной терапии с телапревиром является оптимальным для достижения устойчивого вирусологического ответа через 12 недель после окончания противовирусной терапии у ранее не леченных пациентов с хроническим гепатитом С 1-го генотипа или рецидивом после предшествующего стандартного курса противовирусной терапии, генотипом СС IL28B на начальных стадиях заболевания печени при условии достижения полного быстрого вирусологического ответа, зарегистрированного высокочувствительным методом ПЦР

Aboveground test of an advanced Li2_2MoO4_4 scintillating bolometer to search for neutrinoless double beta decay of 100^{100}Mo

Large lithium molybdate (Li2MoO4) crystal boules were produced by using the low thermal gradient Czochralski growth technique from deeply purified molybdenum. A small sample from one of the boules was preliminary characterized in terms of X-ray-induced and thermally-excited luminescence. A large cylindrical crystalline element (with a size of circle divide 40 x 40 mm) was used to fabricate a scintillating bolometer, which was operated aboveground at similar to 15 mK by using a pulse-tube cryostat housing a high-power dilution refrigerator. The excellent detector performance in terms of energy resolution and alpha background suppression along with preliminary positive indications on the radiopurity of this material show the potentiality of Li2MoO4 scintillating bolometers for low-counting experiment to search for neutrinoless double beta decay of Mo-100. (C) 2015 Elsevier B.V. All rights reserved