Пищевая аллергия у детей с врожденным буллезным эпидермолизом. Результаты собственного наблюдательного исследования

Background: Inherited epidermolysis bullosa (EB) refers to a group of rare inherited disorders characterized by severe damage of skin and in most patients — the gastrointestinal mucosa, what leads to a violation of skin and mucosal barrier properties in relation to allergens. However, the issues of food sensitization and food allergy in this category of patients have not been studied, and the study of this problem is important.Aim: To evaluate the clinical manifestations of food allergy (FA) and IgE-response to food proteins in children with EB.Methods: 82 patients with EB aged from 2 months to 16 years were entered this open non-randomized observational prospective study, including 20 patients with simple form of EB and 62 patients with dystrophic form of EB. We analyzed allergic history and clinical manifestations of the FA in all the patients. Every patient in this study underwent of determination of the concentration of total serum IgE and specific serum IgE to the most important food allergens, as well as to mixtures of household allergens in some cases (UniCAP System, Phadia AB). Results: Skin lesion in patients with EB masks allergic skin manifestations, causing a hypodiagnosis of the FA in this category of patients, which in turn leads to erroneous organization of nutritional support. FA (clinical manifestations) was identified in 20.7% of children with EB (in 10% of cases with simple form of EB and in 24.2% — in patients with dystrophic form of EB). Products containing cow’s milk protein, cereals, and eggs were identified as etiologic factors of FA in most cases. In the group of children with comorbidity FA and EB high and very high levels of total IgE (1000 kUA / l) were detected most frequently. The main cause-significant allergens are cow’s milk proteins, cereals, eggs. Conclusions: Comorbidity with FA is high in patients with dystrophic form of EB. The main cause-significant allergens are cow’s milk proteins, cereals, eggs.Обоснование. Врожденный буллезный эпидермолиз (ВБЭ) относится к группе редких наследственных заболеваний, характеризующихся тяжелым поражением кожных покровов и у большинства больных ― слизистой оболочки желудочно-кишечного тракта, что приводит к нарушению их барьерных свойств по отношению к аллергенам. Однако вопросы пищевой сенсибилизации и пищевой аллергии у данной категории больных не исследованы, и изучение этой проблемы является актуальным. Цель исследования ― оценить особенности клинических проявлений пищевой аллергии (ПА) и сенсибилизации к пищевым белкам у детей с ВБЭ. Методы. Проведено открытое нерандомизированное наблюдательное проспективное исследование. Включены 82 ребенка с ВБЭ в возрасте от 2 мес до 16 лет, в том числе 20 детей с простой и 62 ― с дистрофической формой ВБЭ. Оценивались аллергологический анамнез и клинические проявления ПА; всем больным проводилось определение общей концентрации IgE в сыворотке крови, sIgE сыворотки крови к наиболее значимым пищевым аллергенам, по показаниям ― к смесям бытовых аллергенов с применением технологий UniCAP System, Thermo Fisher Scientific (ранее Phadia АВ). Результаты. Поражение кожи при ВБЭ маскирует проявления ПА у детей, обусловливая гиподиагностику заболевания у этой категории пациентов, что в свою очередь ведет к неправильной организации нутритивной поддержки. ПА была выявлена у 20,7% детей с ВБЭ (в 10% случаев при простой и в 24,2% при дистрофической форме ВБЭ). В качестве этиологического фактора наиболее часто выступали продукты, содержащие белок коровьего молока, злаки, яйца. В группе детей с коморбидностью ПА и ВБЭ наиболее часто встречались высокие и крайне высокие уровни общего IgE(1000 kUA/l). Заключение. Дети с дистрофической формой ВБЭ по сравнению с пациентами с простой формой заболевания чаще имеют клинические проявления ПА. Основными причинно-значимыми аллергенами являются белки коровьего молока, злаки, яйца.

Perception features of the sexual preference object in persons with pedophilia depending on the attitude to sexual desire

The article examines expert and diagnostic aspects of "ego-sintonic / ego-dystonic" types of attitudes to sexual desire and describes importance of studying the basis of desire in the context of sexual offenses against minors. We present results of empirical research which aims to study perception features of the sexual preference object in persons with pedophilia depending on the attitude to sexual desire. The study based on data provided by laboratory of forensic sexology, V.P. Serbsky Federal Medical Research Center of Psychiatry and Addiction, Ministry of Health Care of the Russian Federation. The sample consisted of 30 men with such sexual desire disorder as pedophilia. The results analysis showing differences in the perception of the object of sexual desire according to different attitude to the desire. The results indicate that different types of attitudes to sexual desire correspond to certain characteristics of the perception object. Identified patterns can be used in the creating the criminal prospective portrait, dealing with expert issues, developing correction and preventive programs for patients with a diagnosis of pedophilia

The engaging leisure activities of an industrial town in the early 1950s

This article considers the main leisure activities of Magnitogorsk residents in the early 1950s based on their personal memories, local materials of the clerical sources, and periodicals. The analysis shows how the residents spent their free time and what emotions they had. On the one hand, the leisure options of that time (for example, going to cinemas, theaters, parks, circuses, libraries, concerts, sports sections, hobby clubs, public lectures, public readings of books, educational meetings arranged by the party, as well as organizing holidays and public events, amateur art shows, mass leisure out of town, resort holidays, etc.) were largely defined by the political regime and ideology. On the other hand, the urban community either tacitly rejected or changed those activities that turned out to be unpopular or boring. At the same time, one of the main trends supported by the Magnitogorsk residents was collectivism and publicity while engaging in a leisure activity. The latter two formed an integral part of the Soviet consciousness. Particular attention is paid to the problems faced by the city in the organization of leisure and recreational activities: the construction of cultural and entertainment venues failed to keep up with the growth of the city population; some residents were not properly educated about the value and importance of certain leisure types. The workers were tired because of their hard working shifts at the metallurgical plant and everyday life, thus many of them showed no interest in outdoor activities. It is concluded that the organization of leisure time in Magnitogorsk, which was a role model for the entire Soviet society, was essential in upholding the morale of its residents

Heoretical and methodological aspects physical and sports activities and tourism

The p aper presents theoretical and methodological as­pects of the ongoing changes in educational institutions that are related to human ontokinesiology and the prospects for the development of a general theory, technologies of sports and sports activities and tourism.The formation of the motor activity of schoolchildren and students in the modern education system depends on the level of sociocultural values hat have an impact on the pedagogical process of educating the individual’s physical culture. The authors of the article propose new approaches to pedagogy by means of physical culture and sports activities and tourism from the standpoint of the socio-philosophical component, which places high de­mands on the functioning of both social institutions and the individual.В работе представлены теоретико-методологические аспекты происходящих изменений в учреждениях образования, которые связаны с онтокинезиологией человека и перспективами развития общей теории, технологий физкультурно-спортивной деятельности и туризма. Формирование двигательной активно­сти школьников и студентов в современной системе образования зависит от уровня сформированных социокультурных ценностей, которые оказывают влияние на педагогический процесс воспитания физической культуры личности. Авторами статьи предлагаются новые подходы в педагогике средствами физкультурно-спортивной деятельности и туризма с позиций социально-философского компо­нента, в котором предъявляется высокие требования к функциони­рованию социальных институтов и отдельной личности