Оценка эффективности использования технических средств при реализации инфраструктурных проектов

For the English abstract and full text of the article please see the attached PDF-File (English version follows Russian version).ABSTRACT The evaluation of investment projects is central to the process of study and choice of possible options to invest in development projects. The article shows the main indicators for assessing the effectiveness of investment projects, analyzes the main advantages and disadvantages of each of them. At the same time the socio-economic importance of one of the largest high-speed rail project «Moscow-Kazan» is considered on the basis of calculation of such economic indicators as resource intensity, depreciation intensity, labor intensity and material intensity. Keywords: transport, railways, technical means, large-scale development project, economic efficiency, high-speed rail «Moscow-Kazan». 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STRUCTURE_ID=5098.Last accessed 11.05.2016.Текст аннотации на англ. языке и полный текст статьи на англ. языке находится в прилагаемом файле ПДФ (англ. версия следует после русской версии).Актуальность темы заключается в том, что оценка инвестиционных проектов занимает центральное место в процессе обоснования и выбора возможных вариантов вложения средств в проекты развития. В статье раскрыты основные показатели оценки эффективности инвестиционных проектов, проанализированы основные преимущества и недостатки каждого из них. При этом рассмотрено социально-экономическое значение одного из крупнейших проектов ВСМ «Москва-Казань» на основе расчёта таких экономических показателей, как ресурсоёмкость, амортизациоёмкость, трудоёмкость и материалоёмкость

SPERMATOGENIC TESTICULAR FUNCTION IN MEN WITH CHRONIC UROGENITAL MONOTRICHOMONIASIS AND PATHOSPERMIA

We did not observed significant differences in levels of inhibin B and follicle-stimulating hormone in serum samples of men with chronic urogenital trichomoniasis and different spermogram. It confirmed that spermatogenic testicular function in these men is preserved

Luminescence of Eu 3+ ions in hybrid polymer-inorganic composites based on poly(methyl methacrylate) and zirconia nanoparticles

Spherical nanoparticles of ZrO2 with 2 and 10 mol% EuO1.5 up to 20 nm size were prepared by the method of hydrothermal synthesis for luminescent functionalization of the polymer–inorganic nanocomposites based on poly(methyl methacrylate). Surface modification of oxide nanoparticles was carried out by 3‐(trimethoxysilyl)propyl methacrylate, dimethoxymethylvinyl silane and 2‐hydroxyethyl methacrylate to provide uniform distribution and to prevent agglomeration of nanosized filler in the polymer matrix. Polymer–inorganic composites were synthesized by in situ free radical polymerization in bulk. Structuring of ZrO2‐EuO1.5 nanoparticles in the poly(methyl methacrylate) was studied by very‐small‐angle neutron scattering. According to the results, the dependence of photoluminescent properties of ZrO2‐EuO1.5 nanoparticles on the content of lanthanide, the symmetry of the crystal field, surface treatment and the polymer matrix were established. A correlation was shown between Stark splitting in luminescence spectra of ZrO2‐EuO1.5 nanoparticles and their phase composition. Using MMT‐assay it was shown that composites based on poly(methyl methacrylate) and ZrO2‐EuO1.5 nanoparticles do not have cytotoxic properties, which makes it possible to use them as prosthesis materials with contrasted and luminescent imaging properties

Counterbalance of Stability and Activity Observed for Thermostable Transaminase from Thermobaculum terrenum in the Presence of Organic Solvents

Pyridoxal-5’-phosphate-dependent transaminases catalyze stereoselective amination of organic compounds and are highly important for industrial applications. Catalysis by transaminases often requires organic solvents to increase the solubility of reactants. However, natural transaminases are prone to inactivation in the presence of water-miscible organic solvents. Here, we present the solvent tolerant thermostable transaminase from Thermobaculum terrenum (TaTT) that catalyzes transamination between L-leucine and alpha-ketoglutarate with an optimum at 75 °C and increases the activity ~1.8-fold upon addition of 15% dimethyl sulfoxide or 15% methanol at high but suboptimal temperature, 50 °C. The enhancement of the activity correlates with a decrease in the thermal denaturation midpoint temperature. The blue-shift of tryptophan fluorescence suggested that solvent molecules penetrate the hydration shell of the enzyme. Analysis of hydrogen bonds in the TaTT dimer revealed a high number of salt bridges and surface hydrogen bonds formed by backbone atoms. The latter are sensitive to the presence of organic solvents; they rearrange, conferring the relaxation of some constraints inherent to a thermostable enzyme at low temperatures. Our data support the idea that the counterbalance of stability and activity is crucial for the catalysis under given conditions; the obtained results may be useful for fine-tuning biocatalyst efficiency

Synthesis and Biological Evaluation of New Isoxazolyl Steroids as Anti-Prostate Cancer Agents

Steroids with a nitrogen-containing heterocycle in the side chain are known as effective inhibitors of androgen signaling and/or testosterone biosynthesis, thus showing beneficial effects for the treatment of prostate cancer. In this work, a series of 3β-hydroxy-5-ene steroids, containing an isoxazole fragment in their side chain, was synthesized. The key steps included the preparation of Weinreb amide, its conversion to acetylenic ketones, and the 1,2- or 1,4-addition of hydroxylamine, depending on the solvent used. The biological activity of the obtained compounds was studied in a number of tests, including their effects on 17α-hydroxylase and 17,20-lyase activity of human CYP17A1 and the ability of selected compounds to affect the downstream androgen receptor signaling. Three derivatives diminished the transcriptional activity of androgen receptor and displayed reasonable antiproliferative activity. The candidate compound, 24j (17R)-17-((3-(2-hydroxypropan-2-yl)isoxazol-5-yl)methyl)-androst-5-en-3β-ol, suppressed the androgen receptor signaling and decreased its protein level in two prostate cancer cell lines, LNCaP and LAPC-4. Interaction of compounds with CYP17A1 and the androgen receptor was confirmed and described by molecular docking