399 research outputs found
The NuSTAR, XMM-Newton, and Suzaku View of A3395 at the Intercluster Filament Interface
Galaxy clusters are the largest virialized objects in the universe. Their merger dynamics and their interactions with the cosmic filaments that connect them are important for our understanding of the formation of large-scale structure. In addition, cosmic filaments are thought to possess the missing baryons in the universe. Studying the interaction of galaxy clusters and filaments therefore has the potential to unveil the origin of the baryons and the physical processes that occur during merger stages of galaxy clusters. In this paper, we study the connection between A3395 and the intercluster filament with NuSTAR, XMM-Newton, and Suzaku data. Since the NuSTAR observation is moderately contaminated by scattered light, we present a novel technique developed for disentangling this background from the emission from the intracluster medium. We find that the interface of the cluster and the intercluster filament connecting A3395 and A3391 does not show any signs of heated plasma, as was previously thought. This interface has low temperature, high density, and low entropy, thus we suggest that the gas is cooling, being enhanced by the turbulent or tidal "weather"driven during the early stage of the merger. Furthermore, our temperature results from the NuSTAR data are in agreement with those from XMM-Newton and from joint NuSTAR and XMM-Newton analysis for a region with ∼25% scattered light contamination within 1σ. We show that the temperature constraint of the intracluster medium is valid even when the data are contaminated up to ∼25% for ∼5 keV cluster emission
Isolation and characterization of pokeweed antiviral protein mutations in Saccharomyces cerevisiae: identification of residues important for toxicity.
Genome-wide DNA methylation analysis of transient neonatal diabetes type 1 patients with mutations in ZFP57
BackgroundTransient neonatal diabetes mellitus 1 (TNDM1) is a rare imprinting disorder characterized by intrautering growth retardation and diabetes mellitus usually presenting within the first six weeks of life and resolves by the age of 18 months. However, patients have an increased risk of developing diabetes mellitus type 2 later in life. Transient neonatal diabetes mellitus 1 is caused by overexpression of the maternally imprinted genes PLAGL1 and HYMAI on chromosome 6q24. One of the mechanisms leading to overexpression of the locus is hypomethylation of the maternal allele of PLAGL1 and HYMAI. A subset of patients with maternal hypomethylation at PLAGL1 have hypomethylation at additional imprinted loci throughout the genome, including GRB10, ZIM2 (PEG3), MEST (PEG1), KCNQ1OT1 and NESPAS (GNAS-AS1). About half of the TNDM1 patients carry mutations in ZFP57, a transcription factor involved in establishment and maintenance of methylation of imprinted loci. Our objective was to investigate whether additional regions are aberrantly methylated in ZFP57 mutation carriers.MethodsGenome-wide DNA methylation analysis was performed on four individuals with homozygous or compound heterozygous ZFP57 mutations, three relatives with heterozygous ZFP57 mutations and five controls. Methylation status of selected regions showing aberrant methylation in the patients was verified using bisulfite-sequencing.ResultsWe found large variability among the patients concerning the number and identity of the differentially methylated regions, but more than 60 regions were aberrantly methylated in two or more patients and a novel region within PPP1R13L was found to be hypomethylated in all the patients. The hypomethylated regions in common between the patients are enriched for the ZFP57 DNA binding motif.ConclusionsWe have expanded the epimutational spectrum of TNDM1 associated with ZFP57 mutations and found one novel region within PPP1R13L which is hypomethylated in all TNDM1 patients included in this study. Functional studies of the locus might provide further insight into the etiology of the disease.<br/
Collective Intelligence for Control of Distributed Dynamical Systems
We consider the El Farol bar problem, also known as the minority game (W. B.
Arthur, ``The American Economic Review'', 84(2): 406--411 (1994), D. Challet
and Y.C. Zhang, ``Physica A'', 256:514 (1998)). We view it as an instance of
the general problem of how to configure the nodal elements of a distributed
dynamical system so that they do not ``work at cross purposes'', in that their
collective dynamics avoids frustration and thereby achieves a provided global
goal. We summarize a mathematical theory for such configuration applicable when
(as in the bar problem) the global goal can be expressed as minimizing a global
energy function and the nodes can be expressed as minimizers of local free
energy functions. We show that a system designed with that theory performs
nearly optimally for the bar problem.Comment: 8 page
Natural products and synthetic analogs as a source of antitumor drugs
Cancer is a heterogeneous disease and one of the major issues of health concern, especially for the public health system globally. Nature is a source of anticancer drugs with abundant pool of diverse chemicals and pharmacologically active compounds. In recent decade, some natural products and synthetic analogs have been investigated for the cancer treatment. This article presents the utilization of natural products as a source of antitumor drugs.This work was supported by CONICYT PIA/APOYO CCTE AFB170007
Tracking and imaging gamma ray experiment (TIGRE) for 1 to 100 MEV gamma ray astronomy
A large international collaboration from the high energy astrophysics community has proposed the Tracking and Imaging Gamma Ray Experiment (TIGRE) for future space observations. TIGRE will image and perform energy spectroscopy measurements on celestial sources of gamma rays in the energy range from 1 to 100 MeV. This has been a difficult energy range experimentally for gamma ray astronomy but is vital for the future considering the recent exciting measurements below 1 and above 100 MeV. TIGRE is both a double scatter Compton and gamma ray pair telescope with direct imaging of individual gamma ray events.
Multi‐layers of Si strip detectors are used as Compton and pair converters CsI(Tl) scintillation detectors are used as a position sensitive calorimeter. Alternatively, thick GE strip detectors may be used for the calorimeter. The Si detectors are able to track electrons and positrons through successive Si layers and measure their directions and energy losses. Compton and pair events are completely reconstructed allowing each event to be imaged on the sky. TIGRE will provide an order‐of‐magnitude improvement in discrete source sensitivity in the 1 to 100 MeV energy range and determine spectra with excellent energy and excellent angular resolutions. It’s wide field‐of‐view of π sr permits observations of the entire sky for extended periods of time over the life of the mission
FiberGLAST: a scintillating fiber approach to the GLAST mission
FiberGLAST is a scintillating fiber gamma-ray detector designed for the GLAST mission. The system described below provides superior effective area and field of view for modest cost and risk. An overview of the FiberGLAST instrument is presented, as well as a more detailed description of the principle elements of the primary detector volume. The triggering and readout electronics are described, and Monte Carlo Simulations of the instrument performance are presented
Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on in Vivo Pharmacological Effects and Bioavailability Traits
Luteolin is a naturally occurring secondary metabolite belonging to the class of flavones. As many other natural flavonoids, it is often found in combination with glycosides in many fruits, vegetables, and plants, contributing to their biological and pharmacological value. Many preclinical studies report that luteolin present excellent antioxidant, anticancer, antimicrobial, neuroprotective, cardioprotective, antiviral, and anti-inflammatory effects, and as a consequence, various clinical trials have been designed to investigate the therapeutic potential of luteolin in humans. However, luteolin has a very limited bioavailability, which consequently affects its biological properties and efficacy. Several drug delivery strategies have been developed to raise its bioavailability, with nanoformulations and lipid carriers, such as liposomes, being the most intensively explored. Pharmacological potential of luteolin in various disorders has also been underlined, but to some of them, the exact mechanism is still poorly understood. Given the great potential of this natural antioxidant in health, this review is aimed at providing an extensive overview on the in vivo pharmacological action of luteolin and at stressing the main features related to its bioavailability, absorption, and metabolism, while essential steps determine its absolute health benefits and safety profiles. In addition, despite the scarcity of studies on luteolin bioavailability, the different drug delivery formulations developed to increase its bioavailability are also listed here.This study was partially supported by Çanakkale Onsekiz Mart Üniversitesi (Scientific Research Projects, ID: FYL-2017-1339 and FBA-2017-1268)
Beam test results for the FiberGLAST instrument
The FiberGLAST scintillating fiber telescope is a large-area instrument concept for NASA\u27s GLAST program. The detector is designed for high-energy gamma-ray astronomy, and uses plastic scintillating fibers to combine a photon pair tracking telescope and a calorimeter into a single instrument. A small prototype detector has been tested with high energy photons at the Thomas Jefferson National Accelerator Facility. We report on the result of this beam test, including scintillating fiber performance, photon track reconstruction, angular resolution, and detector efficiency
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