Emergence of visually-evoked reward expectation signals in dopamine neurons via the superior colliculus in V1 lesioned monkeys

Responses of midbrain dopamine (DA) neurons reflecting expected reward from sensory cues are critical for reward-based associative learning. However, critical pathways by which reward-related visual information is relayed to DA neurons remain unclear. To address this question, we investigated Pavlovian conditioning in macaque monkeys with unilateral primary visual cortex (V1) lesions (an animal model of 'blindsight'). Anticipatory licking responses to obtain juice drops were elicited in response to visual conditioned stimuli (CS) in the affected visual field. Subsequent pharmacological inactivation of the superior colliculus (SC) suppressed the anticipatory licking. Concurrent single unit recordings indicated that DA responses reflecting the reward expectation could be recorded in the absence of V1, and that these responses were also suppressed by SC inactivation. These results indicate that the subcortical visual circuit can relay reward-predicting visual information to DA neurons and integrity of the SC is necessary for visually-elicited classically conditioned responses after V1 lesion

The Sunyaev-Zel'dovich Effect at Five Arc-seconds: RXJ1347.5-1145 Imaged by ALMA

We present the first image of the thermal Sunyaev-Zel'dovich effect (SZE) obtained by the Atacama Large Millimeter/submillimeter Array (ALMA). Combining 7-m and 12-m arrays in Band 3, we create an SZE map toward a galaxy cluster RXJ1347.5-1145 with 5 arc-second resolution (corresponding to the physical size of 20 kpc/h), the highest angular and physical spatial resolutions achieved to date for imaging the SZE, while retaining extended signals out to 40 arc-seconds. The 1-sigma statistical sensitivity of the image is 0.017 mJy/beam or 0.12 mK_CMB at the 5 arc-second full width at half maximum. The SZE image shows a good agreement with an electron pressure map reconstructed independently from the X-ray data and offers a new probe of the small-scale structure of the intracluster medium. Our results demonstrate that ALMA is a powerful instrument for imaging the SZE in compact galaxy clusters with unprecedented angular resolution and sensitivity. As the first report on the detection of the SZE by ALMA, we present detailed analysis procedures including corrections for the missing flux, to provide guiding methods for analyzing and interpreting future SZE images by ALMA.Comment: 20 pages, 13 figures. Accepted for publication in PAS

Acetyl-l-carnitine normalizes the impaired long-term potentiation and spine density in a rat model of global ischemia

Aim: The aim of this study was to enhance the knowledge regarding actors and intentions in the development process of a mobile phone platform for self-management of hypertension. Methods: Our research approach was a 14-month longitudinal “real-time ethnography” method of description and analysis. Data were collected through focus groups with patients and providers, patient interviews, and design meetings with researchers and experts. The analysis was informed by the concepts of actors and inscriptions in actor-network theory (ANT). Results: Our study showed that laypersons, scientific actors, as well as technology itself, might influence development processes of support for self-management of hypertension. The intentions were inscribed into the technology design as well as the models of learning and treatment. Conclusions: The study highlighted important aspects of how actors and intentions feature in the development of the mobile phone platform to support self-management of hypertension. The study indicated the multifacetedness of the participating actors, including the prominent role of technology. The concrete results of such processes included questions in the self-report system, learning and treatment models