106 research outputs found
Using the electronic information and educational environment of the university in the training of tourism industry workers
The availability of electronic information and educational environment of an educational institution today is the most important requirement of the Federal state educational standards of higher education in all areas of preparation for the conditions of implementation of educational programs by universities. The purpose of the study is to rationale for use in modern educational process of the University electronic information-educational environment and study of its use in training future employees of the tourism industry. Research methodology: system-structural, competence-based, informational approaches; research methods: theoretical (analysis of normative documents, local acts of the University, experience in implementing the electronic information and educational environment at the University, comparison, synthesis of educational and methodological knowledge on the research problem, the method of analogy, forecasting; empirical (observation, study of educational products, description). The research was carried out on the basis of the faculty of service and tourism of the Kuban state University of physical culture, sport and tourism. Results: the necessity of using the modern educational process of higher school of electronic information and educational environment, discloses the functionality and experience of using electronic information-educational environment in the professional training of tourism industry personnel; the structural-functional components and design principles of the electronic information-educational environment of the University; the ways of implementing forms of educational activities with the use of e-learning technologies in the process of training future employees of the tourism industry and their advantages are revealed. Conclusions: the electronic information and educational environment of a University is a set of tools and resources based on information and communication technologies aimed at ensuring the requirements for the implementation of educational activities; in the training of future employees of the tourist industry used the following electronic information-educational environment: electronic library system; e-library of the University; module "qualifying work" on the platform MEGAPRO, Date Express LLC, management system training courses (virtual learning environments); information system "Document of the University"; the software package "Plans"; system "Antiplagiat.VUZ " electronic portfolio and other components; the advantages of using electronic information and educational environment are: the ability to build the educational process with active interaction of all subjects of the educational system; prompt informing of participants of educational activities about changes in the educational process; the ability to form various virtual communities, etc
Motor activity of Daphnia magna (Crustacea, Cladocera) during thermal selection: Peculiarities of search reactions in the non-uniform environment
We conducted a study of the peculiarities of the motor activity of juvenile and adult individuals of Daphnia magna in the process of thermal selection. On the example of Daphnia, we experimentally proved the assumption that the decrease in the motor activity of the ectotherms in the selected temperature range is a behaviour mechanism typical for thermal selection. The experiment was conducted on the offspring of one parthenogenetic female (pure line) of a laboratory culture maintained over several years at room temperature. The Daphnia individuals had been beforehand acclimated over several generations to 23.4 ΒΊΠ‘, and then were placed in a thermogradient apparatus. The control individuals were maintained at room temperature. The final temperature preference was determined using the so-called "chronic" method, when the tested organisms are maintained in a thermogradient apparatus over several days. TheΒ positions of the Daphnia individuals were recorded daily during 24 days. As a parameter which would characterize the motor activity of Daphnia, we used the parameter of average relative shifting, which was calculated as a difference (in cm) between the position they were found in two sequential records, divided by time (in min) between these records. Over the first 3 days, in the conditions of the temperature gradient, the Daphnia mostly selected heightened temperatures (24β28 ΒΊΠ‘). During the period from the 4th to 24th day, 74% of the Daphnia selected the range of 18β23Β ΒΊΠ‘ and 85% β 17β24 ΒΊΠ‘. Thus, the range of the ultimate selected temperatures decreased by 4 ΒΊΠ‘ compared to the initially selected temperatures and enlarged by 3 ΒΊΠ‘ towards the lower temperatures. In the thermogradient apparatus, the parthenogenetic females had the lowest value of the mean relative movement. In the control, at room temperature, this parameter of the adults was by 43% higher compared to the gradient. The pattern of the dynamic of the indicator in both variants of the experiment was similar for the periods and phases of fluctuations. With the juveniles the value of the parameter of mean relative shifting in the gradient was higher by 40% compared to the adult Daphnia, but close to the parameter of the adults in the control. We determined a relationship between the juveniles selecting the higher temperatures and higher mean relative shifting, which indicates a relationship between the behavioural selective reaction of juvenile Daphnia and general physiological condition of their organism. During the absence of the temperature gradient, the Daphnia were observed to show symmetry in their motor reaction. Occurrence of the asymmetry of the motor reaction of the Daphnia in the condition of the thermogradient, manifesting in the prevalence of shifting to lower or higher temperatures, can indicate more clearly manifested search reaction in the condition of a non-uniform environment
Life safety culture as a pedagogical problem
It is well known that security is a necessary condition for the long-term development of humanity, society, the state and civilization as a whole, ensuring their stability and success. Currently, the Russian Federation pays close attention to the issues of educating the younger generation about a culture of life safety, which is supported by government initiatives, because ensuring the safety of the state citizens is among the priority components of a high standard of living. It is the culture of life safety that is defined as a component of the general culture of an individual and the main target for the activities of educational organizations. In this regard, the problem of the research is to substantiate the culture of life safety as a pedagogical category. The purpose of the research is to substantiate the content of the concept of βlife safety cultureβ as a subject of pedagogical discourse and the basic target of the state educational policy. The methodological basis of the research is represented by the use of methods of analysis, theoretical generalization, and description.The results of the research are as follows: various approaches to the content of the concept of βlife safety cultureβ as a pedagogical category have been analyzed; the structural components of safety culture have been identified; the target guidelines for instilling a life safety culture in educational institutions have been substantiated.Key conclusions: the issues of developing a culture of life safety among students have been considered in two contexts, as a necessary condition for the activities of teachers in developing the experience of safe behavior of students and as the creation of pedagogical conditions for a safe educational environment by all participants in educational activities. The target guidelines for instilling a culture of life safety among students are an integrated set of the following components: psychological, political, economic, environmental and information security of an individual
Trophic diversification and parasitic invasion as ecological niche modulators for gut microbiota of whitefish
Introduction: The impact of parasites on gut microbiota of the host is well documented, but the role of the relationship between the parasite and the host in the formation of the microbiota is poorly understood. This study has focused on the influence that trophic behavior and resulting parasitism has on the structure of the microbiome.
Methods: Using 16S amplicon sequencing and newly developed methodological approaches, we characterize the gut microbiota of the sympatric pair of whitefish Coregonus lavaretus complex and the associated microbiota of cestodes parasitizing their intestine. The essence of the proposed approaches is, firstly, to use the method of successive washes of the microbiota from the cestodeβs surfaces to analyze the degree of bacterial association to the tegument of the parasite. Secondly, to use a method combining the sampling of intestinal content and mucosa with the washout procedure from the mucosa to understand the real structure of the fish gut microbiota.
Results and discussion: Our results demonstrate that additional microbial community in the intestine are formed by the parasitic helminths that caused the restructuring of the microbiota in infected fish compared to those uninfected. Using the desorption method in Ringerβs solution, we have demonstrated that Proteocephalus sp. cestodes possess their own microbial community which is put together from βsurfaceβ bacteria, and bacteria which are weakly and strongly associated with the tegument, bacteria obtained after treatment of the tegument with detergent, and bacteria obtained after removal of the tegument from the cestodes.info:eu-repo/semantics/publishedVersio
Modern features of innovative strategies for the development of hotel business enterprises
The hotel business is the basic sector of the tourism industry, contributes to the increase in tourist flows, the internationalization of financial capital, and the growth of employment. The hotel sector is developing rapidly (with the exception of 2020, which is explained by anti-Covid measures), largely due to the introduction of innovative development strategies. The investment prospects of the hotel sector should be built on the basis of such a systematization of modern innovative trends, and business planning of the activities of hotel enterprises should ensure the best implementation of innovative approaches when developing a strategy in a specific business environment. The purpose of the study is to study the modern features of innovative strategies for the development of hotel business enterprises, their impact on the dynamics of sales of paid services to the population, including the example of the Krasnodar Territory. The research methods are the following: statistical method, competitive analysis method, generalization method, forecasting. The results and conclusions: an analysis of the applied innovative strategies by hospitality enterprises indicates that such strategies are effective tools for effectively solving the problem of survival and ensuring the business security of hotels. Conclusions: innovative strategies are the most important part of the strategic management of a hotel enterprise, they make it possible to strengthen its competitiveness, meet the constantly changing preferences of guests, follow industry trends or even outstrip them
Modern features of benchmarking in the hotel business
The market of hotel services is an actively developing market in which innovative technologies of service of guests are widely used; various loyalty and reservation programs are being developed and improved; new approaches to business process management are applied. Benchmarking is a very relevant area designed to assess and select alternative options for the development of the hotel business, defining tasks and improving management efficiency through a deeper study and borrowing approaches successfully implemented by competitors. The aim of the research is to study the current features of benchmarking in the hospitality industry and its impact on the dynamics of enterprise performance. The research methods used are method of competitive analysis, statistical method, generalization method, forecasting. The results and conclusions: the analysis of the state of the hotel services market has shown a steady growth in the number of facilities and consumers of hotel services, which leads to increased intra-industry competition. Benchmarking helps to correlate the operating performance of the hotel business with the performance of the competitive environment, to move away from the subjective assessments of hoteliers and to identify errors in sales policy. In addition, the use of benchmarking allows you to predict the dynamics of demand in order to minimize managerial errors. The conclusions: benchmarking is part of marketing research and the basis for business process planning in the context of choosing strategic activities of the hotel service company. Conducting such a study is focused on providing the hotel with significant competitive advantages, the quintessence of which is the procedure of studying the experience of operating in the market of business leaders
ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π±Π°ΡΡΠ΅ΡΠ½ΡΡ ΡΠ»ΠΎΠ΅Π² Π΄ΠΈΠΎΠΊΡΠΈΠ΄Π° ΡΠΈΡΠ°Π½Π° Π΄Π»Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΌΡΠ»ΡΡΠΈΡΠ΅ΡΡΠΎΠΈΠΊΠΎΠ² ΡΠ΅ΡΡΠΎΠΌΠ°Π³Π½Π΅ΡΠΈΠΊ/ΡΠ΅Π³Π½Π΅ΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΠΊ
The layered multiferroics Co/PZT were obtained by ion-beam sputtering-deposition method, where PZT is a ferroelectric ceramic based on lead titanate zirconate of the composition PbZr0.45Ti0.55O3 with a thermostable plane-parallel ferroelectric/ferromagnet interface. Using cross-sectional scanning electron microscopy (SEM), we studied the interface of a cobalt layer up to several micrometers thick with a thick ceramic substrate of lead zirconate titanate. It has been shown that the use of a titanium dioxide barrier layer of TiO2 instead of PZT allows quality improvement of the interface by reducing the duration of ion-beam planarization of the ferroelectric substrate, and also to eliminate the formation of intermediate chemical compounds. Based on the data of X-ray phase analysis (XRD), it was concluded that the TiO2 layer is amorphous. Magnetoelectric measurements have shown that the use of titanium dioxide instead of PZT under appropriate planarization modes can increase the low-frequency magnetoelectric effect to 5 mV/(cmβΠΠ΅), compared with structures with a sputtering planarizing layer of PZT, where the magnitude of the low-frequency magnetoelectric effect is 2 mV/(cmβΠe). These results allow us to improve the characteristics of these structures when used as sensitive elements in devices for formation β processing of information and magnetic field sensors based on the magnetoelectric effect.Π‘ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄Π° ΠΈΠΎΠ½Π½ΠΎ-Π»ΡΡΠ΅Π²ΠΎΠ³ΠΎ ΡΠ°ΡΠΏΡΠ»Π΅Π½ΠΈΡ β ΠΎΡΠ°ΠΆΠ΄Π΅Π½ΠΈΡ ΠΏΠΎΠ»ΡΡΠ΅Π½Ρ ΡΠ»ΠΎΠΈΡΡΡΠ΅ ΠΌΡΠ»ΡΡΠΈΡΠ΅ΡΡΠΎΠΈΠΊΠΈ Co/Π¦Π’Π‘ (Π¦Π’Π‘ β ΡΠ΅Π³Π½Π΅ΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠ°Ρ ΠΊΠ΅ΡΠ°ΠΌΠΈΠΊΠ° Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΈΡΠΊΠΎΠ½Π°ΡΠ° ΡΠΈΡΠ°Π½Π°ΡΠ° ΡΠ²ΠΈΠ½ΡΠ° ΡΠΎΡΡΠ°Π²Π° PbZr0,45Ti0,55O3 Ρ ΡΠ΅ΡΠΌΠΎΡΡΠ°Π±ΠΈΠ»ΡΠ½ΡΠΌ ΠΏΠ»ΠΎΡΠΊΠΎΠΏΠ°ΡΠ°Π»Π»Π΅Π»ΡΠ½ΡΠΌ ΠΈΠ½ΡΠ΅ΡΡΠ΅ΠΉΡΠΎΠΌ ΡΠ΅Π³Π½Π΅ΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΠΊ/ΡΠ΅ΡΡΠΎΠΌΠ°Π³Π½Π΅ΡΠΈΠΊ), ΠΎΠ±Π»Π°Π΄Π°ΡΡΠΈΠ΅ Π²ΠΎΡΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΡΠΌΠΈ Π½ΠΈΠ·ΠΊΠΎΡΠ°ΡΡΠΎΡΠ½ΡΠΌΠΈ ΠΌΠ°Π³Π½ΠΈΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ ΠΏΡΠΈ ΠΊΠΎΠΌΠ½Π°ΡΠ½ΠΎΠΉ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ΅. ΠΠ΅ΡΠΎΠ΄ΠΎΠΌ ΡΠ°ΡΡΡΠΎΠ²ΠΎΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ (Π ΠΠ) ΠΏΠΎΠΏΠ΅ΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½Π° Π³ΡΠ°Π½ΠΈΡΠ° ΡΠ°Π·Π΄Π΅Π»Π° ΡΠ»ΠΎΡ ΠΊΠΎΠ±Π°Π»ΡΡΠ° ΡΠΎΠ»ΡΠΈΠ½ΠΎΠΉ Π΄ΠΎ Π½Π΅ΡΠΊΠΎΠ»ΡΠΊΠΈΡ
ΠΌΠΈΠΊΡΠΎΠΌΠ΅ΡΡΠΎΠ² Ρ ΡΠΎΠ»ΡΡΠΎΠΉ ΠΊΠ΅ΡΠ°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΠ΄Π»ΠΎΠΆΠΊΠΎΠΉ ΡΠΈΡΠΊΠΎΠ½Π°ΡΠ° β ΡΠΈΡΠ°Π½Π°ΡΠ° ΡΠ²ΠΈΠ½ΡΠ°. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π±Π°ΡΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ»ΠΎΡ Π΄ΠΈΠΎΠΊΡΠΈΠ΄Π° ΡΠΈΡΠ°Π½Π° TiO2 Π²ΠΌΠ΅ΡΡΠΎ Π¦Π’Π‘ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π΄ΠΎΠ±ΠΈΡΡΡΡ ΡΠ»ΡΡΡΠ΅Π½ΠΈΡ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΈΠ½ΡΠ΅ΡΡΠ΅ΠΉΡΠ° Π·Π° ΡΡΠ΅Ρ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ ΠΈΠΎΠ½Π½ΠΎ-Π»ΡΡΠ΅Π²ΠΎΠΉ ΠΏΠ»Π°Π½Π°ΡΠΈΠ·Π°ΡΠΈΠΈ ΡΠ΅Π³Π½Π΅ΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΠ΄Π»ΠΎΠΆΠΊΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΈΡΠΊΠ»ΡΡΠΈΡΡ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΡΠΎΠΌΠ΅ΠΆΡΡΠΎΡΠ½ΡΡ
Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π΅ Π΄Π°Π½Π½ΡΡ
ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΡΠ°Π·ΠΎΠ²ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° (Π Π€Π) ΡΠ΄Π΅Π»Π°Π½ Π²ΡΠ²ΠΎΠ΄ ΠΎΠ± Π°ΠΌΠΎΡΡΠ½ΠΎΡΡΠΈ ΡΠ»ΠΎΡ TiO2, ΠΊΠΎΡΠΎΡΡΠΉ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ ΠΊΡΠΈΡΡΠ°Π»Π»ΠΈΡΠ΅ΡΠΊΠΈΠΌ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΠ΅Ρ Π±ΠΎΠ»Π΅Π΅ ΡΠ°Π²Π½ΠΎΠΌΠ΅ΡΠ½ΠΎ, Π±Π΅Π· ΠΈΡΠΊΠ°ΠΆΠ΅Π½ΠΈΠΉ, ΠΏΠ΅ΡΠ΅Π΄Π°Π²Π°ΡΡ Π²Π½ΡΡΡΠ΅Π½Π½ΠΈΠ΅ Π½Π°ΠΏΡΡΠΆΠ΅Π½ΠΈΡ, Π²ΠΎΠ·Π½ΠΈΠΊΠ°ΡΡΠΈΠ΅ ΠΌΠ΅ΠΆΠ΄Ρ ΡΠ΅Π³Π½Π΅ΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΠ΄Π»ΠΎΠΆΠΊΠΎΠΉ ΠΈ ΡΠ΅ΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠΌ ΡΠ»ΠΎΠ΅ΠΌ. ΠΡΠΎ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΌΡ ΠΌΠ°Π³Π½ΠΈΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΌΡ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ ΠΈ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌΡ ΠΏΠΎ Π²Π΅Π»ΠΈΡΠΈΠ½Π΅ (Π² Π΅Π΄ΠΈΠ½ΠΈΡΡ β Π΄Π΅ΡΡΡΠΊΠΈ ΠΌΠ/Π) Π½ΠΈΠ·ΠΊΠΎΡΠ°ΡΡΠΎΡΠ½ΠΎΠΌΡ ΠΌΠ°Π³Π½ΠΈΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠΌΡ ΡΡΡΠ΅ΠΊΡΡ ΠΏΡΠΈ ΠΊΠΎΠΌΠ½Π°ΡΠ½ΠΎΠΉ ΡΠ΅ΠΌΠΏΠ΅ΡΠ°ΡΡΡΠ΅. ΠΠ°Π³Π½ΠΈΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈΠ·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΈ, ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΈΠΎΠΊΡΠΈΠ΄Π° ΡΠΈΡΠ°Π½Π° Π²ΠΌΠ΅ΡΡΠΎ Π¦Π’Π‘ ΠΏΡΠΈ ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²ΡΡΡΠΈΡ
ΡΠ΅ΠΆΠΈΠΌΠ°Ρ
ΠΏΠ»Π°Π½Π°ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΡ Π½ΠΈΠ·ΠΊΠΎΡΠ°ΡΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°Π³Π½ΠΈΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ° Π΄ΠΎ 5 ΠΌΠ/(ΡΠΌ βΠ) ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎ ΡΡΡΡΠΊΡΡΡΠ°ΠΌΠΈ Ρ Π½Π°ΠΏΡΠ»Π΅Π½ΠΈΠ΅ΠΌ ΠΏΠ»Π°Π½Π°ΡΠΈΠ·ΡΡΡΠ΅Π³ΠΎ ΡΠ»ΠΎΡ Π¦Π’Π‘, Π³Π΄Π΅ Π²Π΅Π»ΠΈΡΠΈΠ½Π° Π΄Π°Π½Π½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ° ΡΠΎΡΡΠ°Π²Π»ΡΠ΅Ρ 2 ΠΌΠ/(ΡΠΌ βΠ). ΠΡΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΡΠ»ΡΡΡΠΈΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠΈ ΡΠΊΠ°Π·Π°Π½Π½ΡΡ
ΡΡΡΡΠΊΡΡΡ ΠΏΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΡΡ
ΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² Π² ΡΡΡΡΠΎΠΉΡΡΠ²Π°Ρ
ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ β ΠΎΠ±ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΈ Π΄Π°ΡΡΠΈΠΊΠΎΠ² ΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΌΠ°Π³Π½ΠΈΡΠΎΡΠ»Π΅ΠΊΡΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ°
ΠΠΎΠΊΠ°Π»ΡΠ½ΡΠΉ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π· Ρ Π΄Π΅ΡΠ΅ΠΉ ΡΠ°Π½Π½Π΅Π³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ°
TheΒ purpose isΒ toΒ study clinical andΒ X-ray manifestations ofΒ local tuberculosis inΒ children ofΒ theΒ tender age andΒ toΒ detect risk factors promoting theΒ development ofΒ theΒ disease andΒ complicating it, thus theΒ analysis included 82 cases ofΒ children cases underΒ 3 years old who had been treated inΒ Children TB Hospital inΒ 2013-2015. Tuberculosis ofΒ chest lymph nodes was diagnosed inΒ 68.3%ofΒ them, andΒ every fifth child had primary tuberculosis complex. Every other child was suffering fromΒ theΒ complicated course ofΒ local tuberculosis (n =Β 42). TheΒ following forms were registered: bronchial pulmonary lesions (n =Β 27), lymphogenic progression (n =Β 13), including development ofΒ disseminated tuberculosis andΒ meningitis. Positive results ofΒ sputum tests were observed inΒ 14 (17.1%) children, ofΒ them 50% had multiple drug resistance. 10% ofΒ children suffering fromΒ tuberculosis manifested anergy. TheΒ predictors ofΒ such course ofΒ theΒ disease included theΒ absence ofΒ BCG vaccination andΒ super infection with MycobacteriumΒ tuberculosis.Π‘ ΡΠ΅Π»ΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΡΠΎΡΠ²Π»Π΅Π½ΠΈΠΉ Π»ΠΎΠΊΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·Π° Ρ Π΄Π΅ΡΠ΅ΠΉ ΡΠ°Π½Π½Π΅Π³ΠΎ Π²ΠΎΠ·ΡΠ°ΡΡΠ° ΠΈ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΡΠΈΡΠΊΠ°, ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡΡΠΈΡ
ΡΠ°Π·Π²ΠΈΡΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΈ ΠΎΡΡΠ³ΠΎΡΠ°ΡΡΠΈΡ
ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°, ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ Π°Π½Π°Π»ΠΈΠ· 82 ΠΈΡΡΠΎΡΠΈΠΉ Π±ΠΎΠ»Π΅Π·Π½ΠΈ Π΄Π΅ΡΠ΅ΠΉ Π² Π²ΠΎΠ·ΡΠ°ΡΡΠ΅ Π΄ΠΎ 3 Π»Π΅Ρ, Π»Π΅ΡΠΈΠ²ΡΠΈΡ
ΡΡ Π² ΠΠ΅ΡΡΠΊΠΎΠΉ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·Π½ΠΎΠΉ Π±ΠΎΠ»ΡΠ½ΠΈΡΠ΅ Π² 2013-2015 Π³Π³. Π’ΡΠ±Π΅ΡΠΊΡΠ»Π΅Π· Π²Π½ΡΡΡΠΈΠ³ΡΡΠ΄Π½ΡΡ
Π»ΠΈΠΌΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ·Π»ΠΎΠ² Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΡΠΎΠ²Π°Π»ΠΈ Ρ 68,3%, ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΠΉ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·Π½ΡΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ - Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ ΠΏΡΡΠΎΠ³ΠΎ. ΠΡΠ»ΠΎΠΆΠ½Π΅Π½Π½ΠΎΠ΅ ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ Π»ΠΎΠΊΠ°Π»ΡΠ½ΡΡ
ΡΠΎΡΠΌ - Ρ ΠΊΠ°ΠΆΠ΄ΠΎΠ³ΠΎ Π²ΡΠΎΡΠΎΠ³ΠΎ (n = 42). Π Π΅Π³ΠΈΡΡΡΠΈΡΠΎΠ²Π°Π»ΠΈΡΡ: Π±ΡΠΎΠ½Ρ
ΠΎΠ»Π΅Π³ΠΎΡΠ½ΡΠ΅ ΠΏΠΎΡΠ°ΠΆΠ΅Π½ΠΈΡ (n = 27), Π»ΠΈΠΌΡΠΎΠ³Π΅ΠΌΠ°ΡΠΎΠ³Π΅Π½Π½ΠΎΠ΅ ΠΏΡΠΎΠ³ΡΠ΅ΡΡΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ (n = 13), Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Ρ ΡΠ°Π·Π²ΠΈΡΠΈΠ΅ΠΌ Π΄ΠΈΡΡΠ΅ΠΌΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΡΠ±Π΅ΡΠΊΡΠ»Π΅Π·Π°, ΠΌΠ΅Π½ΠΈΠ½Π³ΠΈΡΠ°. ΠΠ°ΠΊΡΠ΅ΡΠΈΠΎΠ²ΡΠ΄Π΅Π»Π΅Π½ΠΈΠ΅ - Ρ 14 (17,1%) Π΄Π΅ΡΠ΅ΠΉ, ΠΈΠ· Π½ΠΈΡ
Ρ ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΡΡΡΡ Π²ΠΎΠ·Π±ΡΠ΄ΠΈΡΠ΅Π»Ρ - Ρ 50,0%. Π’ΡΠ±Π΅ΡΠΊΡΠ»Π΅Π· Ρ 10% Π΄Π΅ΡΠ΅ΠΉ ΠΏΡΠΎΡΠ΅ΠΊΠ°Π» Π½Π° ΡΠΎΠ½Π΅ Π°Π½Π΅ΡΠ³ΠΈΠΈ. Π ΠΏΡΠ΅Π΄ΠΈΠΊΡΠΎΡΠ°ΠΌ ΡΠ°ΠΊΠΎΠ³ΠΎ ΡΠ΅ΡΠ΅Π½ΠΈΡ ΠΎΡΠ½Π΅ΡΠ΅Π½Ρ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΏΡΠΈΠ²ΠΈΠ²ΠΊΠΈ ΠΠ¦Π, ΡΡΠΏΠ΅ΡΠΈΠ½ΡΠ΅ΠΊΡΠΈΡ ΠΠΠ’
ΠΠ»ΠΈΡΠ½ΠΈΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Ρ ΠΈΡΠΎΠ·Π°Π½-Γ-ΡΠΈΠΊΠ»ΠΎΠ΄Π΅ΠΊΡΡΡΠΈΠ½ Ρ Π»Π΅Π²ΠΎΡΠ»ΠΎΠΊΡΠ°ΡΠΈΠ½ΠΎΠΌ Π½Π° ΠΌΠΈΠΊΡΠΎΡΠ»ΠΎΡΡ ΡΠ°Π½ ΠΈ ΡΠΎΠ»ΡΡΠΎΠ³ΠΎ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° ΠΎΡΠ΅ΡΡΠ°
The authors in the article presented the results of determining the effectiveness of using the chitosan-Γ-cyclodextrin complex with levofloxacin in the healing of mechanical wounds of valuable commercial fish sturgeons and their feeding. The experiment was conducted based on the βProgressive biotechnologies in aquacultureβ research laboratory of the Saratov State University of Genetics, Biotechnology and Engineering. N.I. Vavilov. The microflora of incised wounds and the large intestine of sturgeon fingerlings under the influence of fluoroquinolone, represented by levofloxacin based on cyclodextrin, included in the shell of high-molecular chitosan, was studied. The studied microbiological indicators were chosen to determine that changes in the total number of microorganisms show the nature of the course of the inflammatory/pathological process, which contributes to the development of microorganisms (including opportunistic pathogens) and lactic acid bacteria in the intestine. Therefore, they are essential physiological indicators of the formation of β intestinal immunity. It was found that the use of cyclodextrin with levofloxacin in the treatment of incised wounds in sturgeons leads to a significant decrease in the total microbial number (TMC) on their surface (by 10 thousand times compared to the group without treatment). It has been shown that using cyclodextrin with levofloxacin in feeding sturgeons reduces the total microbial number in the large intestine. This complex is characterised by good solubility and bioavailability for fish. The future study results can be used in aquaculture to treat mechanical injuries received during transportation and sorting in the rearing process in fish.ΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° Ρ
ΠΈΡΠΎΠ·Π°Π½-Γ-ΡΠΈΠΊΠ»ΠΎΠ΄Π΅ΠΊΡΡΡΠΈΠ½ Ρ Π»Π΅Π²ΠΎΡΠ»ΠΎΠΊΡΠ°ΡΠΈΠ½ΠΎΠΌ Π² Π·Π°ΠΆΠΈΠ²Π»Π΅Π½ΠΈΠΈ ΠΌΠ΅Ρ
Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°Π½ ΡΠ΅Π½Π½ΡΡ
ΠΏΡΠΎΠΌΡΡΠ»ΠΎΠ²ΡΡ
ΡΡΠ± β ΠΎΡΠ΅ΡΡΠΎΠ² ΠΈ ΠΈΡ
ΠΊΠΎΡΠΌΠ»Π΅Π½ΠΈΠΈ. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½Ρ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Π½Π° Π±Π°Π·Π΅ Π½Π°ΡΡΠ½ΠΎ-ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈ Β«ΠΡΠΎΠ³ΡΠ΅ΡΡΠΈΠ²Π½ΡΠ΅ Π±ΠΈΠΎΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π² Π°ΠΊΠ²Π°ΠΊΡΠ»ΡΡΡΡΠ΅Β» Π‘Π°ΡΠ°ΡΠΎΠ²ΡΠΊΠΎΠ³ΠΎ Π³ΠΎΡΡΠ΄Π°ΡΡΡΠ²Π΅Π½Π½ΠΎΠ³ΠΎ ΡΠ½ΠΈΠ²Π΅ΡΡΠΈΡΠ΅ΡΠ° Π³Π΅Π½Π΅ΡΠΈΠΊΠΈ, Π±ΠΈΠΎΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ ΠΈ ΠΈΠ½ΠΆΠ΅Π½Π΅ΡΠΈΠΈ ΠΈΠΌ. Π.Π. ΠΠ°Π²ΠΈΠ»ΠΎΠ²Π°. ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π»Π°ΡΡ ΠΌΠΈΠΊΡΠΎΡΠ»ΠΎΡΠ° ΡΠ΅Π·Π°Π½ΡΡ
ΡΠ°Π½ ΠΈ ΡΠΎΠ»ΡΡΠΎΠ³ΠΎ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ° ΡΠ΅Π³ΠΎΠ»Π΅ΡΠΊΠΎΠ² ΠΎΡΠ΅ΡΡΠΎΠ² ΠΏΠΎΠ΄ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ ΡΡΠΎΡΡ
ΠΈΠ½ΠΎΠ»ΠΎΠ½Π°, ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Π½ΠΎΠ³ΠΎ Π»Π΅Π²ΠΎΡΠ»ΠΎΠΊΡΠ°ΡΠΈΠ½ΠΎΠΌ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΡΠΈΠΊΠ»ΠΎΠ΄Π΅ΠΊΡΡΡΠΈΠ½Π°, Π²ΠΊΠ»ΡΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π² ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΡ Π²ΡΡΠΎΠΊΠΎΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠ³ΠΎ Ρ
ΠΈΡΠΎΠ·Π°Π½Π°. ΠΡΡΠ»Π΅Π΄ΡΠ΅ΠΌΡΠ΅ ΠΌΠΈΠΊΡΠΎΠ±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ Π±ΡΠ»ΠΈ Π²ΡΠ±ΡΠ°Π½Ρ Π΄Π»Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π½Π° ΡΠΎΠΌ ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ, ΡΡΠΎ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΎΠ±ΡΠ΅Π³ΠΎ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅Ρ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ/ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°, ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΡΡΠ΅Π³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΌΠΈΠΊΡΠΎΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠΎΠ² (Π² Ρ.Ρ. ΡΡΠ»ΠΎΠ²Π½ΠΎ-ΠΏΠ°ΡΠΎΠ³Π΅Π½Π½ΡΡ
) ΠΈ ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΊΠΈΡΠ»ΡΡ
Π±Π°ΠΊΡΠ΅ΡΠΈΠΉ Π² ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ΅, ΠΏΠΎΡΡΠΎΠΌΡ ΡΠ²Π»ΡΡΡΡΡ Π²Π°ΠΆΠ½ΡΠΌΠΈ ΡΠΈΠ·ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ Β«ΠΊΠΈΡΠ΅ΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°Β». ΠΡΠ»ΠΎ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΡΠ΅Π·Π°Π½ΡΡ
ΡΠ°Π½ Ρ ΠΎΡΠ΅ΡΡΠΎΠ² ΡΠΈΠΊΠ»ΠΎΠ΄Π΅ΠΊΡΡΡΠΈΠ½Π° Ρ Π»Π΅Π²ΠΎΡΠ»ΠΎΠΊΡΠ°ΡΠΈΠ½ΠΎΠΌ ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΌΡ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΡ ΠΎΠ±ΡΠ΅Π³ΠΎ ΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠ³ΠΎ ΡΠΈΡΠ»Π° (ΠΠΠ§) Π½Π° ΠΈΡ
ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ (Π² 10 ΡΡΡ. ΡΠ°Π· ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π³ΡΡΠΏΠΏΠΎΠΉ Π±Π΅Π· Π»Π΅ΡΠ΅Π½ΠΈΡ). ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ Π² ΠΊΠΎΡΠΌΠ»Π΅Π½ΠΈΠΈ ΠΎΡΠ΅ΡΡΠΎΠ² ΡΠΈΠΊΠ»ΠΎΠ΄Π΅ΠΊΡΡΡΠΈΠ½Π° Ρ Π»Π΅Π²ΠΎΡΠ»ΠΎΠΊΡΠ°ΡΠΈΠ½ΠΎΠΌ ΡΠ°ΠΊΠΆΠ΅ ΡΠ½ΠΈΠΆΠ°Π΅Ρ ΠΎΠ±ΡΠ΅Π΅ ΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠ΅ ΡΠΈΡΠ»ΠΎ Π² ΡΠΎΠ»ΡΡΠΎΠΌ ΠΊΠΈΡΠ΅ΡΠ½ΠΈΠΊΠ΅. ΠΠ°Π½Π½ΡΠΉ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΠ΅ΡΡΡ Ρ
ΠΎΡΠΎΡΠ΅ΠΉ ΡΠ°ΡΡΠ²ΠΎΡΠΈΠΌΠΎΡΡΡΡ ΠΈ Π±ΠΈΠΎΠ΄ΠΎΡΡΡΠΏΠ½ΠΎΡΡΡΡ Π΄Π»Ρ ΡΡΠ±. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π΅ ΠΌΠΎΠ³ΡΡ Π½Π°ΠΉΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π² Π°ΠΊΠ²Π°ΠΊΡΠ»ΡΡΡΡΠ΅ ΠΏΡΠΈ Π»Π΅ΡΠ΅Π½ΠΈΠΈ ΠΌΠ΅Ρ
Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ°Π²ΠΌ, ΠΏΠΎΠ»ΡΡΠ΅Π½Π½ΡΡ
ΠΏΡΠΈ ΠΏΠ΅ΡΠ΅Π²ΠΎΠ·ΠΊΠ΅ ΠΈ ΡΠΎΡΡΠΈΡΠΎΠ²ΠΊΠ΅ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ Π²ΡΡΠ°ΡΠΈΠ²Π°Π½ΠΈΡ, Ρ ΡΡΠ±
- β¦