I cambiamenti ambientali nella steppa Crimea per tutto il periodo romano di storia antica e di là

Insieme con l'integrazione di paleo suolo riferimento e archeologia, che permette efficiente ricostruzione paleogeografica dell'ambiente naturale nell'Olocene, ques ta zona integra lo studio del suolo in superficie, risalente metodi archeologici, e lo studio dei paesaggi antichi geoarcheologicayesБелгородский государственный университе

EXPERIENCE OF ORGANIZING THE PREVENTING MEASURES FOR «ATYPICAL PNEUMONIA» DELIVERY AND SPREADING IN KRASNOYARSK TERRITORY

Analysis of measures for preventing the delivery and spreading of «atypical pneumonia» in Krasnoyarsk region is presented. Effect of counteracting with this infectious disease of the executive authority organs, State Surveillance service, public health and other interested institutions is emphasized. Further preventing measures against «atypical pneumonia» are determined

Preparation and Characterization of the Extracellular Domain of Human Sid-1

In C. elegans, the cell surface protein Sid-1 imports extracellular dsRNA into the cytosol of most non-neuronal cells, enabling systemic spread of RNA interference (RNAi) throughout the worm. Sid-1 homologs are found in many other animals, although for most a function for the protein has not yet been established. Sid-1 proteins are composed of an N-terminal extracellular domain (ECD) followed by 9–12 predicted transmembrane regions. We developed a baculovirus system to express and purify the ECD of the human Sid-1 protein SidT1. Recombinant SidT1 ECD is glycosylated and spontaneously assembles into a stable and discrete tetrameric structure. Electron microscopy (EM) and small angle x-ray scattering (SAXS) studies reveal that the SidT1 ECD tetramer is a compact, puck-shaped globular particle, which we hypothesize may control access of dsRNA to the transmembrane pore. These characterizations provide inroads towards understanding the mechanism of this unique RNA transport system from structural prospective

НЕКРОТИЗИРУЮЩИЙ ФАСЦИИТ У ДЕТЕЙ

The authors presented a review of literature of necrotizing fasciitis in children. A rare case of necrotizing fasciitis in 3-year-old child is described. The difficulties of differential diagnostics of the given disease are presented.Представлен обзор литературы по некротизирующему фасцииту у детей. Описан редкий случай развития некротизирующего фасциита у ребенка 3 лет. Показаны трудности диагностики и дифференциальной диагностики данного заболевания

Clostridium difficile infection.

Infection of the colon with the Gram-positive bacterium Clostridium difficile is potentially life threatening, especially in elderly people and in patients who have dysbiosis of the gut microbiota following antimicrobial drug exposure. C. difficile is the leading cause of health-care-associated infective diarrhoea. The life cycle of C. difficile is influenced by antimicrobial agents, the host immune system, and the host microbiota and its associated metabolites. The primary mediators of inflammation in C. difficile infection (CDI) are large clostridial toxins, toxin A (TcdA) and toxin B (TcdB), and, in some bacterial strains, the binary toxin CDT. The toxins trigger a complex cascade of host cellular responses to cause diarrhoea, inflammation and tissue necrosis - the major symptoms of CDI. The factors responsible for the epidemic of some C. difficile strains are poorly understood. Recurrent infections are common and can be debilitating. Toxin detection for diagnosis is important for accurate epidemiological study, and for optimal management and prevention strategies. Infections are commonly treated with specific antimicrobial agents, but faecal microbiota transplants have shown promise for recurrent infections. Future biotherapies for C. difficile infections are likely to involve defined combinations of key gut microbiota