599 research outputs found
Archeops: an instrument for present and future cosmology
Archeops is a balloon-borne instrument dedicated to measure the cosmic
microwave background (CMB) temperature anisotropies. It has, in the millimetre
domain (from 143 to 545 GHz), a high angular resolution (about 10 arcminutes)
in order to constrain high l multipoles, as well as a large sky coverage
fraction (30%) in order to minimize the cosmic variance. It has linked, before
WMAP, Cobe large angular scales to the first acoustic peak region. From its
results, inflation motivated cosmologies are reinforced with a flat Universe
(Omega_tot=1 within 3%). The dark energy density and the baryonic density are
in very good agreement with other independent estimations based on supernovae
measurements and big bang nucleosynthesis. Important results on galactic dust
emission polarization and their implications for Planck are also addressed.Comment: 4 pages, 2 figures, to appear in Proceedings of the Multiwavelength
Cosmology Conference, June 2003, Mykonos Island, Greec
The Keck+Magellan Survey for Lyman Limit Absorption I: The Frequency Distribution of Super Lyman Limit Systems
We present the results of a survey for super Lyman limit systems (SLLS;
defined to be absorbers with 19.0 <= log(NHI) <= 20.3 cm^-2) from a large
sample of high resolution spectra acquired using the Keck and Magellan
telescopes. Specifically, we present 47 new SLLS from 113 QSO sightlines. We
focus on the neutral hydrogen frequency distribution f(N,X) of the SLLS and its
moments, and compare these results with the Lyman-alpha forest and the damped
Lyman alpha systems (DLA; absorbers with log(NHI) >= 20.3 cm^-2). We find that
that f(N,X) of the SLLS can be reasonably described with a power-law of index
alpha = -1.43^{+0.15}_{-0.16} or alpha = -1.19^{+0.20}_{-0.21} depending on
whether we set the lower N(HI) bound for the analysis at 10^{19.0} cm^-2 or
10^{19.3}$ cm^-2, respectively. The results indicate a flattening in the slope
of f(N,X) between the SLLS and DLA. We find little evidence for redshift
evolution in the shape of f(N,X) for the SLLS over the redshift range of the
sample 1.68 < z < 4.47 and only tentative evidence for evolution in the zeroth
moment of f(N,X), the line density l_lls(X). We introduce the observable
distribution function O(N,X) and its moment, which elucidates comparisons of HI
absorbers from the Lyman-alpha through to the DLA. We find that a simple three
parameter function can fit O(N,X) over the range 17.0 <= log(NHI) <=22.0. We
use these results to predict that f(N,X) must show two additional inflections
below the SLLS regime to match the observed f(N,X) distribution of the
Lyman-alpha forest. Finally, we demonstrate that SLLS contribute a minor
fraction (~15%) of the universe's hydrogen atoms and, therefore, an even small
fraction of the mass in predominantly neutral gas.Comment: 15 pages, 10 figures, accepted to the Astrophysical Journal. Revision
includes updated reference
Script development as a ‘wicked problem’
© 2018 Intellect Ltd Article. Both a process and a set of products, influenced by policy as well as people, and incorporating objective agendas at the same time as subjective experiences, script development is a core practice within the screen industry –yet one that is hard to pin down and, to some extent, define. From an academic research perspective, we might say that script development is a ‘wicked problem’ precisely because of these complex and often contradictory aspects. Following on from a recent Journal of Screenwriting special issue on script development (2017, vol. 8:3), and in particular an article therein dedicated to reviewing the literature and ‘defining the field’, an expanded team of researchers follow up on those ideas and insights. In this article, then, we attempt to theorize script development as a ‘wicked problem’ that spans a range of themes and disciplines. As a ‘wicked’ team of authors, our expertise encompasses screenwriting theory, screenwriting practice, film and television studies, cultural policy, ethnography, gender studies and comedy. By drawing on these critical domains and creative practices, we present a series of interconnected themes that we hope not only suggests the potential for script development as a rich and exciting scholarly pursuit, but that also inspires and encourages other researchers to join forces in an attempt to solve the script development ‘puzzle’
Antigen receptor repertoires of one of the smallest known vertebrates
The rules underlying the structure of antigen receptor repertoires are not yet fully defined, despite their enormous importance for the understanding of adaptive immunity. With current technology, the large antigen receptor repertoires of mice and humans cannot be comprehensively studied. To circumvent the problems associated with incomplete sampling, we have studied the immunogenetic features of one of the smallest known vertebrates, the cyprinid fish Paedocypris sp. “Singkep” (“minifish”). Despite its small size, minifish has the key genetic facilities characterizing the principal vertebrate lymphocyte lineages. As described for mammals, the frequency distributions of immunoglobulin and T cell receptor clonotypes exhibit the features of fractal systems, demonstrating that self-similarity is a fundamental property of antigen receptor repertoires of vertebrates, irrespective of body size. Hence, minifish achieve immunocompetence via a few thousand lymphocytes organized in robust scale-free networks, thereby ensuring immune reactivity even when cells are lost or clone sizes fluctuate during immune responses
The Deuterium to Hydrogen Abundance Ratio Towards a Fourth QSO: HS0105+1619
We report the measurement of the primordial D/H abundance ratio towards QSO
\object. The column density of the hydrogen in the Lyman limit
system is high, \lnhi \cmm, allowing for the deuterium to
be seen in 5 Lyman series transitions. The measured value of the D/H ratio
towards QSO \object is found to be D/H. The
metallicity of the system showing D/H is found to be solar,
indicating that the measured D/H is the primordial D/H within the measurement
errors. The gas which shows D/H is neutral, unlike previous D/H systems which
were more highly ionized. Thus, the determination of the D/H ratio becomes more
secure since we are measuring it in different astrophysical environments, but
the error is larger because we now see more dispersion between measurements.
Combined with prior measurements of D/H, the best D/H ratio is now D/H, which is 10% lower than the previous value. The new
values for the baryon to photon ratio, and baryonic matter density derived from
D/H are and \ob
respectively.Comment: Minor text and reference changes. To appear in the May 10, 2001 issue
of the Astrophysical Journa
157: Outcomes of cord blood transplantation for Hurler’s syndrome. An EUROCORD-working party inborn errors EBMT survey
Relation between falciparum malaria and bacteraemia in Kenyan children: a population-based, case-control study and a longitudinal study.
BACKGROUND: Many investigators have suggested that malaria infection predisposes individuals to bacteraemia. We tested this hypothesis with mendelian randomisation studies of children with the malaria-protective phenotype of sickle-cell trait (HbAS). METHODS: This study was done in a defined area around Kilifi District Hospital, Kilifi, Kenya. We did a matched case-control study to identify risk factors for invasive bacterial disease, in which cases were children aged 3 months to 13 years who were admitted to hospital with bacteraemia between Sept 16, 1999, and July 31, 2002. We aimed to match two controls, by age, sex, location, and time of recruitment, for every case. We then did a longitudinal case-control study to assess the relation between HbAS and invasive bacterial disease as malaria incidence decreased. Cases were children aged 0-13 years who were admitted to hospital with bacteraemia between Jan 1, 1999, and Dec 31, 2007. Controls were born in the study area between Jan 1, 2006, and June 23, 2009. Finally, we modelled the annual incidence of bacteraemia against the community prevalence of malaria during 9 years with Poisson regression. RESULTS: In the matched case-control study, we recruited 292 cases-we recruited two controls for 236, and one for the remaining 56. Sickle-cell disease, HIV, leucocyte haemozoin pigment, and undernutrition were positively associated with bacteraemia and HbAS was strongly negatively associated with bacteraemia (odds ratio 0·36; 95% CI 0·20-0·65). In the longitudinal case-control study, we assessed data from 1454 cases and 10,749 controls. During the study period, the incidence of admission to hospital with malaria per 1000 child-years decreased from 28·5 to 3·45, with a reduction in protection afforded by HbAS against bacteraemia occurring in parallel (p=0·0008). The incidence of hospital admissions for bacteraemia per 1000 child-years also decreased from 2·59 to 1·45. The bacteraemia incidence rate ratio associated with malaria parasitaemia was 6·69 (95% CI 1·31-34·3) and, at a community parasite prevalence of 29% in 1999, 62% (8·2-91) of bacteraemia cases were attributable to malaria. INTERPRETATION: Malaria infection strongly predisposes individuals to bacteraemia and can account for more than half of all cases of bacteraemia in malaria-endemic areas. Interventions to control malaria will have a major additional benefit by reducing the burden of invasive bacterial disease. FUNDING: Wellcome Trust
Precision Primordial He Measurement with CMB Experiments
Big bang nucleosynthesis (BBN) and the cosmic microwave background (CMB) are
two major pillars of cosmology. Standard BBN accurately predicts the primordial
light element abundances (He, D, He and Li), depending on one
parameter, the baryon density. Light element observations are used as a
baryometers. The CMB anisotropies also contain information about the content of
the universe which allows an important consistency check on the Big Bang model.
In addition CMB observations now have sufficient accuracy to not only determine
the total baryon density, but also resolve its principal constituents, H and
He. We present a global analysis of all recent CMB data, with special
emphasis on the concordance with BBN theory and light element observations. We
find and
(fraction of baryon mass as He) using CMB data alone, in agreement with
He abundance observations. With this concordance established we show that
the inclusion of BBN theory priors significantly reduces the volume of
parameter space. In this case, we find
and . We also find that the inclusion of deuterium
abundance observations reduces the and ranges by a factor
of 2. Further light element observations and CMB anisotropy experiments
will refine this concordance and sharpen BBN and the CMB as tools for precision
cosmology.Comment: 7 pages, 3 color figures made minor changes to bring inline with
journal versio
Inhomogeneous Big Bang Nucleosynthesis and Mutual Ion Diffusion
We present a study of inhomogeneous big bang nucleosynthesis with emphasis on
transport phenomena. We combine a hydrodynamic treatment to a nuclear reaction
network and compute the light element abundances for a range of inhomogeneity
parameters. We find that shortly after annihilation of electron-positron pairs,
Thomson scattering on background photons prevents the diffusion of the
remaining electrons. Protons and multiply charged ions then tend to diffuse
into opposite directions so that no net charge is carried. Ions with Z>1 get
enriched in the overdense regions, while protons diffuse out into regions of
lower density. This leads to a second burst of nucleosynthesis in the overdense
regions at T<20 keV, leading to enhanched destruction of deuterium and lithium.
We find a region in the parameter space at 2.1E-10<eta<5.2E-10 where
constraints
7Li/H<10^{-9.7} and D/H<10^{-4.4} are satisfied simultaneously.Comment: 9 pages, minor changes to match the PRD versio
Gas Accretion via Lyman Limit Systems
In cosmological simulations, a large fraction of the partial Lyman limit
systems (pLLSs; 16<log N(HI)<17.2) and LLSs (17.2log N(HI)<19) probes
large-scale flows in and out of galaxies through their circumgalactic medium
(CGM). The overall low metallicity of the cold gaseous streams feeding galaxies
seen in these simulations is the key to differentiating them from metal rich
gas that is either outflowing or being recycled. In recent years, several
groups have empirically determined an entirely new wealth of information on the
pLLSs and LLSs over a wide range of redshifts. A major focus of the recent
research has been to empirically determine the metallicity distribution of the
gas probed by pLLSs and LLSs in sizable and representative samples at both low
(z2) redshifts. Here I discuss unambiguous evidence for
metal-poor gas at all z probed by the pLLSs and LLSs. At z<1, all the pLLSs and
LLSs so far studied are located in the CGM of galaxies with projected distances
<100-200 kpc. Regardless of the exact origin of the low-metallicity pLLSs/LLSs,
there is a significant mass of cool, dense, low-metallicity gas in the CGM that
may be available as fuel for continuing star formation in galaxies over cosmic
time. As such, the metal-poor pLLSs and LLSs are currently among the best
observational evidence of cold, metal-poor gas accretion onto galaxies.Comment: Invited review to appear in Gas Accretion onto Galaxies, Astrophysics
and Space Science Library, eds. A. J. Fox & R. Dav\'e, to be published by
Springe
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